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| 1 | 湿邪致病大鼠相关T淋巴细胞受体β链可变区基因谱系的研究显示文摘目的:采用实时荧光定量PCR方法检测湿邪致病大鼠(TCRVβ)亚家族基因表达谱,从免疫识别的角度探讨湿邪致病'蒙蔽性'特点。方法:将32只SD大鼠按随机数字表随机分为正常对照组、内湿大鼠模型组、外湿大鼠模型组和内外湿大鼠模型组4组,造模20d后,各组按随机数字表选3只大鼠,检测其TCRVβ亚家族表达水平。结果:与正常对照组比较,外湿大鼠模型组的TCRVβ1、TCRVβ7、TCRVβ9、TCRVβ13表达升高(P<0.05,P<0.01,P<0.001)。与正常对照组比较,内湿大鼠模型组的TCRVβ8、TCRVβ14、TCRVβ18表达降低(P<0.05,P<0.01),内外湿大鼠模型组的TCRVβ8、TCRVβ18表达也降低(P<0.05,P<0.01)。结论:在外湿大鼠模型组部分TCRVβ亚家族比正常对照组表达升高,而在内湿大鼠模型组及内外湿大鼠模型组中部分TCRVβ比正常对照组表达低下,提示内湿之邪可能具有'蒙蔽性'有关,在内湿的环境中,机体可能对外在相关抗原相对不敏感,进而导致湿邪致病大鼠免疫功能障碍而死亡率升高,其机制值得进一步研究。 | Carlini Fan Hardi 张诗军 陈泽雄 朱宝益 王伟 胡斌 | 2010 | 中华中医药杂志2010，25，2： | 14 |
| 2 | 和解法治疗乙型肝炎相关性肝源性糖尿病的临床观察显示文摘目的探讨和解法治疗乙型肝炎相关性肝源性糖尿病的临床疗效。方法将39例乙型肝炎相关性肝源性糖尿病患者随机分为治疗组和对照组2组,治疗组20例采用和解法治疗,对照组19例采用护肝、抗病毒、降糖综合治疗,观察治疗后外周血肝功能、血糖水平及症状的改善情况。结果两组治疗后丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)水平和血清总胆红素(TB)水平较治疗前明显降低(P<0.01),空腹血糖(FBG)、餐后2小时血糖(PBG)水平均较治疗前明显降低(P<0.01),治疗组还能明显升高白蛋白与球蛋白比率(P<0.05)。两组治疗后症状积分均较治疗前明显降低,但治疗组治疗前后3个月和6个月的积分差值要明显高于对照组(P<0.05,P<0.01)。结论和解法治疗乙型肝炎相关性肝源性糖尿病具有一定疗效,而且副作用较小,值得进一步推广应用。 | 郝尧坤 Carlini Fan Hardi 程永华 张诗军 | 2008 | 北京中医药2008，27，8： | 6 |
| 3 | 基于IL-2、IL-8水平变化的湿邪致病机理研究显示文摘目的:通过湿邪致病大鼠IL-2、IL-8水平变化探讨湿邪致病与细胞免疫功能的关系。方法:将40只SD大鼠按随机数字表随机分为正常组、内湿组、外湿组、内外湿组及疲劳组5组,分别造模20天后,采用放射免疫(RLA)方法检测其IL-2、IL-8水平。结果:全组比较,IL-2和IL-8水平在各组的差异有非常显著意义(F=3.102,P=0.028;F=2.657,P=0.049)。两两比较,外湿组和内外湿组的IL-2水平都比正常组明显升高(P=0.005,P=0.028),外湿组的IL-2水平比内湿组明显升高(P=0.015);外湿组的IL-8水平明显升高,与正常组、内湿组、内外湿组相比较差异有显著性(P=0.036,P=0.004,P=0.034)。结论:外湿组的IL-2和IL-8水平比内湿组和正常组明显升高,提示湿邪致病初期外湿与机体的免疫激活和炎症反应密切有关,此阶段机体可能对外在湿邪较内在湿邪的刺激更为敏感,其机理有待于进一步研究。 | Carlini Fan Hardi 张诗军 陈泽雄 林佑武 董霄 | 2010 | 中国中医药咨讯2010，，1： | 6 |
| 4 | Treatment for isolated loco-regional recurrence of gastric adenocarcinoma: Does surgery play a role?显示文摘AIM: To evaluate the role of surgical treatment for isolated loco-regional recurrences of operated gastric adenocarcinoma. METHODS: Among the 837 patients operated for gastric adenocarcinoma between December 1979 and April 2004, 713 (85%) underwent resection with curative intent. A retrospective review of a prospectively collected gastric cancer database was carried out. Overall recurrence rate was 44% (315 cases), with 75% occurring within the first 2 years from the operation. Isolated L-R recurrences were observed in 38 (12%) patients. Symptomatic lesions were observed in 27 (71%). RESULTS: Six (16%) patients were macroscopically resected with curative intent. The recurrence was located in the gastric stump after a STG in three patients, in the esophagojejunal anastomosis after a TG in two patients and in the gastric bed after a TG in one patient. Surgical procedures consisted of three secondary TG, two esophagojejunal resection and one excision of an extraluminal recurrence. Postoperative complications occurred in two patients (33%), including one anastomotic leakage and one hemorrhage. The latter patient died of sepsis 35 d after the surgery (mortality rate 17%). All patients died of recurrent gastric cancer: 2 within 1 year from surgery (8 and 11 mo, respectively), 2 after 16 and 17 mo respectively and 1 after 28 mo from the second operation. CONCLUSION: Surgery plays a very limited role in the treatment for isolated loco-regional recurrence of gastric adenocarcinoma. | Fabio Carboni Pasquale Lepiane Roberto Santoro Riccardo Lorusso Pietro Mancini Massimo Carlini Eugenio Santoro | 2005 | World Journal of Gastroenterology2005，11，44： | 5 |
