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| 1 | SARS-CoV-2 infection aggravates chronic comorbidities of cardiovascular diseases and diabetes in mice显示文摘Background:Cardiovascular diseases(CVDs)and diabetes mellitus(DM)are top two chronic comorbidities that increase the severity and mortality of COVID-19.However,how SARS-CoV-2 alters the progression of chronic diseases remain unclear.Methods:We used adenovirus to deliver h-ACE2 to lung to enable SARS-CoV-2 infection in mice.SARS-CoV-2’s impacts on pathogenesis of chronic diseases were studied through histopathological,virologic and molecular biology analysis.Results:Pre-existing CVDs resulted in viral invasion,ROS elevation and activation of apoptosis pathways contribute myocardial injury during SARS-CoV-2 infection.Viral infection increased fasting blood glucose and reduced insulin response in DM model.Bone mineral density decreased shortly after infection,which associated with impaired PI3K/AKT/mTOR signaling.Conclusion:We established mouse models mimicked the complex pathological symptoms of COVID-19 patients with chronic diseases.Pre-existing diseases could impair the inflammatory responses to SARS-CoV-2 infection,which further aggravated the pre-existing diseases.This work provided valuable information to better understand the interplay between the primary diseases and SARS-CoV-2 infection. | Yuanwu Ma Dan Lu Linlin Bao Yajin Qu Jiangning Liu Xiaolong Qi Lei Yu Xu Zhang Feifei Qi Qi Lv Yunpeng Liu Xudong Shi Caixian Sun Jing Li Jie Wang Yunlin Han Kai Gao Wei Dong Ning Liu Shan Gao Jing Xue Qiang Wei Sidan Pan Hong Gao Lianfeng Zhang Chuan Qin | 2021 | Animal Models and Experimental Medicine2021，4，1： | 3 |
| 2 | Numerical experiment rock fragmentation by combined dynamic and static loads under dual-cutter head显示文摘This paper puts forward a new rock fragmentation loading method of dual-cutter head combined dynamic and static loads.By applying the numerical simulation software-RFPA2D,we have done numerical experiment about the siltstone's crushing effect by dynamic load on single cutter head without confining pressure,dynamic load on single cutter head with confining pressure 10MPa and different dual-cutter heads spacing by combined dynamic and static loads with confining pressure 10MPa.Experimental results show that the confining pressure can obviously affect the rock fragmentation effect.Combined dynamic and static loads can greatly improve the rock fragmentation effect.There exists an optimal spacing of dual-cutter head that can make the rock fragmentation achieve the desired effect.Through analyzing the acoustic emission accumulative energy and quantity,the authors make a conclusion that the optimum spacing is 30 mm. | Zhao Fujun Wang Hongyu Shen Peiwen Chen Caixian Xu Yanfei | 2012 | Engineering Sciences2012，10，2： | 3 |
| 3 | Do Forest Landscape Pattern Planning and Optimization Play a Role in Enhancing Soil Conservation Services in Mountain Areas of Western China?显示文摘The relationship between landscape patterns and soil conservation,as well as the need for nature-based soil erosion control and landscape pattern optimization,have increasingly gained attention in the scientific and political community in the past decade.With the implementation of a series of afforestation/reforestation projects in the western China,the optimization and management of forest landscape patterns will become more important for soil conservation.In this study,the Bailongjiang Watershed(BLJW),in the western China,was used as a case study to explore the relationship between the forest landscape pattern and soil conservation services using mathematical and spatial statistics methods.A spatially-explicit model called the sediment delivery ratio(SDR)model of the Integrated Valuation of Ecosystem Services and Tradeoffs(InVEST)was used to assess the soil conservation service in each sub-basin of BLJW in 1990,2002,and 2014,and landscape indices were used to describe changes in forest landscape patterns in each sub-basin.Nine forest landscape indices,including the percentage of landscape(PLAND),largest patch index(LPI),edge density(ED),landscape shape index(LSI),mean patch