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| 1 | Exploring alternative treatments for Helicobacter pylori infection显示文摘Helicobacter pylori(H. pylori) is a successful pathogen that can persist in the stomach of an infected person for their entire life. It provokes chronic gastric inflammation that leads to the development of serious gastric diseases such as peptic ulcers, gastric cancer and Mucosa associated lymphoid tissue lymphoma. It is known that these ailments can be avoided if the infection by the bacteria can be prevented or eradicated. Currently, numerous antibiotic-based therapies are available. However, these therapies have several inherent problems, including the appearance of resistance to the antibiotics used and associated adverse effects, the risk of re-infection and the high cost of antibiotic therapy. The delay in developing a vaccine to prevent or eradicate the infection has furthered research into new therapeutic approaches. This review summarises the most relevant recent studies on vaccine development and new treatments using natural resources such as plants, probiotics and nutraceuticals. In addition, novel alternatives based on microorganisms, peptides, polysaccharides, and intragastric violet light irradiation are presented. Alternative therapies have not been effective in eradicating the bacteria but have been shown to maintain low bacterial levels. Nevertheless, some of them are useful in preventing the adverse effects of antibiotics, modulating the immune response, gastroprotection, and the general promotion of health. Therefore, those agents can be used as adjuvants of allopathic anti-H. pylori eradication therapy. | Guadalupe Ayala Wendy Itzel Escobedo-Hinojosa Carlos Felipe de la Cruz-Herrera Irma Romero | 2014 | World Journal of Gastroenterology2014，20，6： | 16 |
| 2 | Prognostic factors and time-related changes influence results of colorectal liver metastases surgical treatment:A single-center analysis显示文摘AIM:To analyze the prognostic factors involved in survival and cancer recurrence in patients undergoing surgical treatment for colorectal liver metastases(CLM) and to describe the effects of time-related changes on survival and recurrence in these patients.METHODS:From January 1994 to January 2006,236 patients with CLM underwent surgery with the aim of performing curative resection of neoplastic disease at our institution and 189(80%) of these patients underwent resection of CLM with curative intention.Preoperative,intraoperative and postoperative data,including primary tumor and CLM pathology results,were retrospectively reviewed.Patients were divided into two time periods:a first period from January 1994 to January 2000(n = 93),and a second period from February 2000 to January 2006(n = 143).RESULTS:Global survival at 1,3 and 5 years in patients undergoing hepatic resection was 91%,54% and 47%,respectively.Patients with preoperative extrahepatic disease,carcinoembryonic antigen(CEA) levels over 20 ng/dL,more than four nodules or extrahepatic invasion at pathological analysis had worse survival.Tumor recurrence rate at 1 year was 48.3%,being more frequent in patients with preoperative and pathological extrahepatic disease and CEA levels over 20 ng/dL.Although patients in the second time period had more adverse prognostic factors,no differences in overall survival and recurrence were observed between the two periods.CONCLUSION:Despite advances in surgical technique and better adjuvant treatments and preoperative imaging,careful patient staging and selection is crucial to continue offering a chance of cure to patients with CLM. | Josep Martí María Marta Modolo Josep Fuster Jaume Comas Rebeca Cosa Joana Ferrer Victor Molina Juan Romero Constantino Fondevila Ramón Charco Juan Carlos García-Valdecasas | 2009 | World Journal of Gastroenterology2009，15，21： | 9 |
