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| 1 | Emergency cholecystectomy vs percutaneous cholecystostomy plus delayed cholecystectomy for patients with acute cholecystitis显示文摘BACKGROUND: In low-risk patients with acute cholecystitis who did not respond to nonoperative treatment, we prospectively compared treatment with emergency laparoscopic cholecystectomy or percutaneous transhepatic cholecystostomy followed by delayed cholecystectomy.METHODS: In 91 patients(American Society of Anesthesiologists class I or II) who had symptoms of acute cholecystitis ≥72 hours at hospital admission and who did not respond to nonoperative treatment(48 hours), 48 patients were treated with emergency laparoscopic cholecystectomy and 43 patients were treated with delayed cholecystectomy at ≥4 weeks after insertion of a percutaneous transhepatic cholecystostomy catheter. After initial treatment, the patients were followed up for 23 months on average(range 7-29).RESULT: Compared with the patients who had emergency laparoscopic cholecystectomy, the patients who were treated with percutaneous transhepatic cholecystostomy and delayed cholecystectomy had a lower frequency of conversion to open surgery [19(40%) vs 8(19%); P=0.029], a frequency of intraoperative bleeding ≥100 mL [16(33%) vs 4(9%); P=0.006],a mean postoperative hospital stay(5.3±3.3 vs 3.0±2.4 days;P=0.001), and a frequency of complications [17(35%) vs 4(9%);P=0.003].CONCLUSION: In patients with acute cholecystitis who presented to the hospital ≥72 hours after symptom onset and did not respond to nonoperative treatment for 48 hours, percutaneous transhepatic cholecystostomy with delayed laparoscopic cholecystectomy produced better outcomes and fewer complications than emergency laparoscopic cholecystectomy. | Feza Y Karakayali Aydincan Akdur Mahir Kirnap Ali Harman Yahya Ekici G?han Moray | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，3： | 20 |
| 2 | Visceral hypersensitivity in inflammatory bowel diseases and irritable bowel syndrome: The role of proteases显示文摘Proteases, enzymes catalyzing the hydrolysis of peptide bonds, are present at high concentrations in the gastrointestinal tract. Besides their well-known role in the digestive process, they also function as signaling molecules through the activation of protease-activated receptors(PARs). Based on their chemical mechanism for catalysis, proteases can be classified into several classes: serine, cysteine, aspartic, metallo- and threonine proteases represent the mammalian protease families. In particular, the class of serine proteases will play a significant role in this review. In the last decades, proteases have been suggested to play a key role in the pathogenesis of visceral hypersensitivity, which is a major factor contributing to abdominal pain in patients with inflammatory bowel diseases and/or irritable bowel syndrome. So far, only a few preclinical animal studies have investigated the effect of protease inhibitors specifically on visceral sensitivity while their effect on inflammation is described in more detail. In our accompanying review we describe their effect on gastrointestinal permeability. On account of their promising results in the field of visceral hypersensitivity, further research is warranted. The aim of this review is to give an overview on the concept of visceral hypersensitivity as well as on the physiological and pathophysiological functions of proteases herein. | Hannah Ceuleers Hanne Van Spaendonk Nikita Hanning Jelena Heirbaut Anne-Marie Lambeir Jurgen Joossens Koen Augustyns Joris G De Man Ingrid De Meester Benedicte Y De Winter | 2016 | World Journal of Gastroenterology2016，22，47： | 7 |
| 3 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 4 | Characterization of the humoral and cellular immune responses against hepatitis C virus core induced by DNA-based immunization显示文摘 | Hu G J Wang R Y Han D S | 1999 | Vaccine1999，17，2324： | 2 |
| 5 | Regulation of ginsenoside and phytosterol biosynthesis by RNA interferences of squalene epoxidase gene in Panax ginseng显示文摘 | HAN J Y IN J G KWON Y S | 2010 | Phytochemistry2010，71，1： | 1 |
| 6 | Production by Aspegillus ficuum on semisolid substrate 显示文摘 | HAN Y W GALLAGHER D J WILFED A G | 1987 | Journal of Industrial Microbiology1987，2，： | 1 |
| 7 | An adaptive PID learning control of robot manipulators 显示文摘 | Kuc T Y Han W G | 2000 | Automatica2000，36，5： | 1 |
| 8 | Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with Gefitinib显示文摘 | HAN S W KIM T Y HWANG P G | 2005 | J Clin Oncol2005，23，11： | 1 |
| 9 | The 9-fluorenylmethoxycarbonyl amino-protecting group显示文摘 | Carpino L A Han G Y | 1972 | J OrgChem1972，37，： | 1 |
| 10 | Cluster analysis based on fuzzy equivalence relation显示文摘 | Liang G S Chou T Y Han T C | 2005 | European Journal of Operational Research2005，166，1： | 1 |
| 11 | Nano-hybrid shish-kebab: Isotactic polypropylene epitaxial growth on electrospun polyamide 66 nanofibers via isothermal crystallization显示文摘 | Liang Y Y Zheng G Q Han W J | 2011 | Materials Letters2011，65，： | 1 |
| 12 | The Crystal and Molecular Structure ofFargesin显示文摘 | MA Y L HAN G Q LU Y | 1994 | Chinese J Struct Chem1994，13，4： | 1 |
| 13 | Applicability of a rapid method based on immunomagnetic capture-fluorescent PCR assay for Campylobaeterjejuni显示文摘 | Liu G M Han Y L Li X | 2006 | Fc c dControl2006，17，7： | 1 |
| 14 | Controllable TransmissionCharacteristics of Multi-Channel Long Period Fiber Gratings显示文摘 | Han Y G Lee B H Han W T | 2011 | IEICE Trans Electron2011，84，5： | 1 |
| 15 | Cellular repressor of E1A-stimulated genes inhibits human vascular smooth muscle cell apoptosis v/a bloc- king P38/JNK MAP kinase activation 显示文摘 | Han Y Wu G Deng J | 2010 | J Mol Cell Cardiol2010，48，6： | 1 |
| 16 | A fungal-responsive MAPK cascade regulates phytoalexin biosynthesis in Arabidopsis显示文摘 | Ren D Liu Y Yang K Y Han L Mao G Glazebrook J Zhang S | | 0，，： | 1 |
| 17 | Polarization-dependent in-line Mach-Zehnder interferometer for discrimination of temperature and ambient index sensitivities显示文摘 | Kim H J Han Y G | 2012 | Journal of Lightwave Technology2012，30，8： | 1 |
| 18 | Development of a wireless stress/strain measurement system integrated with pressure-sensitive nickel powder-filled cement-based sensors显示文摘 | HAN B G YU Y HAN B Z | 2008 | Sensors and Actuators A: Physical2008，147，2： | 1 |
| 19 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 20 | Cluster analysis based on fuzzy equivalence relation显示文摘 | Liang G S Chou T Y Han T C | 2005 | European Journal of Operational Research2005，166，1： | 1 |
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