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| 1 | Diagnosis of gluten related disorders: Celiac disease, wheat allergy and non-celiac gluten sensitivity显示文摘Cereal crops and cereal consumption have had a vital role in Mankind's history. In the recent years gluten ingestion has been linked with a range of clinical disorders. Gluten-related disorders have gradually emerged as an epidemiologically relevant phenomenon with an estimated global prevalence around 5%. Celiac disease, wheat allergy and non-celiac gluten sensitivity represent different gluten-related disorders. Similar clinical manifestations can be observed in these disorders, yet there are peculiar pathogenetic pathways involved in their development. Celiac disease and wheat allergy have been extensively studied, while non-celiac gluten sensitivity is a relatively novel clinical entity, believed to be closely related to other gastrointestinal functional syndromes. The diagnosis of celiac disease and wheat allergy is based on a combination of findings from the patient's clinical history and specific tests, including serology and duodenal biopsies in case of celiac disease, or laboratory and functional assays for wheat allergy. On the other hand, non-celiac gluten sensitivity is still mainly a diagnosis of exclusion, in the absence of clear-cut diagnostic criteria. A multimodal pragmatic approach combining findings from the clinical history, symptoms, serological and histological tests is required in order to reach an accurate diagnosis. A thorough knowledge of the differences and overlap in clinical presentation among gluten-related disorders, and between them and other gastrointestinal disorders, will help clinicians in the process of differential diagnosis. | Luca Elli Federica Branchi Carolina Tomba Danilo Villalta Lorenzo Norsa Francesca Ferretti Leda Roncoroni Maria Teresa Bardella | 2015 | World Journal of Gastroenterology2015，21，23： | 8 |
| 2 | Intestinal epithelial barrier and neuromuscular compartment in health and disease显示文摘A number of digestive and extra-digestive disorders,including inflammatory bowel diseases,irritable bowel syndrome,intestinal infections,metabolic syndrome and neuropsychiatric disorders,share a set of clinical features at gastrointestinal level,such as infrequent bowel movements,abdominal distension,constipation and secretory dysfunctions.Several lines of evidence indicate that morphological and molecular changes in intestinal epithelial barrier and enteric neuromuscular compartment contribute to alterations of both bowel motor and secretory functions in digestive and extra-digestive diseases.The present review has been conceived to provide a comprehensive and critical overview of the available knowledge on the morphological and molecular changes occurring in intestinal epithelial barrier and enteric neuromuscular compartment in both digestive and extra-digestive diseases.In addition,our intent was to highlight whether these morphological and molecular alterations could represent a common path(or share some common features)driving the pathophysiology of bowel motor dysfunctions and related symptoms associated with digestive and extra-digestive disorders.This assessment might help to identify novel targets of potential usefulness to develop original pharmacological approaches for the therapeutic management of such disturbances. | Vanessa D’Antongiovanni Carolina Pellegrini Matteo Fornai Rocchina Colucci Corrado Blandizzi Luca Antonioli Nunzia Bernardini | 2020 | World Journal of Gastroenterology2020，26，14： | 6 |
| 3 | Constipation,deficit in colon contractions and alpha-synuclein inclusions within the colon precede motor abnormalities and neurodegeneration in the central nervous system in a mouse model of alphasynucleinopathy显示文摘Background:Gastrointestinal dysfunction can affect Parkinson’s disease(PD)patients long before the onset of motor symptoms.However,little is known about the relationship between gastrointestinal abnormalities and the development of PD.Contrary to other animal models,the human A53T alpha-synuclein(αS)transgenic mice,Line G2–3,developsαS-driven neurological and motor impairments after 9 months of age,displaying a long presymptomatic phase free of central