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| 1 | Overview of recent advances in metastatic triple negative breast cancer显示文摘Metastatic triple negative breast cancer(TNBC)has an aggressive phenotype with a predilection for visceral organs and brain.Best responses to chemotherapy are predominately in the first line.Recent studies have demonstrated improved progression free survival with the combination of atezolizumab/pembrolizumab and chemotherapy in programmed death-ligand 1 positive metastatic TNBC.However,a recent trial in a similar population showed no benefit for atezolizumab and paclitaxel which led to a Food and Drug Administration alert.Two phase III trials(OLYMPIAD and BROCADE3)demonstrated a benefit in progression free survival(PFS)but not overall survival in patients with BRCAassociated metastatic TNBC treated with Olaparib or Talazoparib respectively.For those treated with Talazoparib,the time to deterioration in health related-quality of life was also longer compared to chemotherapy.The BROCADE3 trial demonstrated that the combination of a platinum and veliparib increased PFS in first-line metastatic TNBC but at the cost of increased toxicity.There are no headto-head comparisons of a poly(adenosine diphosphate-ribose)polymerase inhibitors(PARPi)and platinums.There are unanswered questions regarding the role of PARPi maintenance after platinum therapy as is standard of care in BRCAassociated ovarian cancer.Other areas of therapeutic interest include targeting aberrations in the phosphoinositide 3-kinase pathway,protein kinase B,mammalian target of rapamycin or utilising antibody drug conjugates.This review focusses on recent and emerging therapeutic options in metastatic TNBC.We searched PubMed,clinicaltrials.gov and recent international meetings from American Society of Clinical Oncology,San Antonio Breast Cancer Conference and the European Society of Medical Oncology. | David O'Reilly Maha Al Sendi Catherine M Kelly | 2021 | World Journal of Clinical Oncology2021，12，3： | 5 |
| 2 | Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery显示文摘 | Jaya Mishra Catherine Dent Ridwan Tarabishi Mark M Mitsnefes Qing Ma Caitlin Kelly Stacey M Ruff Kamyar Zahedi Mingyuan Shao Judy Bean Kiyoshi Mori Jonathan Barasch Prasad Devarajan | 2005 | The Lancet . 2005 (9466)2005，，： | 2 |
| 3 | Umbilical Herniorrhapy in Cirrhosis: Improved Outcomes with Elective Repair显示文摘 | Stephen H. Gray Catherine C. Vick Laura A. Graham Kelly R. Finan Leigh A. Neumayer Mary T. Hawn | 2008 | Journal of Gastrointestinal Surgery2008，，4： | 2 |
| 4 | The Novel Marker, DOG1 , Is Expressed Ubiquitously in Gastrointestinal Stromal Tumors Irrespective of KIT or PDGFRA Mutation Status显示文摘 | Robert B. West Christopher L. Corless Xin Chen Brian P. Rubin Subbaya Subramanian Kelli Montgomery Shirley Zhu Catherine A. Ball Torsten O. Nielsen Rajiv Patel John R. Goldblum Patrick O. Brown Michael C. Heinrich Matt van de Rijn | 2004 | The American Journal of Pathology2004，，1： | 1 |
| 5 | Capacity to maintain mental set in dementia显示文摘 | MELISSA L CATHERINE CP KELLY LD | 2002 | Neuropsychologia2002，40，4： | 1 |
