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| 1 | Variations in melt supply along an orthogonal supersegment of the Southwest Indian Ridge(16°–25°E)显示文摘The orthogonal supersegment of the ultraslow-spreading Southwest Indian Ridge at 16°–25°E is characterized by significant along-axis variations of mantle potential temperature.A detailed analysis of multibeam bathymetry,gravity,and magnetic data were performed to investigate its variations in magma supply and crustal accretion process.The results revealed distinct across-axis variations of magma supply.Specifically,the regionally averaged crustal thickness reduced systematically from around 7 Ma to the present,indicating a regionally decreasing magma supply.The crustal structure is asymmetric in regional scale between the conjugate ridge flanks,with the faster-spreading southern flank showing thinner crust and greater degree of tectonic extension.Geodynamic models of mantle melting suggested that the observed variations in axial crustal thickness and major element geochemistry can be adequately explained by an eastward decrease in mantle potential temperature of about40℃ beneath the ridge axis.In this work,a synthesized model was proposed to explain the axial variations of magma supply and ridge segmentation stabilities.The existence of large ridge-axis offsets may play important roles in controlling melt supply.Several large ridge-axis offsets in the eastern section(21°–25°E)caused sustained along-axis focusing of magma supply at the centers of eastern ridge segments,enabling quasi-stable segmentation.In contrast,the western section(16°–21°E),which lacks large ridge-axis offsets,is associated with unstable segmentation patterns. | Caicai Zha Jian Lin Zhiyuan Zhou Xubo Zhang Min Xu Fan Zhang | 2021 | Acta Oceanologica Sinica2021，40，5： | 0 |
| 2 | Neural stem cell-derived exosomes regulate cell proliferation,migration,and cell death of brain microvascular endothelial cells via the miR-9/Hes1 axis under hypoxia显示文摘Background:Our previous study found that mouse embryonic neural stem cell(NSC)-derived exosomes(EXOs)regulated NSC differentiation via the miR-9/Hes1 axis.However,the effects of EXOs on brain microvascular endothelial cell(BMEC)dysfunction via the miR-9/Hes1 axis remain unknown.Therefore,the current study aimed to determine the effects of EXOs on BMEC proliferation,migration,and death via the miR-9/Hes1 axis.Methods:Immunofluorescence,quantitative real-time polymerase chain reaction,cell counting kit-8 assay,wound healing assay,calcein-acetoxymethyl/propidium iodide staining,and hematoxylin and eosin staining were used to determine the role and mechanism of EXOs on BMECs.Results:EXOs promoted BMEC proliferation and migration and reduced cell death under hypoxic conditions.The overexpression of miR-9 promoted BMEC prolifera-tion and migration and reduced cell death under hypoxic conditions.Moreover,miR-9 downregulation inhibited BMEC proliferation and migration and also promoted cell death.Hes1 silencing ameliorated the effect of amtagomiR-9 on BMEC proliferation and migration and cell death.Hyperemic structures were observed in the regions of the hippocampus and cortex in hypoxia-induced mice.Meanwhile,EXO treatment improved cerebrovascular alterations.Conclusion:NSC-derived EXOs can promote BMEC proliferation and migra-tion and reduce cell death via the miR-9/Hes1 axis under hypoxic conditions.Therefore,EXO therapeutic strategies could be considered for hypoxia-induced vascular injury. | Xiaojun Deng Xiaoyi Hu Shang Wang Hui Zhao Yaqin Wei Jiaqi Fu Wenhui Wu Jinming Liu Caicai Zhang Lili Wang Ping Yuan | 2024 | Animal Models and Experimental Medicine2024，7，1： | 0 |
| 3 | Privacy-Preserving Multi-Keyword Fuzzy Adjacency Search Strategy for Encrypted Graph in Cloud Environment显示文摘In a cloud environment,outsourced graph data is widely used in companies,enterprises,medical institutions,and so on.Data owners and users can save costs and improve efficiency by storing large amounts of graph data on cloud servers.Servers on cloud platforms usually have some subjective or objective attacks,which make the outsourced graph data in an insecure state.The issue of privacy data protection has become an important obstacle to data sharing and usage.How to query outsourcing graph data safely and effectively has become the focus of research.Adjacency query is a basic and frequently used operation in graph,and it will effectively promote the query range and query ability if multi-keyword fuzzy search can be supported at the same time.This work proposes to protect the privacy information of outsourcing graph data by encryption,mainly studies the problem of multi-keyword fuzzy adjacency query,and puts forward a solution.In our scheme,we use the Bloom filter and encryption mechanism to build a secure index and query token,and adjacency queries are implemented through indexes and query tokens on the cloud server.Our proposed scheme is proved by formal analysis,and the performance and effectiveness of the scheme are illustrated by experimental analysis.The research results of this work will provide solid theoretical and technical support for the further popularization and application of encrypted graph data processing technology. | Bin Wu Xianyi Chen Jinzhou Huang Caicai Zhang Jing Wang Jing Yu Zhiqiang Zhao Zhuolin Mei | 2024 | Computers, Materials & Continua2024，78，3： | 0 |
| 4 | Analysis of a Synechococcus sp. Bloom in the East China Sea and Its Causes显示文摘In the spring of 2007,a Synechococcus sp. bloom was monitored in station A1( 30° N,123° E) in the East China Sea. The abundance of Synechococcus sp. was nearly 2×10~6 cells/ml,and the contribution of Synechococcus sp. to chlorophyll a was nearly 90%. According to the abundance of Synechococcus sp. in the East China Sea and adjacent Changjiang River estuary in the past tow decades,the main reasons why Synechococcus sp. could form a bloom are listed below: the rising level of nutrients and the further eutrophication of the water body provided sufficient nutrients for Synechococcus sp.;with the global warming,the sea water temperature in the East China Sea rose continuously;the number of major predator heterotrophic flagellates was at a low level,reducing predation pressure. | Haofei ZHANG Caicai LIU Bangping DENG | 2020 | Meteorological and Environmental Research2020，11，3： | 0 |
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