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| 1 | Comparative effectiveness of i-SCAN^(TM) and high-definition white light characterizing small colonic polyps显示文摘AIM:To evaluate accuracy of in vivo diagnosis of adenomatous vs non-adenomatous polyps using i-SCAN digital chromoendoscopy compared with high-definition white light.METHODS:This is a single-center comparative effectiveness pilot study.Polyps(n = 103) from 75 averagerisk adult outpatients undergoing screening or surveillance colonoscopy between December 1,2010 and April 1,2011 were evaluated by two participating endoscopists in an academic outpatient endoscopy center.Polyps were evaluated both with high-definition white light and with i-SCAN to make an in vivo prediction of adenomatous vs non-adenomatous pathology.We determined diagnostic characteristics of i-SCAN and highdefinition white light,including sensitivity,specificity,and accuracy,with regards to identifying adenomatous vs non-adenomatous polyps.Histopathologic diagnosis was the gold standard comparison.RESULTS:One hundred and three small polyps,detected from forty-three patients,were included in the analysis.The average size of the polyps evaluated in the analysis was 3.7 mm(SD 1.3 mm,range 2 mm to 8 mm).Formal histopathology revealed that 54/103(52.4%) were adenomas,26/103(25.2%) were hyperplastic,and 23/103(22.3%) were other diagnoses include 'lymphoid aggregates','non-specific colitis,' and 'no pathologic diagnosis.' Overall,the combined accuracy of endoscopists for predicting adenomas was identical between i-SCAN(71.8%,95%CI:62.1%-80.3%) and high-definition white light(71.8%,95%CI:62.1%-80.3%).However,the accuracy of each endoscopist differed substantially,where endoscopist A demonstrated 63.0% overall accuracy(95%CI:50.9%-74.0%) as compared with endoscopist B demonstrating 93.3% overall accuracy(95%CI:77.9%-99.2%),irrespective of imaging modality.Neither endoscopist demonstrated a significant learning effect with i-SCAN during the study.Though endoscopist A increased accuracy using i-SCAN from 59%(95%CI:42.1%-74.4%) in the first half to 67.6%(95%CI:49.5%-82.6%) in the second half,and endoscopist B decreased accuracy using i-SCAN from 100%(95%CI:80.5%-100.0%) in the first half to 84.6%(95%CI:54.6%-98.1%) in the second half,neither of these differences were statistically significant.CONCLUSION:i-SCAN and high-definition white light had similar efficacy predicting polyp histology.Endoscopist training likely plays a critical role in diagnostic test characteristics and deserves further study. | Johanna L Chan Li Lin Michael Feiler Andrew I Wolf Diana M Cardona Ziad F Gellad | 2012 | World Journal of Gastroenterology2012，18，41： | 3 |
| 2 | 2013, Antigenic and genetic characterization of a European avian-like H1N1 swine influenza virus from a boy in China in 2011显示文摘 | Qi x Cui L Jiao Y Pan Y Li X Zu R Huo X Wu B Tang F Song Y Zhou M Wang H Cardona C J Xing Z | 2013 | Archives of Virology2013，158，1： | 1 |
| 3 | Thyroid hormone receptor-binding protein,an LXXLL motif-containing protein,functions as a general coactivator显示文摘 | Ko L Cardona GR Chin WW | | 0，，11： | 1 |
| 4 | 显示文摘 | Schmidt R L McCombe B D Cardona M | 1975 | Physical Review B1975，11，2： | 1 |
| 5 | The synthesis of an N-lobe noncircular gear using Bezier and B-spline nonparametric curve on the design of its displacement law显示文摘 | Quintero Riaza H F Cardona Foix S Jordi Nebot L | | 0，，09： | 1 |
| 6 | Identification and characterization of a tissue-specific coactivator, GT198, that interacts with the DNA-binding domains of nuclear receptors显示文摘 | Ko L Cardona GR Henrion Caude A | 2002 | Mol Cell Biol2002，22，1： | 1 |
| 7 | Dengue virus replication in human hepatoma cells activates NF-κB which in turn induces apoptotic cell death 显示文摘 | Marianneau P Cardona A Edelman L | 1997 | Virology1997，71，4： | 1 |
| 8 | Urban seismic risk evaluation: A holistic approach显示文摘 | Carreno M L Cardona 0 D Barbat A H | 2007 | Natural Hazards2007，40，1： | 1 |
| 9 | 6-Pre- nyloxy-7-methoxycoumarin, a coumaxin-hemiterpene ether from Carduus tenuiflorus显示文摘 | CARDONA L GARICIA B PEDRO J R | 1992 | Phytochemistry1992，31，11： | 1 |
| 10 | Therapy with in termittent pulse cyclophosphamide for pulmonary hypertension associated with systemic lupus erythematosus显示文摘 | Gonzalez Lopez L Cardona | 2004 | Lupus2004，13，： | 1 |
| 11 | Recovery of Siberian sturgeon yearlings after an acute exposure to environmental nitrite: changes in the plasmatic ionic balance, Na^+–K^+ ATPase activity, and gill histology 显示文摘 | Gisbert E Rodríguez A Cardona L | 2004 | Aquaculture2004，239，14： | 1 |
| 12 | Control potential of three hymenopteran parasitoid species against the bean weevil in stored beans:the effect of adult parasitoid nutrition on longevity and progeny production显示文摘 | Schmale I W(a)ckers F L Cardona C Dorn S | 2001 | Biological Control2001，21，： | 1 |
| 13 | Value of spiral computed tomography for the preoperative detection of lymph node involvement in gastric cancer显示文摘 | Espin Alvarez F Bianchi Cardona A Pulido Martinez L | 2009 | Med Clin (Barc)2009，132，6： | 1 |
| 14 | Optical properties and band structure of group IW-WI and group V materials 显示文摘 | Cardona M Greenaway D L | 1964 | Physical Review1964，133，6： | 1 |
| 15 | Electroreflectance at a semiconductor-electrolyte interface显示文摘 | CARDONA M SHAKLEE K L POLLAK F H | 1967 | Phys Rev1967，154，3： | 1 |
| 16 | The first fulleopyrrolidine derivative of ScaN@Ca80: Pronounced chemical sift differences of the genminal protons on the pyrrolidine ring显示文摘 | Cardona C M Herranz M A Echogoyen L | 2005 | J Org Chem2005，70，13： | 1 |
| 17 | B-lymphocytes and co-stimulatory molecules in Mycobacterium tuberculosis infection 显示文摘 | Corominas M Cardona L Gonzalez L | 2004 | IntJ Tuberc Lung Dis2004，8，1： | 1 |
| 18 | Framing Vulnerability,Risk and Societal Responses:the MOVE Framework显示文摘 | Birkmann J Cardona O D Carreno M L Barbat A H Pelling M Schneiderbauer S | 2013 | Natural Hazards2013，67，2： | 1 |
| 19 | Secretory Component显示文摘 | Armelle Phalipon Ana Cardona Jean-Pierre Kraehenbuhl Léna Edelman Philippe J. Sansonetti Blaise Corthésy | 2002 | Immunity2002，，1： | 1 |
| 20 | Process integrationpossibilities for biodiesel production from palm oil using ethanol obtainedfrom lignocellulosic residues of oil palm industry显示文摘 | GUTIERREZ L F SANCHEZ O J CARDONA C A | 2009 | Bioresour Technol2009，100，3： | 1 |
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