| 3 | Deep Learning Based Intelligent Industrial Fault Diagnosis Model显示文摘In the present industrial revolution era,the industrial mechanical system becomes incessantly highly intelligent and composite.So,it is necessary to develop data-driven and monitoring approaches for achieving quick,trustable,and high-quality analysis in an automated way.Fault diagnosis is an essential process to verify the safety and reliability operations of rotating machinery.The advent of deep learning(DL)methods employed to diagnose faults in rotating machinery by extracting a set of feature vectors from the vibration signals.This paper presents an Intelligent Industrial Fault Diagnosis using Sailfish Optimized Inception with Residual Network(IIFD-SOIR)Model.The proposed model operates on three major processes namely signal representation,feature extraction,and classification.The proposed model uses a Continuous Wavelet Transform(CWT)is for preprocessed representation of the original vibration signal.In addition,Inception with ResNet v2 based feature extraction model is applied to generate high-level features.Besides,the parameter tuning of Inception with the ResNet v2 model is carried out using a sailfish optimizer.Finally,a multilayer perceptron(MLP)is applied as a classification technique to diagnose the faults proficiently.Extensive experimentation takes place to ensure the outcome of the presented model on the gearbox dataset and a motor bearing dataset.The experimental outcome indicated that the IIFD-SOIR model has reached a higher average accuracy of 99.6%and 99.64%on the applied gearbox dataset and bearing dataset.The simulation outcome ensured that the proposed model has attained maximum performance over the compared methods. | R.Surendran Osamah Ibrahim Khalaf Carlos Andres Tavera Romero | 2022 | Computers, Materials & Continua2022，，3： | 5 |
| 4 | Carbonaceous residues from biomass gasification as catalysts for biodiesel production显示文摘Tars and alkali ashes from biomass gasification processes currently constitute one of the major problems in biomass valorisation,generating clogging of filters and issues related with the purity of syngas production.To date,these waste residues find no useful applications and they are generally disposed upon generation in the gasification process.A detailed analysis of these residues pointed out the presence of high quantities of Ca(>30 wt%).TG experiments indicated that a treatment under air at moderate temperatures(400-800 C) decomposed the majority of carbon species,while XRD indicated the presence of a crystalline CaO phase.CaO enriched valorized materials turned out to be good heterogeneous catalysts for biodiesel production from vegetable oils,providing moderate to good activities(50%-70% after 12 h) to fatty acid methyl esters in the transesterification of sunflower oil with methanol. | Rafael Luque Antonio Pineda Juan C. Colmenares Juan M. Campelo Antonio A. Romero Juan Carlos Serrano-Ruiz Luisa F. Cabeza Jaime Cot-Gores | 2012 | Journal of Natural Gas Chemistry2012，21，3： | 4 |
