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| 1 | 婴儿胆汁淤积症的热点问题显示文摘 | Anil Dhawan 王建设 | 2009 | 中国循证儿科杂志2009，4，2： | 11 |
| 2 | Cytokine- and chemokine-induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy显示文摘Colorectal cancer(CRC)is a predominant life-threatening cancer,with liver and peritoneal metastases as the primary causes of death.Intestinal inflammation,a known CRC risk factor,nurtures a local inflammatory environment enriched with tumor cells,endothelial cells,immune cells,cancer-associated fibroblasts,immunosuppressive cells,and secretory growth factors.The complex interactions of aberrantly expressed cytokines,chemokines,growth factors,and matrix-remodeling enzymes promote CRC pathogenesis and evoke systemic responses that affect disease outcomes.Mounting evidence suggests that these cytokines and chemokines play a role in the progression of CRC through immunosuppression and modulation of the tumor microenvironment,which is partly achieved by the recruitment of immunosuppressive cells.These cells impart features such as cancer stem cell-like properties,drug resistance,invasion,and formation of the premetastatic niche in distant organs,promoting metastasis and aggressive CRC growth.A deeper understanding of the cytokineand chemokine-mediated signaling networks that link tumor progression and metastasis will provide insights into the mechanistic details of disease aggressiveness and facilitate the development of novel therapeutics for CRC.Here,we summarized the current knowledge of cytokine-and chemokine-mediated crosstalk in the inflammatory tumor microenvironment,which drives immunosuppression,resistance to therapeutics,and metastasis during CRC progression.We also outlined the potential of this crosstalk as a novel therapeutic target for CRC.The major cytokine/chemokine pathways involved in cancer immunotherapy are also discussed in this review. | Ajaz A.Bhat Sabah Nisar Mayank Singh Bazella Ashraf Tariq Masoodi Chandra P.Prasad Atul Sharma Selma Maacha Thasni Karedath Sheema Hashem Syed Besina Yasin Puneet Bagga Ravinder Reddy Michael P.Frennaux Shahab Uddin Punita Dhawan Mohammad Haris Muzafar A.Macha | 2022 | Cancer Communications2022，42，8： | 8 |
| 3 | Anti-HBc screening in Indian blood donors:Still an unresolved issue显示文摘AIM:To study the seroprevalence of antibody to hepatitis B core antigen (anti-HBc) in healthy blood donors negative for HBsAg and to evaluate whether anti-HBc detection could be adopted in India as a screening assay for HBV in addition to HBsAg. METHODS: A total of 1700 serum samples collected from HBsAg-negative healthy blood donors were tested for the presence of anti-HBc antibody (IgM + IgG). All samples reactive for anti-HBc antibody were then investigated for presence of anti-HBs and for liver function tests (LFTs). One hundred serum samples reactive for anti-HBc were tested for HBV DNA by PCR method. RESULTS: Out of 1700 samples tested, 142 (8.4%) blood samples were found to be reactive for anti-HBc. It was signif icantly lower in voluntary (6.9%) as compared to replacement donors (10.4%, P = 0.011). Seventy- two (50.7%) anti-HBc reactive samples were also reactive for anti-HBs with levels > 10 mIU/mL and 70 (49.3%) samples were non-reactive for anti-HBs, these units were labeled as anti-HBc-only. These 142 anti-HBc reactive units were also tested for liver function test. HBV DNA was detected in only 1 of 100 samples tested. CONCLUSION: Keeping in view that 8%-18% of donor population in India is anti-HBc reactive, inclusion of anti- HBc testing will lead to high discard rate. Anti-HBs as proposed previously does not seem to predict clearance of the virus. Cost effectiveness of introducing universalanti-HBc screening and discarding large number of blood units versus considering ID NAT (Individual donor nuclic acid testing) needs to be assessed. | Hari Krishan Dhawan Neelam Marwaha Ratti Ram Sharma Yogesh Chawla Beenu Thakral Karan Saluja Sanjeev Kumar Sharma Manish K Thakur Ashish Jain | 2008 | World Journal of Gastroenterology2008，14，34： | 8 |
