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| 1 | Elucidation of the ‘Honeycrisp’ pedigree through haplotype analysis with a multi-family integrated SNP linkage map and a large apple (Malus×domestica) pedigree-connected SNP data set显示文摘The apple(Malus×domestica)cultivar Honeycrisp has become important economically and as a breeding parent.An earlier study with SSR markers indicated the original recorded pedigree of‘Honeycrisp’was incorrect and‘Keepsake’was identified as one putative parent,the other being unknown.The objective of this study was to verify‘Keepsake’as a parent and identify and genetically describe the unknown parent and its grandparents.A multi-family based dense and high-quality integrated SNP map was created using the apple 8 K Illumina Infinium SNP array.This map was used alongside a large pedigree-connected data set from the RosBREED project to build extended SNP haplotypes and to identify pedigree relationships.‘Keepsake’was verified as one parent of‘Honeycrisp’and‘Duchess of Oldenburg’and‘Golden Delicious’were identified as grandparents through the unknown parent.Following this finding,siblings of‘Honeycrisp’were identified using the SNP data.Breeding records from several of these siblings suggested that the previously unreported parent is a University of Minnesota selection,MN1627.This selection is no longer available,but now is genetically described through imputed SNP haplotypes.We also present the mosaic grandparental composition of‘Honeycrisp’for each of its 17 chromosome pairs.This new pedigree and genetic information will be useful in future pedigree-based genetic studies to connect‘Honeycrisp’with other cultivars used widely in apple breeding programs.The created SNP linkage map will benefit future research using the data from the Illumina apple 8 and 20 K and Affymetrix 480 K SNP arrays. | Nicholas P Howard Eric van de Weg David S Bedford Cameron P Peace Stijn Vanderzande Matthew D Clark Soon Li Teh Lichun Cai James J Luby | 2017 | Horticulture Research2017，4，1： | 9 |
| 2 | One hundred and seventy-eight consecutive pancreatoduodenectomies without mortality:role of the multidisciplinary approach显示文摘BACKGROUND:Pancreatoduodenectomy offers the only chance of cure for patients with periampullary cancers.This,however,is a major undertaking in most patients and is associated with a significant morbidity and mortality.A multidisciplinary approach to the workup and follow-up of patients undergoing pancreatoduodenectomy was initiated at our institution to improve the diagnosis,resection rate,mortality and morbidity.We undertook the study to assess the effect of this approach on diagnosis,resection rates and short-term outcomes such as morbidity and mortality.METHODS:A prospective database of patients presenting with periampullary cancers to a single surgeon between April 2004 and April 2010 was reviewed.All cases were discussed at a multidisciplinary meeting comprising surgeons,gastroenterologists,radiologists,oncologists,radiation oncologists,pathologists and nursing staff.A standardized investigation and management algorithm was followed.Complications were graded according to the Clavien-Dindo classification.RESULTS:A total of 295 patients with a periampullary lesion were discussed and 178 underwent pancreatoduodenectomy (resection rate 60%).Sixty-one patients (34%) required either a vascular or an additional organ resection.Eighty-nine patients experienced complications,of which the commonest was blood transfusion (12%).Thirty-four patients (19%) had major complications,i.e.grade 3 or above.There was no in-hospital,30-day or 60-day mortality.CONCLUSIONS:Pancreatoduodenectomy can safely be performed in high-volume centers with very low mortality.The surgeon's role should be careful patient selection,intensive preoperative investigations,use of a team approach,and an unbiased discussion at a multidisciplinary meeting to optimize the outcome in these patients. | Jaswinder S Samra Raul Alvarado Bachmann Julian Choi Anthony Gill Michael Neale Vikram Puttaswamy Cameron Bell Ian Norton Sarah Cho Steven Blome Ritchie Maher Sivakumar Gananadha Thomas J Hugh | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 8 |
