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| 1 | Treatment with NADPH oxidase inhibitor apocynin alleviates diabetic neuropathic pain in rats显示文摘Increased reactive oxygen species by the activation of NADPH oxidase(NOX) contributes to the development of diabetic complications.Apocynin,a NOX inhibitor,increases sciatic nerve conductance and blood flow in diabetic rats.We investigated potential protective effect of apocynin in rat diabetic neuropathy and its precise mechanism of action at molecular level.Rat models of streptozotocin-induced diabetes were treated with apocynin(30 and 100 mg/kg per day,intragastrically) for 4 weeks.Mechanical hyperalgesia and allodynia were determined weekly using analgesimeter and dynamic plantar aesthesiometer.Western blot analysis and histochemistry/immunohistochemistry were performed in the lumbar spinal cord and sciatic nerve respectively.Streptozotocin injection reduced pain threshold in analgesimeter,but not in aesthesiometer.Apocynin treatment increased pain threshold dose-dependently.Western blot analysis showed an increase in catalase and NOX-p47 phox protein expression in the spinal cord.However,protein expressions of neuronal and inducible nitric oxide synthase(n NOS,i NOS),superoxide dismutase,glutathion peroxidase,nitrotyrosine,tumor necrosis factor-α,interleukin-6,interleukin-1β,aldose reductase,cyclooxygenase-2 or MAC-1(marker for increased microgliosis) in the spinal cord remained unchanged.Western blot analysis results also demonstrated that apocynin decreased NOX-p47 phox expression at both doses and catalase expression at 100 mg/kg per day.Histochemistry of diabetic sciatic nerve revealed marked degeneration.n NOS and i NOS immunoreactivities were increased,while S-100 immunoreactivity(Schwann cell marker) was decreased in sciatic nerve.Apocynin treatment reversed these changes dose-dependently.In conclusion,decreased pain threshold of diabetic rats was accompanied by increased NOX and catalase expression in the spinal cord and increased degeneration in the sciatic nerve characterized by increased NOS expression and Schwann cell loss.Apocynin treatment attenuates neuropathic pain by decelerating the increased oxidative stress-mediated pathogenesis in diabetic rats. | Murat Olukman Aytül onal Fatma Gül celenk Yigit Uyankgil Türker cavusoglu Neslihan Düzenli Sibel ülker | 2018 | Neural Regeneration Research2018，13，9： | 4 |
| 2 | Comparison of the clinical efficacy of two different types of post systems which were restored with composite restorations显示文摘AIM To compare the efficacy of resin composite restorations, retained with either polyethylene or zirconia-rich glass fiber posts. METHODS Sixty-two single rooted maxillary and mandibularcentral incisor teeth in forty-four patients (15 males and 29 females; age range 15-32 years) were restored either with an ultrahigh molecular weight polyethylene(UHMWP) fiber post (Bondable Reinforcement Ribbon, DENSE, Ribbond, Seattle, WA, United States) or a zircon-rich glass fiber post (Snowpost, Lot H 040; Carbotech, Ganges, France). Then, direct resin composite restoration (Clearfil AP-X, Kuraray) was performed for both post systems in tooth color suitable. Patients were recalled for routine inspections at 6 mo, 1, 2 and 3 years.RESULTS The restorations were assessed during each recall evaluation according to predetermined clinical and radiographic criteria (periapical lesion; marginal leakage and integrity; color stability; surface stain and loss of retention of the post or the composite buildup material). The follow-up data showed no significant difference in these criteria between polyethylene fibre posts and zirconia-rich glass fibre posts.CONCLUSION The efficacy of resin composite restorations, retained with either polyethylene or zirconia-rich glass fiber posts were similar, suggesting that both types of fiber post can be used successfully to help retain resin composite restorations. | Buket Ayna Emrah Ayna Sema Celenk Emine Goncü Bacaran Berivan Dündar Yιlmaz Ìbrahim Halil Tacir Mehmet Cudi Tuncer | 2018 | World Journal of Clinical Cases2018，6，3： | 1 |
