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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Improvmg tlae proaucuvlty of order picking of a manual-pick and multi-level rack distribution warehouse through the implementation of class-based storage显示文摘 | Felix TS Chan Chan HK | 2011 | Expert Systems with Applications2011，38，3： | 1 |
| 3 | Chronic sclerosing dacryoadenitis: part of the spectrum of IgG4-related Sclerosing disease? 显示文摘 | Cheuk W Yuen HK Chan JK | 2007 | Am J Surg Pathol2007，31，4： | 1 |
| 4 | The use of postoperative topical mi tomycin C in the treatment of reeuren! conjunctival papilloma 显示文摘 | Yuen HK Yeung EF Chan NR | 2002 | Cornea2002，21，8： | 1 |
| 5 | Direct toxicity effects of sulfo-conjugated trogUtazone on human hepatocytes 显示文摘 | Saha S New LS Ho HK Chui WK Chan EC | 2010 | Toxicol Lett2010，195，23： | 1 |
| 6 | Inhibition of caspases promotes long-term survival and reinnervation by axotomized spinal motoneurons of denervated muscle in newborn rats显示文摘 | Chan YM Yick LK Yip HK | 2003 | Exp Neurol2003，181，2： | 1 |
| 7 | Dry powder aerosol drug delivery-opportunities for colloid and surface scientists显示文摘 | Chan HK | 2006 | Colloids Surfaces A:Physicochem Engine Asp2006，284，： | 1 |
| 8 | Effect of particle size of dry powder mannitol on the lung deposition in healthy volunteers显示文摘 | Clover W Chan HK Eberl S | 2008 | Int J Pharm2008，349，112： | 1 |
| 9 | Effect of moisture on the electrostatic charge properties of metered dose inhaler aerosols 显示文摘 | Kwok PCL Noakes T Chan HK | 2008 | JAerosol Sci2008，39，3： | 1 |
| 10 | SPECT imaging for radioaerosol deposition and clearance studies显示文摘 | Eberl S Chan HK Daviskas E | 2006 | J Aerosol Med2006，19，1： | 1 |
| 11 | Inhalation drug delivery devices and emerging technologies 显示文摘 | Chan HK | 2003 | Expert Opin Ther Patents2003，13，9： | 1 |
| 12 | Diffusion-weighted magenetic resonance imaging for the evalution of prostate cancer:optimal b value at 3T显示文摘 | Ji HK Chan HK Dongil C | 2013 | Korean J Radiol2013，14，： | 1 |
| 13 | Chronic sclerosing dacryoadenitis: part of the spectrum of IgG4-related Sclerosing disease?显示文摘 | Cheuk W Yuen HK Chan JK | 2007 | Am J Surg Pathol2007，31，4： | 1 |
| 14 | Effect of particle size of dry powder mannitol on the lung deposition in healthy volunteers显示文摘 | Glover W Chan HK Eberl S | 2008 | Int J Pharm2008，349，12： | 1 |
| 15 | A disintegrin and metalloproteinase33 protein in patients with asthma:relevance to aiallow limiration显示文摘 | Lee JY Park SW Chans HK | 2006 | Am J Respir Crit Care Med2006，173，7： | 1 |
| 16 | Use of aerosels for bronchial provocation testing in the laboratory:where we have been and where we a going显示文摘 | Anderson SD Brannan JD Chan HK | 2002 | J Aerosol Med2002，15，3： | 1 |
| 17 | Pitfalls of Intraoperative Neuromonitoring for Predicting Postoperative Recurrent Laryngeal Nerve Function during Thyroidectomy显示文摘 | Wai-Fan Chan MBBS(HK) Chung-Yau Lo MBBS(HK) MS(HK) | 2006 | World Journal of Surgery2006，，5： | 1 |
| 18 | Chronic sclerosing dacryoadenitis : part of the spectrum of IgG4-related Sclerosing disease 显示文摘 | Cheuk W Yuen HK Chan JK | 2007 | Am J Surg Pathol2007，31，4： | 1 |
| 19 | Physicochemical characterization and stability of rifampicin liposome dry powder formulations for inhalation 显示文摘 | Changsan N Chan HK Separovic F | 2009 | J Pharm Sci2009，98，2： | 1 |
| 20 | Self- efficacy and quality of life among stoma patients in Hong Kong 显示文摘 | Wu HK Chan JP Twinn S | 2007 | Cancer Numing2007，30，3： | 1 |
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