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| 1 | Levels of matrix metalloproteinase-1 and tissue inhibitors of metalloproteinase-1 in gastric cancer显示文摘AIM:To evaluate the levels of preoperative serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in gastric cancer.METHODS:One hundred gastric cancer patients who underwent gastrectomy were enrolled in this study.The serum concentrations of MMP-1 and TIMP-1 in these patients and in fifty healthy controls were determined using an enzyme-linked immunosorbent assay.RESULTS:Higher serum MMP-1 and TIMP-1 levels were observed in patients than in controls (P < 0.001).Serum MMP-1 and TIMP-1 levels were positively associated with morphological appearance,tumor size,depth of wall invasion,lymph node metastasis,liver metastasis,perineural invasion,and pathological stage.They were not significantly associated with age,gender,tumor location,or histological type.CONCLUSION:Increased MMP-1 and TIMP-1 were associated with gastric cancer.Although these markers are not good markers for diagnosis,these markers show in advanced gastric cancer. | Ozgur Kemik Ahu Sarbay Kemik Aziz Sümer Ahmet Cumhur Dulger Mine Adas Huseyin Begenik Ismail Hasirci Ozkan Yilmaz Sevim Purisa Erol Kisli Sefa Tuzun Cetin Kotan | 2011 | World Journal of Gastroenterology2011，17，16： | 10 |
| 2 | Portable lensless wide-field microscopy imaging platform based on digital inline holography and multi-frame pixel super-resolution显示文摘In this paper,an irregular displacement-based lensless wide-field microscopy imaging platform is presented by combining digital in-line holography and computational pixel super-resolution using multi-frame processing.The samples are illuminated by a nearly coherent illumination system,where the hologram shadows are projected into a complementary metal-oxide semiconductor-based imaging sensor.To increase the resolution,a multi-frame pixel resolution approach is employed to produce a single holographic image from multiple frame observations of the scene,with small planar displacements.Displacements are resolved by a hybrid approach:(i)alignment of the LR images by a fast feature-based registration method,and(ii)fine adjustment of the sub-pixel information using a continuous optimization approach designed to find the global optimum solution.Numerical method for phase-retrieval is applied to decode the signal and reconstruct the morphological details of the analyzed sample.The presented approach was evaluated with various biological samples including sperm and platelets,whose dimensions are in the order of a few microns.The obtained results demonstrate a spatial resolution of 1.55 μm on a field-of-view of<30 mm^(2). | Antonio C Sobieranski Fatih Inci H Cumhur Tekin Mehmet Yuksekkaya Eros Comunello Daniel Cobra Aldo von Wangenheim Utkan Demirci | 2015 | Light(Science & Applications)2015，4，1： | 7 |
| 3 | Expression of Notch pathway components (Numb, Itch, and Siah-1) in colorectal tumors: A clinicopathological study显示文摘BACKGROUND The role of the Notch pathway in carcinogenesis and tumor progression has been demonstrated in many organs,including the colon.Accordingly,studies aimed at developing therapies targeting this pathway in various cancers require the identification of several factors that may play a role in regulating Notch-1 expression.Although Numb,Itch,and seven in absentia homolog-1(Siah-1)have been shown to contribute to the regulation of Notch signaling,their role in colorectal carcinogenesis and tumor progression has not been fully elucidated to date.AIM To evaluate Numb,Itch,and Siah-1 expression in colorectal tumors to clarify their relationship with Notch-1 expression and their role in carcinogenesis and tumor behavior.METHODS Expression of Notch-1,Numb,Itch,and Siah-1 was investigated in 50 colorectal carcinomas,30 