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| 1 | P-glycoprotein multidrug transporter in inflammatory bowel diseases: More questions than answers显示文摘The gastrointestinal barrier is constantly exposed to numerous environmental substrates that are foreign and potentially harmful. These xenobiotics can cause shifts in the intestinal microbiota composition, affect mucosal immune responses, disturb tissue integrity and impair regeneration. The multidrug transporter ABCB1/MDR1 p-glycoprotein (p-gp) plays a key role at the front line of host defence by efficiently protecting the gastrointestinal barrier from xenobiotic accumulation. This Editorial discusses how altered expression and function of ABCB1/MDR1 p-gp may contribute to the development and persistence of chronic intestinal inflammation in inflammatory bowel diseases (IBD). Recent evidence implies multiple interactions between intestinal microbiota, innate immunity and xenobiotic metabolism via p-gp. While decreased efflux activity may promote disease susceptibility and drug toxicity, increased efflux activity may confer resistance to therapeutic drugs in IBD. Mice deficient in MDR1 A develop spontaneously chronic colitis, providing a highly valuable murine IBD model for the study of intestinal epithelial barrier function, immunoregulation, infectious co-triggers and novel therapeutic approaches. Possible associations of human ABCB1 gene polymorphisms with IBD susceptibility have been evaluated, but results are inconsistent. Future studies must focus on further elucidation of the pathophysiological relevance and immunological functions of p-gp and how its ambiguous effects could be therapeutically targeted in IBD. | Elke Cario | 2017 | World Journal of Gastroenterology2017，23，9： | 5 |
| 2 | Purse-string suture technique to enable laparoscopic management of the interstitial gestation of a heterotopic pregnancy显示文摘 | Thomas Aust Aoife O’Neill Gregory Cario | 2011 | Fertility and Sterility2011，，1： | 2 |
| 3 | Shear Analysis and Design of Ductile Steel Plate Walls显示文摘 | Carios E Ventura M | 2005 | Journal of Structural Engineering2005，131，6： | 1 |
| 4 | Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C 显示文摘 | Cario E Gerken G Podolsky D K | 2004 | Gastroenterology2004，127，1： | 1 |
| 5 | Toll-like receptors in inflammatory bowel diseases:a decade later显示文摘 | Cario E | 2010 | Inflamm Bowel Dis2010，16，9： | 1 |
| 6 | Lipopolysaccharide activates distinct signaling pathways in intestinal cell lines expressing Toll-like receptors 显示文摘 | Cario E Rosenberg IM Brandwein SL | 2000 | Immunol2000，164，： | 1 |
| 7 | Treatment with hydroxyurea in thalassemia intermedia with paravertebral pseudotumors of extramedullary hematopoiesis显示文摘 | Cario H Wegener M Debatin K | 2002 | Am Hematol2002，81，： | 1 |
| 8 | Polymor-phisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population显示文摘 | Schnakenberg E Mehles A Cario G | 2005 | BMC Med Genet2005，6，： | 1 |
| 9 | Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing toll-like receptors显示文摘 | Cario E Rosenberg IM Brandwein SL | 2000 | J Immunol2000，164，2： | 1 |
| 10 | Explicit authorship显示文摘 | CARIOS G L | 1996 | Bulletion of the ecological society of America1996，77，4： | 1 |
| 11 | Toll-like receptor 2controls mucosal inflammation by regulating epithelial barrier function 显示文摘 | CARIO E GERKEN G PODOLSKY D K | 2007 | Gastroenterology2007，132，4： | 1 |
| 12 | Bacterial interactions with cells of the intestinal mucosa Toll-like receptors and NOD2 显示文摘 | CARIO E | 2005 | Gut2005，54，8： | 1 |
| 13 | Trace Analysis of Sulfonylurea Herbicides in Water:Extraction and Purification by a Carbograph 4 Cartridge,Followed by Liquid Chromatography with UV Detection,and Confirmatory Analysis by an Electrospray/Mass Detector显示文摘 | ANTONIO D C CARIO C ROBERTB S | 1997 | Anal Chem1997，69，： | 1 |
| 14 | Early gene expression differences in inbred mouse strains with susceptibility to pulmonary adenomas显示文摘 | Steam T M Cario C L Savage H S | 2012 | Exp Mol Pathol2012，93，3： | 1 |
| 15 | Factor XIII modulates intestinal epithelial wound healing in vitro 显示文摘 | Cario E Goebell H Dignass A U | 1999 | Scand J Gastroenlerol1999，34，6： | 1 |
| 16 | Toll-like receptors in inflammatory bowel diseases: a decade later 显示文摘 | Cario E | 2010 | Inflammatory Bowel Diseases2010，16，9： | 1 |
| 17 | Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models 显示文摘 | Carios Portera-Cailliau John C Hedreen Donald L Price | 1995 | J Neurosci1995，15，5： | 1 |
| 18 | Global robust disturbance attenuation and almost disturbance decoupling for uncertain cascaded nonlinear systems显示文摘 | Su Weizhou Xie Lihua Carios Souza de E | 1999 | Automatiea1999，35，： | 1 |
| 19 | Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 ( TLR3 ) and TLR4 in inflammatory bowel disease 显示文摘 | Cario E Podolsky DK | 2000 | Infect Immun2000，68，12： | 1 |
| 20 | A critical appraisal of vitiligo etiologic theories:is melanocyte loss a melanocytorrhagy显示文摘 | Gauthier Y Cario André M Ta(i)eb A | 2003 | Pigment Cell Res2003，16，4： | 1 |
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