nervous system(CNS)dysfunction.Methods:To determine whether this line can be suitable to study constipation as it occurs in prodromal PD,gastrointestinal functionality was assessed in young mice through a multidisciplinary approach,based on behavioral and biochemical analysis combined with electrophysiological recordings of mouse intestinal preparations.Results:We found that the A53TαS mice display remarkable signs of gastrointestinal dysfunction that precede motor abnormalities andαS pathology in the CNS by at least 6 months.YoungαS mice show a drastic delay in food transit along the gastrointestinal tract,of almost 2 h in 3 months old mice that increased to more than 3 h at 6 months.Such impairment was associated with abnormal formation of stools that resulted in less abundant but longer pellets excreted,suggesting a deficit in the intestinal peristalsis.In agreement with this,electrically evoked contractions of the colon,but not of the ileum,showed a reduced motor response in both longitudinal and circular muscle layers inαS mice already at 3 months of age,that was mainly due to an impaired cholinergic transmission of the underlying enteric nervous system.Interestingly,the presence of insoluble and aggregatedαS was found in enteric neurons in both myenteric and submucosal plexi only in the colon of 3 months oldαS mice,but not in the small intestine,and exacerbated with age,mimicking the increase in transit delay and the contraction deficit showed by behavioral and electrical recordings data.Conclusions:Gastrointestinal dysfunction in A53TαS mice represents an early sign ofαS-driven pathology without concomitant CNS involvement.We believe that this model can be very useful to study disease-modifying strategies that could extend the prodromal phase of PD and haltαS pathology from reaching the brain. | Lucia Rota Carolina Pellegrini Laura Benvenuti Luca Antonioli Matteo Fornai Corrado Blandizzi Antonino Cattaneo Emanuela Colla | 2019 | Translational Neurodegeneration2019，8，1： | 5 |
| 4 | NKG2A and COVID-19: another brick in the wall显示文摘Coronavirus disease 2019(COVID-19)is a viral infection caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2;formerly designated as 2019-nCoV),a novel betacoronavirus firstly identified during a burst of respiratory illness cases in Wuhan City,Hubei Province,China.1 Unfortunately,within a few weeks,the SARS-COV2 virus started to spread globally,producing a pandemic of an extremely spreadable and potentially fatal disease,becoming a cause of great concern for global public health.1 Despite the current estimates of COVID-19 case fatality rate suggest that this coronavirus is less deadly than other pathogens driving other large-scale outbreaks,such as SARS,Middle East respiratory syndrome,or Ebola,the main concern is that this infection is able to spread more easily than other diseases,including seasonal influenza. | Luca Antonioli Matteo Fornai Carolina Pellegrini Corrado Blandizzi | 2020 | Cellular & Molecular Immunology2020，17，6： | 3 |
| 5 | Recovery of polyols from flexible polyurethane foam by'split-phase' glycolysis: Study on the influence of reaction parameters显示文摘 | Carolina Molero Antonio de Lucas Juan F Rodr guez | 2008 | Polymer Degradation and Stability2008，93，： | 1 |
| 6 | Polyvalent mRNA vaccination elicited potent immune response to monkeypox virus surface antigens显示文摘Dear Editor,The global monkeypox(Mpox)outbreak leads to a surge in demand for vaccine.The Mpox vaccine in short supply is JYNNEOS(modified vaccinia ankara,MVA)due to less side effects,while ACAM2000 supply is abundant because of the strategic stockpile in U.s.1 The ACAM2000 replaced the first-generation smallpox vaccine Dryvax that has a questionable safety profile.However,the ACAM2000 is associated with high rate of myocarditis and pericarditis,and can cause severe illness in immunocompromised patients,foreshadowing the need to update the strategic stockpile. | Zhenhao Fang Valter S.Monteiro Paul A.Renauer Xingbo Shang Kazushi Suzuki Xinyu Ling Meizhu Bai Yan Xiang Andre Levchenko Carmen J.Booth Carolina Lucas Sidi Chen | 2023 | Cell Research2023，33，5： | 1 |
| 7 | Recovery of polyols from flexible polyurethane foam by ' split-phase' glycolysis: Study on the influence of reaction parameters 显示文摘 | CAROLINA M LUCAS A D RODRiGUEZ J F | 2008 | Polym Degrad Stab2008，93，2： | 1 |
