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| 1 | Cancer and age related colonic crypt deficiencies in cytochrome c oxidase Ⅰ显示文摘AIM: To investigate whether defi ciency of expressionof cytochrome c oxidase I (CcOI) in colonic crypts is associated with colon cancer.METHODS: The pattern and level of expression of CcOI in non-neoplastic colonic crypts,and in dysplastic tissues,was assessed using standard immunohis-tochemical methods.Biopsies were obtained from individuals undergoing colonoscopies for screening purposes or for a medically indicated reason.Tissue samples were also obtained from surgical colonic resections.Samples from resections were taken from colonic mucosa 1 and 10 cm from tumors and from the tumors themselves.Samples were evaluated for frequency of crypts with reduced or absent expression of CcOI.In most crypts the loss was apparent throughout the entire crypt,while in a small minority the loss was segmental.The strong immunoreactivity using this monoclonal antibody makes the scoring unambiguous.The percent of crypts with reduced or absent expression of CcOI or (infrequent) segmented loss of expression was then calculated.Data analyses were performed using SPSS statistical package 17.0.RESULTS: The average frequency of CcOI deficient crypts (CcOI-DC) is low in individuals between 20 and 39 years of age,with 0.48% ± 0.40% CcOI-DC for women and 1.80% ± 0.35% for men.CcOI-DC increases after age 40 years,so that between the ages of 40 and 44 years the average frequency of CcOI- DC goes up to 5.89% ± 0.84% in women and 2.15% ± 1.27% in men.By 80-84 years of age,the average frequency of CcOI-DC goes up in women to 15.77% ± 0.97% and in men to 22.6% ± 0.65%.The increases in CcOI-DC from ages 40-44 years compared to 80-84 years in women and men are significantly different with P < 0.01.For women over age 60 years,deficiency of CcOI expression is greater in those women who have had a cancer in their colon.The frequency of CcOI-DC,measured in men,increased in tissues adjacent to colon cancer,being 4.03% ± 0.27% in individuals free of neoplasia in the age range 55-64 yearsand 14.13% ± 0.35% in resected histologically normal tissue of men with cancer in the same age range,P < 0.001.Similar signifi cant differences were noted in older age ranges.The frequency of CcOI-DC crypts in the cecum and sigmoid colon of an individual are signifi cantly correlated,with an R2 = 0.414 for women and R2 = 0.528 for men,P < 0.001.This suggests that the factors determining the level of CcOI deficiency act throughout the colon.Most defective crypts are in clusters of two or more,a likely consequence of crypt fission.In the non-neoplastic margins of cancers,crypts are frequently defi cient for CcOI,and such crypts may appear in large clusters,some containing more than 100 defi cient crypts.CcOI defi ciency is also apparent in colon cancers and sometimes involves a large section of the tumor.Overall,CcOI deficient cells can be visualized in segments of crypts,in whole crypts that increase in frequency with age,in crypts undergoing f ission,in clusters of crypts where the clusters increase in size with age,in increased frequency near tumors,in large clusters in the intimate margins of tumors,and in the tumors themselves.There is no clear dividing line between early stages that can be considered aspects of aging and later stages that can be considered aspects of the progression to cancer.This ambiguity may re ect a rather general situation leading to adult cancer where the early stages of cellular change appear to be relatively innocuous features of the aging process but over decades may evolve into malignancy.CONCLUSION: CcOI defi cient crypts increase in frequency with age,and clusters of defi cient crypts are associated with,and may give rise to,colon cancer. | Carol Bernstein Alexander Facista Huy Nguyen Beryl Zaitlin Nadia Hassounah Cristy Loustaunau Claire Margaret Payne Bhaskar Banerjee Steve Goldschmid V Liana Tsikitis Robert Krouse Harris Bernstein | 2010 | World Journal of Gastrointestinal Oncology2010，2，12： | 5 |