| 5 | Fatty liver disease,an emerging etiology of hepatocellular carcinoma in Argentina显示文摘AIM To investigate any changing trends in the etiologies of hepatocellular carcinoma(HCC) in Argentina during the last years. METHODS A longitudinal cohort study was conducted by 14 regional hospitals starting in 2009 through 2016. All adult patients with newly diagnosed HCC either with pathology or imaging criteria were included. Patients were classified as presenting non-alcoholic fatty liver disease(NAFLD) either by histology or clinically, provided that all other etiologies of liver disease were ruled out, fatty liver was present on abdominal ultrasound and alcohol consumption was excluded. Complete follow-up was assessed in all included subjects since the date of HCC diagnosis until death or last medical visit.RESULTS A total of 708 consecutive adults with HCC were included. Six out of 14 hospitals were liver transplant centers(n = 484). The prevalence of diabetes mellitus was 27.7%. Overall, HCV was the main cause of liver disease related with HCC(37%) including cirrhotic and non-cirrhotic patients, followed by alcoholic liver disease 20.8%, NAFLD 11.4%, cryptogenic 9.6%, HBV 5.4% infection, cholestatic disease and autoimmune hepatitis 2.2%, and other causes 9.9%. A 6-fold increase in the percentage corresponding to NAFLDHCC was detected when the starting year, i.e., 2009 was compared to the last one, i.e., 2015(4.3% vs 25.6%; P < 0.0001). Accordingly, a higher prevalence of diabetes mellitus was present in NAFLD-HCC group 61.7% when compared to other than NAFLD-HCC 23.3%(P < 0.0001). Lower median AFP values at HCC diagnosis were observed between NAFLD-HCC and non-NAFLD groups(6.6 ng/m L vs 26 ng/m L; P = 0.02). Neither NAFLD nor other HCC etiologies were associated with higher mortality.CONCLUSION The growing incidence of NAFLD-HCC documented in the United States and Europe is also observed in Argentina, a confirmation with important Public Health implications. | Federico Pinero Josefina Pages Sebastián Marciano Nora Fernández Jorge Silva Margarita Anders Alina Zerega Ezequiel Ridruejo Beatriz Ameigeiras Claudia D’Amico Luis Gaite Carla Bermúdez Manuel Cobos Carlos Rosales Gustavo Romero Lucas McCormack Virginia Reggiardo Luis Colombato Adrián Gadano Marcelo Silva | 2018 | World Journal of Hepatology2018，10，1： | 4 |
| 6 | Management of hypertensive crises in the elderly显示文摘高血压的危机比 180/120 mmHg 高是血压的举起。这些能迫切或突现,取决于结束机关损坏的存在。高血压的危机的临床的演讲在老病人是相当可变的,并且临床医生们必须怀疑非特定的症状。在 pathophysiological 的过细的知识在他们改变的老病人需要的设法的高血压的危机,药理学选择,使用的药的 pharmacokinetics,他们的副作用,和他们和另外的药的相互作用。Clevidipine, nicardipine, labetalol, esmolol,和 fenoldopam 在比较喜欢的选择在之中由于他们的功效和 tolerability 老。除非没有可得到的另外的选择, Nitroprusside, hydralazine,和 nifedipine 应该被避免,由于复杂并发症和无法预言的回答的高风险。 | Abbas Alshami Carlos Romero America Avila Joseph Varon | 2018 | Journal of Geriatric Cardiology2018，15，7： | 3 |
| 7 | Safety and efficacy of sorafenib for the treatment of recurrent hepatocellular carcinoma after liver transplantation显示文摘 | Abhijeet Waghray Bengi Balci Galal El‐Gazzaz Richard Kim Robert Pelley KV Narayanan Menon Bassam Estfan Carlos Romero‐Marrero Federico Aucejo | 2013 | Clin Transplant2013，，4： | 3 |
| 8 | Chemical and spectroscopic characterization of humic substances from sediment and riparian soil of a highly polluted urban river (Suquía River, Cordoba, Argentina)显示文摘The Suquía River,the largest urban river in C ordoba(Argentina),has been severely polluted for decades.Actions must be taken to restore its environmental quality by managing riparian zones for increased water-self purification.The current study aimed to characterize organic matter(OM)dynamics and humic substances(HS)spectrochemical properties along the lower-middle basin of the Suquía River.Riparian soil(0e20 cm)and sediment(0e10 cm)samples were collected from a reference location(S1)and four polluted sites(S2eS5)during a low-flow period.The contents of soil and sedimentary OM and HS fractions were analyzed by wet oxidation,as well as HS Fourier transform infrared(FT-IR)and ultravioletevisible(UVeVis)spectrochemical properties.The OM and HS fractions from riparian soil were high upstream of C ordoba City(S1 and S2,50.2e50.4 g/kg OM)and