| 6 | A Prospective Study of Hepatitis B Vaccination – A Comparison of Responders versus Nonresponders显示文摘 | Catherine M. Brown Sheila Donlon Patrick O’Kelly Anne Marie Casey Cathal Collier Peter J. Conlon John J. Walshe | 2011 | Renal Failure2011，，3： | 1 |
| 7 | Alpha-1 antitrypsin deficiency显示文摘 | Emer Kelly Catherine M. Greene Tomas P. Carroll Noel G. McElvaney Shane J. O’Neill | 2010 | Respiratory Medicine2010，，6： | 1 |
| 8 | Heterocyclic polycatenar liquid crystals 显示文摘 | Catherine Fang He Riehards G J Kelly S M | 2007 | Liquid Crystals2007，34，11： | 1 |
| 9 | How Are Our MPAs Doing? Challenges in Assessing Global Patterns in Marine Protected Area Performance显示文摘 | Helen E. Fox Jed l. Holtzman Kelly M. Haisfield Catherine G. McNally Gonzalo A. Cid Michael B. Mascia John E. Parks Robert S. Pomeroy | 2014 | Coastal Management2014，，3： | 1 |
| 10 | Impact of the Surgical Research Methodology Program on Surgical Residents’ Research Profiles显示文摘 | Forough Farrokhyar Nalin Amin Deepak Dath Mohit Bhandari Stephan Kelly Ann M. Kolkin Catherine Gill-Pottruff Martina Skot Susan Reid | 2014 | Journal of Surgical Education2014，，： | 1 |
| 11 | Radio Frequency Identification Tags in Modem Distribution Processes显示文摘 | Patricia Kelly Catherine Robertello | 2011 | ARMY SUS- TAINTMENT2011，43，3： | 1 |
| 12 | Staging of pancreatic cancer before and after neoadjuvant chemoradiation显示文摘 | Rebekah R. White M.D. Erik K. Paulson M.D. Kelly S. Freed M.D. May T. Keogan M.D. Herbert I. Hurwitz M.D. Catherine Lee M.D. Michael A. Morse M.D. Marcia R. Gottfried M.D. John Baillie M.D. Malcolm S. Branch M.D. Paul S. Jowell M.D. Kevin M. McGrath M.D. | 2001 | Journal of Gastrointestinal Surgery2001，，6： | 1 |
| 13 | The Theory of Planned Behavior and Ecstasy Use: Roles for Habit and Perceived Control over Taking versus Ob- taining Substances显示文摘 | Orbell Sheina Catherine Blai Kellie Sherlock and Mark Conner | 2001 | Journal of Applied Social Psychology2001，1，： | 1 |
| 14 | Quantitative multiparametric magnetic resonance imaging can aid non-alcoholic steatohepatitis diagnosis in a Japanese cohort显示文摘BACKGROUND Non-invasive assessment of non-alcoholic steatohepatitis(NASH)is increasing in desirability due to the invasive nature and costs associated with the current form of assessment;liver biopsy.Quantitative multiparametric magnetic resonance imaging(mpMRI)to measure liver fat(proton density fat fraction)and fibroinflammatory disease[iron-corrected T1(cT1)],as well as elastography techniques[vibration-controlled transient elastography(VCTE)liver stiffness measure],magnetic resonance elastography(MRE)and 2D Shear-Wave elastography(SWE)to measure stiffness and fat(controlled attenuated parameter,CAP)are emerging alternatives which could be utilised as safe surrogates to liver biopsy.AIM To evaluate the agreement of non-invasive imaging modalities with liver biopsy,and their subsequent diagnostic accuracy for identifying NASH patients.METHODS From January 2019 to February 2020,Japanese patients suspected of NASH were recruited onto a prospective,observational study and were screened using noninvasive imaging techniques;mpMRI with LiverMultiScan®,VCTE,MRE and 2DSWE.Patients were subsequently biopsied,and samples were scored by three independent pathologists.The diagnostic performances of the non-invasive imaging modalities were