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| 1 | Predictors of kidney tubular dysfunction induced by adefovir treatment for chronic hepatitis B显示文摘AIM:To investigate the predictors of proximal kidney tubular dysfunction(PKTD)induced by adefovir dipivoxil(ADV)treatment for chronic hepatitis B.METHODS:Seventy-nine patients(age at the evaluation of PKTD:56.9±10.7 years)with chronic hepatitis B undergoing long-term oral antiviral nucleos(t)ide analogue treatment were consecutively recruited.PKTD was defined by the presence of at least two of the following five abnormalities:phosphate diabetes,nondiabetic glucosuria,metabolic acidosis,β2-microglobulinuria,or renal hypouricemia.The single-nucleotide polymorphisms(SNPs)in the SLC22A6 gene encoding human organic anion transporter 1(h OAT1)and ABCC2 encoding multidrug resistance protein 2(MRP2)were analyzed using the Taq Man Allelic Discrimination Demonstration Kit.RESULTS:Nine(30.0%)of the 30 ADV-treated patients were diagnosed with PKTD,while no patients without ADV developed PKTD(P<0.001).Three patients with ADV were diagnosed with symptomatic osteomalacia.Among the patients who took ADV,those with PKTD were of higher age at initiation,had significantly longer treatment duration,and had a significantly lower body mass index than those without PKTD.The incidence of PKTD dramatically increased after 96 mo from the start of ADV administration.In contrast,the SNPs were not correlated with PKTD.Logistic regression analysis extracted older age at initiation(OR=5.0,95%CI:1.1-23.4;P=0.040)and longer treatment duration(OR=3.2,95%CI:1.2-8.6;P=0.020)as significant factors associated with PKTD.CONCLUSION:Our results suggest that the tubular function of the kidney of older patients undergoing longterm ADV treatment should be carefully evaluated. | Motohiro Shimizu Norihiro Furusyo Hiroaki Ikezaki Eiichi Ogawa Takeo Hayashi Takeshi Ihara Yuji Harada Kazuhiro Toyoda Masayuki Murata Jun Hayashi | 2015 | World Journal of Gastroenterology2015，21，7： | 18 |
| 2 | Liver-targeted hydrodynamic gene therapy: Recent advances in the technique显示文摘One of the major research focuses in the field of gene therapy is the development of clinically applicable, safe, and effective gene-delivery methods. Since the first case of human gene therapy was performed in 1990, a number of gene-delivery methods have been developed, evaluated for efficacy and safety, and modified for human application. To date, viral-vectormediated deliveries have shown effective therapeutic results. However, the risk of lethal immune response and carcinogenesis have been reported, and it is still controversial to be applied as a standard therapeutic option. On the other hand, delivery methods for nonviral vector systems have been developed, extensively studied, and utilized in in vivo gene-transfer studies. Compared to viral-vector mediated gene transfer, nonviral systems have less risk of biological reactions. However, the lower gene-transfer efficiency was a critical hurdle for applying them to human gene therapy. Among a number of nonviral vector systems, our studies focus on hydrodynamic gene delivery to utilize physical force to deliver naked DNA into the cells in the living animals. This method achieves a high gene-transfer level by DNA solution injections into the tail vein of rodents, especially in the liver. With the development of genome editing methods, in vivo gene-transfer therapy using this method is currently the focus in this research field. This review explains the method principle, efficiency, safety, and procedural modifications to achieve a high level of reproducibility in large-animal models. | Takeshi Yokoo Kenya Kamimura Hiroyuki Abe Yuji Kobayashi Tsutomu Kanefuji Kohei Ogawa Ryo Goto Masafumi Oda Takeshi Suda Shuji Terai | 2016 | World Journal of Gastroenterology2016，22，40： | 3 |