within a 50 km downstream location(S5,30.9 g/kg OM)owing to a surplus of fresh plant biomass-carbon(C)inputs.Highly heterogeneous sediment samples did not show any significant differences among sites(P>0.05).The lowest values of the ratio of absorbances at 465 and 665 nm(E4/E6)(1.78)and the Δ log K(0.15)coefficient(a measure of HS maturity degree)were obtained downstream of C ordoba City,for both riparian soil and sediment,indicating that HS were enriched by more condensed aromatic structures within highly degraded portions of the river.All samples exhibited similar IR spectra,implying overlapping recalcitrant-C structures at the functional group level,but with different absorbance intensity.Data from the current study constitute a baseline for understanding the chemical nature of HS from sediment and riparian soil along the Suquía River and can be used as a reference for future studies tracking OM compositional changes over time. | Carolina Merlo Carolina Vázquez Ana Graciela Iriarte Carlos Matías Romero | 2020 | International Journal of Sediment Research2020，35，3： | 3 |
| 9 | Factors associated with early virological response to peginterferon-α-2a/ribavirin in chronic hepatitis C显示文摘AIM: To evaluate the impact of sociodemographic/clinical factors on early virological response (EVR) to pegin-terferon/ribavirin for chronic hepatitis C (CHC) in clinical practice. METHODS: We conducted a multicenter, cross-sectional, observational study in Hepatology Units of 91 Spanish hospitals. CHC patients treated with peginterferon α-2a plus ribavirin were included. EVR was defined as undetectable hepatitis C virus (HCV)-ribonucleic acid (RNA) or ≥ 2 log HCV-RNA decrease after 12 wk of treatment. A bivariate analysis of sociodemographic and clinical variables associated with EVR was carried out. Independent factors associated with an EVR were analyzed using a multiple regression analysis that included the following baseline demographic and clinical variables: age (≤ 40 years vs > 40 years), gender, race, educational level, marital status and family status, weight, alcohol and tobacco consumption, source of HCV infection, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, and gamma glutamyl transpeptidase (GGT) (≤ 85 IU/mL vs > 85 IU/mL), serum ferritin, serum HCV-RNA concentration (< 400 000 vs ≥ 400 000), genotype (1/4 vs 3/4), cirrhotic status and ribavirin dose (800/1000/1200 mg/d).RESULTS: A total of 1014 patients were included in the study. Mean age of the patients was 44.3 ± 9.8 years, 70% were male, and 97% were Caucasian. The main sources of HCV infection were intravenous drug abuse (25%) and blood transfusion (23%). Seventyeight percent were infected with HCV genotype 1/4 (68% had genotype 1) and 22% with genotypes 2/3. The HCV-RNA level was > 400 000 IU/mL in 74% of patients. The mean ALT and AST levels were 88.4 ± 69.7 IU/mL and 73.9 ± 64.4 IU/mL, respectively, and mean GGT level was 82 ± 91.6 IU/mL. The mean ferritin level was 266 ± 284.8 μg/L. Only 6.2% of patients presented with cirrhosis. All patients received 180 mg of peginterferon α-2a. The most frequently used ribavirin doses were 1000 mg/d (41%) and 1200 mg/d (41%). The planned treatment duration was 48 wk for 92% of patients with genotype 2/3 and 24 wk for 97% of those with genotype 1/4 (P < 0.001). Seven percent of patients experienced at least one reduction in ribavirin or peginterferon α-2a dose, respectively. Only 2% of patients required a dose reduction of both drugs. Treatment was continued until week 12 in 99% of patients. Treatment compliance was ≥ 80% in 98% of patients. EVR was achieved in 87% of cases (96% vs 83% of patients with genotype 2/3 and 1/4, respectively; P < 0.001). The