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| 1 | Fault Diagnosis for Manifold Absolute Pressure Sensor(MAP) of Diesel Engine Based on Elman Neural Network Observer显示文摘Intake system of diesel engine is a strong nonlinear system, and it is difficult to establish accurate model of intake system; and bias fault and precision degradation fault of MAP of diesel engine can't be diagnosed easily using model-based methods. Thus, a fault diagnosis method based on Elman neural network observer is proposed. By comparing simulation results of intake pressure based on BP network and Elman neural network, lower sampling error magnitude is gained using Elman neural network, and the error is less volatile. Forecast accuracy is between 0.015?0.017 5 and sample error is controlled within 0?0.07. Considering the output stability and complexity of solving comprehensively, Elman neural network with a single hidden layer and with 44 nodes is presented as intake system observer. By comparing the relations of confidence intervals of the residual value between the measured and predicted values, error variance and failures in various fault types. Then four typical MAP faults of diesel engine can be diagnosed: complete failure fault, bias fault, precision degradation fault and drift fault. The simulation results show: intake pressure is observable and selection of diagnostic strategy parameter reasonably can increase the accuracy of diagnosis;the proposed fault diagnosis method only depends on data and structural parameters of observer, not depends on the nonlinear model of air intake system. A fault diagnosis method is proposed not depending system model to observe intake pressure, and bias fault and precision degradation fault of MAP of diesel engine can be diagnosed based on residuals. | WANG Yingmin ZHANG Fujun CUI Tao ZHOU Jinlong | 2016 | Chinese Journal of Mechanical Engineering2016，29，2： | 17 |
| 2 | Analysis of characteristics and predictive factors of immune checkpoint inhibitor-related adverse events显示文摘Objective:We aimed to retrospectively analyze the toxicity profiles and predictors of immune-related adverse events(irAEs)as well as the correlation between irAEs and the clinical efficacy of multi-type immune checkpoint inhibitors(ICIs)in patients with advanced pan-cancer in a real-world setting.Methods:We retrospectively analyzed data from 105 patients with advanced pan-cancer treated with multi-type ICIs at the First Hospital of Jilin University between January 1,2016 and August 1,2020.We used logistic regression analyses to investigate the associations of irAEs with clinical baseline characteristics,blood count parameters,and biochemical indicators during treatment.Receiver operating characteristic curves were used to determine cutoff values for parameters and area under the curve values.Kaplan–Meier and Cox multivariate regression analyses were performed to estimate the relationships of baseline characteristics and irAEs with progression-free survival(PFS)and overall survival(OS).Results:A lower relative lymphocyte count(cutoff=28.5%),higher albumin level(cutoff=39.05 g/L),and higher absolute eosinophil count(AEC)(cutoff=0.175×10^(9)/L)were significantly associated with the occurrence of irAEs,among which a higher AEC(cutoff=0.205×10^(9)/L)was strongly associated with skin-related irAEs[odds ratios(ORs)=0.163,P=0.004].Moreover,a higher lactate dehydrogenase level(cutoff=237.5 U/L)was an independent predictor of irAEs of grade≥3(OR=0.083,P=0.023).In immune cell subgroup analysis,a lower absolute count of CD8+CD28−suppressor T cells(OR=0.806;95%confidence interval:0.643–1.011;P=0.062),which are regulatory T lymphocytes,was associated with the occurrence of irAEs,although the difference was not statistically significant.Furthermore,a higher percentage of CD19+B cells was associated with the occurrence of irAEs of grade≥3(P=0.02)and grade≥2(P=0.051).In addition,patients with any grade of irAE had a significantly high PFS(8.37 vs.3.77 months,hazard ratios(HR)=2.02,P=0.0038)and OS(24.77 vs.13.83 months,HR=1.84;P=0.024).Conclusions:This retrospective study reports clinical profile data for irAEs in unselected patients in a real-world setting and explored some parameters that may be potential predictive markers of the occurrence,type,or grade of irAEs in clinical practice.Evidence of a correlation between safety and efficacy may facilitate a complete assessment of the risk-benefit ratio for patients treated with ICIs. | Rilan Bai Naifei Chen Xiao Chen Lingyu Li Wei Song Wei Li Yuguang Zhao Yongfei Zhang Fujun Han Zheng Lyu Jiuwei Cui | 2021 | Cancer Biology & Medicine2021，18，4： | 4 |
