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| 1 | Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation显示文摘AIM: To investigate coping mechanisms, constipation symptoms and anorectal physiology in 80 constipated subjects and 18 controls.METHODS: Constipation was diagnosed by Rome Ⅱ criteria.Coping ability and anxiety/depression were assessed by validated questionnaires. Transit time and balloon distension test were performed.RESULTS: 34.5% patients were classified as slow transit type of constipation. The total colonic transit time (56 h vs 10 h, P<0.0001) and rectal sensation including urge sensation (79 mL vs 63 mL, P = 0.019) and maximum tolerable volume (110 mL vs95 mL, P = 0.03) differed in patients and controls. Constipated subjects had significantly higher anxiety and depression scores and lower SF-36 scores in all categories. They also demonstrated higher scores of'monitoring' coping strategy (14+6 vs9+3, P = 0.001),which correlated with the rectal distension sensation (P = 0.005), urge sensation (P=0.002), and maximum tolerable volume (P = 0.035). The less use of blunting strategy predicted slow transit constipation in both univariate (P = 0.01) and multivariate analysis (P = 0.03).CONCLUSION: Defective or ineffective use of coping strategies may be an important etiology in functional constipation and subsequently reflected in abnormal anorectal physiology. | Annie OO Chan Cecilia Cheng Wai Mo Hui Wayne HC Hu Nina YH Wong KF Lam Wai Man Wong Kam Chuen Lai Shiu Kum Lam Benjamin CY Wong | 2005 | World Journal of Gastroenterology2005，11，34： | 92 |
| 2 | Association of time to prostate-specific antigen nadir and logarithm of prostate-specific antigen velocity after progression in metastatic prostate cancer with prior primary androgen deprivation therapy显示文摘我们与优先的主要雄激素剥夺治疗(ADT ) 在变形前列腺癌症在前进木头(PSAVAP ) 以后调查了前列腺特定的抗原天底(TTPN ) 和前列腺特定的抗原速度的对数的时间的协会。从 2000 ~ 2009 与主要 ADT 对待的所有变形前列腺癌症病人被考察。开发了疾病前进的病人在随后的分析被包括。病人们根据他们的 TTPN 被分成三个组:< 的 TTPN; 3 个月, 3-17 月,和 > 17 个月。我们用 Mann-Whitney U-test 和 Kruskal-Wallis 测试比较了在不同 TTPN 组之间的木头(PSAVAP ) 。木头(PSAVAP ) 上的进一步多重的线性回归分析被执行为使因素惊讶的另外的潜力调整。在与主要 ADT 被对待的 419 个病人之中, 306 个病人与 28 个月的中部的后续开发了疾病前进。更长的 TTPN 与更低的木头(PSAVAP ) 被联系(P = 0.008 ) 在所有亚群分析以内(< 的 TTPN; 3 对 3-17 月, P = 0.020;3-17 对 > 的 TTPN; 17 个月, P = 0.009;并且 < 的 TTPN; 3 对 > 17 个月, P = 0.001 ) 。在多重线性回归分析之上,基线 PSA (回归系数 0.001 , P = 0.045 ), PSA 天底(回归系数 0.002 , P = 0.040 ),并且 TTPN (回归系数 − ; 0.030 , P = 0.001 )是显著地与木头( PSAVAP )被联系的三个因素。在结论,更长的 TTPN 在跟随主要 ADT 的变形前列腺癌症病人与更低的木头(PSAVAP ) 被联系。在 3 个月和 17 个月的 TTPN cut-offs 看起来在预言木头(PSAVAP ) 有预示的意义。TTPN 可以在与疾病前进在病人决定治疗策略用作好预示的指示物。 | Jeremy YC Teoh James HL Tsu Steffi KK Yuen Peter KF Chiu Samson YS Chan Ka-Wing Wong Kwan-Lun Ho Simon SM Hou Chi-Fai Ng Ming-Kwong Yiu | 2017 | Asian Journal of Andrology2017，19，1： | 6 |
| 3 | Hepatic arteriogram for gestational trophoblastic tumor: is it useful?显示文摘 | Tam KF Chau MT Chan YM | 2005 | Cancer Investigation2005，23，8： | 1 |
| 4 | Validated questionnaire on diagnosis and symptom severity functional constipation in the Chinese population 显示文摘 | Chan AO Lam KF Hui WM | 2005 | Aliment Pharmacol2005，5，22： | 1 |