bivariate analysis showed that patients who failed to achieve EVR were older (P < 0.005), had higher ALT (P < 0.05), AST (P < 0.05), GGT (P < 0.001) and ferritin levels (P < 0.001), a diagnosis of cirrhosis (P < 0.001), and a higher baseline viral load (P < 0.05) than patients reaching an EVR. Age < 40 years [odds ratios (OR): 0.543, 95%CI: 0.373-0.790, P < 0.01], GGT < 85 IU/mL (OR: 3.301, 95%CI: 0.192-0.471, P < 0.001), low ferritin levels (OR: 0.999, 95%CI: 0.998-0.999, P < 0.01) and genotype other than 1/4 (OR: 4.716, 95%CI: 2.010-11.063, P < 0.001) were identified as independent predictors for EVR in the multivariate analysis. CONCLUSION: CHC patients treated with peginterferon-α-2a/ribavirin in clinical practice show high EVR. Older age, genotype 1/4, and high GGT were associated with lack of EVR. | Javier García-Samaniego Miriam Romero Rafael Granados Remedios Alemán Miguel Jorge Juan Dolores Suárez Ramón Pérez Gregorio Castellano Carlos González-Portela | 2013 | World Journal of Gastroenterology2013，19，12： | 2 |
| 10 | 加权目标规划在牲畜饲料配方中的应用显示文摘在确定某一营养需要水平的最小费用牲畜饲料配方时,线性规划可能是各种数学最优化技术中应用得最普遍的一种技术。线性规划应用于动物饲料研究已有近40年的历史了,但其理论多年来未有新的突破,直到1981年才有人将目标规划方法应用于饲料配方的研究。 | Tahir Rehman Carlos Romero 季芳 | 1991 | 内蒙古畜牧科学1991，，1： | 2 |
| 11 | Genetic diversity evaluation of a loquat ( Eriobotrya japonica ( Thunb ) Lindl) gerrnplasm collection by SSRs and S-allele fragments显示文摘 | Ana Delia Gisbert Carlos Romero Jose MartineZ-Cal- vo | 2009 | Eu- phytica2009，168，： | 1 |
| 12 | Expression of the yeast trehalose-6-phosphate synthase gene in transgenic tobacco plants :pleiotropic phenotypes include drought tolerance 显示文摘 | CARLOS ROMERO JOSE M BELLES JOSE L | 1997 | Planta1997，201，： | 1 |
| 13 | Total Cholesterol Content of Erythrocyte Membranes Is Increased in Patients With Acute Coronary Syndrome显示文摘 | Dimitrios N. Tziakas Juan Carlos Kaski Georgios K. Chalikias Carlos Romero Salim Fredericks Ioannis K. Tentes Alexandros X. Kortsaris Dimitrios I. Hatseras David W. Holt | 2007 | Journal of the American College of Cardiology2007，，21： | 1 |
| 14 | An architecture for making recommendations to courseware authors using association rule mining and collaborative filtering显示文摘 | Enrique García Cristóbal Romero Sebastián Ventura Carlos de Castro | 2009 | User Modeling and User-Adapted Interaction2009，，1： | 1 |
| 15 | Sexual function after partial penectomy for penile cancer显示文摘 | Frederico Ramalho Romero Karen Richter Pereira dos Santos Romero Marcus Augusto Elias de Mattos Carlos Ricardo Camargo Garcia Roni de Carvalho Fernandes Marjo Deninson Cardenuto Perez | 2005 | Urology2005，，： | 1 |
| 16 | Expression of the yeast trehalose-Phosphate synthase gene in transgenic tobacco plants: pleiotropic phenotypes include drought tolerance显示文摘 | BELLES JOSE L VAYA | 1997 | Planta1997，201，： | 1 |
| 17 | Ultrasound as pretreatment to convective drying of Andean blackberry (Rubus glaucus Benth)显示文摘 | CARLOS A ROMERO J | 2015 | Ultrasonics Sonochemistry2015，22，： | 1 |
| 18 | An Architecture for Making Recommendations to Courseware Authors Using Association Rule Mining and Collaborative Filtering 显示文摘 | Garcfa Enrique Romero Crist6bal Ventura Sebasti0n Castro Carlos De | 2009 | User Modeling and User-Adapted Interaction2009，，2： | 1 |
| 19 | Study of elemental mercury re-emission in a simulated wet scrubber显示文摘 | Naruhito Omine Carlos E. Romero Hirofumi Kikkawa Song Wu Sandhya Eswaran | 2011 | Fuel2011，，1： | 1 |
| 20 | Expession of the yeast trehalose-phosphate synthase gene in transgenic tobacco plant pleiotropic phenotypes include drorght tolerance 显示文摘 | Carlos Romero Jose M Belles Jose L Vaya | 1997 | Planta1997，201，： | 1 |
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