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| 1 | Non-invasive diagnosis of gastric mucosal atrophy in an asymptomatic population with high prevalence of gastric cancer显示文摘AIM: To validate a non-invasive method to detect gastric mucosal atrophy in a Chilean population with high prevalence of gastric cancer and a poor survival rate. METHODS: We first determined the optimal cut-off level of serum pepsinogen (PG)-1, PG-1/PG-2 ratio and 17-gastrin in 31 voluntary symptomatic patients (mean age: 66.1 years), of them 61% had histologically confirmed gastric atrophy. Then, in a population-based sample of 536 healthy individuals (209 residents in counties with higher relative risk and 327 residents in counties with lower relative risk for gastric cancer), we measured serum anti-H pylori antibodies, PG and 17-gastrin and estimated their risk of gastric cancer. RESULTS: We found that serum PG-1 < 61.5 μg/L, PG-1/PG-2 ratio < 2.2 and 17-gastrin > 13.3 pmol/L had a high specificity (91%-100%) and a fair sensitivity (56%-78%) to detect corpus-predominant atrophy. Based on low serum PG-1 and PG-1/PG-2 ratio together as diagnostic criteria, 12.5% of the asymptomatic subjects had corpus-predominant atrophy (0% of those under 25 years and 20.2% over 65 years old). The frequency of gastric atrophy was similar (12% vs 13%) but H pylori infection rate was slightly higher (77% vs 71%) in the high-risk compared to the low-risk counties. Based on their estimated gastric cancer risk, individuals were classified as: low-risk group (no H pylori infection and no atrophy; n = 115; 21.4%); moderate-risk group(H pylori infection but no atrophy; n = 354, 66.0%); and high-risk group (gastric atrophy, with or without H pylori infection; n = 67, 12.5%). The high-risk group was significantly older (mean age: 61.9 ± 13.3 years), more frequently men and less educated as compared with the low-risk group. CONCLUSION: We propose to concentrate on an upper gastrointestinal endoscopy for detection of early gastric cancer in the high-risk group. This intervention model could improve the poor prognosis of gastric cancer in Chile. | Antonio Rollan Catterina Ferreccio Alessandra Gederlini Carolina Serrano Javiera Torres Paul Harris | 2006 | World Journal of Gastroenterology2006，12，44： | 14 |
| 2 | Management of Helicobacter pylori infection in Latin America: A Delphi technique-based consensus显示文摘AIM: To optimize diagnosis and treatment guidelines for this geographic region, a panel of gastroenterologists, epidemiologists, and basic scientists carried out a structured evaluation of available literature.METHODS: Relevant questions were distributed among the experts, who generated draft statements for consideration by the entire panel. A modified three-round Delphi technique method was used to reach consensus. Critical input was also obtained from representatives of the concerned medical community. The quality of the evidence and level of recommendation supporting each statement was graded according to United States Preventive Services Task Force criteria.RESULTS: A group of ten experts was established. The survey included 15 open-ended questions that were distributed among the experts, who assessed the articles associated with each question. The levels of agreement achieved by the panel were 50% in the first round, 73.3% in the second round and 100% in the third round. Main consensus recommendations included:(1) when available, urea breath and stool antigen test(HpSA) should be used for non-invasive diagnosis;(2) detect and eradicate Helicobacter pylori(H. pylori) in all gastroscopy patients to decrease risk of peptic ulcer disease, prevent o retard progression in patients with preneoplastic lesions, and to prevent recurrence in patients treated for gastric cancer;(3) further investigate implementation issues and health outcomes of H. pylorieradication for primary prevention of gastric cancer in high-risk populations;(4) prescribe standard 14-d triple therapy or sequential therapy for first-line treatment;(5) routinely