shape(SHAPEMN),patch cohesion index(COHESION),landscape division index(DIVISION),splitting index(SPLIT)and aggregation index(AI),were significantly correlated to the soil conservation service.PLAND,AI,LSI and SPLIT of forestland were determined to be the more important landscape indicators.The results also indicated that soil conservation was substantially scale-dependent.The results demonstrated that landscape type diversity greatly affected watershed soil conservation and can be used for forest landscape restoration and management.Furthermore,spatial statistics analysis indicated that the Spatial Lag Model(SLM)was superior to the Ordinary Least Squares(OLS)for soil conservation regressions in 1990 and 2014,while OLS was more appropriate for the regression in 2002.These findings will be useful for enhancing soil conservation and for optimizing mountainous forest landscape patterns for afforestation/reforestation and regional development.Future planning and implementation of ecological restoration should focus more on strategic spatial planning and integrated landscape management with full consideration of future climate,water availability/consumption,hydrological regime,topography,and watershed features,especially on afforestation and revegetation projects in western mountainous China,where the socio-ecological system is fragile and poor. | GONG Jie ZHANG Jinxi ZHANG Yunxia ZHU Yuehua JIN Tiantian XU Caixian | 2021 | Chinese Geographical Science2021，31，5： | 3 |
| 4 | Knock in of a hexanucleotide repeat expansion in the C9orf72 gene induces ALS in rats显示文摘Background:The GGGGCC(G4C2)repeat expansion in the human open reading frame 72 on chromosome 9,C9orf72,is the most common cause of amyotrophic lateral sclerosis(ALS).Studies in transgenic mouse models have linked the pathogenic mechanism of G4C2 repeat expansion to RNA foci or the accumulation of unnatural dipeptide repeats in neurons.However,only one of the existing transgenic mouse lines developed typical ALS.Methods:C9orf72 knockin rats were generated by knockin of 80 G4C2 repeats with human flanking fragments within exon1a and exon1b at the rat C9orf72 locus.Protein expression was detected by western blot.Motor coordination and grip force were measured using a Rotarod test and a grip strength test.Neurodegeneration was assessed by Nissl staining with cresyl violet.Results:C9orf72 haploinsufficiency reduced C9orf72 protein expression 40%in the cerebrum,cerebellum and spinal cords from knockin rats(P<.05).The knockin(KI)rats developed motor deficits from 4 months of age.Their falling latencies and grip force were decreased by 67%(P<.01)and 44%(P<.01),respectively,at 12 months of age compared to wild-type(WT)mice.The knockin of the hexanucleotide repeat expansion(HRE)caused a 47%loss of motor neurons in the spinal cord(P<.001)and 25%(5/20)of female KI rats developed hind limb paralysis at 13 to 24 months.Conclusion:Motor defects in KI rats may result from neurotoxicity caused by HRE and the resulting reduction in C9orf72 protein due to haploinsufficiency.These KI rats could be a useful model for investigating the contributions of loss-of-function to neurotoxicity in C9orf72-related ALS. | Wei Dong Li Zhang Caixian Sun Xiang Gao Feifei Guan Jing Li Wei Chen Yuanwu Ma Lianfeng Zhang | 2020 | Animal Models and Experimental Medicine2020，3，3： | 2 |
| 5 | Evodiamine derivatives improve cognitive abilities in APP^(swe)/PS1^(ΔE9) transgenic mouse models of Alzheimer's disease显示文摘Background: Alzheimer's disease(AD) is a complex neurodegenerative disease. Due to the complexity of its molecular pathogenesis and the interaction of the numerous factors involved, the etiology and pathogenesis of AD have not been fully elucidated. Therefore, effective treatment for AD remains to be developed. Evodiamine, a quinolone alkaloid, has been found to improve learning and memory ability to in the APP^(swe)/PS1^(ΔE9) mouse model of dementia. However, the cytotoxicity and physicochemical properties of evodiamine have limited its use in the treatment of AD.Methods: Evodiamine and its derivatives were effectively synthesized by EDCImediated condensation at room temperature. These target compounds