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| 1 | Expression of COX-2, PCNA, Ki-67 and p53 in gastrointestinal stromal tumors and its relationship with histopathological parameters显示文摘AIM: To investigate the expression of Cyclooxygenase-2 (COX-2), proliferating cell nuclear antigen (PCNA), Ki-67 and p53 in gastrointestinal stromal tumors (GISTs) and its relationship with histopathological parameters. METHODS: Twenty-five GISTs were examined by light microscopy and immunohistochemistry. c-kit, CD34, SMA, S-100 protein, COX-2, PCNA, Ki-67 and p53 were detected immunohistochemically and the relationship was evaluated among histopathologic parameters such as mitotic index (MI), tumor grade, tumor size, COX-2, PCNA, Ki-67 and p53. RESULTS: COX-2 protein expression was found in 19 of 25 (76%) of the tumors, and expression was noted in the cytoplasm of the tumor cells. p53 was significantly related to MI and tumor grade but no relationship was found between COX-2, proliferation markers and MI, tumor grade and tumor size. CONCLUSION: COX-2 is expressed in most GISTs and it may play an important role in the proliferation and progression of these tumors or a useful marker to identify GIST. Although immunohistochemical assessment of p53 can be used for distinguishing the risk groups of GISTs, tumor size and mitotic rate should be considered at the same time. | Derya Gumurdulu Seyda Erdogan Fazilet Kayaselcuk Gulsah Seydaoglu Cem K Parsak Orhan Demircan Ilhan Tuncer | 2007 | World Journal of Gastroenterology2007，13，3： | 21 |
| 2 | Comparison of subconjunctivally injected bevacizumab, ranibizumab, and pegaptanib for inhibition of corneal neovascularization in a rat model显示文摘AIM: To compare the efficacies of subconjunctival bevacizumab, ranibizumab, and pegaptanib sodium injections for the inhibition of corneal neovascularization in an experimental rat model. METHODS: Sixteen corneas of 16 rats were chemically cauterized and randomized into four groups: bevacizumab group that treated with 0.05mL/1.25mg bevacizumab, ranibizumab group that treated with 0.05mL/0.5mg ranibizumab, pegaptanib group that treated with 0.05mL/0.15mg pegaptanib sodium, and control group that treated with 0.05mL saline solution. Digital photographs of the corneas were taken and analyzed using an image analysis software program. All corneas were excised and examined histologically on the 15 th day. RESULTS: Each treatment group had significantly less neovascularized corneal areas and fewer blood vessels than the control group (all P <0.05). In addition, bevacizumab group had significantly less neovascu-larized corneal areas and fewer blood vessels than ranibizumab and pegaptanib groups (both P <0.05). However, there was no significant difference between the ranibizumab and pegaptanib groups regarding percentage of neovascularized corneal areas and number of blood vessels (both P >0.05). CONCLUSION: Subconjunctival bevacizumab, ranibiz-umab, and pegaptanib sodium were effective with no corneal epitheliopathy for inhibiting corneal neovascularization after corneal burn in rats .Bevacizumab was more effective than ranibizumab and pegaptanib sodium. | Ebru Eren Akar Veysi ner Cem Küükerdnmez Yonca Aydin Akova | 2013 | International Journal of Ophthalmology(English edition)2013，6，2： | 9 |
| 3 | Hepatic cystic echinococcosis:Percutaneous treatment as an outpatient procedure显示文摘Objective:To demonstrate utility and safety of the puncture aspiration injection and reospiration(PAIR)technique for outpatients.Methods:Percutaneous treatment with US guidance was applied to 33 patients for 44 cysts.Patients treated with the PAIR technique,were outpatients.PAIR and catheterization technique were evaluated for efficacy and safety of procedure and complication rates.Results:Thirty-five of 44 cysts were treated with the PAIR and 9 of 44 were treated with the catheterization technique.The success rate of the cysts Gharbi type 1(CEI)and type 2(Ct3a)treated with the PAIR technique was 1009.hi the follow up of 9 cysts treated with the catheterization technique,2 of them(22%)developed cyst infection and 1(11%)developed a biliary fistula.Conclusions:The PAIR technique was found to be an effective and safe approach in order to treat Gharbi type 1 and type 2 cysts percutaneously for outpatients.It has a very low complication rate in comparison with the catheterization technique.So every effort should be mode to finish the treatment with PAIR technique. | Mert Kroglu Bekir Erol Cemil Gürses Baris Türkbey Cem Yunus Bas Ahmet Sükrü Alparslan Banu Kale Kroglu Iclal Erdem Toslak Bülent eki Okan Akhan | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，3： | 4 |