| 3 | Mandibular asymmetry in differentocclusion patterns显示文摘 | Sezgin OS Celenk P Arici S | 2007 | Angle Orthod2007，77，5： | 1 |
| 4 | Apocynin restores endo- thelial dysfunction in streptozotocin diabetic rats through regulation of nitric oxide synthase and NADPH oxidase expressions 显示文摘 | Olukman M Orhan CE Celenk FG | 2010 | J Diabetes Complications2010，24，6： | 1 |
| 5 | Nasolabial cyst: case report with CT and MRI findings显示文摘 | A. Pinar Sumer Peruze Celenk Mahmut Sumer N. Tuba Telcioglu Omer Gunhan | 2010 | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology2010，，2： | 1 |
| 6 | Expression of cyclooxyge- nase-2, 12-lipoxygenase, and inducible nitric oxide synthase in head and neck squamous cell carcinoma 显示文摘 | Celenk F Bayramoglu I Yilmaz A | 2013 | J Craniofac Surg2013，24，4： | 1 |
| 7 | Absence of contralatcral suppression of transiently evoked otoacoustic emissions in fibromyalgia syndrome 显示文摘 | Gunduz B Bayazit YA Celenk F | 2008 | J Laryngol Otol2008，122，6： | 1 |
| 8 | Management of cerebro-spinal fluid leak following retrosigmoid posterior cranial fossasurgery显示文摘 | Bayazit YA Celenk F Duzlu M | 2009 | ORL J Otorhinolaryngol Relat Spec2009，71，6： | 1 |
| 9 | Value of Doppler sonography in assessing the progression of chronic viral hepatitis and in the diagnosis and grading of cirrhosis 显示文摘 | Haktanir A Cihan BS Celenk C | 2005 | Ultrasound Med2005，24，： | 1 |
| 10 | UV-C light inactivation and modeling kinetics of Alicyclobacillus acidoterrestris spores in white grape and apple juice 显示文摘 | Baysal AH Celenk M Sevcan U | 2013 | Int J Food Microbiol2013，166，： | 1 |
| 11 | Impact of prognostic factors on recovery from sudden hearing loss显示文摘 | Ceylan A Celenk F Kemalolu YK | 2007 | J Laryngol Otol2007，121，11： | 1 |
| 12 | Plasma cytokine levels in ulcerative colitis显示文摘 | Vedat Goral Tahir Celenk Abdurahman Kaplan | 2007 | Hepatogastroenterology2007，54，76： | 1 |
| 13 | Management of cerebrospinal fluid leak following retrosigmoid posterior cranial fossa surgery 显示文摘 | Bayazit YA Celenk F Duzlu M | 2009 | J Otorhinolaryngol Relat Spec2009，71，6： | 1 |
| 14 | Mandibular asymmetry in differentocclusion patterns显示文摘 | Sezgin OS Celenk P Arici S | 2007 | Angle Orthod2007，77，5： | 1 |
| 15 | UV-C light inactivation and modeling kinetics of Alicyclobacillus acidoterrestris spores in white grape and apple juices显示文摘 | Ayse Handan Baysal Celenk Molva Sevcan Unluturk et 01 | 2013 | International Journal of Food Microbiology2013，166，： | 1 |
| 16 | Content-based Image Retrieval Based on ROI Detection and Relevance Feedback显示文摘 | Zhou Qiang Ma Limin Celenk M | | 0，，11： | 1 |
| 17 | Content-based image retrieval based on ROI deteetion and relevance feedback显示文摘 | Zhou Qing Limin MA Mehmet Celenk | 2005 | Multimedia Tools and Applications2005，27，2： | 1 |
| 18 | Mandibular asymmetry in different occlusion patterns显示文摘 | Sezgin O S Celenk P Arici S | | 0，，05： | 1 |
| 19 | A color clustering technique for image segmentationn显示文摘 | Celenk M | 1990 | Computer Vision Graphics and Image Proceks1990，52，： | 1 |
| 20 | Expression of cyclooxygenase-2,12-lipoxygenase,and inducible nitric oxide synthase in head and neck squamous cell carcinoma显示文摘 | Celenk F Bayramoglu I Yilmaz A | 2013 | J Craniofac Surg2013，24，4： | 1 |
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