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| 1 | The HEPD particle detector of the CSES satellite mission for investigating seismo-associated perturbations of the Van Allen belts显示文摘CSES(China Seismo-Electromagnetic Satellite) is a mission developed by CNSA(Chinese National Space Administration) and ASI(Italian Space Agency), to investigate the near-Earth electromagnetic, plasma and particle environment, for studying the seismo-associated disturbances in the ionosphere-magnetosphere transition zone. The anthropogenic and electromagnetic noise,as well as the natural non-seismic electromagnetic emissions is mainly due to tropospheric activity. In particular, the mission aims to confirming the existence of possible temporal correlations between the occurrence of earthquakes for medium and strong magnitude and the observation in space of electromagnetic perturbations, plasma variations and precipitation of bursts with highenergy charged particles from the inner Van Allen belt. In this framework, the high energy particle detector(HEPD) of the CSES mission has been developed by the Italian LIMADOU Collaboration. HEPD is an advanced detector based on a tower of scintillators and a silicon tracker that provides good energy and angular resolution and a wide angular acceptance, for electrons of 3–100 Me V, protons of 30–200 Me V and light nuclei up to the oxygen. CSES satellite has been launched on February 2^(nd), 2018 from the Jiuquan Satellite Launch Center(China). | AMBROSI Giovanni BARTOCCI Simona BASARA Laurent BATTISTON Roberto BURGER William J. CARFORA Luca CASTELLINI Guido CIPOLLONE Piero CONTI Livio CONTIN Andrea DE DONATO Cinzia DE SANTIS Cristian FOLLEGA Francesco M. GUANDALINI Cristina IONICA Maria IUPPA Roberto LAURENTI Giuliano LAZZIZZERA Ignazio LOLLI Mauro MANEA Christian MARCELLI Laura MASCIANTONIO Giuseppe MERGE Matteo OSTERIA Giuseppe PACINI Lorenzo PALMA Francesco PALMONARI Federico PANICO Beatrice PATRIZII Laura PERFETTO Francesco PICOZZA Piergiorgio POZZATO Michele PUEL Matteo RASHEVSKAYA Irina RICCI Ester RICCI Marco RICCIARINI Sergio Bruno SCOTTI Valentina SOTGIU Alessando SPARVOLI Roberta SPATARO Bruno VITALE Vincenzo | 2018 | Science China(Technological Sciences)2018，61，5： | 6 |
| 2 | Soil activities related to nitrogen cycle under three plant cover types in Mediterranean environment显示文摘 | Rutigliano FA Castaldi S D'Ascoli R Papa S Carfora A Marzaioli R Fioretto A | 2009 | Applied Soil Ecology2009，43，： | 1 |
| 3 | Inhibition of net nitrification activity in Mediterranean woodland:Possible role of chemicals produced by Arbutus unedo显示文摘 | CASTALDI S CARFORA A FIORENTINO A | 2009 | Plant and soil2009，315，： | 1 |
| 4 | Inhibition of net nitrification activity in a Mediterranean woodland:Possible role of chemicals produced by Arbutus unedo显示文摘 | Castaldi S Carfora A Fiorentino A | 2009 | Plant Soil2009，315，： | 1 |
| 5 | Isolated stenosis of the let anterior descending coronary artery and regional function of the left ventricle显示文摘 | COLLE J P Le GOFF G CARFORA A | 1986 | Arch Mal Coeur Vaiss1986，79，13： | 1 |
| 6 | Soil activities related to nitrogen cycle under three plant cover types in Mediterranean environment显示文摘 | F.A. Rutigliano S. Castaldi R. D’Ascoli S. Papa A. Carfora R. Marzaioli A. Fioretto | 2009 | Applied Soil Ecology2009，，1： | 1 |
| 7 | Enterotoxin genes,entero- toxin production,and methicillin resistance in Staphylococcus aureus isolated from milk and dairy products in Central Italy 显示文摘 | V Carfora A Caprioli N Marri | 2015 | International Dairy Journal2015，42，： | 1 |
| 8 | Inhibition of net nitrification activity in Mediterranean woodland: possible role of chemicals produced by Arbu- tus unedo显示文摘 | CASTALDI S CARFORA A FIORENTINO A | 2009 | Plant and Soil2009，315，： | 1 |
| 9 | En-terotoxin genes, enterotoxin production,and methi-cillin resistance in Staphylococcus aureus isolated frommilk and dairy products in Central Italy 显示文摘 | CARFORA V CAPRIOLI A MARRI N | 2015 | Interna-tional Dairy Journal2015，42，： | 1 |
| 10 | Dose escalation of adalimumab as a strategy to overcome anti-drug antibodies:A case report of infantile-onset inflammatory bowel disease显示文摘BACKGROUND Treatment of infantile-onset inflammatory bowel disease(IO-IBD)is often challenging due to its aggressive disease course and failure of standard therapies with a need for biologics.Secondary loss of response is frequently caused by the production of anti-drug antibodies,a well-known problem in IBD patients on biologic treatment.We present a case of IO-IBD treated with therapeutic drug monitoring(TDM)-guided high-dose anti-tumor necrosis factor therapy,in which dose escalation monitoring was used as a strategy to overcome anti-drug antibodies.CASE SUMMARY A 5-mo-old boy presented with a history of persistent hematochezia from the 10th d of life,as well as relapsing perianal abscess and growth failure.Hypoalbuminemia,anemia,and elevated inflammatory markers were also present.Endoscopic assessment revealed skip lesions with deep colic ulcerations,inflammatory anal sub-stenosis,and deep fissures with persistent abscess.A diagnosis of IO-IBD Crohn-like was made.The patient was initially treated with oral steroids and fistulotomy.After the perianal abscess healed,adalimumab(ADA)was administered with concomitant gradual tapering of steroids.Clinical and biochemical steroid-free remission was achieved with good trough levels.After 3 mo,antibodies to ADA(ATA)were found with undetectable trough levels;therefore,we optimized the therapy schedule,first administering 10 mg weekly and subsequently up to 20 mg weekly(2.8 mg/kg/dose).After 2 mo of high-dose treatment,ATA disappeared,with concomitant high trough levels and stable clinical and biochemical remission of the disease.CONCLUSION TDM-guided high-dose ADA treatment as a monotherapy overcame ATA production.This strategy could be a good alternative to combination therapy,especially in very young patients. | Silvana Ancona Sara Signa Chiara Longo Giuliana Cangemi Roberta Carfora Enrico Drago Alessandro La Rosa Marco Crocco Andrea Chiaro Paolo Gandullia Serena Arrigo | 2023 | World Journal of Gastroenterology2023，29，38： | 0 |
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