assess eradication success post-treatment in clinical settings; and(6) select second- and third-line therapies according to antibiotic susceptibility testing.CONCLUSION: These achievable steps toward better region-specific management can be expected to improve clinical health outcomes. | Antonio Rollan Juan Pablo Arab M Constanza Camargo Roberto Candia Paul Harris Catterina Ferreccio Charles S Rabkin Juan Cristóbal Gana Pablo Cortés Rolando Herrero Luisa Durán Apolinaria García Claudio Toledo Alberto Espino Nicole Lustig Alberto Sarfatis Catalina Figueroa Javier Torres Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，31： | 2 |
| 3 | 14-day triple, 5-day concomitant, and 10-day sequential therapies for Helicobacter pylori infection in seven Latin American sites: a randomised trial显示文摘 | E Robert Greenberg Garnet L Anderson Douglas R Morgan Javier Torres William D Chey Luis Eduardo Bravo Ricardo L Dominguez Catterina Ferreccio Rolando Herrero Eduardo C Lazcano-Ponce María Mercedes Meza-Montenegro Rodolfo Pe?a Edgar M Pe?a Eduardo Salazar- | 2011 | The Lancet2011，，9790： | 2 |
| 4 | Incidence and survival of stomach cancer in a high-risk population of Chile显示文摘AIM:To study the incidence and survival rate of stomach cancer(SC)and its associated factors in a high risk population in Chile. METHODS:The population-based cancer registry of Valdivia,included in the International Agency for Research on Cancer system,covers 356 396 residents of Valdivia Province,Southern Chile.We studied all SC cases entered in this Registry during 1998-2002 (529 cases).Population data came from the Chilean census(2002).Standardized incidence rates per 100 000 inhabitants(SIR)using the world population, cumulative risk of developing cancer before age 75, and rate ratios by sex,age,ethnicity and social factors were estimated.Relative survival(EdererⅡmethod) and age-standardized estimates(Brenner method) were calculated.Specific survival rates(Kaplan-Meier) were measured at 3 and 5 years and survival curves were analyzed with the Logrank and Breslow tests. Survival was studied in relation to demographics, clinical presentation,laboratory results and medical management of the cases.Those variables significantly associated with survival were later included in a Cox multivariate model. RESULTS:Between 1998 and 2002,529 primary gastric cancers occurred in Valdivia(crude incidence rate 29.2 per 100000 inhabitants).Most cases were male(69.0%), residents of urban areas(57.5%)and Hispanic(83.2%), with a low education level(84.5%<8 school years). SC SIR was higher in men than women(40.8 and 14.8 respectively,P<0.001),risk factors were low education RR 4.4(95%CI:2.9-6.8)and 1.6,(95%CI:1.1-2.1) for women and men respectively and Mapuche ethnicity only significant for women(RR 2.2,95%CI:1.2-3.7).Of all cases,76.4%were histologically confirmed,11.5% had a death certificate only(DCO),56.1%were TNM stageⅣ;445 cases(84.1%)were eligible for survival analysis,all completed five years follow-up;42 remained alive,392 died of SC and 11 died from other causes. Specific 5-year survival,excluding cases with DCO,was 10.6%(95%CI:7.7-13.5);5-year relative survival rate was 12.3%(95%CI:9.1-16.1),men 10.9%(95%CI: 7.4-15.2)and women 16.1%(95%CI:9.5-24.5).Fiveyear specific survival was higher for patients aged<55 years(17.3%),with intestinal type of cancer(14.6%), without metastasis(22.2%),tumor size<4 cm(60.0%), without lymphatic invasion(77.1%),only involvement of the mucous membrane(100%).Statistically significant independent prognostic factors were:TNM staging, diffuse type,metastasis,supraclavicular adenopathy, palpable tumor,and hepatitis or ascites. CONCLUSION:Social determinants are the main risk factors for SC,but not for survival.An advanced clinical stage at consultation is the main cause of poor SC survival. | Katy Heise Enriqueta Bertran Marcelo E Andia Catterina Ferreccio | 2009 | World Journal of Gastroenterology2009，15，15： | 2 |