| 3 | Prunus genetics and applications after de novo genome sequencing:achievements and prospects显示文摘Prior to the availability of whole-genome sequences,our understanding of the structural and functional aspects of Prunus tree genomes was limited mostly to molecular genetic mapping of important traits and development of EST resources.With public release of the peach genome and others that followed,significant advances in our knowledge of Prunus genomes and the genetic underpinnings of important traits ensued.In this review,we highlight key achievements in Prunus genetics and breeding driven by the availability of these whole-genome sequences.Within the structural and evolutionary contexts,we summarize:(1)the current status of Prunus whole-genome sequences;(2)preliminary and ongoing work on the sequence structure and diversity of the genomes;(3)the analyses of Prunus genome evolution driven by natural and man-made selection;and(4)provide insight into haploblocking genomes as a means to define genome-scale patterns of evolution that can be leveraged for trait selection in pedigree-based Prunus tree breeding programs worldwide.Functionally,we summarize recent and ongoing work that leverages whole-genome sequences to identify and characterize genes controlling 22 agronomically important Prunus traits.These include phenology,fruit quality,allergens,disease resistance,tree architecture,and self-incompatibility.Translationally,we explore the application of sequence-based marker-assisted breeding technologies and other sequence-guided biotechnological approaches for Prunus crop improvement.Finally,we present the current status of publically available Prunus genomics and genetics data housed mainly in the Genome Database for Rosaceae(GDR)and its updated functionalities for future bioinformatics-based Prunus genetics and genomics inquiry. | Maria JoséAranzana Véronique Decroocq Elisabeth Dirlewanger Iban Eduardo Zhong Shan Gao Ksenija Gasic Amy Iezzoni Sook Jung Cameron Peace Humberto Prieto Ryutaro Tao Ignazio Verde Albert G.Abbott Pere Arús | 2019 | Horticulture Research2019，6，1： | 8 |
| 4 | Organizational effectiveness: A comparison of multiple models显示文摘 | Cameron K S Whetten D A | 1983 | New York: Academic Press1983，，： | 1 |
| 5 | Dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influenza neuraminidase including HSN1 avian influenza显示文摘 | Macdonald S J Cameron R Demaine D A | 2005 | J Med Chem2005，48，8： | 1 |
| 6 | Synergy of demethylation and histone deacetylase inhibition in there: expression of genes silenced in cancer显示文摘 | Cameron E E Bachman K E Myohanen S | 1999 | Nat Genet1999，21，1： | 1 |
| 7 | Back pain among workers in the United States:national estimates and workers at high risk显示文摘 | Guo HR Tauaka S Cameron LL | 1995 | Am J Ind Med1995，28，： | 1 |
| 8 | Choledochal cyst disease in children and adults:a 30-year single-institution experience显示文摘 | Edil BH Cameron JL Reddy S | 2008 | J Am Coll Surg2008，206，5： | 1 |
| 9 | Influence of pocket gopher mounds on a Texas coastal prairi显示文摘 | Spencer S R Cameron G N Eshelman B D | 1985 | Oecolo- gia1985，66，1： | 1 |
| 10 | 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial显示文摘 | Ian Smith Marion Procter Richard D Gelber Sébastien Guillaume Andrea Feyereislova Mitch Dowsett Aron Goldhirsch Michael Untch Gabriella Mariani Jose Baselga Manfred Kaufmann David Cameron Richard Bell Jonas Bergh Robert Coleman Andrew Wardley Nadia Harbec | 2007 | The Lancet2007，，9555： | 1 |
| 11 | Murray river water,raised cyanobacterial counts and gastrointestinal and dermatological symptoms显示文摘 | El Saadi O Esterman A J Cameron S | 1995 | Medical Journal of Australia1995，162，： | 1 |
| 12 | A prospective randomized study of anterior cruciate ligament reconstruction:a comparison of patellar tendon and quadruple-strand semitendinosus/gracilis tendons fixed with bioabsorbable interference screws显示文摘 | Maletis G B Cameron S L Tengan J J | | 0，，03： | 1 |
| 13 | Choledochal cyst disease in children and adults: a 30-year single-institution experience显示文摘 | Edil BH Cameron JL Reddy S | 2008 | J Am Coll Surg2008，206，5： | 1 |
| 14 | UV-B phototherapy clears psoriasis through local effects显示文摘 | Dawe RS Cameron H Yule S | 2002 | Arch Dermatol2002，138，8： | 1 |
| 15 | Finding deeply-buried deposits using geochemistry显示文摘 | Cameron E M Hamilton S M Leyboume M I | 2004 | Geochemistry: Exploration Environment Analysis2004，4，1： | 1 |
| 16 | The introduction of renal biopsy into ncphrology from 1901 to 1961: a paradigm of the forming of nephrology by technology显示文摘 | CAMERON J S HICKS J | 1997 | American Journal of Nephrology1997，17，34： | 1 |
| 17 | Prevent developments of angiotension coverting enzyme inhibition muscle and nerve dysfunction and stimulates angiogenisis in streprtozocin diabetic rats显示文摘 | Cameron NE Catter MA Robertson S | 1992 | Diabetologia1992，35，1： | 1 |
| 18 | Redox, pH and SP variation over mineralization in thick gla eial overburden显示文摘 | Hamilton S M Cameron E M McClenaghan M B | 2004 | Geochemistry: Exploration Environ ment AnaLysis2004，4，： | 1 |
| 19 | Nitrate removal from three different effluents using large-scale denitrification beds显示文摘 | Schipper L A Cameron S C Warneke S | 2010 | Ecological Engineering2010，36，11： | 1 |
| 20 | Using actual andcontingent behavior data with differing levels of time aggregation to modelrecreation demand显示文摘 | CAMERON T A SHAW W D RAGLAND S E | 1996 | Journal of Agricultural and Resource Economics1996，21，： | 1 |
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