adenomas,and 20 healthy colonic tissues by immunohistochemistry and quantitative real-time polymerase chain reaction(PCR)analyses.RESULTS In contrast to Notch-1,which is expressed at higher levels in tumor tissues and adenomas,expression of Numb,Itch,and Siah-1 was stronger and more frequent in normal mucosa(P<0.01).There was a positive correlation between Notch-1 expression and high histological grade,the presence of lymph node metastasis,and advanced-stage tumors,whereas expression of Numb,Itch,and Siah-1 was absent or reduced in tumors with these clinicopathological parameters(P<0.05).In survival analysis,expression of Notch was related to poor prognosis but that of Numb,Itch,and Siah-1 correlated with improved survival(P<0.05).Multivariate analysis revealed Notch-1 expression and loss of Numb expression to be independent prognostic parameters together with lymph node metastasis(P<0.05).CONCLUSION Our findings support the role of Notch-1 in colorectal carcinoma and indicate that loss of Numb,Itch,and Siah-1 expression is associated with carcinogenesis.Our data also suggest that these three proteins might be involved in the Notch-1 pathway during colorectal carcinoma(CRC)progression and might play an essential role in approaches targeting Notch as novel molecular therapies for CRC. | Sinem Cil Gonulcu Betul Unal Ibrahim Cumhur Bassorgun Mualla Ozcan Hasan Senol Coskun Gulsum Ozlem Elpek | 2020 | World Journal of Gastroenterology2020，26，26： | 5 |
| 4 | Clinical risk factors for the development of consecutive exotropia:a comparative clinical study显示文摘AIM: To compare a group of patients with consecutive exotropia with patients who had ≤10 prism diopters(PD)esotropia or no deviation postoperatively in terms of probable clinical risk factors for the development of consecutive exotropia.METHODS: The study recruited fourteen patients who developed consecutive exodeviation during follow-up period after the correction of esotropia who were categorized as group 1 and thirty-one patients who had still ≤10 PD esotropia or no deviation at the final visit that were considered as group 2. Clinical risk factors leading the development of consecutive deviation were analyzed as the main outcome measures.RESULTS: The mean age of patients was 4.57±3.11 y in group 1 and 5.10±3.52 y in group 2(P =0.634). There was no significant difference of preoperative near and distant deviations among two groups(P =0.835, 0.928respectively). The mean amount of medial rectus recession and lateral rectus resection was similar in both groups(P =0.412, 0.648 respectively). Convergence insufficiency and neurological diseases were more frequent in group 1(P =0.007, 0.045). Accompanying neurological disease was found to be as a significant factor increasing the risk of the development of consecutive exotropia significantly [odds ratios(OR):5.75(1.04-31.93)]. CONCLUSION: Accompanying neurological disease appears to be a significant clinical risk factor for the development of consecutive exodeviation during postoperative follow-up after the correction of esotropia.However, larger studies are needed in order to interpret the results to the clinical practice and to ascertain other concurrent risk factors. | Hande Tayla Sekeroglu Kadriye Erkan Turan Jale Karakaya Emin Cumhur Sener Ali Sefik Sanac | 2016 | International Journal of Ophthalmology(English edition)2016，9，6： | 2 |