assessed using area under receiver operating characteristic curve(AUC)with the median of the histology scores as the gold standard diagnoses.Concordance between all three independent pathologists was further explored using Krippendorff’s alpha(a)from weighted kappa statistics.RESULTS N=145 patients with mean age of 60(SD:13 years.),39%females,and 40%with body mass index≥30 kg/m2 were included in the analysis.For identifying patients with NASH,MR liver fat and cT1 were the strongest performing individual measures(AUC:0.80 and 0.75 respectively),and the mpMRI metrics combined(cT1 and MR liver fat)were the overall best non-invasive test(AUC:0.83).For identifying fibrosis≥1,MRE performed best(AUC:0.97),compared to VCTE-liver stiffness measure(AUC:0.94)and 2D-SWE(AUC:0.94).For assessment of steatosis≥1,MR liver fat was the best performing non-invasive test(AUC:0.92),compared to controlled attenuated parameter(AUC:0.75).Assessment of the agreement between pathologists showed that concordance was best for steatosis(a=0.58),moderate for ballooning(a=0.40)and fibrosis(a=0.40),and worst for lobular inflammation(a=0.11).CONCLUSION Quantitative mpMRI is an effective alternative to liver biopsy for diagnosing NASH and non-alcoholic fatty liver,and thus may offer clinical utility in patient management. | Kento Imajo Louise Tetlow Andrea Dennis Elizabeth Shumbayawonda Sofia Mouchti Timothy J Kendall Eve Fryer Shogi Yamanaka Yasushi Honda Takaomi Kessoku Yuji Ogawa Masato Yoneda Satoru Saito Catherine Kelly Matt D Kelly Rajarshi Banerjee Atsushi Nakajima | 2021 | World Journal of Gastroenterology2021，27，7： | 1 |
| 15 | 人口迁徙、汇款、生活轨迹及社会应变能力显示文摘我们认为,人口变化的方方面面,包括迁徙,都影响个人和团体的社会应变能力以及基本资源基础的可持续性。社会应变能力是应对和适应通过适当的制度调节的环境和社会变化的能力。我们调查了当今越南沿海地区人口变化、社会应变能力以及可持续发展之间关系的一个侧面:迁徙和汇款对依赖于资源的人口源区居民群的影响。利用有关生活来源的纵向运动数据,我们发现移民出境和汇款对一个逐渐形成的社会和政治范围内的应变能力有抵消作用。移民出境是与不可持续的沿海养殖业的发展同时并存的,而不是起推动作用。日益增加的经济不平等削弱了社会应变能力。同时,多种经营和收入水平的不断提高有助于应变能力的增强。 | W.Neil Adger P.Mick Kelly Alexandra Winkels Luong Quang Huy Catherine Locke 林宝法 | 2002 | AMBIO-人类环境杂志2002，31，4： | 1 |
| 16 | Unmasking Evans syndrome: T -cell phenotype and apoptotic response reveal autoimmune lymphoprolifetative syndrome(ALPS) 显示文摘 | David T Catherine S Kelly M | 2005 | Blood2005，105，6： | 1 |
| 17 | Subcortical Gray Matter Volume Abnormalities in Healthy Bipolar Offspring: Potential Neuroanatomical Risk Marker for Bipolar Disorder?显示文摘 | CECILE D. LADOUCEUR JORGE R.C. ALMEIDA BORIS BIRMAHER DAVID A. AXELSON SHARON NAU CATHERINE KALAS KELLY MONK DAVID J. KUPFER MARY L. PHILLIPS | 2008 | Journal of the American Academy of Child & Adolescent Psychiatry2008，，5： | 1 |
| 18 | Capacity to maintain mental set in dementia显示文摘 | Melissa Lamar Catherine C Kelly L | 2002 | Neuropsychologia2002，40，4： | 1 |
| 19 | Biomolecular surface coating to enhance orthopaedic tissue healing and integration Biomaterials显示文摘 | Catherine D R Timothy A P Kellie L B | 2007 | 28(21):3228-352007，28，21： | 1 |
| 20 | Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation显示文摘 | Timotheus Y.F. Halim Catherine A. Steer Laura Math? Matthew J. Gold Itziar Martinez-Gonzalez Kelly M. McNagny Andrew N.J. McKenzie Fumio Takei | 2014 | Immunity2014，，3： | 1 |
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