| 5 | Synthesis and Characterization of Iron-Rich Glass Ceramic Materials:A Model for Steel Industry Waste Reuse显示文摘Wastes deriving from steel industry, containing large amounts of iron oxides and heavy metals, when collected in landfills are subjected to atmospheric agents, with consequent release of toxic substances in the soil and groundwater. The reuse of these wastes as raw materials for the production of advanced materials is a viable way both to overcome the environmental impact and to reduce the disposal costs,proposing new technologically advanced materials. This work aims to simulate these interesting glassceramics by using glass cullet coming from recycled municipal waste and high amount of iron(III) oxide(from 25 wt% to 50 wt%), the prevalent component of steel waste. The oxide was mixed with glass cullet and vitrified. The samples composition and the microstructure were investigated by scanning electron microscopy(SEM), and X-ray diffraction(XRD) was used to evaluate the nature of the crystalline phases.The chemical stability of the materials, in terms of ionic release into saline solution, was assessed. The electrical behavior of the samples was also investigated by varying the iron ions content and controlling the crystallization process. It is possible to obtain chemically stable materials with a nearly semiconducting behavior. | Riccardo Carlini Ilaria Alfieri Gilda Zanicchi Francesco Soggia Enos Gombia Andrea Lorenzi | 2016 | Journal of Materials Science & Technology2016，32，11： | 2 |
| 6 | Correlation between pathogenesis of dampness syndrome and Interleukin-2,Interleukin-8 in rats显示文摘OBJECTIVE: To explore the pathogenesis of dampness syndrome by detecting the changes of interleukin-2 (IL-2) and interleukin-8 (IL-8) levels. METHODS: Female Sprague Dawley rats were divided randomly into five groups according to the random number table: a normal group (GroupⅠ), an external dampness group (GroupⅡ), an internal dampness group (Group Ⅲ), and an external and internal dampness group (GroupⅣ). Twenty days after the model made, IL-2 and IL-8 levels were detected by radioimmunoassay method. RESULTS: The IL-2 and IL-8 levels among groups were significant (F=3.102, P<0.05; F=2.657, P<0.05, respectively). The level of IL-2 in Group Ⅱ and Group Ⅲ were higher than that in GroupⅠ(P<0.05, P<0.01, respectively), especially higher in the Group Ⅲ compared with GroupⅡ (P<0.05). The lev- el of IL-8 in Group Ⅲ were higher than those inGroupⅠ, GroupⅡ and GroupⅣ (P<0.05, P<0.01, P< 0.05, respectively). In the GroupⅢ, the 24-hour wa ter and body weight were higher than that in the GroupⅣ (all P<0.05), and spontaneous movemen frequency was higher than those in GroupⅡ and GroupⅣ (P<0.05). CONCLUSION: Immune activation and inflammato ry reaction might be easily caused by externa danpness other than internal dampness. | Xiaolin Chen Youwu Lin Shijun Zhang Zexiong Chen Carlini Fan Hardi Ting Xiang Baoguo Sun | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 2 |
