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| 1 | Defining response to radiotherapy in rectal cancer using magnetic resonance imaging and histopathological scales显示文摘AIM To define good and poor regression using pathology and magnetic resonance imaging(MRI) regression scales after neo-adjuvant chemotherapy for rectal cancer.METHODS A systematic review was performed on all studies up to December 2015, without language restriction, t h a t w e r e i d e n t i f i e d f r o m M E D L I N E, C o c h r a n e Controlled Trials Register(1960-2015), and EMBASE(1991-2015). Searches were performed of article bibliographies and conference abstracts. MeS H and text words used included 'tumour regression', 'mr TRG', 'poor response' and 'colorectal cancers'. Clinical studies using either MRI or histopathological tumour regression grade(TRG) scales to define good and poor responders were included in relation to outcomes [local recurrence(LR), distant recurrence(DR), disease-free survival(DFS), and overall survival(OS)]. There was no age restriction or stage of cancer restriction for patient inclusion. Data were extracted by two authors working independently and using pre-defined outcome measures.RESULTS Quantitative data(prevalence) were extracted and analysed according to meta-analytical techniques using comprehensive meta-analysis. Qualitative data(LR, DR, DFS and OS) were presented as ranges. The overall proportion of poor responders after neo-adjuvant chemoradiotherapy(CRT) was 37.7%(95%CI: 30.1-45.8). There were 19 different reported histopathological scales and one MRI regression scale(mrT RG). Clinical studies used nine and six histopathological scales for poor and good responders, respectively. All studies using MRI to define good and poor response used one scale. The most common histopathological definition for good response was the Mandard grades 1 and 2 or Dworak grades 3 and 4; Mandard 3, 4 and 5 and Dworak 0, 1 and 2 were used for poor response. For histopathological grades, the 5-year outcomes for poor responders were LR 3.4%-4.3%, DR 14.3%-20.3%, DFS 61.7%-68.1% and OS 60.7-69.1. Good pathological response 5-year outcomes were LR 0%-1.8%, DR 0%-11.6%, DFS 78.4%-86.7%, and OS 77.4%-88.2%. A poor response on MRI(mr TRG 4,5) resulted in 5-year LR 4%-29%, DR 9%, DFS 31%-59% and OS 27%-68%. The 5-year outcomes with a good response on MRI(mrT RG 1,2 and 3) were LR 1%-14%, DR 3%, DFS 64%-83% and OS 72%-90%.CONCLUSION For histopathology regression assessment, Mandard 1, 2/Dworak 3, 4 should be used for good response and Mandard 3, 4, 5/Dworak 0, 1, 2 for poor response. MRI indicates good and poor response by mr TRG1-3 and mrT RG4-5, respectively. | Muhammed RS Siddiqui Jemma Bhoday Nicholas J Battersby Manish Chand Nicholas P West Al-Mutaz Abulafi Paris P Tekkis Gina Brown | 2016 | World Journal of Gastroenterology2016，22，37： | 6 |
| 2 | Novel biomarkers for patient stratification in colorectal cancer:A review of definitions,emerging concepts,and data显示文摘Colorectal cancer(CRC) treatment has become more personalised,incorporating a combination of the individual patient risk assessment,gene testing,and chemotherapy with surgery for optimal care.The improvement of staging with high-resolution imaging has allowed more selective treatments,optimising survival outcomes.The next step is to identify biomarkers that can inform clinicians of expected prognosis and offer the most beneficial treatment,while reducing unnecessary morbidity for the patient.The search for biomarkers in CRC has been of significant interest,with questions remaining on their impact