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| 1 | Successful surgical management of ruptured umbilical hernias in cirrhotic patients显示文摘Acute umbilical hernia rupture in patients with hepatic cirrhosis and ascites is an unusual,but potentially lifethreatening complication,with postoperative morbidity about 70% and mortality between 60%-80% after supportive care and 6%-20% after urgent surgical repair.Management options include primary surgical repair with or without concomitant portal venous system decompression for the control of the ascites.We present a retrospective analysis of our centre's experience over the last 6 years.Our cohort consisted of 11 consecutive patients(median age:53 years,range:36-63 years) with advanced hepatic cirrhosis and refractory ascites.Appropriate patient resuscitation and optimisation with intravenous fluids,prophylactic antibiotics and local measures was instituted.One failed attempt for conservative management was followed by a successful primary repair.In all cases,with one exception,a primary repair with non-absorbable Nylon,interrupted sutures,without mesh,was performed.The perioperative complication rate was 25% and the recurrence rate 8.3%.No mortality was recorded.Median length of hospital stay was 14 d(range:4-31 d).Based on our experience,the management of ruptured umbilical hernias in patients with advanced hepatic cirrhosis and refractory ascites is feasible without the use of transjugular intrahepatic portosystemic shunt routinely in the preoperative period,provided that meticulous patient optimisation is performed. | Nikolaos A Chatzizacharias J Andrew Bradley Simon Harper Andrew Butler Asif Jah Emmanuel Huguet Raaj K Praseedom Michael Allison Paul Gibbs | 2015 | World Journal of Gastroenterology2015，21，10： | 4 |
| 2 | Fluid balance concepts in medicine:Principles and practice显示文摘The regulation of body fluid balance is a key concern in health and disease and comprises three concepts. The first concept pertains to the relationship between total body water(TBW) and total effective solute and is expressed in terms of the tonicity of the body fluids. Disturbances in tonicity are the main factor responsible for changes in cell volume, which can critically affect brain cell function and survival. Solutes distributed almost exclusively in the extracellular compartment(mainly sodium salts) and in the intracellular compartment(mainly potassium salts) contribute to tonicity, while solutes distributed in TBW have no effect on tonicity. The second body fluid balance concept relates to the regulation and measurement of abnormalities of sodium salt balance and extracellular volume. Estimation of extracellular volume is more complex and error prone than measurement of TBW. A key function of extracellular volume, which is defined as the effective arterial blood volume(EABV), is to ensure adequate perfusion of cells and organs. Other factors, including cardiac output, total and regional capacity of both arteries and veins, Starling forces in the capillaries, and gravity also affect the EABV. Collectively, these factors interact closely with extracellular volume and some of them undergo substantial changes in certain acute and chronic severe illnesses. Their changes result not only in extracellular volume expansion, but in the need for a larger extracellular volume compared with that of healthy individuals. Assessing extracellular volume in severe illness is challenging because the estimates of this volume by commonly used methods are prone to large errors in many illnesses. In addition, the optimal extracellular volume may vary from illness to illness, is only partially based on volume measurements by traditional methods, and has not been determined for each illness. Further research is needed to determine optimal extracellular volume levels in several illnesses. For these reasons, extracellular volume in severe illness merits a separate third concept of body fluid balance. | Maria-Eleni Roumelioti Robert H Glew Zeid J Khitan Helbert Rondon-Berrios Christos P Argyropoulos Deepak Malhotra Dominic S Raj Emmanuel I Agaba Mark Rohrscheib Glen H Murata Joseph I Shapiro Antonios H Tzamaloukas | 2018 | World Journal of Nephrology2018，7，1： | 3 |
