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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Multiple evolutionary origins of knockdown resistance ( kdr ) in pyrethroid-resistant Colorado potato beetle, Leptinotarsa decemlineata显示文摘 | Frank D. Rinkevich Cathy Su Tomás A. Lazo David J. Hawthorne Ward M. Tingey Samir Naimov Jeffrey G. Scott | 2012 | Pesticide Biochemistry and Physiology2012，，3： | 2 |
| 3 | Volume and Autocovarianees in Short - horison Individual Security Return 显示文摘 | CONRAD JENNIFER S ALLAUDEEN HAMEED CATHY NEDEN | 1994 | Journal of Fi- nance1994，，49： | 1 |
| 4 | llncidence of Class 1 and class2 integrases in clinical and commensal bacteria from live- stock, companion animals and exotics显示文摘 | Cathy G Margie D L Susan S | 2001 | Antimierob Agents Che- mother2001，45，3： | 1 |
| 5 | Moving Beyond the Limitations of the Visual Analog Scale for Measuring Pain: Novel Use of the General Labeled Magnitude Scale in a Clinical Setting显示文摘 | Marlís González-Fernández Nilasha Ghosh Tambrea Ellison Julia C. McLeod Cathy A. Pelletier Kayode Williams | 2014 | American Journal of Physical Medicine & Rehabilitation2014，，1： | 1 |
| 6 | Combretastatin A4 prodrug study of effect on the growth and the microvascttlature of colorectal liver metastases in a murine modell 显示文摘 | CATHY M W VIJAYARAGAVAN M STEWART S | 2001 | Clin Cancer Res2001，7，： | 1 |
| 7 | Calcitonin and insulin in isobutylcyanoacrylate nanocap sules: protection against proteases and effect on intestinal absorption in rats显示文摘 | PHILIP J L CATHY S T | 1994 | J Pharm Pharmacol1994，46，： | 1 |
| 8 | Comparing risks of death and recurrent vascular events between lacunar and non-acunar infarction 显示文摘 | Caroline J Cathie S | 2005 | Brain2005，128，11： | 1 |
| 9 | Prognostic significance of lymph node metastasis found during pulmonary metastasectomy for extrapulmonary carcinoma显示文摘 | Sina Ercan Francis C Nichols Victor F Trastek Claude Deschamps Mark S Allen Daniel L Miller Cathy D Schleck Peter C Pairolero | 2004 | The Annals of Thoracic Surgery2004，，5： | 1 |
| 10 | Evaluation of transgenic tomato plants expressing an additional phytoene synthase in a fruit-specific manner显示文摘 | Paul D F Susanne R Cathie A S | 2002 | Proceedings of the National Academy of Sciences2002，99，2： | 1 |
| 11 | Extractive fermentation of aroma with supercritical C02 显示文摘 | Cathy E Fabre Condoret J S Marty A | 1999 | Biotechnology and Bioengineering1999，64，4： | 1 |
| 12 | Consensus-degenerate hybrid oligonucleotide primers for amplification of priming glycosyltransferase genes of the exopolysaccharide locus in strains of the lactobacillus casei group显示文摘 | Cathy PC Gisele L Stephane S | 2003 | Appl Environmental Microbiol2003，69，： | 1 |
| 13 | Patient-related risk factors for fracture-healing complications in the United Kingdom General Practice Research Database显示文摘 | Rohini K Hernandez Thy P Do Cathy W Critchlow Ricardo E Dent Susan S Jick | 2012 | Acta Orthopaedica2012，，6： | 1 |
| 14 | Upholding theprinciples of primary care in preceptors practices 显示文摘 | Margo S R Beverley L Cathy M | 2002 | Family Medicine2002，34，10： | 1 |
| 15 | Evaluation of membranes used for electroblotting of proteins for direct automated microsequencing 显示文摘 | Cathy S B Michael J D Magdi H Y | 1991 | Electrophoresis1991，12，： | 1 |
| 16 | Serum YKL-40 is associated with osteoarthritis and atherosclerosis in nonhuman primates显示文摘 | Thomas C Register Cathy S | 2001 | Clinical Chemistry2001，47，： | 1 |
| 17 | A multicenter comparison of intraaortic balloon pump utilization in isolated coronary artery bypass graft surgery显示文摘 | Roger J.F Baskett Gerald T O’Connor Gregory M Hirsch William A Ghali Kathy Sabadosa Jeremy R Morton Cathy S Ross Felix Hernandez William C Nugent Stephen J Lahey Donato A Sisto Lawrence J Dacey John D Klemperer Robert E Helm Andrew Maitland | 2003 | The Annals of Thoracic Surgery2003，，6： | 1 |
| 18 | Incidence of Class 1 and class 2 integrases in clinical and commensal bacteria from livestock, companion animals, and exotics显示文摘 | Cathy G Margie DL Susan S | 2001 | Antimicrob Agents Chemother2001，45，3： | 1 |
| 19 | Outbreaks of renal failure associated with melamine and cyanuricacid in dogs and cats in 2004 and 2007 显示文摘 | CATHY A B JEONG K S ROBERT H | 2007 | J Vet Diagn Invest2007，19，5： | 1 |
| 20 | Incidence of class 1 and 2 integrases in clinical and commensal bacteria from livestock ,companion animals, and exotics 显示文摘 | Cathy G Margie D Susan S | 2001 | Antimicrob Agents Chemother2001，45，3： | 1 |
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