| 4 | Mesenchymal stem cell therapy in patients with small bowel transplantation:Single center experience显示文摘AIM:To study the effects of mesenchymal stem cell(MSC) therapy on the prevention of acute rejection and graft vs host disease following small bowel transplantation.METHODS: In our transplantation center, 6 isolated intestinal transplants have been performed with MSC therapy since 2009. The primary reasons for transplants were short gut syndrome caused by surgical intestine resection for superior mesenteric artery thrombosis(n = 4), Crohn's disease(n = 1) and intestinal aganglionosis(n = 1). Two of the patients were children. At the time of reperfusion, the first dose of MSCs cultured from the patient's bone marrow was passedinto the transplanted intestinal artery at a dose of 1000000 cells/kg. The second and third doses of MSCs were given directly into the mesenteric artery through the arterial anastomosis using an angiography catheter on day 15 and 30 post-transplant.RESULTS: The median follow-up for these patients was 10.6 mo(min: 2 mo-max: 30 mo). Three of the patients developed severe acute rejection. One of these patients did not respond to bolus steroid therapy. Although the other two patients did respond to antirejection treatment, they developed severe fungal and bacterial infections. All of these patients died in the 2nd and 3rd months post-transplant due to sepsis. The remaining patients who did not have acute rejection had good quality of life with no complications observed during the follow-up period. In addition, their intestinal grafts were functioning properly in the 13th, 25th and 30th month post-transplant. The patients who survived did not encounter any problems related to MSC transplantation.CONCLUSION: Although this is a small case series and not a randomized study, it is our opinion that small bowel transplantation is an effective treatment for intestinal failure, and MSC therapy may help to prevent acute rejection and graft vs host disease following intestinal transplantation. | Sait Murat Do?an Sel?uk K?l?n? Eyüp Kebap?? Cem Tu?men Mustafa ?lmez Cezmi Karaca Alp Gürkan Ma?allah Baran Yusuf Kurtulmu? | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 5 | Sliding mode measurement feedback control for antilock braking systems 显示文摘 | Cem U Pushkin K | 1999 | IEEE Trans on Control Systems Technology1999，7，2： | 1 |
| 6 | A probabilistic model applied to emergency service vehicle location显示文摘 | Hari K Rajagopalan Cem Saydamb Jing X | 2009 | European Journal of Operational Research2009，196，1： | 1 |
| 7 | Comparison of Conjunctival Autograft With Amniotic Membrane Transplantation for Pterygium Surgery: Surgical and Cosmetic Outcome显示文摘 | Cem Kü?ükerd?nmez Yonca A Akova Dilek Dursun Altn?rs | 2007 | Cornea2007，，4： | 1 |
| 8 | Vulvar syringoma exacerbated during pregnancy显示文摘 | Cem Turan Mustafa Ugur Lale Kutluay Selahattin Kükner Tülin Dabakoglu Tugrul Aydogdu Yusuf Ergün Omer Cobanoglu | 1996 | European Journal of Obstetrics and Gynecology1996，，1： | 1 |
| 9 | Transcriptional and epige- netic regulation of KIAA1199 gene expression in human breast cancer显示文摘 | Cem K Nikki E Deborah K | 2012 | PLoS One2012，7，： | 1 |
| 10 | Cas9-chromatin binding information enables more accurate CRISPR off-target prediction 显示文摘 | Ritambhara S Cem K Aaron Q | 2015 | Nucleic Acids Res2015，43，18： | 1 |
| 11 | Expression and activity lev- els of matrix metalloproteinase-7 and in situ localization of ca- seinolytic activity in eolorectal cancer显示文摘 | Didem K Baha A Cem T | 2014 | Clin Biochem2014，47，1314： | 1 |
| 12 | Regional disparities in the European U- nion and the enlargement process:an exploratory spatial data analysis,1995--2000 显示文摘 | Cem E Wilfried K | 2006 | The Annals of Regional Science2006，40，4： | 1 |
| 13 | Regional disparities in the European Union and the enlargement process: an exploratory spatial data analysis, 1995-2000显示文摘 | Cem E Wilfried K | 2006 | Ann Reg Sci2006，40，7： | 1 |
| 14 | Anchor application in Karatepe andesite rock slope,Izmir-Tiirkiye显示文摘 | Mehmet Y K Cem K Ahmet T A | 2011 | International Journal of Rock Mechanics and Mining Sciences2011，48，2： | 1 |
| 15 | Endoscopic retrograde cholangiography by double balloon enteroscopy in patients with Roux-en-Y hepaticojejunostomy显示文摘 | Erkan Parlak Bahattin ?i?ek Sel?uk Di?ibeyaz Cem Cengiz Mehmet Yurdakul Meral Akdo?an Mesut Z. Y. K?l?? Nurgül ?a?maz Turhan Cumhur Burhan ?ahin | 2010 | Surgical Endoscopy2010，，2： | 1 |
| 16 | Rheological properties of reduced-fat and low-fat ice cream containing whey protein isolate and inulin显示文摘 | Ayse S A Cem K Gulfem U | 2008 | European Food Research and Technology2008，227，3： | 1 |
| 17 | Sanitary landfill leachates and their trea tment显示文摘 | CHINA E S K AS CEM DEWALLE F B | 1976 | Am soc Civileng Environ Enga Div J1976，102，： | 1 |
| 18 | The role of low-molecular-weight heparin in recurrent implantation failure: a prospective, quasi-randomized, controlled study显示文摘 | Bülent Berker Salih Ta?k?n Korhan Kahraman Elif Aylin Ta?k?n Cem Atabeko?lu Murat S?nmezer | 2011 | Fertility and Sterility2011，，8： | 1 |
| 19 | Diagnostic Value of D-Dimer and Antithrombin-Ⅲ Levels in Predicting Prosthetic tteart Valve Thrombosis显示文摘 | Ozan K Bahattin T | 2003 | Tex Heart Inst J2003，30，： | 1 |
| 20 | Acute phase proteins and other systemic responses to inflammation显示文摘 | Cem G M D Irving K M D | 1999 | Mechanisms of Disease1999，340，： | 1 |
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