contained 1 thio-and 21 oxo-evodiamine derivatives with different substituted groups. The cytotoxicity of evodiamine and its derivatives and the neuroprotective effects of the evodiamine derivatives against H_2O_2-induced cell loss in SH-SY5 Y cells were investigated using the WST-8 assay. The Morris water-maze test was used to detect the effect of evodiamine and its derivatives on improving learning and memory in APP^(swe)/PS1^(ΔE9) mice.Results: In this study, a series of oxo-and thio-evodiamine derivatives was synthesized. Several derivatives showed lower cytotoxicity and stronger neuroprotective effects than evodiamine and elicited enhanced cognitive improvement, especially in the test of spatial memory in APP^(swe)/PS1^(ΔE9) mice.Conclusion: Our study provides insights for developing novel evodiamine derivatives for chemical intervention and treatment of AD. | Shuo Pang Caixian Sun Shan Gao Yajun Yang Xiandao Pan Lianfeng Zhang | 2020 | Animal Models and Experimental Medicine2020，3，2： | 2 |
| 6 | Electro-chimica Acta显示文摘 | Chang Caixian Xiang Jiangfeng Shi Xixi | 2008 | 53(5):22322008，53，5： | 1 |
| 7 | Study on the non-isothermal crystallization kinetics of novel polyamide 6/silica nanocomposites containing epoxy resins显示文摘 | Caixian Zhao Ping Zhang and Lanhua Yi | 2008 | 27(4): 412-4192008，27，4： | 1 |
| 8 | Origins of root-mediated pH changes in the rihizosphere and their responses to environmental constrains:A review显示文摘 | Hinsinger P Claude Plassard C Caixian Tang C | | 0，，： | 1 |
| 9 | Rheological phase reaction synthesis and electrochemical performance of Li3V2 (PO4)3/carbon cathode for lithium ion batteries显示文摘 | Chang Caixian Xiang Jiangfeng Shi Xixi | 2008 | Electrochimica Acta2008，53，5： | 1 |
| 10 | Rheological phase reaction synthesis and electrochemical performance of Li3V2 ( PO4 )3/carbon cathode for lithium ion batteries 显示文摘 | Chang Caixian Xiang Jiangfeng Shi Xixi | 2008 | Electrochimica Acta2008，53，： | 1 |
| 11 | Bi- oleaching of heavy metals from sewage sludgeusing indigenous i- ron - oxidizing microorganisms 显示文摘 | Ye - Ming Wen Ying Cheng Caixian Tang | 2013 | Soils Sediments2013，13，： | 1 |
| 12 | Bioleaching of heavy metals from sewage sludge using indigenous iron-oxidizing microorganisms显示文摘 | Ye-Ming Wen Ying Cheng Caixian Tang Zu-Liang Chen | 2013 | Journal of Soils and Sediments2013，，1： | 1 |
| 13 | Interspecific facilitation of nutrient uptake by intercropped maize and faba bean显示文摘 | Long Li Fusuo Zhang Xiaolin Li Peter Christie Jianhao Sun Sicun Yang Caixian Tang | 2003 | Nutrient Cycling in Agroecosystems2003，，1： | 1 |
| 14 | Studies on the properties of a new hybrid materials containing hyperbranched polymer and SiO2-TiO2 networks显示文摘 | LU SHAORONG ZHANG HAILIANG ZHAO CAIXIAN | 2005 | Journal of Macromolecular Science Part A: Pure and Applied Chemistry2005，42，： | 1 |
| 15 | Interspecific facilitation of nutrient uptake by intercropped maize and faba bean显示文摘 | Long Li Fusuo Zhang Xiaolin Li Peter Christie Jianhao Sun Sicun Yang Caixian Tang | 2003 | Nutrient Cycling in Agroecosystems2003，，1： | 1 |
| 16 | Facilitation of pentachlorophenol degradation in the rhizosphere of ryegrass ( Lolium perenne L.)显示文摘 | Yan He Jianming Xu Caixian Tang Yuping Wu | 2005 | Soil Biology and Biochemistry2005，，11： | 1 |
| 17 | Application of 16S rDNA-PCR amplification and DGGE fingerprinting for detection of shift in microbial community diversity in Cu-, Zn-, and Cd-contaminated paddy soils 显示文摘 | LI Zhaojun XU Jianming TANG Caixian | 2006 | Chemosphere2006，62，8： | 1 |
| 18 | Phosphorus Deficiency Delays the Onset of Nodule Function in Soybean显示文摘 | Yunfa Qiao Caixian Tang Xiaozeng Han Sujie Miao | 2007 | Journal of Plant Nutrition2007，，9： | 1 |
| 19 | Study on the Non-isothermal Crystallization Behaviors of PA6/silica nanocomposites Prepared by the Sol-gel Process显示文摘 | ZHAO Caixian ZHANG Ping LU Shaorong | 2007 | Journal of Materials Science2007，42，21： | 1 |
| 20 | Chickpea facilitates phosphorus uptake by intercropped wheat from an organic phosphorus source显示文摘 | Long Li Caixian Tang Zdenko Rengel Fusuo Zhang | 2003 | Plant and Soil2003，，1： | 1 |
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