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| 1 | Operative complications and economic outcomes of cholecystectomy for acute cholecystitis显示文摘BACKGROUND Recent management of acute cholecystitis favors same admission(SA)or emergent cholecystectomy based on overall shorter hospital stay and therefore cost savings.We adopted the practice of SA cholecystectomy for the treatment of acute cholecystitis at our tertiary care center and wanted to evaluate the economic benefit of this practice.We hypothesized that the existence of complications,particularly among patients with a higher degree of disease severity,during SA cholecystectomy could negate the cost savings.AIM To compare complication rates and hospital costs between SA vs delayed cholecystectomy among patients admitted emergently for acute cholecystitis.METHODS Under an IRB-approved protocol,complications and charges for were obtained for SA,later after conservative management(Delayed),or elective cholecystectomies over an 8.5-year period.Patients were identified using the acute care surgery registry and billing database.Data was retrieved via EMR,operative logs,and Revenue Cycle Operations.The severity of acute cholecystitis was graded according to the Tokyo Guidelines.TG18 categorizes acute cholecystitis by Grades 1,2,and 3 representing mild,moderate,and severe,respectively.Comparisons were analyzed withχ2,Fisher’s exact test,ANOVA,ttests,and logistic regression;significance was set at P<0.05.RESULTS Four hundred eighty-six(87.7%)underwent a SA while 68 patients(12.3%)received Delayed cholecystectomy.Complication rates were increased after SA compared to Delayed cholecystectomy(18.5%vs 4.4%,P=0.004).The complication rates of patients undergoing delayed cholecystectomy was similar to the rate for elective cholecystectomy(7.4%,P=0.35).Mortality rates were 0.6%vs 0%for SA vs Delayed.Patients with moderate disease(Tokyo 2)suffered more complications among SA while none who were delayed experienced a complication(16.1%vs 0.0%,P<0.001).Total hospital charges for SA cholecystectomy were increased compared to a Delayed approach($44500±$59000 vs$35300±$16700,P=0.019).The relative risk of developing a complication was 4.2x[95%confidence interval(CI):1.4-12.9]in the SA vs Delayed groups.Among eight patients(95%CI:5.0-12.3)with acute cholecystitis undergoing SA cholecystectomy,one patient will suffer a complication.CONCLUSION Patients with Tokyo Grade 2 acute cholecystitis had more complications and increased hospital charges when undergoing SA cholecystectomy.This data supports a selective approach to SA cholecystectomy for acute cholecystitis. | Christopher P Rice Krishnamurthy B Vaishnavi Celia Chao Daniel Jupiter August B Schaeffer Whitney R Jenson Lance W Griffin William J Mileski | 2019 | World Journal of Gastroenterology2019，25，48： | 8 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Opportunities for low-cost CO2storage demonstration projects in China显示文摘 | Meng K C Williams R H Celia M A | 2007 | Energy Policy2007，35，4： | 1 |
| 4 | Radiation therapy fol- lowing surgery or localized breast cancer:outcome predic- tion by classical prognostic factors and approximated ge- netic subtypes显示文摘 | Pacelli R Conson M Celia L | 2013 | J Radiat Res2013，54，2： | 1 |
| 5 | Recommended methods for determining responsiveness and minimally important differences for patient-reported outcomes 显示文摘 | Revicki D Hays R D Celia D | 2008 | J Clin Epidemiol2008，61，2： | 1 |
| 6 | A general mass-conservative numerical solution for the unsaturated flow equation显示文摘 | Celia M A Bouloutas E T Zarba R L | 1990 | Water Resour Res1990，26，： | 1 |
| 7 | Safe storage of CO2 in deep saline aquifers 显示文摘 | Bruant R G Guswa A J Celia M A | 2002 | Environmental Science & Technology2002，36，11： | 1 |
| 8 | A general mass-conservative numerical solution for the unsaturated flow equation显示文摘 | Celia M A Bouloutas E T Zarba R L | 1990 | Water Resource1990，，26： | 1 |
| 9 | Modeling support of functional relationships between capillary pressure, saturation, interfacial area and common lines 显示文摘 | Held R J Celia M A | 2001 | Advances in Water Resources2001，24，34： | 1 |
| 10 | Effects of sorafenib on symptoms and quality of life : results from a large randomized placebo-controlled study in renal cancer 显示文摘 | Bukowski R Celia D Gondek K | 2007 | Am J Clin Oncol2007，30，： | 1 |
| 11 | Omentin Plasma Levels and Gene Expression Are Decreased in Obesity 显示文摘 | CELIA M S B YANG R Z LEE M J | 2007 | Diabetes2007，56，6： | 1 |
| 12 | Influence tithe CD14 C-260T promoter polymorphism on Creactive Protein levels in patients with coronary heart disease 显示文摘 | Esther Bemardo Dominick J Celia R | 2006 | Am J Cardiol2006，98，： | 1 |
| 13 | Orthogonal collocation and alternating-direction procedures for unsaturated flow problems显示文摘 | Celia M A Ahuja L R Pinder G F | 1987 | Advances in Water Resources1987，10，4： | 1 |
| 14 | Potential restrictions for CO2sequestration sites due to shale and tight gas production显示文摘 | Elliot T R Celia M A | 2012 | Environmental science&technology2012，46，7： | 1 |
| 15 | A general mass-conservative numerical solution for the unsaturated flow equation显示文摘 | Celia M A Bouloutas E T Zarba R L | 1990 | Water Resource Reseacher1990，26，7： | 1 |
| 16 | Successful imple- mentation of evidence-based nursing practice : the indis- pensable role of staff development 显示文摘 | Wittmann-Price R Celia L Dunn R | 2013 | J Nurses Prof Dev2013，29，4： | 1 |
| 17 | Chlorpromazine Interactions to Sera Albumins: A Study by the Quenching of Fluorescence 显示文摘 | Dilson S Celia M C Sonia R W L | 2004 | Speetrochim Aeta Part A2004，60，5： | 1 |
| 18 | Fractionated stereot- actic radiation therapy for orbital optic nerve sheath menin-gioma-a single institution experience and a short review of the literature 显示文摘 | Pacelli R Celia L Consort M et ol | 2011 | J Radiat Res2011，52，1： | 1 |
| 19 | Functional relationship to describe temporal statistics of soil moisture averaged over different depths显示文摘 | Puma M J Celia M A Rodriguez-Iturbe R | 2005 | Advances in Water Resources2005，28，6： | 1 |
| 20 | Safe storage of CO2in deep saline aquifers显示文摘 | Bruant R G Jr Guswa A J Celia M A | 2002 | Environmental Science and Technology2002，36，11： | 1 |
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