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| 1 | Structure and function of aggrecan显示文摘Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure (via its interaction with hyaluronan and link protein) that endows the cartilage with load-bearing properties. It is also crucial in chondroskeletal morphogenesis during development. Aggrecan is a multimodular molecule expressed by chondrocytes. Its core protein is composed of three globular domains (G1, G2, and G3) and a large extended region (CS) between G2 and G3 for glycosaminoglycan chain attachment. G1 comprises the amino terminus of the core protein. This domain has the same structural motif as link protein. Functionally, the G1 domain interacts with hyaluronan acid and link protein, forming stable ternary complexes in the extracellular matrix. G2 is homologous to the tandem repeats of G1 and of link protein and is involved in product processing. G3 makes up the carboxyl terminus of the core protein. It enhances glycosaminoglycan modification and product secretion. Aggrecan plays an important role in mediating chondrocyte-chondrocyte and chondrocyte-matrix interactions through its ability to bind hyaluronan. | CHRIS KIANI, LIWEN CHEN, YAO JIONG WU, ALBERT J YEE, BURTON B YANG, Sunnybrook and Women’s College Health Sciences Centre and Department of Laboratory Medicine and Patobiology, 2 Department of Surgeny, Faculty of Medicine, University of Toronto, Canada | 2002 | Cell Research2002，12，1： | 27 |
| 2 | Symmetric-key cryptosystem with DNA technology显示文摘DNA cryptography is a new field which has emerged with progress in the research of DNA computing. In our study, a symmetric-key cryptosystem was designed by applying a modern DNA biotechnology, microarray, into cryptographic technologies. This is referred to as DNA symmetric-key cryptosystem (DNASC). In DNASC, both encryption and decryption keys are formed by DNA probes, while its ciphertext is embedded in a specially designed DNA chip (microarray). The security of this system is mainly rooted in difficult biology processes and problems, rather than conventional computing technology, thus it is unaffected by changes from the attack of the coming quantum computer. The encryption process is a fabrication of a specially designed DNA chip and the decryption process is the DNA hybridization. In DNASC, billions of DNA probes are hybridized and identified at the same time, thus the decryption process is conducted in a massive, parallel way. The great potential in vast parallelism computation and the extraordinary information density of DNA are displayed in DNASC to some degree. | LU MingXin1,2*, LAI XueJia3*, XIAO GuoZhen4,2 & QIN Lei5 1 Department of Information Management, Nanjing University, Nanjing 210093, China 2 State Key Lab of Information Security, Institute of Software of Chinese Academy of Science, Beijing 100049, China 3 Department of Computer Science & Engineer, Shanghai Jiao Tong University, Shanghai 200030, China 4 State Key Lab of ISN, Xidian University, Xi’an 710071, China 5 Cancer Research Institute, Queen’s University, Kingston, Ontario, K7L3N6, Canada | 2007 | Science in China(Series F)2007，50，3： | 14 |
| 3 | Biologic and molecular characterization of Toxoplasma gondii isolates from pigs from Portugal显示文摘 | de Sousa S Ajzenberg D Canada N | 2006 | Vet Parasitol2006，135，2： | 1 |
| 4 | Foliar uptake of ^15N fromrain 显示文摘 | Evans L S Canada D C Santucci K A | 1986 | Environ Exp Bot1986，26，2： | 1 |
| 5 | Self-handicapping and the five factor model of personality:Mediation between neuroticism and conscientiousness显示文摘 | Ross S R Canada K E | | 0，，07： | 1 |
| 6 | Directed evolution of toluene ortho-monooxygenase for enhanced 1-naphthol synthesis and chlorinated ethene degradation 显示文摘 | Canada K A Iwashita S Shim H | 2002 | Journal of Bacteriology2002，184，： | 1 |
| 7 | A study of the subgross pulmonary anatomy in various mammals显示文摘 | MCLAUGHLIN R F TYLER W S CANADA R O | 1961 | Am J Anat1961，108，2： | 1 |
| 8 | Biologic and molecular characterization of Toxoplasma gondii isolates from pigs from Portugal显示文摘 | Sousa S Ajzenberg D Canada N | 2006 | Veterinary Parasitology2006，135，2： | 1 |
| 9 | Erlotinib in previously treated non-small cell lung cancer显示文摘 | Shepherd FA Rodrigues Pereira J Ciuleanu T Tan EH Hirsh V Thongprasert S Campos D Maoleekoonpiroj S Smylie M Martins R van Kooten M Dediu M Findlay B Tu D Johnston D Bezjak A Clark G Santabárbara P Seymour L National Cancer Institute of Canada Clinical T | | 0，，02： | 1 |
| 10 | Polymorphic chromosomes bearing the Tox2 loci to Cochliobolus carbonum behave as homologs during meiosis显示文摘 | DUNKLE L U | 1997 | Appl and Environ Microbiol1997，69，3： | 1 |
| 11 | Isolation of viable Toxoplasma gondii from naturally infected aborted bovine fetuses显示文摘 | Canada N Meireles C S Rocha A | 2002 | J Parasitol2002，88，6： | 1 |
| 12 | Hydrogen peroxide production by monoamine oxidase during ischemia-reperfusion in the rat rain显示文摘 | SIMONSON S G ZHANG J CANADA A T | 1993 | J Cere Blood Flow Metab1993，13，1： | 1 |
| 13 | Pregnancy outcomes after assisted human reproduction 显示文摘 | Society of Obstetricians and Gynaecologists of Canada Okun N Siet ra S | 2014 | J Obstet Gynaecol Can2014，36，1： | 1 |
| 14 | Association between ambulatory physical activity and injuries during United States Army Basic Combat Training显示文摘 | Knapik JJ Hauret KG Canada S | 2011 | J Phys Act Health2011，8，4： | 1 |
| 15 | Directed evolution of toluene ortho monooxygenase for enhanced 1-naphthol synthesis and chlorinated ethane degradation显示文摘 | Canada K A Lwashita S Shim H | 2002 | J Bacteriol2002，184，： | 1 |
| 16 | Case report: Treatment failure using propanolol for treatment of focal subglottic hemangio- ma显示文摘 | Canadas KT Baum El) Lee S | 2010 | Int J Pediatr Otorhinolaryngol2010，74，8： | 1 |
| 17 | Polymorphic chromo- somes bearing the Tox2 locus in Cochliobolus carbonum behave as homologs during meiosis 显示文摘 | CANADA S R DUNKLE L D | 1997 | Applied and Environmental Microbiology1997，63，3： | 1 |
| 18 | Liapunov - type inequalities and Neumann boundary value problems at resonance显示文摘 | CANADA A MONTERO J A VILLEGAS S | 2005 | Math Inequal Appl2005，3，： | 1 |
| 19 | Interrelations between elastic energy and strain in a tensegrity model: Contribution to the analysis of the mechanical response in living cells 显示文摘 | Wendling S CaNadas P Oddou C | 2002 | Comput Methods Biomech BME2002，5，1： | 1 |
| 20 | Pregnancy outcomes after assisted human reproduction显示文摘 | Society of Obstetricians and Gynaecologists of Canada Okun N Sierra S | 2014 | J Obstet Gynaecol Can2014，36，： | 1 |
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