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| 1 | DNA end binding activity and Ku70/80 heterodimer expression in human colorectal tumor显示文摘AIM: To determine the DNA binding activity and protein levels of the Ku70/80 heterodimer, the functional mediator of the NHEJ activity, in human colorectal carcinogenesis.METHODS: The Ku70/80 DNA-binding activity was determined by electrophoretic mobility shift assays in 20 colon adenoma and 15 colorectal cancer samples as well as matched normal colonic tissues. Nuclear and cytoplasmic protein expression was determined by immunohistochemistry and Western blot analysis.RESULTS: A statistically significant difference was found in both adenomas and carcinomas as compared to matched normal colonic mucosa (P<0.00). However,changes in binding activity were not homogenous with approximately 50% of the tumors showing a clear increase in the binding activity, 30% displaying a modest increase and 15% showing a decrease of the activity.Tumors, with increased DNA-binding activity, also showed a statistically significant increase in Ku70 and Ku86nuclear expression, as determined by Western blot and immunohistochemical analyses (P<0.001). Cytoplasmic protein expression was found in pathological samples,but not in normal tissues either from tumor patients or from healthy subjects.CONCLUSION: Overall, our DNA-binding activity and protein level are consistent with a substantial activation of the NHEJ pathway in colorectal tumors. Since the NHEJ is an error prone mechanism, its abnormal activation can result in chromosomal instability and ultimately lead to tumorigenesis. | Paola Mazzarelli Paola Parrella Davide Seripa Emanuela Signori Giuseppe Perrone Carla Rabitti Domenico Borzomati Armando Gabbrielli Maria Giovanna Matera Carolina Gravina Marco Caricato Maria Luana Poeta Monica Rinaldi Sergio Valeri Roberto Coppola Vito Michele Fazio | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 2 | Risk factors and outcome of Acinetobacter baumanii infection in severe trauma patients显示文摘 | Caricato A Montini L Bello G | 2009 | Intensive Care Med2009，35，11： | 1 |
| 3 | Boron carbonitride films de posited by pulsed laser ablation显示文摘 | Caricato A P Luches A | 1998 | Appl Sur Sci1998，133，4： | 1 |
| 4 | Retrospective analysis of long- Ierm defunctioning stoma complications after colorectal surgery 显示文摘 | Caricato M Ausania F Ripetti V | 2007 | Colorectal Dis2007，9，6： | 1 |
| 5 | Boron Carbon Nitride Films Deposited by Sequential Pulses Laser Deposition显示文摘 | Dinescu M Perrone A P Caricato A P | 1998 | Applied Surface Science1998，127，： | 1 |
| 6 | Risk factors and outcome of Acinetobacter baumanii infection in severe trauma patients显示文摘 | Caricato A Montini L Bello G | 2009 | Intensive Care Med2009，35，11： | 1 |
| 7 | Risk factors and outcome of Acinetobacter baumanii infection in severe trauma patients显示文摘 | Caricato A Montini L Bello G | 2009 | In- tensive Care Med2009，35，11： | 1 |
| 8 | Integrated use of biomarkers (acetylcholinesterase and antioxidant enzymes activities) in Mytilus galloprovincialis and Mullus barbatus in an Italian coastal marine area显示文摘 | LIONETTO M G CARICATO R GIORDANO M E | 2003 | Marine Pollution Bulletin2003，46，3： | 1 |
| 9 | Lysosome activity in embryos and larvae of sea bass (Dicentrarchus labrax L),spawned by broodstocks fed with vitamin C enriched diets显示文摘 | CECCHINI S TEROVA G CARICATO G | 2000 | Bull Eur Assoc Fish Pathol2000，20，： | 1 |
| 10 | A rare case of complicated Meckel's diverticulum显示文摘 | Caricato M Mangiameli G Miecadei F | 2010 | Case Report and Images2010，81，6： | 1 |
| 11 | Calcination of Co-based Fischer-Tropsch synthesis catalysts显示文摘 | Van de Loosdrecht J Barradas S Caricato E A | 2003 | Topics in Catalysis2003，26，14： | 1 |
| 12 | Parallel tabu search for a pickup and delivery problem under track contention显示文摘 | Caricato P Ghiani G Grieco A Guerriero E | 2003 | Parallel Computing2003，29，5： | 1 |
| 13 | Usefulness of transcranial echography in patients with decompressive craniectomy: A comparison with computed tomography scan*显示文摘 | Anselmo Caricato Vittorio Mignani Maria Grazia Bocci Mariano Alberto Pennisi Claudio Sandroni Alessandra Tersali Alessandra Antonaci Chiara de Waure Massimo Antonelli | 2012 | Critical Care Medicine2012，，6： | 1 |
| 14 | Integrated use of biomarkers(acetyl cholinesterase and antioxidant enzymes activities)in Mytilus galloprovincialis and Mullus barbatus in an Italian coastal marine area显示文摘 | Lionetto M G Caricato R Giordano M E | 2003 | Marine Pollution Bulletin2003，46，3： | 1 |
| 15 | Bedside detection of acute epidural hematoma by transcranial sonography in a head-injured patient显示文摘 | A. Caricato V. Mignani C. Sandroni D. Pietrini | 2010 | Intensive Care Medicine2010，，6： | 1 |
| 16 | Rectal perforation,retropneumoperitoneum,and pneumomediastinum after stapling procedure for prolapsed hemorrhoids:report of a case and subsequent considerations显示文摘 | Ripetti V Caricato M Arullani A | | 0，，02： | 1 |
| 17 | Effects of PEEP on the intracranial system of patients with head injury and subarachnoid hemorrhage: the role of respiratory system compliance显示文摘 | Caricato A Conti G Della-Corte F | 2005 | J Trauma2005，58，3： | 1 |
| 18 | Integrated use of biomarkers (acetylcholinesterase and antioxidant enzymes activities) in Mytilus galloprovincialis and Mullus barbatus in an Italian coastal marine area显示文摘 | LIONETTO M G CARICATO R GIORDANO M E | 2003 | Marine Pollution Bulletin2003，46，3： | 1 |
| 19 | Boron carbonitride films deposited by pulsed laser ablation显示文摘 | Perrone A Caricato A P Luches A | 1998 | Appl Surf Sci1998，133，4： | 1 |
| 20 | Electrical and optical properties of ITO and ITO/Cr-doped ITO films显示文摘 | A. P. Caricato M. Cesaria A. Luches M. Martino G. Maruccio D. Valerini M. Catalano A. Cola M. G. Manera M. Lomascolo A. Taurino R. Rella | 2010 | Applied Physics A2010，，4： | 1 |
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