| 4 | 儿童肝移植相关问题显示文摘 | 郑树森 Anil Dhawan 郑珊 肖现民 | 2009 | 中国循证儿科杂志2009，4，1： | 6 |
| 5 | Noninvasive biomarkers in non-alcoholic fatty liver disease:Current status and a glimpse of the future显示文摘The development of non invasive biomarkers of disease has become a major focus of interest in nonalcoholic fatty liver disease(NAFLD). The large prevalence of the disease and the invasive nature of the investigation means that screening with liver biopsy is impractical.In addition to screening, the differentiation of those with simple steatosis vs steatohepatitis and fibrosis is clinically important as the prognosis of each differs.Serum biomarkers may be a combination of simple markers derived from large data sets or direct markers of disease activity. Serum markers of inflammation,apoptosis and oxidative stress in addition to fibrosis have been extensively studied in patients with NAFLD.Other techniques such as transient elastography,magnetic resonance elastography and acoustic radiation force imaging are becoming more established as noninvasive methods of detecting fibrosis in a variety of chronic liver conditions in addition to NAFLD. Newer high throughput methods such as proteomics and glycomics allow the nonhypothesis-driven identification of novel markers and may also potentially contribute to our understanding of the pathogenesis of the condition.This review addresses some of the methodological issues which need to be considered in the search for the ideal biomarker. It is likely that a combination of serum biomarkers and techniques such as transient elastography may provide the optimal diagnostic discrimination however this remains to be proven in large studies. | Emer Fitzpatrick Anil Dhawan | 2014 | World Journal of Gastroenterology2014，20，31： | 6 |
| 6 | Vitamin D,calcium homeostasis and aging显示文摘Osteoporosis is characterized by low bone mass and microarchitecture deterioration of bone tissue, leading to enhanced bone fragility and consequent increase in fracture risk. Evidence is accumulating for an important role of calcium deficiency as the process of aging is associated with disturbed calcium balance. Vitamin D is the principal factor that maintains calcium homeostasis. Increasing evidence indicates that the reason for disturbed calcium balance with age is inadequate vitamin D levels in the elderly. In this article, an overview of our current understanding of vitamin D, its metabolism, and mechanisms involved in vitamin D-mediated maintenance of calcium homeostasis is presented. In addition, mechanisms involved in age-related dysregulation of 1,25(OH)_2D_3action, recommended daily doses of vitamin D and calcium, and the use of vitamin D analogs for the treatment of osteoporosis(which remains controversial) are reviewed. Elucidation of the molecular pathways of vitamin D action and modifications that occur with aging will be an active area of future research that has the potential to reveal new therapeutic strategies to maintain calcium balance. | Vaishali Veldurthy Ran Wei Leyla Oz Puneet Dhawan Yong Heui Jeon Sylvia Christakos | 2016 | Bone Research2016，4，3： | 5 |
| 7 | Inflammatory bowel disease:Therapeutic limitations and prospective of the stem cell therapy显示文摘Inflammatory bowel disease(IBD),consisting primarily of ulcerative colitis and Crohn’s disease,is a group of debilitating auto-immune disorders,which also increases the risk of colitis-associated cancer.However,due to the chronic nature of the disease and inconsistent treatment outcomes of current anti-IBD drugs(e.g.,approximately 30%non-responders to anti-TNFαagents),and related serious side effects,about half of all IBD patients(in millions)turn to alternative treatment options.In this regard,mucosal healing is gaining acceptance as a measure of disease activity in IBD patients as recent studies have correlated the success of mucosal healing with improved prognosis.However,despite the increasing clinical realization of the significance of the concept of mucosal healing,its regulation and means of therapeutic targeting remain largely unclear.Here,stemcell