| 3 | Simple scoring system for predicting cirrhosis in nonalcoholic fatty liver disease显示文摘AIM:To investigate a simple noninvasive scoring system for predicting liver cirrhosis in nonalcoholic fatty liver disease(NAFLD)patients.METHODS:A total of 1048 patients with liver-biopsyconfirmed NAFLD were enrolled from nine hepatology centers in Japan(stage 0,216;stage 1,334;stage 2,270;stage 3,190;stage 4,38).The weight and height of the patients were measured using a calibrated scale after requesting the patients to remove their shoes and any heavy clothing.Venous blood samples were obtained in the morning after the patients had fasted overnight for 12 h.Laboratory evaluation was performed in all patients.Statistical analysis was conducted using SPSS version 12.0.Continuous variables were expressed as mean±SD.RESULTS:The optimal cutoff value of platelet count,serum albumin,and aminotransferase/alanine aminotransferase ratio(AAR)was set at<15.3 104/μL,<4.0g/dL,and>0.9,respectively,by the receiver operating characteristic curve.These three variables were combined in an unweighted sum(platelet count=1 point,serum albumin=1 point,AAR=1 point)to form an easily calculated composite score for predicting cirrhosis in NAFLD patients,called the PLALA(platelet,albumin,AAR)score.The diagnosis of PLALA≥2 had sufficient accuracy for detecting liver cirrhosis in NAFLD patients.CONCLUSION:The PLALA score may be an ideal scoring system for detecting cirrhosis in NAFLD patients with sufficient accuracy and simplicity to be considered for clinical use. | Takaomi Kessoku Yuji Ogawa Masato Yoneda Kento Imajo Yoshio Sumida Yuichiro Eguchi Hideki Fujii Hideyuki Hyogo Masafumi Ono Yasuaki Suzuki Takumi Kawaguchi Kazuaki Chayama Saiyu Tanaka Kazuma Fujimoto Keizo Anzai Toshiji Saibara Michio Sata Yoshito Itoh Atsushi Nakajima Takeshi Okanoue Japan Study Group of NAFLD(JSG-NAFLD) | 2014 | World Journal of Gastroenterology2014，20，29： | 2 |
| 4 | Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling显示文摘 | Kento Imajo Koji Fujita Masato Yoneda Yuichi Nozaki Yuji Ogawa Yoshiyasu Shinohara Shingo Kato Hironori Mawatari Wataru Shibata Hiroshi Kitani Kenichi Ikejima Hiroyuki Kirikoshi Noriko Nakajima Satoru Saito Shiro Maeyama Sumio Watanabe Koichiro Wada Atsus | 2012 | Cell Metabolism2012，，1： | 2 |
| 5 | Emerging drugs for non-alcoholic steatohepatitis显示文摘 | Wataru Tomeno Masato Yoneda Kento Imajo Yuji Ogawa Takaomi Kessoku Satoru Saito Yuichiro Eguchi Atsushi Nakajima | 2013 | Expert Opinion on Emerging Drugs2013，，3： | 2 |
| 6 | Tenascin-C is upregulated in the skin lesions of patients with atopic dermatitis显示文摘 | Kaoru Ogawa Mikito Ito Kaori Takeuchi Akiko Nakada Masayuki Heishi Hajime Suto Kouichi Mitsuishi Yuji Sugita Hideoki Ogawa Chisei Ra | 2005 | Journal of Dermatological Science2005，，： | 1 |
| 7 | Devel- opment of Continuous Sernisteel and Decarburization Process Using BOF 显示文摘 | Ogawa Yuji Yano Masataka Kitamura Shinya | 2001 | Testu to-Hagane2001，87，1： | 1 |
| 8 | Paraoxonase gene Gln192Arg (Q192R) polymorphism is associated with coronary artery spasm显示文摘 | Teruhiko Ito Hirofumi Yasue Michihiro Yoshimura Shota Nakamura Masafumi Nakayama Yukio Shimasaki Eisaku Harada Yuji Mizuno Hiroaki Kawano Hisao Ogawa | 2002 | Human Genetics2002，，1： | 1 |
| 9 | Evaluation of pathological features of hepatocellular carcinoma by contrast-enhanced ultrasonography: Comparison with pathology on resected specimen显示文摘 | Sadanobu Ogawa Takashi Kumada Hidenori Toyoda Hideo Ichikawa Toshiaki Kawachi Katsuhiko Otobe Toshio Hibi Kenji Takeshima Seiki Kiriyama Yasuhiro Sone Makoto Tanikawa Yasuhiro Hisanaga Akihiro Yamaguchi Masatoshi Isogai Yuji Kaneoka Junji Washizu | 2006 | European Journal of Radiology2006，，1： | 1 |
| 10 | Plasma Level of B-Type Natriuretic Peptide as a Prognostic Marker After Acute Myocardial Infarction: A Long-Term Follow-Up Analysis显示文摘 | Satoru Suzuki Michihiro Yoshimura Masafumi Nakayama Yuji Mizuno Eisaku Harada Teruhiko Ito Shota Nakamura Koji Abe Megumi Yamamuro Tomohiro Sakamoto Yoshihiko Saito Kazuwa Nakao Hirofumi Yasue Hisao Ogawa | 2004 | Circulation2004，，11： | 1 |
| 11 | Dysregulated expression of fatty acid oxidation enzymes and iron‐regulatory genes in livers of Nrf2‐null mice显示文摘 | Yuji Tanaka Takanori Ikeda Kazuo Yamamoto Hiroshi Ogawa Toshinori Kamisako | 2012 | Journal of Gastroenterology and Hepatology2012，，11： | 1 |
| 12 | Develop- ment of the Continuous Dephosphorization and Deearbonization Process Using BOF显示文摘 | Yuji Ogawa Masataka Yano Shinya Kitamura | | 0，，01： | 1 |
| 13 | Activated inflammatory cells participate in thrombus size through tissue factor and plasminogen activator inhibitor-1 in acute coronary syndrome: Immunohistochemical analysis显示文摘 | Tetsuo Sakai Shin Inoue Masatoshi Takei Genyo Ogawa Yuji Hamazaki Hidekazu Ota Youichi Koboyashi | 2011 | Thrombosis Research2011，，5： | 1 |