| 5 | Alvarado, Eskelinen, Ohhmann and Raja Isteri Pengiran Anak Saleha Appendicitis scores for diagnosis of acute appendicitis显示文摘AIM:To assess the reliability and practical applicability of the widely used Alvarado,Eskelinen,Ohhmann and Raja Isteri Pengiran Anak Saleha Appendicitis(RIPASA)scoring systems in patients with suspected acute appendicitis.METHODS:Patients admitted to our tertiary center due to suspected acute appendicitis constituted the study group.Patients were divided into two groups.appendicitis group(Group A)consisted of patients who underwent appendectomy and were histopathologically diagnosed with acute appendicitis,and non-appendicitis group(Group N-A)consisted of patients who underwent negative appendectomy and were diagnosed with pathologies other than appendicitis and patients that were followed non-operatively.The operative findings for the patients,the additional analyses from follow up of the patients and the results of those analyses were recorded using the follow-up forms.RESULTS:One hundred and thirteen patients with suspected acute appendicitis were included in the study.Of the 113 patients(62 males,51 females),the mean age was 30.2±10.1(range 18-67)years.Of the 113patients,94 patients underwent surgery,while the rest were followed non-operatively.Of the 94 patients,77patients were histopathologically diagnosed with acute appendicitis.Our study showed a sensitivity level of81%for the Alvarado system when a cut-off value of 6.5was used,a sensitivity level of 83.1%for the Ohmann system when a cut-off value of 13.75 was used,a sensitivity level of 80.5%for the Eskelinen system when a cut-off value of 63.72 was used,and a sensitivity level of 83.1%for the RIPASA system when a cut-off value of 10.25 was used.CONCLUSION:The Ohmann and RIPASA scoring systems had the highest specificity for the diagnosis of acute appendicitis. | Hasan Erdem Süleyman etinkünar Koray Das Enver Reyhan Cumhur Deger Mehmet Aziret Hilmi Bozkurt Seluk Uzun Selim Szen Oktay rkrücü | 2013 | World Journal of Gastroenterology2013，19，47： | 2 |
| 6 | Effects of precementation desensitizing laser treatment and conventional desensitizing Agents on Crown Retention显示文摘 | Cumhur Sipahi D Murat Cehreli Julide Ozen | 2007 | J Prosthodont2007，20，3： | 1 |
| 7 | Multidetector CT angiography of renal vasculature: normal anatomy and variants 显示文摘 | Turkvatan A Ozdemir M Cumhur T | 2009 | Eur Radiol2009，19，1： | 1 |
| 8 | Cement Augmentation Techniques in Traumatic Thoracolumbar Spine Fractures显示文摘 | F Cumhur Oner Jorrit-Jan Verlaan Abraham J. Verbout Wouter J. A. Dhert | 2006 | Spine (S Suppl)2006，，11： | 1 |
| 9 | Multidetector CT urography of renal fusion anomalies显示文摘 | Turkvatan A Olcer T Cumhur T | 2009 | Diagn Interv Radiol2009，15，2： | 1 |
| 10 | Neurophysiology of swallowing显示文摘 | Cumhur Ertekin Ibrahim Aydogdu | 2003 | Clinical Neurophysiology2003，，12： | 1 |
| 11 | Outcome of surgical treatment of intestinal perforation in typhoid fever显示文摘AIM:To represent our clinical experience in the treatment of intestinal perforation arising from typhoid fever.METHODS:The records of 22 surgically-treated patients with typhoid intestinal perforation were evaluated retrospectively.RESULTS:There were 18 males and 4 females,mean age 37 years(range,8-64 years).Presenting symptoms were fever,abdominal pain,diarrhea or constipation.Sixteen cases were subjected to segmental resection and end-to-end anastomosis,while 3 cases received 2-layered primary repair following debridement,one case with multiple perforations received 2-layered primary repair and end ileostomy,one case received segmental resection and end-to-end anastomosis followed by an end ileostomy,and one case received segmental resection and end ileostomy with mucous fistula operation.Postoperative morbidity was seen in 5 cases and mortality was found in one case.CONCLUSION:Intestinal perforation resulting from Salmonella typhi is an important health problem in Eastern and Southeastern Turkey.In management of this illness,early and appropriate surgical intervention is vital. | Aziz Sümer zgür Kemik Ahmet Cumhur Dülger Aydemir Olmez Ismail Hasirci Erol Kisli Vedat Bayrak Gulay Bulut etin Kotan | 2010 | World Journal of Gastroenterology2010，16，33： | 1 |
