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| 1 | Systemic treatment strategies for triple-negative breast cancer显示文摘Triple-negative breast cancer(TNBC) is defined by the lack of immunohistochemical expression of the estrogen and progesterone receptors and human epidermal growth factor receptor 2(EGFR2). Most TNBC has a basal-like molecular phenotype by gene expression profiling and shares clinical and pathological features with hereditary BRCA1 related breast cancers. This review evaluates the activity of available chemotherapy and targeted agents in TNBC. A systematic review of PubM ed and conference databases was carried out to identify randomised clinical trials reporting outcomes in women with TNBC treated with chemotherapy and targeted agents. Our review identified TNBC studies of chemotherapy and targeted agents with different mechanisms of action, including induction of synthetic lethality and inhibition of angiogenesis, growth and survival pathways. TNBC is sensitive to taxanes and anthracyclins. Platinum agents are effective in TNBC patients with BRCA1 mutation, either alone or in combination with poly adenosine diphosphate polymerase 1 inhibitors. Combinations of ixabepilone and capecitabine have added to progression-free survival(PFS) without survival benefit in metastatic TNBC. Antiangiogenic agents, tyrosine kinase inhibitors and EGFR inhibitorsin combination with chemotherapy produced only modest gains in PFS and had little impact on survival. TNBC subgroups respond differentially to specific targeted agents. In future, the treatment needs to be tailored for a specific patient, depending on the molecular characteristics of their malignancy. TNBC being a chemosensitive entity, combination with targeted agents have not produced substantial improvements in outcomes. Appropriate patient selection with rationale combinations of targeted agents is needed for success. | Budhi Singh Yadav Suresh C Sharma Priyanka Chanana Swaty Jhamb | 2014 | World Journal of Clinical Oncology2014，5，2： | 18 |
| 2 | Biomarkers in triple negative breast cancer:A review显示文摘Breast cancer is an intrinsically heterogeneous disease. In the world about 1 million cases of breast cancer are diagnosed annually and more than 170000 are triplenegative. Characteristic feature of triple negative breast cancer(TNBC) is that it lacks expression of oestrogen,progesterone and human epidermal growth factor receptor-2/neu receptors. They comprise 15%-20% of all breast cancers. We did a systematic review of Pub Med and conference databases to identify studies published on biomarkers in TNBC. We included studies with biomarkers including: Epidermal growth factor receptor,vascular endothelial growth factor,c-Myc,C-kit and basal cytokeratins,Poly(ADP-ribose) polymerase-1,p53,tyrosinase kinases,m-TOR,heat and shock proteins and TOP-2A in TNBC. We also looked for studies published on synthetic lethality and inhibition of angiogenesis,growth,and survival pathways. TNBC is a complex disease subtype with many subclasses. Majority TNBC have a basal-like molecular phenotype by gene expression profiling. Their clinical and pathologic features overlap with hereditary BRCA1 related breast cancers. Management of these tumours is a challenge to the clinician because of its aggressive behaviour,poor outcome,and absence of targeted therapies. As the complexity of this disease is being simplified over time new targets are also being discovered for the treatment of this disease. There are many biomarkers in TNBC being used in clinical practice. Biomarkers may be useful as prognostic or predictive indicators as well as suggest possible targets for novel therapies. Many targeted agents are being studied for treatment of TNBC. | Budhi S Yadav Priyanka Chanana Swaty Jhamb | 2015 | World Journal of Clinical Oncology2015，6，6： | 13 |