| 14 | Hyperglycemia rapidly suppresses flow-mediated endothelium- dependent vasodilation of brachial artery显示文摘 | Hiroaki Kawano Takeshi Motoyama Osamu Hirashima Nobutaka Hirai Yuji Miyao Tomohiro Sakamoto Kiyotaka Kugiyama Hisao Ogawa Hirofumi Yasue | 1999 | Journal of the American College of Cardiology1999，，1： | 1 |
| 15 | ElevaTed plasma interleukin- 6 levels in patients with acute myocardial infarction显示文摘 | Yuji Miyao Hirofumi Yasue Hisao Ogawa | 1993 | Am Heart J1993，126，6： | 1 |
| 16 | Emerging drugs for non-alcoholic steatohepatitis显示文摘 | Wataru Tomeno Masato Yoneda Kento Imajo Yuji Ogawa Takaomi Kessoku Satoru Saito Yuichiro Eguchi Atsushi Nakajima | 2013 | Expert Opinion on Emerging Drugs2013，，3： | 1 |
| 17 | Quantitative multiparametric magnetic resonance imaging can aid non-alcoholic steatohepatitis diagnosis in a Japanese cohort显示文摘BACKGROUND Non-invasive assessment of non-alcoholic steatohepatitis(NASH)is increasing in desirability due to the invasive nature and costs associated with the current form of assessment;liver biopsy.Quantitative multiparametric magnetic resonance imaging(mpMRI)to measure liver fat(proton density fat fraction)and fibroinflammatory disease[iron-corrected T1(cT1)],as well as elastography techniques[vibration-controlled transient elastography(VCTE)liver stiffness measure],magnetic resonance elastography(MRE)and 2D Shear-Wave elastography(SWE)to measure stiffness and fat(controlled attenuated parameter,CAP)are emerging alternatives which could be utilised as safe surrogates to liver biopsy.AIM To evaluate the agreement of non-invasive imaging modalities with liver biopsy,and their subsequent diagnostic accuracy for identifying NASH patients.METHODS From January 2019 to February 2020,Japanese patients suspected of NASH were recruited onto a prospective,observational study and were screened using noninvasive imaging techniques;mpMRI with LiverMultiScan®,VCTE,MRE and 2DSWE.Patients were subsequently biopsied,and samples were scored by three independent pathologists.The diagnostic performances of the non-invasive imaging modalities were assessed using area under receiver operating characteristic curve(AUC)with the median of the histology scores as the gold standard diagnoses.Concordance between all three independent pathologists was further explored using Krippendorff’s alpha(a)from weighted kappa statistics.RESULTS N=145 patients with mean age of 60(SD:13 years.),39%females,and 40%with body mass index≥30 kg/m2 were included in the analysis.For identifying patients with NASH,MR liver fat and cT1 were the strongest performing individual measures(AUC:0.80 and 0.75 respectively),and the mpMRI metrics combined(cT1 and MR liver fat)were the overall best non-invasive test(AUC:0.83).For identifying fibrosis≥1,MRE performed best(AUC:0.97),compared to VCTE-liver stiffness measure(AUC:0.94)and 2D-SWE(AUC:0.94).For assessment of steatosis≥1,MR liver fat was the best performing non-invasive test(AUC:0.92),compared to controlled attenuated parameter(AUC:0.75).Assessment of the agreement between pathologists showed that concordance was best for steatosis(a=0.58),moderate for ballooning(a=0.40)and fibrosis(a=0.40),and worst for lobular inflammation(a=0.11).CONCLUSION Quantitative mpMRI is an effective alternative to liver biopsy for diagnosing NASH and non-alcoholic fatty liver,and thus may offer clinical utility in patient management. | Kento Imajo Louise Tetlow Andrea Dennis Elizabeth Shumbayawonda Sofia Mouchti Timothy J Kendall Eve Fryer Shogi Yamanaka Yasushi Honda Takaomi Kessoku Yuji Ogawa Masato Yoneda Satoru Saito Catherine Kelly Matt D Kelly Rajarshi Banerjee Atsushi Nakajima | 2021 | World Journal of Gastroenterology2021，27，7： | 1 |
| 18 | Development of the Continuous Dephosphorization and Decarburization Process Using BOF显示文摘 | Yuji Ogawa | 2003 | Steel Research2003，74，2： | 1 |
| 19 | Measurement of fractional anisotropy using diffusion tensor MRI in supratentorial astrocytic tumors显示文摘 | Takaaki Beppu Takashi Inoue Yuji Shibata Akira Kurose Hiroshi Arai Kuniaki Ogasawara Akira Ogawa Shinichi Nakamura Hiroyuki Kabasawa | 2003 | Journal of Neuro - Oncology2003，，2： | 1 |
| 20 | Serum cystatin C as a marker for early detection of chronic kidney disease and grade 2 nephropathy in Japanese patients with type 2 diabetes显示文摘 | Yoshitake Suzuki Kazuyuki Matsushita Masanori Seimiya Toshihiko Yoshida Yuji Sawabe Makoto Ogawa Fumio Nomura | 2012 | Clinical Chemistry and Laboratory Medicine2012，，10： | 1 |
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