| 8 | Laparoscopic Ventral Rectopexy for Internal Rectal Prolapse Using Biological Mesh: Postoperative and Short-Term Functional Results显示文摘 | Pierpaolo Sileri Luana Franceschilli Elisabetta Luca Sara Lazzaro Giulio P. Angelucci Valeria Fiaschetti Carolina Pasecenic Achille L. Gaspari | 2012 | Journal of Gastrointestinal Surgery2012，，3： | 1 |
| 9 | Multi-objective forest harvesting under sustainable and economic principles显示文摘Selective logging is well-recognized as an effective practice in sustainable forest management.However,the ecological efficiency or resilience of the residual stand is often in doubt.Recovery time depends on operational variables,diversity,and forest structure.Selective logging is excellent but is open to changes.This may be resolved by mathematical programming and this study integrates the economic-ecological aspects in multi-objective function by applying two evolutionary algorithms.The function maximizes remaining stand diversity,merchantable logs,and the inverse of distance between trees for harvesting and log landings points.The Brazilian rainforest database(566 trees)was used to simulate our 216-ha model.The log landing design has a maximum volume limit of 500 m3.The nondominated sorting genetic algorithm was applied to solve the main optimization problem.In parallel,a sub-problem(p-facility allocation)was solved for landing allocation by a genetic algorithm.Pareto frontier analysis was applied to distinguish the gradientsα-economic,β-ecological,andγ-equilibrium.As expected,the solutions have high diameter changes in the residual stand(average removal of approximately 16 m^(3) ha^(-1)).All solutions showed a grouping of trees selected for harvesting,although there was no formation of large clearings(percentage of canopy removal<7%,with an average of 2.5 ind ha^(-1)).There were no differences in floristic composition by preferentially selecting species with greater frequency in the initial stand for harvesting.This implies a lower impact on the demographic rates of the remaining stand.The methodology should support projects of reduced impact logging by using spatial-diversity information to guide better practices in tropical forests. | Talles Hudson Souza Lacerda Luciano Cavalcante de Jesus Franca Isáira Leite e Lopes Sammilly Lorrayne Souza Lacerda Evandro OrfanóFigueiredo Bruno Henrique Groenner Barbosa Carolina Souza Jarochinski e Silva Lucas Rezende Gomide | 2023 | Journal of Forestry Research2023，34，5： | 0 |
| 10 | Appropriate search techniques to estimate Weibull function parameters in a Pinus spp.plantation显示文摘The Weibull function,a continuous probability distribution,is widely used for diameter distribution modelling,in which parameter estimation performance is affected by stand attributes and fitting methods.The Weibull cumulative distribution function is nonlinear,and classical fitting methods may provide a not optimal solution.Invoking the use of artificial intelligence by metaheuristics is reasonable for this optimisation task.Therefore,aimed and compared(1)the metaheuristics genetic algorithm and simulated annealing performance over the moment and percentile methods;(2)the hybrid strategy merging the metaheuristics tested and the percentile method and,(3)the metaheuristics fitness functions under basal area and density errors.A long-term experiment in a Pinus taeda stand subjected to crown thinning was used.According to our findings,all methods have a similar performance,independent of the thinning regimes and age.The pattern of the estimated parameters tends to be acceptable,as b increases over time and c increases after thinning.Overall,our findings suggest that methods based on metaheuristics have a higher precision than classical methods for estimating Weibull parameters.According to the classification test,the methods that involved simulated annealing stood out.The hybrid method involving this metaheuristic also stood out,with accurate estimates.Classical methods showed the poorest performance,and we therefore suggest the use of simulated annealing due to its faster processing time and high-quality solution. | Lais Almeida Araujo Rafael Menali Oliveira Mario Dobner Jr Carolina Souza Jarochinskie Silva Lucas Rezende Gomide | 2021 | Journal of Forestry Research2021，32，6： | 0 |
