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| 1 | Multiple cells of origin in cholangiocarcinoma underlie biological,epidemiological and clinical heterogeneity显示文摘Recent histological and molecular characterization of cholangiocarcinoma(CCA) highlights the heterogeneity of this cancer that may emerge at different sites of the biliary tree and with different macroscopic or morphological features.Furthermore,different stem cell niches have been recently described in the liver and biliarytree,suggesting this as the basis of the heterogeneity of intrahepatic(IH)-and extrahepatic(EH)-CCAs,which are two largely different tumors from both biological and epidemiological points of view.The complexity of the organization of the liver stem cell compartments could underlie the CCA clinical-pathological heterogeneity and the criticisms in classifying primitive liver tumors.These recent advances highlight a possible new classification of CCAs based on cells of origin and this responds to the need of generating homogenous diagnostic,prognostic and,hopefully,therapeutic categories of IH-and EH-CCAs. | Vincenzo Cardinale Guido Carpino Lola Reid Eugenio Gaudio Domenico Alvaro | 2012 | World Journal of Gastrointestinal Oncology2012，4，5： | 10 |
| 2 | Cholangiocytes and blood supply显示文摘胆汁的树的微脉管的供应,仙子胆管丛(PBP ) ,源自肝的动脉树枝和流动进肝窦状隙。PBP 的详细三维的研究被使用扫描电子执行了显微镜学脉管的腐蚀演员组(SEMvcc ) 技术。认为 PBP 在支持胆汁的上皮的能分泌、吸收性的功能起一个基本作用,他们在常态和病理的组织被探索。正常的肝证明 PBP 安排在 extra-附近 -- 并且肝内的胆汁的树。在小门道, PBP 被日益增多地继续了它显示出一个更复杂的脉管的网络的额外的肝的 PBP 的 capillaries 的单个层描绘。在普通的管结扎(BDL ) 以后,胆汁管和 PBP 增长的进步修正被观察。PBP 介绍在许多胆汁管附近安排的一个三维的网络并且作为容器的捆出现,由有典型圆网孔结构的同类的直径的 capillaries 镇静。PBP 网络从显得正常的正弦曲线网络是容易可区分的。在 BDL 期间考虑 PBP 的庞大的延期,脉管的内皮生长因素(VEGF ) 起的可能的作用被评估。VEGF -- A, VEGF-C 和他们的相关受体高度出现了在 BDL 老鼠的增殖的 cholangiocytes 积极的免疫。到象肝的动脉结扎一样的 BDL 老鼠的 anti-VEGF-A 或 anti-VEGF-C 抗体的管理导致了一个减少的胆汁管团。rVEGF 的管理 -- 到 BDL 肝的动脉的 A 绑扎老鼠阻止了 cholangiocyte 增长和 VEGF 的减少 -- 表情作为与 BDL 控制老鼠相比。这些数据处于 cholangiocyte 增长的条件建议胆汁的树的动脉的血供给的角色,例如它发生在长期的胆汁郁积期间。在另一方面, VEGF 作为在 cholangiocytes 和 PBP endothelial 之间的串音的一个工具起的作用建议 VEGF 版本和功能的那操作能为肝的动脉或胆汁的树的损坏描绘的人的病理学的条件代表治疗学的策略。 | Eugenio Gaudio Antonio Franchitto Luigi Pannarale Guido Carpino Gianfranco Alpini Heather Francis Shannon Glaser Domenico Alvaro Paolo Onori | 2006 | World Journal of Gastroenterology2006，12，22： | 9 |
| 3 | Common features between neoplastic and preneoplastic lesions of the biliary tract and the pancreas显示文摘the bile duct system and pancreas show many similarities due to their anatomical proximity and common embryological origin.Consequently,preneoplastic and neoplastic lesions of the bile duct and pancreas share analogies in terms of molecular,histological and pathophysiological features.Intraepithelial neoplasms are reported in biliary tract,as biliary intraepithelial neoplasm(BilIN),and in pancreas,as pancreatic intraepithelial neoplasm(PanIN).Both can evolve to invasive carcinomas,respectively cholangiocarcinoma(CCA)and pancreatic ductal adenocarcinoma(PDAC).Intraductal papillary neoplasms arise in biliary tract and pancreas.Intraductal papillary neoplasm of the biliary tract(IPNB)share common histologic and phenotypic features such as pancreatobiliary,gastric,intestinal and oncocytic types,and biological behavior with the pancreatic counterpart,the intraductal papillary mucinous neoplasm of the pancreas(IPMN).All these neoplastic lesions exhibit similar immunohistochemical phenotypes,suggesting a common carcinogenic process.Indeed,CCA and PDAC display similar clinic-pathological features as growth pattern,poor response to conventional chemotherapy and radiotherapy and,as a consequence,an unfavorable prognosis.The objective of this review is to discuss similarities and differences between the neoplastic lesions of the pancreas and biliary tract with potential implications on a common origin from similar stem/progenitor cells. | Piera Zaccari Vincenzo Cardinale Carola Severi Federica Pedica Guido Carpino Eugenio Gaudio Claudio Doglioni Maria Chiara Petrone Domenico Alvaro Paolo Giorgio Arcidiacono Gabriele Capurso | 2019 | World Journal of Gastroenterology2019，25，31： | 6 |