therapy,which uses hematopoietic stem cells or mesenchymal stem cells,remains a promising option.Stem cells are the pluripotent cells with ability to differentiate into the epithelial and/or immune-modulatory cells.The overreaching concept is that the stem cells can migrate to the damaged areas of the intestine to provide curative help in the mucosal healing process.Moreover,by differentiating into the mature intestinal epithelial cells,the stem cells also help in restoring the barrier integrity of the intestinal lining and hence prevent the immunomodulatory induction,the root cause of the IBD.In this article,we elaborate upon the current status of the clinical management of IBD and potential role of the stem cell therapy in improving IBD therapy and patient’s quality of life. | Rangnath Mishra Punita Dhawan Anand S Srivastava Amar B Singh | 2020 | World Journal of Stem Cells2020，12，10： | 4 |
| 8 | 血脂异常与睑板腺功能障碍严重程度的关系显示文摘目的:分析北方汉德地区三级保健医院血脂异常与睑板腺功能(MGD)紊乱严重程度的关系。方法:这项前瞻性观察研究为期1a,共纳入50例MGD患者。患者接受详细病史调查(包括眼表疾病指数问卷)和检查(包括眼底质量、表达能力和数字染色)。根据2011年睑板腺功能障碍与管理国际研讨会提交的指南对MGD进行分级。对所有患者进行空腹血脂测定。总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)和极低密度脂蛋白(VLDL)等参数与MGD严重程度相关。采用Chi-square检验进行统计学分析(P<0.05)。结果:2级MGD是最常见的疾病(60%,n=30)。年龄的增加与MGD的严重程度呈显著正相关(P=0.004)。高TC(>200 mg/dL)、TG(>150 mg/dL)、LDL(>130 mg/dL)和VLDL(>22 mg/dL)水平与MGD的严重程度呈正相关(P=0.001,0.019,0.001,0.016)。结论:监测空腹血脂水平可以帮助确定MGD的严重程度,进一步的研究可以确定血脂异常在治疗MGD中的作用。 | Aeshvarya Dhawan Tarannum Shakeel | 2020 | 国际眼科杂志2020，20，8： | 3 |
| 9 | Microwave-assisted reduction roasting–magnetic separation studies of two mineralogically different low-grade iron ores显示文摘The microwave-assisted reduction behaviours of two low-grade iron ores having a similar Fe content of 49wt%but distinctly different mineralogical and liberation characteristics were studied.Their performances in terms of the iron grade and recovery as obtained from statistically designed microwave(MW)roasting followed by low-intensity magnetic separation(LIMS)experiments were compared.At respective optimum conditions,the titano-magnetite ore(O1)could yield an iron concentrate of 62.57%Fe grade and 60.01%Fe recovery,while the goethitic ore(O2)could be upgraded to a concentrate of 64.4%Fe grade and 33.3%Fe recovery.Compared with the goethitic ore,the titanomagnetite ore responded better to MW heating.The characterization studies of the feed and roasted products obtained at different power and time conditions using X-ray diffraction,optical microscopy,vibrating-sample magnetometry,and electron-probe microanalysis explain the sequential reduction in the iron oxide phases.Finally,taking advantage of the MW absorbing character of the titano-magnetite ore,a blend of the same with the goethite-rich ore at a weight ratio of 60:40(O2:O1)was subjected to MW roasting that resulted in a concentrate of 61.57%Fe grade with a Fe recovery of 64.47%. | Subhnit K.Roy Deepak Nayak Nilima Dash Nikhil Dhawan Swagat S.Rath | 2020 | International Journal of Minerals,Metallurgy and Materials2020，27，11： | 3 |
| 10 | Pancreatoblastoma:A rare indication for liver transplantation in children显示文摘Pancreatoblastoma(PB)is one of the exocrine pancreatic tumors and the most common malignant pancreatic tumor in young children.Patients can present with abdominal distension,pain,fatigue,vomiting and failure to thrive.Exocrine pancreatic tumors usually affect patients between 1 and 8 years,with a median age of 5 years.There is a slight preponderance in males and those of Asian descent[1].PB is considered to be embryonic in origin with moderately raised serum alpha-fetoprotein(AFP)levels[2].Axial imaging is necessary to assess other organ involvement,a common complication in adult patients,but diagnosis is confirmed on tissue histology[3].Complete surgical resection is the treatment of choice,if achievable.Indications for neoadjuvant systemic chemotherapy include large tumors that involve adjacent major blood vessels or other organs and metastatic disease[1].Herein we report a pediatric case of PB with liver metastases who underwent liver transplantation for metastatic liver disease. | Maria Mercadal-Hally Sucheta Vaidya Hector Vilca-Melendez Nigel Heaton Anil Dhawan Tassos Grammatikopoulos | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，5： | 2 |