| 11 | Epidemiological and clinical characteristics of COVID-19 in a Brazilian public hospital显示文摘BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has become a major health concern worldwide.In that context,the understanding of epidemiological and clinical features associated with the disease and its severity is crucial for the establishment of strategies aimed at disease control and remedy.AIM To describe epidemiological features,signs,symptoms,and laboratory findings among severely ill COVID-19 patients from an inten-sive care unit in northeastern Brazil as well as to evaluate predictor factors for disease outcomes.METHODS This is a prospective single-center study that evaluated 115 patients admitted to the intensive care unit in a northeastern Brazilian hospital.RESULTS The patients had a median age of 65.60±15.78 years.Dyspnea was the most frequent symptom,affecting 73.9%of the patients,followed by cough(54.7%).Fever was reported in approximately one-third of patients and myalgia in 20.8%of the patients.At least two comorbidities were found in 41.7%of the patients,and hypertension was the most prevalent(57.3%).In addition,having two or more comorbidities was a predictor of mortality,and lower platelet count was positively associated with death.Nausea and vomiting were two symptoms that were predictors of death,and the presence of a cough was a protective factor.CONCLUSION This is the first report of a negative correlation between cough and death in severely ill severe acute respiratory syndrome coronavirus 2-infected individuals.The associations between comorbidities,advanced age,and low platelet count and the outcomes of the infection were similar to the results of previous studies,highlighting the relevance of these features. | Fillipe Dantas Pinheiro Luana Weber Lopes Rafael Santos Dantas Miranda Dórea Glauber Rocha Lima Araújo Filipe Antônio França da Silva Breno Bittencourt de Brito Maria Luísa Cordeiro Santos Geovani Moreno Santos Júnior Maria Teresa Araújo de Lorenzo Barcia Renata de Amorim Marques AndréBezerra Botelho Anna Carolina Saúde Dantas Davi Tanajura Costa Adriano Fernandes Teixeira Cláudio Lima Souza Lucas Miranda Marques Guilherme Barretos Campos Márcio Vasconcelos Oliveira Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo | 2023 | World Journal of Clinical Cases2023，11，8： | 0 |
| 12 | Therapeutic Properties of Flavonoids in Treatment of Cancer through Autophagic Modulation:A Systematic Review显示文摘Cancers have high morbidity and mortality rates worldwide.Current anticancer therapies have demonstrated specific signaling pathways as a target in the involvement of carcinogenesis.Autophagy is a quality control system for proteins and plays a fundamental role in cancer carcinogenesis,exerting an anticarcinogenic role in normal cells and can inhibit the transformation of malignant cells.Therefore,drugs aimed at autophagy can function as antitumor agents.Flavonoids are a class of polyphenolic secondary metabolites commonly found in plants and,consequently,consumed in diets.In this review,the systematic search strategy was used,which included the search for descriptors'flavonoids'AND'mTOR pathway'AND'cancer'AND'autophagy',in the electronic databases of PubMed,Cochrane Library,Web of Science and Scopus,from January 2011 to January 2021.The current literature demonstrates that flavonoids have anticarcinogenic properties,including inhibition of cell proliferation,induction of apoptosis,autophagy,necrosis,cell cycle arrest,senescence,impaired cell migration,invasion,tumor angiogenesis and reduced resistance to multiple drugs in tumor cells.We demonstrate the available evidence on the roles of flavonoids and autophagy in cancer progression and inhibition.(Registration No.CRD42021243071 at PROSPERO) | Guilherme Vinicio de Sousa Silva Ana Luiza Vieira Ferreira Guimaraes Lopes Isis Carolina Viali Lucas Zannini Medeiros Lima Matheus Ribeiro Bizuti Fabiana Brum Haag Débora Tavares de Resende e Silva | 2023 | Chinese Journal of Integrative Medicine2023，29，3： | 0 |
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