| 2 | Prevalence of Malnutrition and Frailty in Elderly Cancer Patients and Resulting Impact on Primary Treatment Recommendations in Colorectal and Breast Cancer显示文摘Objectives To estimate the prevalence of malnutrition in elderly cancer patients and its association with frailty and primary cancer treatment recommendations in patients with the two most prevalent cancers(colorectal cancer,CRC and breast cancer,BC)in the Centre-Val de Loire region of France.Methods The entire cohort of 704 patients aged 75 years or older presenting with cancer who underwent comprehensive geriatric assessment(CGA)between 2014 and 2017 was included.Nutritional status,frailty(defined by the Balducci classification system based on CGA parameters and comorbidity),and pathological criteria were analyzed in terms of the cancer treatment recommendations suggested by geriatricians both in the whole cohort and in those with CRC and BC.Results In the whole group of 704 patients(84.3+/-4.8 years),the prevalence of malnutrition was 62.9%,and was higher in CRC than in BC patients(71.1%vs 55.4%,P<0.01).In a multivariate analysis,malnutrition and frailty(as determined by the Balducci classification system)were independently related in CRC patients(OR:7.28,95%CI,1.58~34.03;P=0.012)and were unrelated to metastasis[odds ratio(OR):1.34,95%CI,0.56~3.18;P=0.5].By contrast,malnutrition in BC patients was related exclusively to the extent of metastasis(OR:3.52,95%CI,1.50~8.24;P=0.002).It was also demonstrated that geriatricians had a greater tendency to suggest only palliative care to CRC patients presenting with malnutrition(15.4%vs 2.7%,P=0.006)than to BC patients(9.8%vs 5.4%,NS).Conclusion Malnutrition in elderly cancer patients is prevalent,especially in those with colorectal cancer,where malnutrition is frailty-related and may strongly impact on cancer treatment strategies. | Vittoria Balzano Véronique Dardaine Giraud Carine Sauger Carole Lefebvre Patrick Heitzmann Thierry Lecomtef Étienne Dorvalg | 2020 | Journal of Nutritional Oncology2020，5，4： | 2 |
| 3 | Plant FtsZ1 and FtsZ2 expressed in a eukaryotic host: GTPase activity and self-assembly显示文摘 | Aaron G S Carol B J Stanislav V et ol | 2010 | FEBS letters2010，584，1： | 1 |
| 4 | Spinal Surgery Patient Care显示文摘 | Harvey Carol V | 2005 | Orthopaedic Nursing2005，24，6： | 1 |
| 5 | Biomedical Appli- cations of Carbon Adsorbents显示文摘 | Sergey V Susan R Carol A Gary J etal | 2012 | Novel Carbon Adsorbents2012，，： | 1 |
| 6 | Avian osteoclasts 显示文摘 | Carol V | 1991 | Calcified Tissue International1991，49，： | 1 |
| 7 | Daniel ,and cosgrove daniel J, purification and characterization of four expansins (Zea m 1 Isoforms) from maize pollen 显示文摘 | LI L C BEDINGER P A CAROL V | 2003 | Plant Physiology2003，132，： | 1 |
| 8 | Protections of fiber and fabric uses and the factors contributing to military clothing comfort and satisfaction显示文摘 | HOWARD G S ARM AND V C CAROLE W | 2005 | Textile Research Journal2005，75，3： | 1 |
| 9 | Tobacco protein separation 1 aqueous two - phase extraction 显示文摘 | Deepa B Carol W Kevin V C | 2003 | Joural of Chromatography A2003，989，： | 1 |
| 10 | Mononuclear leuko- cytes bind to specific hyaluronan structures on colon mucosal smooth muscle cells treated with polyinosinic acid: polycytidylic acid:inter-a-trypsin inhibitor is crucial to structure and function 显示文摘 | CAROL A HASCALL V C DRAZBA J | 2003 | Am J Pathol2003，163，1： | 1 |
| 11 | Sequential study comparing preferences for carbidopa-levodopa or ally disintegrating tablets and conventional tablets in subjects with Parkinson's disease显示文摘 | Kathleen V Kastenhol Z Carole DR | 2005 | Clinical Therapeutics2005，27，1： | 1 |
| 12 | Invasive Filamentous Growthof Candida albicaus Is Promoted by Czflp-Dependent Relief of Ef-glp-Mediated Repressiom显示文摘 | Angela DG Marcelo V Carol AK | 2002 | Genetics2002，160，4： | 1 |
| 13 | A Quantita-tive Risk Analysis Approach to Port Hydrocarbon Logis-tics 显示文摘 | RONZA A CAROL S ESPEJO V | 2006 | Journal of Hazardous Materials2006，128，1： | 1 |
| 14 | Volatile aldehydes in smoked fish: analysis methods, occurence and mechanisms of formation显示文摘 | VINCENT V CAROLE P THIERRY S | 2007 | Food Chemistry2007，105，： | 1 |
| 15 | Flexion and extension structural properties and strengths for male cervical spine segments 显示文摘 | NIGHTINGALE R W CAROL CHANCEY V OTTAVb ANO D | 2007 | J Bio mech2007，40，3： | 1 |
| 16 | Aqueous phase oxidation of sulfites by ozone in the presence of iron and manganese 显示文摘 | Halstead H Timothy V Carol S M | 1982 | AtmospheficEnvironment1982，16，5： | 1 |
| 17 | Tobacco protein separation by aqueous two-phase extraction 显示文摘 | Deepa B Carol W Kevin V C | 2003 | Journal of Chromatography A2003，，989： | 1 |
| 18 | Characterising electrosprayed biomolecules using tandem-MS the non-covalent GroEL chaperonin assembly显示文摘 | Frank S Carol V R | 2004 | Int J Mass Spectr2004，236，： | 1 |
| 19 | Tobacco protein separation by aqueous two-phase extraction显示文摘 | Deepa B Carol W Kevin V C | 2003 | Journal of Chromatography A2003，989，： | 1 |
| 20 | Regulation of serine transhydroxy-methylase activity in salmonella typhimurium显示文摘 | Stanfffer George V Baker Carol A Brenchley Jean E | 1974 | Journal of Bacteriology1974，120，3： | 1 |
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