| 4 | Role of sex hormones in the modulation of cholangiocyte function显示文摘Over the last years,cholangiocytes,the cells that line the biliary tree,have been considered an important object of study for their biological properties which involves bile formation,proliferation,injury repair,fibrosis and angiogenesis.Cholangiocyte proliferation occurs in all pathologic conditions of liver injury where it is associated with inflammation and regeneration.During these processes,biliary cells start to secrete different cytokines,growth factors,neuropeptides and hormones which represent potential mechanisms for cross talk with other liver cells.Several studies suggest that hormones,and in particular,sex hormones,play a fundamental role in the modulation of the growth of this compartment in the injured liver which functionally conditions the progression of liver disease.Understanding the mechanisms of action and the intracellular pathways of these compounds on cholangiocyte pathophysiology will provide new potential strategies for the management of chronic liver diseases.The purpose of this review is to summarize the recent findings on the role of sex hormones in cholangiocyte proliferation and biology. | Romina Mancinelli Paolo Onori Sharon DeMorrow Heather Francis Shannon Glaser Antonio Franchitto Guido Carpino Gianfranco Alpini Eugenio Gaudio | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，2： | 3 |
| 5 | 猪精子细胞中胰岛素诱导产生的一氧化氮自由基促进精子获能显示文摘近期,胰岛素被证实具有诱导猪精子获能的能力。在不同的哺乳动物中,精子获能被认为与一氧化氮信号通路相关;因此,本研究使用荧光激活细胞分选技术探究经胰岛素处理的猪精子中一氧化氮水平。在同一样本中,用金霉素染色、蛋白质酪氨酸磷酸化模式和顶体状态来评估精子获能。结果显示经胰岛素处理的精子内一氧化氮水平及三种评价精子获能的指标均有显著提高;相反,用一氧化氮合成酶抑制剂(N-硝基-L-精氨酸甲酯)或抗胰岛素受体β抗体预处理的精子中胰岛素相关的作用全被逆转。这些结果表明胰岛素具有增强猪精子细胞内一氧化氮浓聚的能力并且提示胰岛素可能通过一氧化氮促进精子获能。 | Saveria Aquila Francesca Giordano Carmela Guido Vittoria Rago Amalia Carpino | 2013 | Asian Journal of Andrology2013，15，6： | 2 |
| 6 | Calculation of stiffness and damping coefficients for elastically supported gas foil bcarings显示文摘 | Peng J P Carpino M | 1993 | ASME Journal of Tribology1993，115，2： | 1 |
| 7 | The 9-fluorenylmethoxycarbonyl amino-protecting group显示文摘 | Carpino L A Han G Y | 1972 | J OrgChem1972，37，： | 1 |
| 8 | Adnexal gland secretion markers in unexplained asthenozoospermia显示文摘 | Carpino A Sisci D Aquila S | 1994 | Arch Androl1994，32，1： | 1 |
| 9 | Al-pha-SMA exprossionin hepatic stellate cells and quan-titative analysis of hepatic'fibrosis incirrhosis and inrecurrent chronic hepatifis after liver transplantation显示文摘 | Carpino G Morini S Ginanni Corradini S | 2005 | Dig Liver Dis2005，37，5： | 1 |
| 10 | Review of companies and drug clas-ses in the 2007 - 2011 antihypertensive patent literature 显示文摘 | CARPINO PA FLYNN D | 2012 | Pharrn Pat Anal2012，1，1： | 1 |
| 11 | Hepatic “stem” cells: State of the art显示文摘 | Mancino MG Carpino G Onori P | 2007 | Ital J Anat Embryol2007，112，2： | 1 |
| 12 | Low seminal zinc bound to high molecular weight proteins in asthenozoospermic patients: evidence of increased sperm zinc content in oligoasthenozoospermic patients 显示文摘 | Carpino A Siciliano L Petroni MF | 1998 | Hum Reprod1998，13，1： | 1 |
| 13 | PPHvs MilliganMorgan:early and late complications in the treatment of haemorrhoidal disease with circumferential prolapse显示文摘 | Sammarco G Ferrari F Carpino A | 2013 | Ann Ital Chir2013，23，7： | 1 |
| 14 | An overview on im- mune system and migraine 显示文摘 | Bruno PP Carpino F Carpino G | 2007 | Eur Rev Med Pharmacol Sci2007，11，4： | 1 |
| 15 | 9-Fluorenylmethoxycarbonyl function,a new base-sensitive amino-protection group显示文摘 | Han G Y | 1970 | Journal of the American Chemical Society1970，92，19： | 1 |
| 16 | Calculation of Stiffness and Damping Coefficients for Elastically Supported Gas Foil Bearings 显示文摘 | Peng J P Carpino M | 1993 | ASME Tribol1993，115，： | 1 |
| 17 | New approaches to the synthesis of trans -alkene isosteres of dipeptides显示文摘 | Spaltenstein A Carpino PA Miyake F | 1987 | J Org Chem1987，52，： | 1 |
| 18 | Essential nonreduntant role for the phosphoinostitde 3-kinase p1 10delta in signaling by the B-cell receptor complex显示文摘 | Jou ST Carpino N Takahashi Y | 2002 | Mol Cell Biol2002，22，24： | 1 |
| 19 | Composition and aroma compounds of ragusano cheese:Native pasture and total mixed rations显示文摘 | Carpino S Mallia S La Terra S | | 0，，04： | 1 |
| 20 | GFAP expression in the liver as an early marker of stellate cells activation显示文摘 | Morini S Carotti S Carpino G | 2005 | Ital J Anat Embryol2005，110，4： | 1 |
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