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| 1 | Responsive and self-healing structural color supramolecular hydrogel patch for diabetic wound treatment显示文摘The treatment of diabetic wounds remains a great challenge for medical community.Here,we present a novel structural color supramolecular hydrogel patch for diabetic wound treatment.This hydrogel patch was created by using N-acryloyl glycinamide(NAGA)and 1-vinyl-1,2,4-triazole(VTZ)mixed supramolecular hydrogel as the inverse opal scaffold,and temperature responsive poly(N-isopropylacrylamide)(PNIPAM)hydrogel loaded with vascular endothelial cell growth factor(VEGF)as a filler.Supramolecular hydrogel renders hydrogel patch with superior mechanical properties,in which NAGA and VTZ also provide self-healing and antibacterial properties,respectively.Besides,as the existence of PNIPAM,the hydrogel patch was endowed with thermal-responsiveness property,which could release actives in response to temperature stimulus.Given these excellent performances,we have demonstrated that the supramolecular hydrogel patch could significantly enhance the wound healing process in diabetes rats by downregulating the expression of inflammatory factors,promoting collagen deposition and angiogenesis.Attractively,due to responsive optical property of inverse opal scaffold,the hydrogel patch could display color-sensing behavior that was suitable for the wound monitoring and management as well as guidance of clinical treatment.These distinctive features indicate that the presented hydrogel patches have huge potential values in biomedical fields. | Canwen Chen Yu Wang Han Zhang Hui Zhang Weiliang Dong Weijian Sun Yuanjin Zhao | 2022 | Bioactive Materials2022，7，9： | 2 |
| 2 | The developing condition analysis of semiconductor laser frequency stabilization technology显示文摘The frequency stability of free-running semiconductor lasers is influenced by several factors, such as driving current and external operating environment. The frequency stabilization of laser has become an international research hotspot in recent years. This paper reviews active frequency stabilization technologies of laser diodes and elaborates their principles. Based on differences of frequency discrimination curves, these active frequency stabilization technologies are classified into three major types, which are harmonic frequency stabilization,Pound-Drever-Hall(PDH) technology and curve subtraction frequency stabilization. Further, merits and demerits of each technology are compared from aspects of frequency stability and structure complexity. Finally, prospects of frequency stabilization technologies of semiconductor lasers are discussed in detail. Combining several of these methods are future trends, especially the combination of frequency stabilization of F–P cavity. And PID electronic control for optimizing the servo system is generally added in the methods mentioned above. | Yijun Yao Canwen Zou Haiyang Yu Jinjin Guo Yaming Li Jianguo Liu | 2018 | Journal of Semiconductors2018，39，11： | 1 |
| 3 | Antioxidant defense mechanisms and fatty acid catabolism in Red-billed Leiothrix(Leiothrix lutea)exposed to high temperatures显示文摘Extreme hot weather is occurring more frequently due to global warming,posing a significant threat to species survival.Birds in particular are more likely to overheat in hot weather because they have a higher body temperature.This study used a heat stress model to investigate the antioxidant defense mechanisms and changes in fatty acid catabolism in Red-billed Leiothrix(Leiothrix lutea)to gain an understanding of how birds adapt to high temperatures.The birds were divided into five groups:a control group(30℃for 0 days),1 D group(40℃for 1 day),3 D group(40℃for 3 days),14 D group(40℃for 14 days)and recovery group(40℃for 14 days,then 30℃for 14 days).Our results indicated that when Red-billed Leiothrix are subjected to heat stress,malondialdehyde(MDA)content in the liver significantly increased,as did the enzyme activities of catalase(CAT),glutathione-SH-peroxidase(GSH-PX)and total antioxidant capacity(T-AOC)in the liver.Furthermore,there was a significant increase in heat shock protein 70(HSP70)expression in the liver,while avian uncoupling protein(avUCP)expression in muscle was significantly reduced.Additionally,there was a significant reduction in fatty acid catabolism enzyme activity such as 3-hydroxyacyl-CoAdehydrogenase(HOAD)activity in the heart,and carnitine palmitoyl transferase 1(CPT-1)and citrate synthase(CS)activity in the heart and liver.Furthermore,fatty acid translocase(FAT/CD36)in the heart,heart-type fatty acid binding protein(H-FABP)and fatty acid binding protein(FABP-pm)in the liver and heart were also significantly decreased.These changes reverted after treatment,but not to the same level as the control group.Our results indicated that when Red-billed Leiothrix are exposed to heat stress their internal antioxidant defense system is activated to counteract the damage caused by high temperatures.However,even with high antioxidant levels,prolonged high temperature exposure still caused some degree of oxidative damage possibly requiring a longer recovery time.Additionally,Red-billed Leiothrix may be able to resist heat stress by reducing fatty acid transport and catabolism. | Ruiping Xu Canwen Yu Liyao Mao Mengchen Jiang Luyao Gao Ming Li Jinsong Liu | 2022 | Avian Research2022，13，1： | 0 |
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