| 7 | Cisplatin,epirubicin,leucovorin and 5-fluorouracil(PELF) is more active than 5-fluorouracil,doxorubicin and methotrexate(FAMTX) in advanced gastric carcinoma显示文摘 | Cocconi G Carlini P Gamboni A | 2003 | Annals of Oncology2003，14，8： | 1 |
| 8 | Gastric cancer in elderly and young patients: a Western experience 显示文摘 | Santoro R Carlini M Carboni F | 2003 | Tumori2003，89，4： | 1 |
| 9 | Apoptotic stress pat- hway ctivation mediated by iron on endothelial cells in vitro显示文摘 | Carlini RG Alonzo E Bellorin-Font E | 2006 | Nephrol Dial Transplant2006，21，11： | 1 |
| 10 | Differential effects of fluoxetine and venlafaxine on memory recognition:possible mechanisms of action 显示文摘 | Valeria Paola Carlini Maria Belen Poretti Mathias Rask- Andersen | 2012 | Prog Neuropsychopharmacol Biol Psychiatry2012，38，2： | 1 |
| 11 | Integrating variable renewables in europe: current status and recent extreme events显示文摘 | ACKERMANN T CARLINI E M ERNST B | 2015 | IEEE Power and Energy Magazine2015，13，6： | 1 |
| 12 | UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan显示文摘 | Carlini LE Meropol NJ Bever J | 2005 | Clin Cancer Res2005，11，： | 1 |
| 13 | Selective uterine artery embolization: a new therapeutic approach in a patient with low-risk gestational trophoblastic disease 显示文摘 | Carlini L Villa A Busci L | 2006 | Am J Obstet Gynecol2006，195，1： | 1 |
| 14 | Ghrelin increases anxiety- like behavior and memory retention in rats显示文摘 | Carlini VP Monzo n ME Varas MM | 2002 | Biochemical and Bioph- ysical Research Communications2002，299，5： | 1 |
| 15 | Clinical prac- tice guidelines for the prevention, diagnosis, evaluation and trea- tment of mineral and bone disorders in chronic kidney disease (CKD-MBD) in adults 显示文摘 | Bellprin-Font E Ambrosoni P Carlini RG | 2013 | Nefrologia2013，331，： | 1 |
| 16 | Acute ghrelin administration reverses depressive like behavior induced by bilateral olfactory bulbeetomy in mice显示文摘 | Carlini V P Machado D G Buteler F | 2012 | Peptides2012，35，2： | 1 |
| 17 | Diferential role of the h- ippocampus, amygdala, and dorsal raphe nucleus in regulating feeding, memory, and anxiety like behavioral responses to ghrelin显示文摘 | Carlini VP Varas MM Craguolini AB | 2004 | Biochem Biophys Res Commun2004，313，3： | 1 |
| 18 | Gemcitabine with or without continuous infusion 5-FU in advanced pancreatic cancer: a randomised phase Ⅱ trial of the italian pncology group for clinical research (GOIRC) 显示文摘 | Di Costanzo F Carlini P Doni L | 2005 | Br J Cancer2005，93，： | 1 |
| 19 | Estrogen receptor beta and epidermal growth factor receptor as early - stage prognostic biomarkers of non - small cell lung cancer 显示文摘 | Mauro LV M Dalurzo MJ Carlini | 2010 | Oncol Rep2010，24，5： | 1 |
| 20 | Ghrelin and memory:differentialeffects on acquisition and retrieval显示文摘 | Carlini VP Ghersi M Schi (o)th HB | 2012 | Peptides2012，31，6： | 1 |
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