| 11 | Microbial Mannanases: An Overview of Production and Applications显示文摘 | Samriti Dhawan Jagdeep Kaur | 2007 | Critical Reviews in Biotechnology2007，，4： | 2 |
| 12 | Transient Elastography Is a Useful Noninvasive Tool for the Evaluation of Fibrosis in Paediatric Chronic Liver Disease显示文摘 | Emer Fitzpatrick Alberto Quaglia Sunitha Vimalesvaran Maria Sole Basso Anil Dhawan | 2013 | Journal of Pediatric Gastroenterology and Nutrition2013，，1： | 2 |
| 13 | Role of SPECT/CT in differentiated thyroid cancer显示文摘 | Tara D. Barwick Ranju T. Dhawan Valerie Lewington | 2012 | Nuclear Medicine Communications2012，，8： | 2 |
| 14 | Correlation between soluble receptor for advanced glycation end products levels and coronary artery disease in postmenopausal nondiabetic women显示文摘BACKGROUND The established cardiovascular risk factors cannot explain the overall risk of coronary artery disease(CAD),especially in women.Therefore,there is a growing need for the assessment of novel biomarkers to identify women at risk.The receptor for advanced glycation end products(RAGE)and its interaction with the advanced glycation end product(AGE)ligand have been associated with atherogenesis.The soluble fraction of RAGE(sRAGE)antagonizes RAGE signaling and exerts an antiatherogenic effect.AIM The study aim was to explore the association between plasma levels of sRAGE and CAD in nondiabetic postmenopausal women.METHODS This case-control study included 110 nondiabetic postmenopausal women who were enrolled in two groups.Group I included 55 angiographically proven CAD subjects with>50%stenosis in at least one of the major coronary arteries and Group II included 55 healthy control women who did not have CAD or had<50%stenosis of the coronary arteries.Stenosis was confirmed by invasive angiography.Plasma sRAGE was determined by an enzyme-linked immunosorbent assay.RESULTS We observed significantly lower plasma sRAGE concentrations in subjects with CAD vs healthy controls(P<0.05).Univariate and multivariate logistic regression analysis also revealed a significant correlation between plasma sRAGE levels and CAD(P=0.01).Multivariate odds ratios for CAD revealed that subjects with sRAGE concentrations below 225 pg/mL(lowest quartile)had a 6-fold increase in CAD prevalence independent of other risk factors.CONCLUSION Our findings indicated that low sRAGE levels were independently associated with CAD in nondiabetic postmenopausal women.Risk assessment of CAD in postmenopausal women can be improved by including sRAGE along with other risk factors. | Soumitra Ghosh Divya Kapoor Rajesh Vijayvergiya Sonal Sangwan Sujata Wangkheimayum Sakshi Mehta Veena Dhawan | 2021 | World Journal of Cardiology2021，13，5： | 2 |
| 15 | Acute liver failure显示文摘 | William Bernal Georg Auzinger Anil Dhawan Julia Wendon | 2010 | The Lancet2010，，9736： | 2 |
| 16 | Lumbar sagittal contour after posterior interbody fusion:threaded devices alone versus vertical cages plus posterior instrumentation显示文摘 | Klemme WR Owens BD Dhawan A | 2001 | Spine2001，26，5： | 1 |
| 17 | Induction of cathelicidin in normal and CF bronchial epithelial cells by 1, 25-dihydroxyvitamin D3 显示文摘 | Yim S Dhawan P Ragunath C | 2007 | Journal of Cystic Fibrosis2007，6，6： | 1 |
| 18 | Regulatory role of zinc on the biokinetics and biodistribution of (65)zn during the initiation of experimentally induced colon cancer显示文摘 | Chadha VD Goel A Dhawan D | 2011 | Nutr Cancer2011，63，2： | 1 |
| 19 | Lumbar sagittal contour after posterior interbody fusion:threa-ded devices alone versus vertical cages plus posterior instrumentation显示文摘 | Klemme WR Owens BD Dhawan A | 2000 | Spine2000，26，： | 1 |
| 20 | Targeting the FOXOI/ KLF6 axis regulates EGFR signaling and treatment response 显示文摘 | Sangodkar J Dhawan NS Melville H | 2012 | JClin Invest2012，122，7： | 1 |
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