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您的检索式：作者名="Caiguang Liu"
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| 1 | Why are oseltamivir and zanamivir effective against the newly emerged influenza A virus (A/HIN1)?显示文摘 | Kunqian Yu Cheng Luo Guangrong Qin Zhijian Xu Ning Li Hong Liu Xu Shen Jianpeng Ma Qinghua Wang Caiguang Yang Weiliang Zhu Hualiang Jiang | 2009 | Cell Research2009，19，10： | 6 |
| 2 | Dynamic modifications of biomacromolecules: mechanism and chemical interventions显示文摘Biological macromolecules(proteins,nucleic acids,polysaccharides,etc.)are the building blocks of life,which constantly undergo chemical modifications that are often reversible and spatial-temporally regulated.These dynamic properties of chemical modifications play fundamental roles in physiological processes as well as pathological changes of living systems.The Major Research Project(MRP)funded by the National Natural Science Foundation of China(NSFC)—'Dynamic modifications of biomacromolecules:mechanism and chemical interventions'aims to integrate cross-disciplinary approaches at the interface of chemistry,life sciences,medicine,mathematics,material science and information science with the following goals:(i)developing specific labeling techniques and detection methods for dynamic chemical modifications of biomacromolecules,(ii)analyzing the molecular mechanisms and functional relationships of dynamic chemical modifications of biomacromolecules,and(iii)exploring biomacromolecules and small molecule probes as potential drug targets and lead compounds. | Chu Wang Peng Zou Caiguang Yang Lei Liu Liang Cheng Xiaopeng He Liang Zhang Yan Zhang Hualiang Jiang Peng RChen | 2019 | Science China(Life Sciences)2019，62，11： | 2 |
| 3 | Development and validation of a nomogram to predict indolent course in patients with ulcerative colitis:a single-center retrospective study显示文摘Background:The natural disease course for patients with ulcerative colitis(UC)is heterogeneous and few data are available on the indolent course of UC and its related factors.We aimed to develop and validate a nomogramto predict indolent course in patients with UC.Methods:Data of patients diagnosed with UC in the First Affiliated Hospital of Sun Yat-sen University(Guangzhou,China)between April 2007 and February 2021 were retrospectively analysed.Indolent course was defined as a disease course without need for strict interventions(steroids,immunomodulators,biological agents,hospitalization,or surgery therapy)during the follow-up period.The whole cohort was randomly divided into training set and validation set.The nomogram was constructed in the training set based on the results of univariate and multivariate Cox regression analyses.The performance of the nomogram was assessed by the concordance index(C-index),area under the receiver-operating characteristic curve(AUC),and calibration plots.In addition,we internally validated the nomogramvia the bootstrap method and the validation set.Results:Of 969 treatment-naive patients with UC,771(79.6%)had an indolent course after diagnosis.Of these,313 patients were included in the development and validation of the nomogram.The nomogram incorporating age,disease activity,C-reactive protein,and platelet count showed good calibration and discrimination.The C-index was 0.759(0.741 in bootstrap validation)and the AUC at 2,4,and 6 years was 0.767,0.782,and 0.775,respectively.The nomogramperformed well when applied to the validation set.Conclusion:A majority of patients with UC had an indolent course after diagnosis.The nomogram developed in this study might be useful in therapeutic decision-making and follow-up management for patients with UC. | Na Li Shukai Zhan Caiguang Liu Tong Li Tong Tu Baili Chen Yao He Minhu Chen Zhirong Zeng Xiaojun Zhuang | 2022 | Gastroenterology Report2022，10，1： | 0 |
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