| 5 | Maternal hemoglobin and risk of gesta-tional diabetes mellitus in Chinese women显示文摘 | LaoTT Chan PL Tam KF* | 2002 | Obstet Gynecol2002，99，51： | 1 |
| 6 | Prevalence of eo- loreetal neoplasm among patients with newly diagnosed coronary artery disease显示文摘 | Chan AO Jim MH Lam KF | 2007 | JAMA2007，298，12： | 1 |
| 7 | Reactive hemophagocytic syndrome-a clinic pathologic study of 40 patients in an Oriental population显示文摘 | Wong KF Chan JK | 1992 | Am J Med1992，93，2： | 1 |
| 8 | Superselective transarterial chemoembolization vs hepatic resection for resectable earlystage hepatocellular carcinoma in pations with Child-Pugh class a liver function显示文摘 | Hsu KF Chu CH Chan DC | 2012 | Eur J Radiol2012，81，3： | 1 |
| 9 | Differential expression of the suppressor PML and Ki-67 identifies three subtypes of human nasopharyngeal carcinoma显示文摘 | Chan JY Meng CL To KF | 2002 | Eur J Cancer2002，38，12： | 1 |
| 10 | Quantitative detection of methylated SOCS-1,a tumor suppressor gene,by a modified protocol of quantitative real time methylation-specific PCR using SYBR GreenⅠand its use in early gastric cancer detection显示文摘 | Chan MW Chu ES To KF | 2004 | Biotechnol Lett2004，26，16： | 1 |
| 11 | 20-year experience of managing profuse bleeding in gestational tropboblastic disease 显示文摘 | Tse KY Chan KK Tam KF | 2007 | J Reprod Med2007，52，5： | 1 |
| 12 | Increased production of interferon-gamma by tumour infiltrating T lymphocytes in nasopharyngeal carcinoma: indicative of an activated status显示文摘 | Chan SH Loh KS | 1999 | Cancer Lett1999，140，12： | 1 |
| 13 | Control of shiveing umder regional anesthesia in obstetric patients with tramadol 显示文摘 | Chan AM Fig KF Tong EW | 1999 | Can J Anaesth1999，46，： | 1 |
| 14 | Antineutrophil eytoplasmic autoantibodies : Diagnostically specific immune markers 显示文摘 | Tan EM Chan EKL Sullivan KF | 1998 | Clin Exp Immunol1998，47，： | 1 |
| 15 | Cyclooxygenase-2 pathway correlates with vascular endothelial growth factor expression and tumor anglogenesis in hepatitis B virus associated hepatocytes carcinoma 显示文摘 | Cheng AS Chan HL TO KF | 2004 | Int J Oncol2004，24，4： | 1 |
| 16 | Holmium : YAG lithotripsy: Photothermal mechanism 显示文摘 | Vassar GJ Chan KF Teichman JM | 1999 | J Endourol1999，13，： | 1 |
| 17 | Reactive hemophagocytic syndrome-a clinicopathologic study of 40 patients in an oriental population显示文摘 | Chan JK | 1992 | Am J Med1992，93，2： | 1 |
| 18 | Specific patterns of gene methylation in natural killer cell lymphomas : p73 is consistently involved 显示文摘 | Siu L Chan J Wong KF | 2002 | Am J Pathol2002，160，1： | 1 |
| 19 | Deep sequencing to identity the causes of viral encephalitis显示文摘 | Chan BK Wilson T Fischer KF | 2014 | PLoS One2014，9，4： | 1 |
| 20 | Evaluation of extraction methods from paraffin wax embedded tissues for PCR amplification of human and viral DNA 显示文摘 | Chan PKS Chan PPC To KF | 2001 | J Clin Path o12001，54，5： | 1 |
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