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| 1 | A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection显示文摘Interleukin-17(IL-17),a member of the IL-17 cytokine family,plays a crucial role in mediating the immune response against extracellular bacteria and fungi in the lung.Although there is increasing evidence that IL-17 is involved in protective immunity against H1 and H3 influenza virus infections,little is known about the role of IL-17 in the highly pathogenic H5N1 influenza virus infection.In this study,we show that H5N1-infected IL-17 knockout(KO)mice exhibit markedly increased weight loss,more pronounced lung immunopathology and significantly reduced survival rates as compared with infected wild-type controls.Moreover,the frequency of B cells in the lung were substantially decreased in IL-17 KO mice after virus infection,which correlated with reduced CXCR5 expression in B cells and decreased CXCL13 production in the lung tissue of IL-17 KO mice.Consistent with this observation,B cells from IL-17 KO mice exhibited a significant reduction in chemokine-mediated migration in culture.Taken together,these findings demonstrate a critical role for IL-17 in mediating the recruitment of B cells to the site of pulmonary influenza virus infection in mice. | Xiaohui Wang Chris CS Chan Min Yang Jun Deng Vincent KM Poon Virtual HC Leung King-Hung Ko Jie Zhou Kwok Yung Yuen Bo-Jian Zheng Liwei Lu | 2011 | Cellular & Molecular Immunology2011，8，6： | 2 |
| 2 | Regeneration of intervertebral disc by mesenchymal stem ceils : potentials, limitations, and future direction 显示文摘 | Leung VY Chan D Cheung KM | 2006 | Eur Spine J2006，3，： | 1 |
| 3 | Prevalence of human papillomavirus in cervical cancer:a multicenter study in China 显示文摘 | Lo WK Wong YF Chan KM et at | 2002 | Int J Cancer2002，100，3： | 1 |
| 4 | Rheumatic mitral valve disease;current sulcal status显示文摘 | Zakkar M Amirak E Chan KM | 2009 | Pkog Cardiovasc Dis2009，51，6： | 1 |
| 5 | Secondary tricuspid regurgitation or dilatation:which should be the criteria for surgical repair显示文摘 | Dreyfus GD Corbi PJ Chan KM | | 0，，1： | 1 |
| 6 | Solution structure of the dimerization domain of ribosomal protein P2 provides insights for the structural organization of eukaryotic stalk显示文摘 | Lee KM Yu CW Chan DS | 2010 | Nucleic Acids Res2010，38，15： | 1 |
| 7 | Adenosquamous/squamous cell carcinoma of the gallbladder 显示文摘 | Chan KM Yu MC Lee WC | 2007 | J Surg Oncol2007，95，2： | 1 |
| 8 | Use of patient controlled analgesia with alfentanil for burns dressing procedures: a preliminary report of five patients显示文摘 | Sim KM Hwang NC Chan YW | 1996 | Burns1996，22，3： | 1 |
| 9 | An epididymis-specific beta-defensin is important for the initiation of sperm maturation显示文摘 | Zhou CX Zhang YL Xiao L Zheng M Leung KM Chan MY Lo PS Tsang LL Wong HY Ho LS | | 0，，05： | 1 |
| 10 | Modes of Helicobacter coloni- zation and gastric epithelial damage 显示文摘 | Chan WY Hui PK Leung KM | 1992 | Histopathology1992，21，6： | 1 |
| 11 | ES-cell derived hematopoietic cells induce transplantation tolerance显示文摘 | Bonde S Chan KM Zavazava N | 2008 | PloS ONE2008，3，9： | 1 |
| 12 | A direet colorimetric assay for Ca^2+ stimulated ATPase activity显示文摘 | Chan KM Delfert D Junger KD | 1986 | Aual Biochem1986，157，： | 1 |
| 13 | Determining the influence of biocompatible oxygenators during cardiopulmonary bypass by 99m Te-DTPA aerosol assessment of pulmonary permeability 显示文摘 | Dixon KL Agrawal SK Chan KM | 2002 | Nucl Med Commun2002，23，3： | 1 |
| 14 | Fractured patella: operative treatment using the tension band principal显示文摘 | Hung LK Chan KM Chow YN | 1985 | Injury1985，16，5： | 1 |
| 15 | Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemic显示文摘 | Zhu Z Chan JF Tee KM | 2016 | Emerg Microbes Infect2016，，5： | 1 |
| 16 | Breast pathology in complications associated with polyacrylamide hydrogel (PAAG) mammoplasty显示文摘 | LEUNG KM YEOH GP CHAN KW | 2007 | Hong Kong Med J2007，13，2： | 1 |
| 17 | Transvenous embolisation of dural carotid-cavernous fistulas by multiple venous routes:a series of 27 cases显示文摘 | Chan CM Cheung YL | 2003 | Acta Neurochir (Wien)2003，145，： | 1 |
| 18 | Extraction and activity of carnosine, a naturally occurring antioxidant in beef muscle 显示文摘 | Chan KM Decker EA Means WJ | 1993 | J Food Sci1993，58，1： | 1 |
| 19 | Genomic instability in laminopa-thy-based premature aging显示文摘 | Liu B* Wang J Chan KM | 2005 | Nat Med2005，11，7： | 1 |
| 20 | Secondary tricuspid regurgitation or dilatation: which should be the criteria for surgical repair? 显示文摘 | Dreyfus GD Corbi PJ Chan KM | 2005 | Ann Thorac Surg2005，79，1： | 1 |
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