| 5 | Gastric cancer incidence and mortality is associated with altitude in the mountainous regions of Pacific Latin America显示文摘 | Javier Torres Pelayo Correa Catterina Ferreccio Gustavo Hernandez-Suarez Rolando Herrero Maria Cavazza-Porro Ricardo Dominguez Douglas Morgan | 2013 | Cancer Causes & Control2013，，2： | 2 |
| 6 | Epidemiology of Helicobacter pylori infection in six Latin American countries (SWOG Trial S0701)显示文摘 | Carolina Porras Jesse Nodora Rachael Sexton Catterina Ferreccio Silvia Jimenez Ricardo L. Dominguez Paz Cook Garnet Anderson Douglas R. Morgan Laurence H. Baker E. Robert Greenberg Rolando Herrero | 2013 | Cancer Causes & Control2013，，2： | 2 |
| 7 | A comparison of single and combined visual,cytologic,and virologic tests as screening strategies in a region at high Risk of cervical cancer显示文摘 | Catterina F Maria CB Mark ES | 2003 | Cancer Ep idemiology2003，12，9： | 1 |
| 8 | Serological response to H elicobacter pylori infection among L atin A merican populations with contrasting risks of gastric cancer显示文摘 | M. Constanza Camargo Mauricio Beltran Carlos J. Conde‐Glez Paul R. Harris Angelika Michel Tim Waterboer Astrid Carolina Flórez Javier Torres Catterina Ferreccio Joshua N. Sampson Michael Pawlita Charles S. Rabkin | 2015 | Int. J. Cancer2015，，12： | 1 |
| 9 | Fifty-Year Study of Lung and Bladder Cancer Mortality in Chile Related to Arsenic in Drinking Water显示文摘 | Catterina F Yan Y | 2007 | Journal of the National Cancer Institute2007，99，12： | 1 |
| 10 | A comparison of single and combined visual,cytologic,and virologic tests as screening strategies in a region at high risk of cervical cancer显示文摘 | Catterina Ferreccio Maria C Bratti Mark E Sherman | 2003 | Cancer Epidemiology Biomarkers & Prevention2003，12，9： | 1 |
| 11 | A comparison of single and combined visual,cytologic, and virologic tests as screening strategies in a region at high risk of cervical cancer显示文摘 | Catterina Ferreceio Maria C Bratti Mark E Sherman | 2003 | Cancer Epidemiology Biomarkers&Prevention2003，12，9： | 1 |
| 12 | Epidemiology of Helicobacter pylori infection in six Latin American countries (SWOG Trial S0701)显示文摘 | Carolina Porras Jesse Nodora Rachael Sexton Catterina Ferreccio Silvia Jimenez Ricardo L. Dominguez Paz Cook Garnet Anderson Douglas R. Morgan Laurence H. Baker E. Robert Greenberg Rolando Herrero | 2013 | Cancer Causes & Control2013，，2： | 1 |
| 13 | Arsenic methylation and lung and bladder cancer in a case-control study in northern Chile显示文摘 | Dawit Melak Catterina Ferreccio David Kalman Roxana Parra Johanna Acevedo Liliana Pérez Sandra Cortés Allan H. Smith Yan Yuan Jane Liaw Craig Steinmaus | 2014 | Toxicology and Applied Pharmacology2014，，2： | 1 |
| 14 | 14-day triple, 5-day concomitant, and 10-day sequential therapies for Helicobacter pylori infection in seven Latin American sites: a randomised trial显示文摘 | E Robert Greenberg Garnet L Anderson Douglas R Morgan Javier Torres William D Chey Luis Eduardo Bravo Ricardo L Dominguez Catterina Ferreccio Rolando Herrero Eduardo C Lazcano-Ponce María Mercedes Meza-Montenegro Rodolfo Pe?a Edgar M Pe?a Eduardo Salazar- | 2011 | The Lancet2011，，9790： | 1 |
| 15 | Gastric cancer is related to early Helicobacter pylori infection in a high-prevalence country 显示文摘 | Catterina F Antonio R Paul R | 2007 | Cancer Epidemiol Biomarkers Prev2007，662，： | 1 |
| 16 | A comparison of single and combined visual,cytologic,and virologic tests as screening strategies in a region at high risk of cervical cancer显示文摘 | Catterina Ferreccio Maria C Bratti Mark E Sherman | 2003 | Cancer Epidemiology Biomarkers & Prevention2003，，9： | 1 |
| 17 | 14-day triple, 5-day concomitant, and 10-day sequential therapies for Helicobacter pylori infection in seven Latin American sites: a randomised trial显示文摘 | E Robert Greenberg Garnet L Anderson Douglas R Morgan Javier Torres William D Chey Luis Eduardo Bravo Ricardo L Dominguez Catterina Ferreccio Rolando Herrero Eduardo C Lazcano-Ponce María Mercedes Meza-Montenegro Rodolfo Pe?a Edgar M Pe?a Eduardo Salazar- | 2011 | The Lancet2011，，9790： | 1 |
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