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| 1 | Stem cells for liver tissue repair:Current knowledge and perspectives显示文摘Stem cells from extra-or intrahepatic sources have been recently characterized and their usefulness for the generation of hepatocyte-like lineages has been demonstrated. Therefore, they are being increasingly considered for future applications in liver cell therapy. In that field, liver cell transplantation is currently regarded as a possible alternative to whole organ transplantation, while stem cells possess theoretical advantages on hepatocytes as they display higher in vitro culture performances and could be used in autologous transplant procedures. However, the current research on the hepatic fate of stem cells is still facing difficulties to demonstrate the acquisition of a full mature hepatocyte phenotype, both in vitro and in vivo. Furthermore, the lack of obvious demonstration of in vivo hepatocyte-like cell functionality remains associated to low repopulation rates obtained after current transplantation procedures. The present review focuses on the current knowledge of the stem cell potential for liver therapy. We discuss the characteristics of the principal cell candidates and the methods to demonstrate their hepatic potential in vitro and in vivo. We finally address the question of the future clinical applications of stem cells for liver tissue repair and the technical aspects that remain to be investigated. | Philippe A Lysy David Campard Fran oise Smets Mustapha Najimi Etienne M Sokal | 2008 | World Journal of Gastroenterology2008，14，6： | 22 |
| 2 | The processing and biolog- ical function of the human amyloid precursor protein (APP) : lessons from different cellular models 显示文摘 | Kienlen - Campard P Tasiaux B Octave JN | 2000 | Exp Geronto12000，35，67： | 1 |
| 3 | Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte - like cells显示文摘 | Campard D Lysy PA Najimi M | 2008 | Gastroenterology2008，134，： | 1 |
| 4 | Native Umbilical Cord Matrix Stem Cel s Express Hepatic Markers and Differentiate Into Hepatocyte-like Cel s显示文摘 | Campard D Philippe A Lysy | | 0，，03： | 1 |
| 5 | Hepato-biliary profile of potential candidate liver progenitor cells from healthy rat liver显示文摘AIM:To evaluate the presence of progenitor cells in healthy adult rat liver displaying the equivalent advanced hepatogenic profile as that obtained in humans.METHODS:Rat fibroblastic-like liver derived cells (rFLDC) were obtained from collagenase-isolated liver cell suspensions and characterized and their phenotype profile determined using flow cytometry,immunocytochemistry,reverse transcription polymerase chain reaction and functional assays.RESULTS:rFLDC exhibit fibroblastoid morphology,express mesenchymal (CD73,CD90,vimentin,-smooth muscle actin),hepatocyte (UGT1A1,CK8) and biliary (CK19) markers.Moreover,these cells are able to store glycogen,and have glucose 6 phosphatase activity,but not UGT1A1 activity.Under the hepatogenic differentiation protocol,rFLDC display an up-regulation of hepatocyte markers expression (albumin,tryptophan 2,3-dioxygenase,G6Pase) correlated to a down-regulation of the expression of the biliary marker CK19.CONCLUSION:Advanced hepatic features observed in human liver progenitor cells could not be demonstrated in rFLDC.However,we demonstrated the presence of an original rodent hepato-biliary cell type. | Cédric Maerckx Isabelle Scheers Tatiana Tondreau David Campard Omar Nyabi Mustapha Najimi Etienne Sokal | 2012 | World Journal of Gastroenterology2012，18，27： | 1 |
| 6 | Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte-like cells 显示文摘 | Campard D Lysy PA Najimi M | 2008 | Gastroenterology2008，134，3： | 1 |
| 7 | Native umbilical cord ma- trix stem cells express hepatic markers and differentiate into hepato- cyte-like cells 显示文摘 | Campard D Lysy PA Najimi M | 2008 | Gastroenterology2008，134，3： | 1 |
| 8 | Native umbilical cord matrix stern cells express hepatic markers and differentiate into hepatocyte-like cells显示文摘 | Campard D Lysy PA Najimi M | 2008 | Gastroenterology2008，134，3： | 1 |
| 9 | The processing and biological function of the human amloid precursor protein (APP): lessons from different cellular models 显示文摘 | Tasiaux B Octave JN | 2000 | Exp Geronto2000，35，： | 1 |
| 10 | Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte -like cells显示文摘 | Campard D Lysy PA Najimi M | 2008 | Gastroenterology2008，134，3： | 1 |
| 11 | Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte-like cells 显示文摘 | Campard D Lysy PA Najimi M | 2008 | Gastroenterology2008，134，3： | 1 |
| 12 | Native Umbilical Cord Matrix Stem Cells Express Hepatic Markers and Differentiate Into Hepatocyte-like Cells显示文摘 | David Campard Philippe A. Lysy Mustapha Najimi Etienne Marc Sokal | 2008 | Gastroenterology2008，，3： | 1 |
| 13 | Stem cel s for liver tissue repair:Current knowledge and perspectives显示文摘 | Lysy PA Campard D Smets F | | 0，，： | 1 |
| 14 | The processing and biological function of the human amyloid precursor protein(APP) :lessons from different cellular models 显示文摘 | Campard PK Tasiaux B Octave JN | 2000 | Exp Gerontol2000，35，67： | 1 |
| 15 | Native umbilical cord matrix stem ceils express hepatic markers and differentiation into hepatocute-like cells显示文摘 | Campard D Lysy PA Najimi M | 2008 | Gastroenterol2008，134，3： | 1 |
| 16 | Native Umbilical Cord Matrix Stem Cells Express Hepatic Markers and Differentiate Into Hepatocyte2like Cells显示文摘 | Campard D Philippe A Lysy | 2008 | Gastroenterology2008，134，3： | 1 |
| 17 | The processing and biological function of the human am ylold precursor protein: lessons from different cellular models显示文摘 | KIENLEN CAMPARD P K TASIAUX B OCTAVE J N | 2000 | Exp Geronto2000，35，： | 1 |
| 18 | Stem cel s for liver tissue repair:Current knowledge and perspectives显示文摘 | Lysy PA Campard D Smets F | | 0，，06： | 1 |
| 19 | Native umbilical cord matrix stem cells express hepatic markers and differentiation into hepatocute-like ceils 显示文摘 | Campard D Lysy PA Najimi M | 2008 | Gastroenterology2008，134，3： | 1 |
| 20 | Persistence of a chimerical phenotype after hepatocyte differentiation of human bone marrow mesenchymal stem cells 显示文摘 | Lysy PA Campard D Smets F | 2008 | Cell Prolif2008，41，1： | 1 |
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