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| 1 | Dust mite allergen-specific immunotherapy increases IL4 DNA methylation and induces Der p-specific T cell tolerance in children with allergic asthma显示文摘Allergen-specific immunotherapy(allergen-SIT)is a highly effective treatment for children with allergic asthma(AA),an immune-mediated chronic disease leading to bronchial muscle hypertrophy and airway obstruction in response to specific allergens.T helper cells and secreted cytokines play important roles in the pathogenesis of asthma,and epigenetic modulation controls genes important for T cell development and cytokine expression.This study evaluated T helper cell-secreted cytokines and DNA methylation patterns in children treated with Dermatophagoides pteronyssinus(Der p)allergen-SIT.Our results showed that after Der p challenge,peripheral blood mononuclear cells(PBMCs)from the SIT group,compared with the non-SIT AA group,produced lower levels of IL-4,IL-5 and IL-2.The SIT group,compared with the AA group,exhibited decreased sensitivity to the Der p allergen,concurrent with IL-4 down-modulation due to increased promoter DNA methylation,as estimated in PBMCs.Our results showed that SIT decreased IL-4 and IL-5,and inhibited T cell proliferation,by inhibiting IL-2 production after the specific allergen challenge.These results suggest that decreased IL-2 production and increased IL-4 cytokine promoter methylation is a potential mechanism of Der p-specific allergen desensitization immunotherapy. | Chuang-Ming Wang Chia-Bin Chang Michael WY Chan Zhi-Hong Wen Shu-Fen Wu | 2018 | Cellular & Molecular Immunology2018，15，11： | 5 |
| 2 | 高血压合并2型糖尿病患者是否需要个体化的收缩压管理目标?显示文摘目前糖尿病管理的趋势支持用个体化的、以患者为中心的收缩压目标取代单一的标准。但是对于收缩压的治疗目标仍未达成共识。该研究目的是评估收缩压和糖尿病患者心血管病风险、全因死亡之间的联系,从而明确以患者为中心的治疗目标。研究者对接受社区医疗的糖尿病合并高血压的中国成年患者95086例进行了回顾性研究。通过收缩压年平均记录和中位数为5.9年的随访,应用Cox比例风险回归,对总体心血管病风险、全因死亡以及它们与收缩压的相关性进行评估。 | 刘莉 叶鹏 Wan EYF Yu EYT Fung CSC Chin WY Fong DYT Chan AKC Lam CLK | 2017 | 中华高血压杂志2017，25，11： | 3 |
| 3 | Prognostic significance of stromal metalloproteinase-2 in ovarian adenocarcinoma and its relation to carcinoma progression 显示文摘 | Tomg PL Mao TL Chan WY | 2004 | Gynecol Oncol2004，92，4： | 1 |
| 4 | Bcl-2andp53protein expression,apoptosis and p53 mutation inhuman epithelial ovarian cancers显示文摘 | Chan WY Cheung KK Schorge JO | 2000 | Am J Pathol2000，156，： | 1 |
| 5 | Acute renal failure following cardiac surgery : incidence , outcomes and risk factors显示文摘 | Mangos GJ Brown MA Chan WY | 1995 | Aust N Z J Med1995，25，4： | 1 |
| 6 | Maternal anxiety and feelings of control during labour:a study of Chinese first-time pregnant women显示文摘 | Cheung W Ip WY Chan D | 2007 | Midwifery2007，23，2： | 1 |
| 7 | Proteomic analysis of mitochondrial proteins in a mouse model of type 2 diabetes显示文摘 | Essop MF Chan WY Hattingh S | | 0，，04： | 1 |
| 8 | Genetic axpression of wilson dis ease in cell culture:a diagnostic marker显示文摘 | Cushing W Coffman | 1980 | Science1980，208，29： | 1 |
| 9 | Cosolvent effects on the spontaneous formation of vesicles from 1:1 anionic and cationic surfactant mixtures显示文摘 | YU WY YANG YM CHAN CH | 2005 | Langmuir2005，21，： | 1 |
| 10 | Modes of Helicobacter coloni- zation and gastric epithelial damage 显示文摘 | Chan WY Hui PK Leung KM | 1992 | Histopathology1992，21，6： | 1 |
| 11 | Primary B-cell lymphoma and lymphoma-like lesions of the uterine cervix显示文摘 | Au WY Chan BC Chung LP | 2003 | Am J Hematol2003，13，4： | 1 |
| 12 | Endocrine ductal carcinoma in situ (EDCIS) of the breast:a form of low-grade DCIS with distinctive clinicopathologic and biologic characteristics显示文摘 | Chan JK | 1996 | Am J Surg Pathol1996，20，8： | 1 |
| 13 | T cell receptor Vbeta repertoire expression reflects gastric carcinoma progression显示文摘 | Zhang XY Chan WY Whitney BM | 2001 | Clin Immunol2001，101，1： | 1 |
| 14 | Epstein-Barr Virus-associated gastric lymphomas are distinct from mucosa-associated lymphoid tissue-type lymphomas:genetic abnormalities of p53 gene显示文摘 | Chan WY Chan EK Chow JH | 2001 | Diagn Mol Pathol2001，10，3： | 1 |
| 15 | Genetic heterogeneity of constitutively activating mutations of the human luteinizing hormone receptor in familial male- limited precocious puberty显示文摘 | Laue L Chan WY Hsueh A J | 1995 | Proc Natl Acad Sci USA1995，92，6： | 1 |
| 16 | Maternal anxiety and feelings of control during labour: A study of Chinese first- time pregnant women 显示文摘 | Cheung W Ip WY Chan D | 2007 | Midwifery2007，23，2： | 1 |
| 17 | Bcl-2 and p53 Protein Expression,Apoptosis,and p53 Mutation in Human Epithelial Ovarian Cancers显示文摘 | Chan WY Cheung KK Schorge JO | 2000 | Am J Pathol2000，156，： | 1 |
| 18 | DOC-2,a candidate tumor suppressor gene in human epithelial ovarian cancer显示文摘 | Mok SC Chan WY Wong KK | 1998 | Oncogene1998，16，18： | 1 |
| 19 | Homer-1c/Vesl-1L modulates the cell surface targeting of metabotropic glutamate receptor type 1alpha: evidence for an anchoring function 显示文摘 | Ciruela F Soloviev MM Chan WY | 2000 | Mol Cell Neurosci2000，15，1： | 1 |
| 20 | Potent Antioxidative and UVB protective effect of water extract of Eclipta prostrata显示文摘 | Chan CF Huang WY Guo HY | 2014 | Sci World J2014，2，75： | 1 |
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