| 3 | Adenocarcinoma of the third and fourth portions of the duodenum: The capsule endoscopy value显示文摘Primary adenocarcinoma of the small intestine occurs in over 50% of cases in the duodenum. However,its location in the third and fourth duodenal portions occurs rarely and is a diagnostic challenge. The aim of this work is to report an adenocarcinoma of the third and fourth duodenal portions,emphasizing its diagnostic difficulty and the value of video capsule endoscopy. A man,40 years old,with no medical history,with abdominal discomfort and progressive fatigue,presented four months ago with one episode o f m o d e ra t e m e l e n a. T h e p hy s i c a l e x a m i n a t i o n was normal,except for mucosal pallor. Blood tests were consistent with microcytic,hypochromic iron deficiency anemia with 7.8 g/d L hemoglobin. The upper and lower endoscopy were normal. Additional work-up with video capsule endoscopy showed a polypoid lesion involving the third and fourth portions o f t h e d u o d e n u m. B i o p s y s h o w e d a m o d e ra t e l y differentiated adenocarcinoma. Abdominal computed tomography showed a wall thickening from the third duodenal portion to the proximal jejunum,without distant metastasis. The patient underwent segmental resection(distal duodenum and proximal jejunum) with duodenojejunostomy. The surgical specimen histology confirmed the biopsy diagnosis,with transmural infiltration,without nodal involvement. Conclusion: Adenocarcinoma of the third and fourth portions of the duodenum is difficult to diagnose and capsule endoscopy is of great value. | Feliciano Chanana Paquissi Ana Henriqueta Filipe Bunga Pimentel Lima Maria de Fátima do Nascimento Vieira Lopes Francisco Viamontes Diaz | 2015 | World Journal of Gastroenterology2015，21，31： | 2 |
| 4 | SuStained Na /H exchanger activation promotes gliotransmitter release from reac- tive hippocampal astrocytes following oxygen - glucose depriva- tion显示文摘 | Cengiz P Kintner D B Chanana V | 2014 | PloS one2014，9，84： | 1 |
| 5 | Comparison of Sen transformer and unified power flow controller onspot price variation of real and reactive power unde rmaximum loadability condition显示文摘 | Saurabh Chanana Ashwani Kumar | 2008 | Electric PowerComponents and System2008，36，： | 1 |
| 6 | Activation of microglia depends on Na+/H+ exchange-mediated H+ ho- meostasis显示文摘 | LIU Y KINTNER DB CHANANA V | 2010 | J Neurosci2010，30，15： | 1 |
| 7 | Congenital ectropion uveae with iris coloboma and telecanthus显示文摘 | Vinod kumar Kshmar kumar Bhuvan chanana | 2011 | Contact Lens & Anterior Eye2011，34，： | 1 |
| 8 | Role of sodi um/hydrogen exchanger isoform 1 in microglial activation and proinflammatory responses in ischemic brains 显示文摘 | SHI Y CHANANA V WATTERS JJ | 2011 | J Neurochem2011，119，1： | 1 |
| 9 | Boron neutron capture therapy for malignant gliomas显示文摘 | Diaz AZ Coderre JA Chanana AD | 2000 | Ann Med2000，32，1： | 1 |
| 10 | Morphogenesis in isolated microspore cultures of Brassica juncea 显示文摘 | Chanana N P Dhawan V Bhojwani S S | 2005 | Plant Cell Tissue and Organ Culture2005，83，： | 1 |
| 11 | Dengue infection in pregnancy显示文摘 | N. Malhotra C. Chanana S. Kumar | 2006 | International Journal of Gynecology and Obstetrics2006，，2： | 1 |
| 12 | Coordinated expression and immunogenicity of an outer membrane protein from Salmonella enterica serovar Typhi under iron limitation, oxidative stress and anaerobic conditions 显示文摘 | Chanana V Majumdar S Ray P | 2006 | J Biomed Sci2006，13，3： | 1 |
| 13 | Comparison of perinatal outcome of growth-restricted fetuses with normal and abnormal umbilical artery Doppler waveforms 显示文摘 | Malhotra N Chanana C Kumar S | 2006 | Indian J Med Sci2006，60，8： | 1 |
| 14 | Comparison ofSen transformer and unified power flow controller onspot price variation of real and reactive power undermaximum loadability condition显示文摘 | Saurabh Chanana Ashwani Kumar | 2008 | Electric PowerComponents and System2008，36，： | 1 |
| 15 | Primary vitrectomy versus conventional retinal detachment surgery in phakic rhegmatoge-nous retinal detachment显示文摘 | Azad RV Chanana B SharmaYR | 2007 | Acta Ophthalmol Scand2007，85，2： | 1 |
| 16 | Primary vitrectomy versus conventional retinal detachment surgery in phakic rhegmatogenous retinal detachment 显示文摘 | Azad RV Chanana B Sharma YR | 2007 | Acta Ophthalmol Scand2007，85，5： | 1 |
| 17 | Mor- phogenesis in isolated microspore cultures of Brassica juncea 显示文摘 | CHANANA N P DHAWAN V BHOJWANI S S | 2005 | Plant Cell Tissue and Organ Culture2005，83，2： | 1 |
| 18 | Liver metasta- sis in a ease of adenoid cystic carcinoma of the Bartholin 's gland: a rare presentation 显示文摘 | Shahabi S Nathan LM Chanana C | 2009 | Arch Gynecol Obstet2009，279，5： | 1 |
| 19 | Morphogenesis in Isolated Microspore Cultures of Brassica juncea显示文摘 | Nidhi P. Chanana Vibha Dhawan Sant S. Bhojwani | 2005 | Plant Cell Tissue and Organ Culture2005，，2： | 1 |
| 20 | Primary vitrectomy versus conventional retinal detachment surgery in phakic rhegmatogenous retinal detachment显示文摘 | Azad RV Chanana B Sharma YR Vohra R | | 0，，05： | 1 |
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