| 3 | Hypertonicity:Clinical entities,manifestations and treatment显示文摘Hypertonicity causes severe clinical manifestations and is associated with mortality and severe short-term and longterm neurological sequelae. The main clinical syndromes of hypertonicity are hypernatremia and hyperglycemia.Hypernatremia results from relative excess of body sodium over body water. Loss of water in excess of intake,gain of sodium salts in excess of losses or a combination of the two are the main mechanisms of hypernatremia.Hypernatremia can be hypervolemic,euvolemic or hypovolemic. The management of hypernatremia addresses both a quantitative replacement of water and,if present,sodium deficit,and correction of the underlying pathophysiologic process that led to hypernatremia.Hypertonicity in hyperglycemia has two components,solute gain secondary to glucose accumulation in the extracellular compartment and water loss through hyperglycemic osmotic diuresis in excess of the losses of sodium and potassium. Differentiating between these two components of hypertonicity has major therapeutic implications because the first component will be reversed simply by normalization of serum glucose concentration while the second component will require hypotonic fluid replacement. An estimate of the magnitude of the relative water deficit secondary to osmotic diuresis is obtained by the corrected sodium concentration,which represents a calculated value of the serum sodium concentration that would result from reduction of the serum glucose concentration to a normal level. | Helbert Rondon-Berrios Christos Argyropoulos Todd S Ing Dominic S Raj Deepak Malhotra Emmanuel I Agaba Mark Rohrscheib Zeid J Khitan Glen H Murata Joseph I Shapiro Antonios H Tzamaloukas | 2017 | World Journal of Nephrology2017，6，1： | 2 |
| 4 | Geologically constrained probabilistic mapping of gold potential, Baguio District, Philippines 显示文摘 | Emmanuel J Carranza M Martin H | 2000 | Natural Resources Research2000，9，3： | 1 |
| 5 | Robust principal component analysis? 显示文摘 | Emmanuel J Cands Li Xiaodong Ma Yi | 2011 | Journal of the ACM (JACM)2011，58，3： | 1 |
| 6 | Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study显示文摘 | Sheila A Bingham Nicholas E Day Robert Luben Pietro Ferrari Nadia Slimani Teresa Norat Fran?oise Clavel-Chapelon Emmanuelle Kesse Alexandra Nieters Heiner Boeing Anne Tj?nneland Kim Overvad Carmen Martinez Miren Dorronsoro Carlos A Gonzalez Timothy J Key | 2003 | The Lancet2003，，9368： | 1 |
| 7 | Designing novel nanoporous architectures of carbon nanotubes for hydrogen storage显示文摘 | Emmanuel Tylianakis Georgios K Dimitrakakis Francisco J Martin-Martinez | 2014 | Int J Hydro gen Energy2014，39，： | 1 |
| 8 | A Monte-Carlo simulation method for setting the underfrequency load shedding relays and selecting the spinning reserve policy in autonomous power systems显示文摘 | Emmanuel J Thalassinakis Evangelos N Dialynas | 2004 | IEEE Transactions on Power Systems2004，19，4： | 1 |
| 9 | Definition and grading of anastomotic leakage following anterior resection of the rectum: A proposal by the International Study Group of Rectal Cancer显示文摘 | Nuh N. Rahbari Jürgen Weitz Werner Hohenberger Richard J. Heald Brendan Moran Alexis Ulrich Torbj?rn Holm W. Douglas Wong Emmanuel Tiret Yoshihiro Moriya S?ren Laurberg Marcel den Dulk Cornelis van de Velde Markus W. Büchler | 2010 | Surgery2010，，3： | 1 |
| 10 | Production of recombinant Potato mop-top virus coat protein in Escherichia coli and generation of antisera recognizing native virus protein 显示文摘 | Valerie H Emmanuel J Maryse G | 2003 | Journal of Virology Methods2003，110，： | 1 |
| 11 | What is the Incidence of Metastatic Lymph Node Involvement After Significant Pathologic Response of Primary Tumor Following Neoadjuvant Treatment for Locally Advanced Rectal Cancer?显示文摘 | Hadrien Tranchart Jérémie H. Lefèvre Magali Svrcek Jean-Fran?ois Flejou Emmanuel Tiret Yann Parc | 2013 | Annals of Surgical Oncology2013，，5： | 1 |
| 12 | Rapid silver staining and recovery of PCR products separated on polyacrylamide gels显示文摘 | Carlos J S Emmanuel D N Andrew F G | 1994 | Biotechniques1994，17，5： | 1 |
| 13 | An introduction to compressive sampling 显示文摘 | EMMANUEL J MICHEL B | 2008 | IEEE Transaction on Signal Processing2008，25，2： | 1 |
| 14 | Long_ term fol-low-up of meningiomas of the cavernous sinus after sur-gical treatment along 显示文摘 | Marc S Ernesto W Emmanuel J | 2007 | J Neurosurg2007，107，： | 1 |
| 15 | Lovastatin stimulates human vascular smooth muscle cellexpression of bone morphogenetic protein-2,a potent inhibitor oflow-density lipoprotein-stimulated cell growth 显示文摘 | EMMANUELE L ORTMANN J DOERFLINGER T | 2003 | Biochemicaland biophysical research communications2003，302，1： | 1 |
| 16 | 3-Nitropropionic acid: a mitoehondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease显示文摘 | Emmanuel B Carine J Nicolas B | 2005 | J Neurochem2005，95，： | 1 |
| 17 | Broiler performance, body weight variance, feed and water intake, and carcass quality at different stocking densities显示文摘 | Feddes J J R Emmanuel E J Zuidhof M J | 2002 | Poult Sci2002，81，： | 1 |
| 18 | Synthesis and biological evaluation of several 3-(coumarin- 4-yl )tetrahydroisoxazole and 3-(coumarin-4-yl)dihydropyrazole Derivatives显示文摘 | Emmanuel G A A Fylaktakidou K C Hadjipavlou L D J | 2001 | J Heterocvclic Chem2001，38，： | 1 |
| 19 | Rapid silver staining and recovery of PCR products separated on polyacrylamide gel 显示文摘 | Carlos J S Emmanuel D N Andrew F G | 1994 | Biotechniques1994，17，5： | 1 |
| 20 | Finite element analysis of automotive cushion discs显示文摘 | Samir S Emmanuel B Fortin J | 2009 | Thin-Walled Structures2009，47，4： | 1 |
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