| 3 | Preparation of monoclonal antibody against human KIAA0100 protein and Northern blot analysis of human KIAA0100 gene显示文摘Monoclonal antibodies(MAbs) are important tools for the study of proteins′ function and structure. But there has been no report on the preparation of MAbs against human KIAA0100 protein up to date. Here, first, we generated the mouse MAb against human KIAA0100 protein using purified recombinant 6×Histidinc(6×His)-tagged human KIAA0100 protein segment(1557–2234) as an antigen; then, the m RNA expression of human KIAA0100 gene was detected in U937 cells using Northern blot analysis. The results showed that the mouse MAb against human KIAA0100 protein could sensitively recognize the human KIAA0100 protein using Western blot analysis and immunocytochemistry analysis. Besides, Western blot analysis revealed that human KIAA0100 gene possibly encoded two different protein products(254 k Da and < 250 k Da) in U937 cells. Moreover,Northern blot analysis confirmed that human KIAA0100 gene might produced two different m RNA products(6000–10000 bp and 5000–6000 bp) in U937 cells. The results provide a basis for large-scale production of the MAb against human KIAA0100 protein, which will be useful for the study of human KIAA0100 protein′s function/structure and MAb-targeted drugs in the future. | He Cui Xi Lan Shemin Lu Fujun Zhang Wanggang Zhang | 2017 | Journal of Pharmaceutical Analysis2017，7，3： | 4 |
| 4 | A New and Facile Strategy for Determination of Lead and Cadmium Using Silver Electrodes Manufactured from Digital Versatile Discs显示文摘 | CUI Wenyu FAN Lishuang GENG Lin AN Maozhong ZHANG Fujun | 2017 | Chemical Research in Chinese Universities2017，33，5： | 1 |
| 5 | miR-200b suppresses cell proliferation, migration and enhances chemosensitivityin prostate cancer by regulating Bmi-1显示文摘 | Junjie Yu Youyi Lu Di Cui Enhui Li Yipin Zhu Yuyang Zhao Fujun Zhao Shujie Xia | 2014 | Oncology Reports2014，，2： | 1 |
| 6 | Bioinformatic prediction and functional characterization of human KIAA0100 gene显示文摘Our previous study demonstrated that human KIAA0100 gene is a novel acute monocytic leukemia-associated antigen(MLAA) gene. But the functional characterization of human KIAA0100 gene has remained unknown to date. Here, firstly, bioinformatic prediction of human KIAA0100 gene was carried out using online software;Secondly, human KIAA0100 gene expression was downregulated by the clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated(Cas) 9 system in U937 cells. Cell proliferation and apoptosis were next evaluated in KIAA0100-knockdown U937 cells. The bioinformatic prediction showed that human KIAA0100 gene was located on 17q11.2, and human KIAA0100 protein was located in the secretory pathway. Besides, human KIAA0100 protein contained a signal peptide, a transmembrane region, three types of secondary structures(alpha helix, extended strand, and random coil), and four domains from mitochondrial protein 27(FMP27). The observation on functional characterization of human KIAA0100 gene revealed that its downregulation inhibited cell proliferation, and promoted cell apoptosis in U937 cells. To summarize, these results suggest human KIAA0100 gene possibly comes within mitochondrial genome; moreover, it is a novel anti-apoptotic factor related to carcinogenesis or progression in acute monocytic leukemia, and may be a potential target for immunotherapy against acute monocytic leukemia. | He Cui Xi Lan Shemin Lu Fujun Zhang Wanggang Zhang | 2017 | Journal of Pharmaceutical Analysis2017，7，1： | 1 |
| 7 | One-pot synthesis of dimethyl carbonate using ethylene oxide,methanol,and carbon dioxide under supercritical conditions显示文摘 | Cui Hongyou Wang Tao Wang Fujun | 2003 | Industrial & Engineering Chemistry Research2003，42，： | 1 |
| 8 | Kinetic study on the one-pot systhesis of dimethyl carbonate in supercritical CO2 conditions显示文摘 | Cui Hongyou Wang Tao Wang Fujun | 2004 | Industrial & Engineering Chemistry Research2004，43，： | 1 |
| 9 | Engineering graphene/carbon nanotube hybrid for direct electron transfer of glucose oxidase and glucose biosensor显示文摘 | Jianli Chen Xianliang Zheng Fujun Miao Jienan Zhang Xiaoqiang Cui Weitao Zheng | 2012 | Journal of Applied Electrochemistry2012，，10： | 1 |
| 10 | Optimization of Waste Gate Drive Circuit of Two-Stage Turbocharging System显示文摘A two stage turbocharging control system was proposed,in which the pressure regulator valve with a close-loop pressure adjusting function instead of a high speed on-off solenoid valve,is used as a driving mechanism of waste gate.A digital-analog(DA)conversion circuit based on pulse width modulation(PWM)generates one analog voltage signal required by the pressure regulating valve control.The principle of the DA conversion circuit was analyzed,meanwhile,the performance of the conversion circuit was improved by adopting a speed-up capacitor,which helps to increase the stability and responsiveness of the control voltage generated by the conversion circuit;the structure parameters of the circuit was optimized by simulation.After the optimization,the ripple wave of circuit output voltage was kept within16mV under the 12bit conversion accuracy,the conversion time of the circuit could be reduced to 4ms.The engine bench test show that the turbocharging boost pressure control system which adopted the circuit had a rather good stable control accuracy(the steady state within 0.8%)and dynamic response(the regulation time is less than 4s). | Fujun Zhang Jiahang Chang Tao Cui Meng Xia | 2017 | Journal of Beijing Institute of Technology2017，26，3： | 0 |
