4篇
您的检索式：作者名="Caroline Low"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Targeting the PI3K/AKT/mTOR pathway in epithelial ovarian cancer,therapeutic treatment options for platinum-resistant ovarian cancer显示文摘The survival rates for women with ovarian cancer have shown scant improvement in recent years,with a 5-year survival rate of less than 40%for women diagnosed with advanced ovarian cancer.High-grade serous ovarian cancer(HGSOC)is the most lethal subtype where the majority of women develop recurrent disease and chemotherapy resistance,despite over 70%-80%of patients initially responding to platinum-based chemotherapy.The phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)signaling pathway regulates many vital processes such as cell growth,survival and metabolism.However,this pathway is frequently dysregulated in cancers including different subtypes of ovarian cancer,through amplification or somatic mutations of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha(PIK3CA),amplification of AKT isoforms,or deletion or inactivation of PTEN.Further evidence indicates a role for the PI3K/AKT/mTOR pathway in the development of chemotherapy resistance in ovarian cancer.Thus,targeting key nodes of the PI3K/AKT/mTOR pathway is a potential therapeutic prospect.In this review,we outline dysregulation of PI3K signaling in ovarian cancer,with a particular emphasis on HGSOC and platinum-resistant disease.We review pre-clinical evidence for inhibitors of the main components of the PI3K pathway and highlight past,current and upcoming trials in ovarian cancers for different inhibitors of the pathway.Whilst no inhibitors of the PI3K/AKT/mTOR pathway have thus far advanced to the clinic for the treatment of ovarian cancer,several promising compounds which have the potential to restore platinum sensitivity and improve clinical outcomes for patients are under evaluation and in various phases of clinical trials. | Natasha Rinne Elizabeth LChristie Anastasia Ardasheva Chun Hei Kwok Nikita Demchenko Caroline Low Catherine Tralau-Stewart Christina Fotopoulou Paula Cunnea | 2021 | Cancer Drug Resistance2021，4，3： | 3 |
| 2 | Meckel’s diverticular complications in children: is laparoscopy the order of the day?显示文摘 | T. R. Sai Prasad Chan Hon Chui Fatima Reyaz Singaporewalla Choo Phaik Caroline Ong Yee Low Te Lu Yap Anette Sundfor Jacobsen | 2007 | Pediatric Surgery International2007，，2： | 2 |
| 3 | Diagnosis of acute bacterial meningitis in children at a district hospital in sub-Saharan Africa显示文摘 | James A Berkley Isiah Mwangi Caroline J Ngetsa Salim Mwarumba Brett S Lowe Kevin Marsh Charles RJC Newton | 2001 | The Lancet2001，，9270： | 1 |
| 4 | Double vision显示文摘 | Liying Low Waqaar Shah Caroline J MacEwen | 2016 | 英国医学杂志中文版2016，19，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员