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| 1 | Stem cells for liver tissue repair:Current knowledge and perspectives显示文摘Stem cells from extra-or intrahepatic sources have been recently characterized and their usefulness for the generation of hepatocyte-like lineages has been demonstrated. Therefore, they are being increasingly considered for future applications in liver cell therapy. In that field, liver cell transplantation is currently regarded as a possible alternative to whole organ transplantation, while stem cells possess theoretical advantages on hepatocytes as they display higher in vitro culture performances and could be used in autologous transplant procedures. However, the current research on the hepatic fate of stem cells is still facing difficulties to demonstrate the acquisition of a full mature hepatocyte phenotype, both in vitro and in vivo. Furthermore, the lack of obvious demonstration of in vivo hepatocyte-like cell functionality remains associated to low repopulation rates obtained after current transplantation procedures. The present review focuses on the current knowledge of the stem cell potential for liver therapy. We discuss the characteristics of the principal cell candidates and the methods to demonstrate their hepatic potential in vitro and in vivo. We finally address the question of the future clinical applications of stem cells for liver tissue repair and the technical aspects that remain to be investigated. | Philippe A Lysy David Campard Fran oise Smets Mustapha Najimi Etienne M Sokal | 2008 | World Journal of Gastroenterology2008，14，6： | 22 |
| 2 | Liver cell transplantation for Crigler-Najjar syndrome type Ⅰ: Update and perspectives显示文摘Liver cell transplantation is an attractive technique to treat liver-based inborn errors of metabolism. The feasibility and efficacy of the procedure has been demonstrated, leading to medium term partial metabolic control of various diseases. Crigler-Najjar is the paradigm of such diseases in that the host liver is lacking one function with an otherwise normal parenchyma. The patient is at permanent risk for irreversible brain damage. The goal of liver cell transplantation is to reduce serum bilirubin levels within safe limits and to alleviate phototherapy requirements to improve quality of life. Preliminary data on Gunn rats, the rodent model of the disease, were encouraging and have led to successful clinical trials. Herein we report on two additional patients and describe the current limits of the technique in terms of durability of the response as compared to alternative therapeutic procedures. We discuss the future developments of the technique and new emerging perspectives. | Philippe A Lysy Mustapha Najimi Xavier Stéphenne Annick Bourgois Franoise Smets Etienne M Sokal | 2008 | World Journal of Gastroenterology2008，14，22： | 9 |
| 3 | Esophageal obstruction due to enteral feed bezoar:A case report and literature review显示文摘This paper describes a rare complication of enteral feeding,esophageal obstruction due to feeding formula bezoar,and reviews the published cases. An attempt to re-insert the nasogastric tube in a chronically ventilated 80-year-old female fed via a nasogastric tube with Jevity failed. An esophagogastroduodenoscopy revealed an 18 cm-long concretion of the feeding formula,fi-lling most of the esophageal lumen,which was removed endo scopically. Forty-two cases of feeding formula esophageal bezoars have been reported in the literature. The formation of feeding formula bezoars is triggered by acidic gastroesophageal reflux. The acidic pH in the esophagus causes clotting of the casein in the formula. Predisposing factors for bezoar formation are:mechanical ventilation,supine position,neurological diseases,diabetes mellitus,hypothyroidism,obesity and history of partial gastrectomy. Diagnosis and removal of the bezoar is done endoscopically. Feeding in a semi-recumbent position,administration of prokinetic agents and proton pump inhibitors may prevent this complication. | Esther-Lee Marcus Ron Arnon Arkadiy Sheynkman Yehezkel G Caine Joseph Lysy | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，10： | 3 |
| 4 | Childhood hygiene isassociated with the risk for inflammatory bowel disease: apopulation-based study显示文摘 | Klement E Lysy J Hoshen M | 2008 | Am J Gastroenterol2008，103，7： | 1 |
| 5 | Topital capsaicin--a novel and effective treatment for idiopathic intractable pruritus ani: a randomized, placebo controlled, crossover study显示文摘 | Lysy J Sistiery-Ittah M Israelit Y | 2003 | Gut2003，52，： | 1 |
| 6 | The prevalence of chronic diarrhea among diabetic patients显示文摘 | Lysy J Israeli E Goldin E | 1999 | Am J Gastroenterol1999，94，8： | 1 |
| 7 | Human skin fibreblasts:from mesodernal to hepatocyte-like differentiation显示文摘 | Lysy PA Smets F Sibille C | | 0，，： | 1 |
| 8 | The over-claiming technique:Measuring self-enhancement independent of ability显示文摘 | Paulhus D.L Harms P.D Bruce M.N Lysy D.C | | 0，，04： | 1 |
| 9 | Human skin fibroblasts: Frommesodermal to hepatocyte-Iike differentiation 显示文摘 | Lysy PA Smets F Sibille C | 2007 | Hepatology2007，46，5： | 1 |
| 10 | Biofeedback on heart rate variability in cardiac rehabilitation:practical feasibili- ty and psycho-physiological effects 显示文摘 | Climov D Lysy C Berteau S | 2014 | Acta Cardiol2014，69，3： | 1 |
| 11 | Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte - like cells显示文摘 | Campard D Lysy PA Najimi M | 2008 | Gastroenterology2008，134，： | 1 |
| 12 | Decreased substance P content in the rectal mucosa of diabeties with diarrhea and constipation 显示文摘 | Lysy J Karmeli F Sestieri M | 1997 | Metabolism1997，46，7： | 1 |
| 13 | Native Umbilical Cord Matrix Stem Cel s Express Hepatic Markers and Differentiate Into Hepatocyte-like Cel s显示文摘 | Campard D Philippe A Lysy | | 0，，03： | 1 |
| 14 | Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte-like cells 显示文摘 | Campard D Lysy PA Najimi M | 2008 | Gastroenterology2008，134，3： | 1 |
| 15 | Native umbilical cord ma- trix stem cells express hepatic markers and differentiate into hepato- cyte-like cells 显示文摘 | Campard D Lysy PA Najimi M | 2008 | Gastroenterology2008，134，3： | 1 |
| 16 | Native umbilical cord matrix stern cells express hepatic markers and differentiate into hepatocyte-like cells显示文摘 | Campard D Lysy PA Najimi M | 2008 | Gastroenterology2008，134，3： | 1 |
| 17 | Clinic and diagnosis of enteric infections in man by Yersinia enterocolitica 显示文摘 | Knapp W Lysy J Knapp C | 1973 | Infection1973，1，2： | 1 |
| 18 | Preliminary study of genetic variation in Hawaiian isolates of Beauveria bassiana (Hypocreales:Cordycipitaceae)显示文摘 | Hollingsworth RG Lysy AM Matsumoto TK | | 0，，： | 1 |
| 19 | Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte -like cells显示文摘 | Campard D Lysy PA Najimi M | 2008 | Gastroenterology2008，134，3： | 1 |
| 20 | Clinic and diagnosis of enteric infections in man by Yersinia enterocolitica显示文摘 | Knapp W Lysy J Knapp C | 1973 | Infection1973，1，2： | 1 |
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