| 11 | LOCAL AND GLOBAL EXISTENCE OF SOLUTIONS OF THE GINZBURG-LANDAU TYPE EQUATIONS显示文摘 | Zhou Fujun Cui Shangbin | 2007 | Journal of Partial Differential Equations2007，20，3： | 0 |
| 12 | LOCAL SOLVABILITY OF THE CAUCHY PROBLEM OF A FIFTH-ORDER NONLINEAR DISPERSIVE EQUATION显示文摘第五顺序的非线性的散方程(partialderiv ) 的解决之可能性 _t u +α u ((部分 deriv )_xu )~ 2 + β(部分 deriv )_x^3u + γ(部分 deriv )_x^5u = 0 被学习。由为相应线性问题使用 Kenig ,妓院老板和 Vega 和一些 Strichartz 估计的途径,如果起始的函数 u_0 属于 H^s (R)和 s ,它被证明那> 1/4 ,那么, Cauchy 问题在 C 有一个唯一的解决方案([- T , T ], H^s (R))为一些 T > 0 。 | Zhou Fujun Cui Shangbin | 2005 | Applied Mathematics(A Journal of Chinese Universities)2005，20，4： | 0 |
| 13 | Morphology and Molecular Identification of Ulva Forming Green Tides in Qingdao,China显示文摘Green tides are caused by the proliferation of chlorophytes under suitable hydrographic conditions.These blooms lead to environmental degradation and negatively impact the waters and seagrass beds,as well as fishing and other recreational activities in the bay.A comprehensive ecological understanding of the bloom dynamics,including the origin and persistence,is needed to foster management decisions.The algae in the great majority of green tide blooms usually belong to two genera of Ulvophyceae,Ulva and Enteromorpha.Ulva has been observed more often in recent years.In China,green tides occurred for the first time in the middle area of the Yellow Sea in 2007,and a large-scale algae blooming broke out in the middle and southern areas of the Yellow Sea in late May 2008.We identified them as Ulva prolifera by comparative analysis of the rDNA internal transcribed spacer 1 (ITS1),5.8S and ITS2 sequences in combination with microscopic observation.Morphological differences were found between the free-floating algae and the attached thalli.Various reproduction patterns of the free-floating algae include sexual,asexual and vegetative propagations,which played important roles in the long-term green tide persistence in China.The ITS sequences of the blooming algae were identical to those of the samples from the Lianyungang sea area but were different from the attached samples from the Qingdao sea area.The results infer that the blooms are originated from other sea areas rather than from the local attached populations. | KONG Fanna MAO Yunxiang CUI Fujun ZHANG Xingkui GAO Zhen | 2011 | Journal of Ocean University of China2011，10，1： | 0 |
| 14 | Taxifolin attenuates inflammation via suppressing MAPK signal pathway in vitro and in silico analysis显示文摘Objective:Taxifolin is a natural flavonoid compound that can be isolated from onions,grapes,oranges and grapefruit.It also acts as a medicine food homology with extraordinary antioxidant and antiinflammatory activity.This study aims to explain the protective effects and potential mechanisms of taxifolin against inflammatory reaction.Methods:Levels of interleukin(IL)-6,IL-1βand intracellular reactive oxygen species(ROS)were assessed in different time after the treatment of taxifolin in RAW264.7 cells induced by lipopolysaccharide(LPS).Subsequently,the m RNA and protein levels of inducible nitric oxide synthase(i NOS),vascular endothelial growth factor(VEGF),cyclooxygenase(COX)-2,tumor necrosis factor(TNF)-a and the phosphorylation expression levels of the MAPK signal pathway were also evaluated.A silico analysis was used to explain the binding situation for the investigation of taxifolin and MAPK signal pathway.And then MAPK inhibitors were used to reveal the expression level of i NOS,VEGF,COX-2 and TNF-a in RAW264.7 cells.Results:It was demonstrated that cell inflammatory damage induced by LPS was significantly alleviated after the treatment of taxifolin.Then,the m RNA and protein levels of i NOS,VEGF,COX-2 and TNF-a were reduced and the phosphorylation expression levels of the MAPK signal pathway were down-regulated remarkably as well.In silico analysis,taxifolin could form a relatively stable combination with MAPK signal pathway.MAPK inhibitors showed increasing or decreasing effect in the m RNA levels of i NOS,VEGF,COX-2 and TNF-a,which suggesting that taxifolin down-regulated i NOS,VEGF,COX-2 and TNF-a expressions were not entirely through the MAPK pathway.Conclusion:This finding demonstrated that taxifolin improved the inflammatory responses that partly involved in the phosphorylation expression level of MAPK signal pathway in RAW264.7 cells exposed to acute stress. | Xingyan Zhang Xiaoyan Lian Huling Li Wenjing Zhao Xin Li Fujun Zhou Yutong Zhou Tao Cui Yuli Wang Changxiao Liu | 2022 | Chinese Herbal Medicines2022，14，4： | 0 |
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