| 12 | Characterization of thermostable α-glucosidases from newly isolated Geobacillus sp. A333 and thermophilic bacterium A343显示文摘 | Arzu Coleri Cihan Birgul Ozcan Cumhur Cokmus | 2009 | World Journal of Microbiology and Biotechnology2009，，12： | 1 |
| 13 | Association of the MEFV Gene Variations With Inflammatory Bowel Disease in Turkey显示文摘 | Filiz Akyuz Fatih Besisik Duran Ustek Cumhur Ekmek?i Aytul Uyar Binnur Pinarbasi Kadir Demir Sadakat Ozdil Sabahattin Kaymakoglu Gungor Boztas Zeynel Mungan Ahmet Gul | 2013 | Journal of Clinical Gastroenterology2013，，3： | 1 |
| 14 | Superior mesenteric artery blood flow in patients with small bowel disease : evaluation with duplex doppler sonography显示文摘 | Erden A Cumhur T Olcer T | 1998 | Clin Ultrasound1998，26，1： | 1 |
| 15 | STAT pathway in the regulation of zoledronic acid-induced apoptosis in chronic myeloid leukemia cells显示文摘 | Hatice Demet Kiper Burcin Tezcanli Aysun Adan Gokbulut Nur Selvi Cigir Biray Avci Buket Kosova Guniz Iskender Cumhur Gunduz Fahri Sahin Yusuf Baran Guray Saydam | 2013 | Biomedicine & Pharmacotherapy2013，，： | 1 |
| 16 | Prognostic significance of primary tumor localization in stage Ⅱ and Ⅲ colon cancer显示文摘IM To investigate the effects of tumor localization on disease free survival(DFS) and overall survival(OS) in patients with stage Ⅱ-Ⅲ colon cancer.METHODS This retrospective study included 942 patients with stage Ⅱ and Ⅲ colon cancer, which were followed up in our clinics between 1995 and 2017. The tumors from the caecum to splenic flexure were defined as right colon cancer(RCC) and those from splenic flexure to the sigmoid colon as left colon cancer(LCC).RESULTS The median age of the patients was 58 years(range: 19-94 years). Male patients constituted 54.2%. The rates of RCC and LCC were 48.4%(n = 456) and 51.6%(n = 486), respectively. During the median follow-up of 90 mo(range: 6-252 mo), 14.6% of patients developed recurrence and 9.1% of patients died. In patients with stage Ⅱ and Ⅲ disease with or without adjuvant therapy, DFS was similar in terms of primary tumor localization(stage Ⅱ; P = 0.547 and P = 0.481, respectively; stage Ⅲ; P = 0.976 and P = 0.978, respectively). In patients with stage Ⅱ and Ⅲ disease with or without adjuvant therapy, OS was not statistically significant with respect to primary tumor localization(stage Ⅱ; P = 0.381 and P = 0.947, respectively; stage Ⅲ; P = 0.378 and P = 0.904, respectively). The difference between median OS of recurrent RCC(26 ± 6.2 mo) and LCC(34 ± 4.9 mo) cases was eight months(P = 0.092).CONCLUSION Our study showed no association of tumor localization with either DFS or OS in patients with stage Ⅱ or Ⅲ colon cancer managed with or without adjuvant therapy. However, post-recurrence OS appeared to be worse in RCC patients. | Abdullah Sakin Serdar Arici Saban Secmeler Orcun Can Caglayan Geredeli Nurgul Yasar Cumhur Demir Osman Gokhan Demir Sener Cihan | 2018 | World Journal of Gastrointestinal Oncology2018，10，11： | 1 |
| 17 | Primary torsion of the omentum mimicking acute appendicitis: Report of a case显示文摘 | A. Murat Sara? Cumhur Ye?en A. ?zdemir Aktan Rifat Yalin | 1997 | Surgery Today1997，，3： | 1 |
| 18 | Producing 3D city model with the combined photogrammetric and laser scanner data in the example of Taksim Cumhuriyet square显示文摘 | Cumhur Sahin Ayhan Alkis Bahadir Ergun Sitki Kulur Fatmagul Batuk Ali Kilic | 2012 | Optics and Lasers in Engineering2012，，12： | 1 |
| 19 | Comparison of chest computed tomography and chest x-ray in the diagnosis of rib fractures in patients with blunt chest trauma 显示文摘 | Rasih Y Gokhan E Cumhur M | 2012 | Jour- nal of Academic Emergency Medicine2012，11，3： | 1 |
| 20 | Multidetector CT urography of renal fusion anomalies 显示文摘 | Turkvatan A Older T Cumhur T | 2009 | Diagn Interv Radiol2009，15，2： | 1 |
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