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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | Lack of microRNA‐101 causes E‐cadherin functional deregulation through EZH2 up‐regulation in intestinal gastric cancer显示文摘 | Joana Carvalho Nicole C van Grieken Patricia M Pereira Sónia Sousa Marianne Tijssen Tineke E Buffart Bego?a Diosdado Heike Grabsch Manuel AS Santos Gerrit Meijer Raquel Seruca Beatriz Carvalho Carla Oliveira | 2012 | J Pathol2012，，1： | 3 |
| 3 | T-cell ageing in end-stage renal disease patients:Assessment and clinical relevance显示文摘End-stage renal disease(ESRD) patients have a defective T-cell-mediated immune system which is related to excessive premature ageing of the T-cell compartment.This is likely to be caused by the uremia-associated pro-inflammatory milieu,created by loss of renal function.Therefore,ESRD patients are highly susceptible for infections,have an increased risk for virus-associated cancers,respond poorly to vaccination and have an increased risk for atherosclerotic diseases.Three ageing parameters can be used to assess an immunological T-cell age.First,thymic output can be determined by assessing the T-cell receptor excision circlescontent together with CD31 expression within the naive T cells.Second,the telomere length of T cells and third the T-cell differentiation status are also indicators of T-cell ageing.Analyses based on these parameters in ESRD patients revealed that the immunological T-cell age is increased by on average 20 years compared to the chronological age.After kidney transplantation(KTx) the aged T-cell phenotype persists although the pro-inflammatory milieu is diminished.This might be explained by epigenetic modifications at hematopoietic stem cells level.Assessment of an immunological T-cell age could be an important tool to identify KTx recipients who are at risk for allograft rejection or to prevent over-immunosuppression. | Ruud WJ Meijers Michiel GH Betjes Carla C Baan Nicolle HR Litjens | 2014 | World Journal of Nephrology2014，3，4： | 2 |
| 4 | Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia显示文摘 | Francielle Tramontini Gomes de Sousa Cardozo Carla Maísa Camelini Alessandra Mascarello Márcio José Rossi Ricardo José Nunes Célia Regina Monte Barardi Margarida Matos de Mendon?a Cláudia Maria Oliveira Sim?es | 2011 | Antiviral Research2011，，1： | 2 |
| 5 | Keratin8, 10, 13, and 17 are useful markers in the diagnosis of human cervix carcinomas显示文摘 | Carla C Matos A Landim B | 2004 | Hum Pathol2004，35，5： | 1 |
| 6 | Naphthenic Acids, Total Acid Number and Sulfur Content Profile Cha- racterization in Isthmus and Maya Crude Oils显示文摘 | GEORGINA C L CARLA R L REGINA E A | 2004 | Fuel2004，83，： | 1 |
| 7 | Passive UHF RFID Tag for Airport Suitcase Tracking and Identification 显示文摘 | CARLA R M JORGE R C CARLOS A F | 2011 | IEEE Antennas and Wireless Propagation Letters2011，10，： | 1 |
| 8 | Degradable biomaterials based on Magnesium corrosion 显示文摘 | Frank W Norbert H Carla V Smadar C Karl U K Regine W Frank F | 2008 | Current Opinion in Solid State and Materials Science2008，12，56： | 1 |
| 9 | Multiple sclerosis recurrence risk for siblings in an isolated popilation of central Sandinia, Italy 显示文摘 | Montomoli C Prokopenko I Carla A | 2002 | Genet Epidemiol2002，22，3： | 1 |
| 10 | Screening for Down syndrome-incidental diagnosis of other aneuploidies显示文摘 | Carla D Howard C Yuval Y | 2014 | Prenat Diagn2014，34，： | 1 |
| 11 | Effectiveness of a interven- tion on metabolic syndrome:A randomized cont roiled trial 显示文摘 | Simona Bo Giovannino C Carla B | 2007 | J Gen Intern Med2007，22，12： | 1 |
| 12 | An analytical model for wireless sensor networks with sleeping nodes 显示文摘 | CARLA - FABIANA C MICHELE G | 2006 | IEEE Transactions on Mobile Computing2006，5，12： | 1 |
| 13 | Towards the bio-production of trans-carveol and carvone from limonene:induction after cell growth on limonene and toluene显示文摘 | Carla C C R de carvalho M Manuela R da Fonseca | | 0，，： | 1 |
| 14 | Classi- fication of Brazilian honeys by physical and chemical analyti- cal methods and low field nuclear magnetic resonance (LFIH NMR) 显示文摘 | Roberta de O R R Eliane T M Carla da S C | 2014 | LWT- Food Science and Technology2014，55，： | 1 |
| 15 | Rapid expansion of recycling stem cells cultures of plastic adherent cells from human bone marrow 显示文摘 | David C Reiner C Carla Metal | 2000 | Pro Nat Acad Sci USA2000，97，7： | 1 |
| 16 | Parallels in knowledge cycles 显示文摘 | CARLA C NICK B | 2011 | Computers in Human Behavior2011，27，4： | 1 |
| 17 | E-cadherin dysfunction in gastric cancer - Cellular consequences, clinical applications and open questions显示文摘 | Patrícia Carneiro Maria Sofia Fernandes Joana Figueiredo Joana Caldeira Joana Carvalho Hugo Pinheiro Marina Leite Soraia Melo Patrícia Oliveira Joana Sim?es-Correia Maria José Oliveira Fátima Carneiro Céu Figueiredo Joana Paredes Carla Oliveira Raquel Ser | 2012 | FEBS Letters2012，，18： | 1 |
| 18 | Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow 显示文摘 | David C Colter Reiner Class Carla MD | 2000 | Cell Biology2000，97，7： | 1 |
| 19 | The calcium-sensing receptor is si- lenced by genetic and epigenetic mechanisms in unfavorable neuro- blastomas and its reactivation induces ERK1/2-dependent apoptosis 显示文摘 | Carla C Estel G Jos L | 2012 | Carcinogenesis2012，34，2： | 1 |
| 20 | Rapid expansion of recycling stem cells in cultrues of plastic - adherent cells from human bone marrow显示文摘 | David CC Reiner C Carla M | 2000 | Proc Natl Acad Sci USA2000，97，： | 1 |
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