and applicability.The study of biomarkers can be broadly divided into metabolic,molecular,micro RNA,epithelial-to-mesenchymal-transition(EMT),and imaging classes.Although numerous molecules have claimed to impact prognosis and treatment,their clinical application has been limited.Furthermore,routine testing of prognostic markers with no demonstrable influence on response to treatment is a questionable practice,as it increases cost and can adversely affect expectations of treatment.In this review we focus on recent developments and emerging biomarkers with potential utility for clinical translation in CRC.We examine and critically appraise novel imaging and molecular-based approaches; evaluate the promising array of micro RNAs,analyze metabolic profiles,and highlight key findings for biomarker potential in the EMT pathway. | Manish Chand Deborah S Keller Reza Mirnezami Marc Bullock Aneel Bhangu Brendan Moran Paris P Tekkis Gina Brown Alex Mirnezami Mariana Berho | 2018 | World Journal of Gastrointestinal Oncology2018，10，7： | 2 |
| 3 | Fungal inoculum properties and its effect on growth and enzyme activity of trametes versicolor in soil 显示文摘 | Schmidt K R Chand S Gostomski P A | 2005 | Biotechnol Prog2005，21，： | 1 |
| 4 | Microsatellite loci in the eastern form of the giant freshwater prawn ( Macrobrachium rosenbergii) 显示文摘 | Chand V de Bruyn M Mather P B | 2005 | Mol Ecol Res2005，，5： | 1 |
| 5 | 显示文摘 | Chand P | 2005 | Mater Lett2005，59，： | 1 |
| 6 | Fungal inoculum properties and its effect on growth and enzyme activity of Trametes versicolor in soil显示文摘 | Schmidt K R Chand S Gostomski P A | 2005 | Biotechnol Prog2005，21，2： | 1 |
| 7 | Improved construction of nonlinear resilient S-Boxes 显示文摘 | CHAND K SARKAR P | 2005 | IEEE Trans Information Theory2005，51，： | 1 |
| 8 | Detection of brucella specific protein-A reactive antibodies in buffaloes by dot enzyme-linked immunosorbent assay 显示文摘 | Chand P Batra H V Sadana J R | 1989 | Veterinary Record1989，122，： | 1 |
| 9 | A dynamic lot sizing model with learning in setups 显示文摘 | Chand S Sethi S P | 1990 | Operations Research1990，38，4： | 1 |
| 10 | Mutational analysis of BMP15 and GDF9 as candidate genes for premature ovarian failure显示文摘 | Chand A L Ponnampalam A P Harris S E | 2006 | Fertil Steril2006，86，4： | 1 |
| 11 | Catalytic wet per- oxide oxidation of azo dye(Congo Red) using modified Y zeolite as catalyst显示文摘 | Kondru A K Kumar P Chand S | 2009 | Hazard Mater2009，166，1： | 1 |
| 12 | Eleetroporation-mediated improvement of plant regeneration from colt cherry (Prunus aviumxpseudocerasus ) protoplasts显示文摘 | OCHATT S J CHAND P K DAVEY M R POWER J B | 1988 | Plant Science1988，54，： | 1 |
| 13 | Systematic structure based design and stereoselective synthesis of novel multisubstitu tedcy-clopentane derivatives with potent antiinfluenzaactivity显示文摘 | CHAND P KOTIAN P L DEHGHANI A | 2001 | J Med Chem2001，44，25： | 1 |
| 14 | Effect of Gd1-xdoping on magnetic, electric and dielectric proper- ties of MgGd, Fe2-xO, ferrites processed by solid state reaction technique 显示文摘 | Chand J Kumar G Kumar P | 2011 | Journal of Alloys and Compounds2011，509，40： | 1 |
| 15 | Use of positioning stents inlingual carcinoma patients subjected to radiotherapy显示文摘 | Goel A Tripathi A Chand P | 2010 | Int JProsthodont2010，23，5： | 1 |
| 16 | Quetiapine for insomnia in Parkinson disease: results from an open-label trial显示文摘 | Juri C Chand P Tapia J | 2005 | Clin Neuropharmacol2005，28，4： | 1 |
| 17 | Advances in phothodegradation and stabilization of polyurethanes 显示文摘 | Thapliyal B P Chand R | 1990 | Prog Polym Sci1990，，15： | 1 |
| 18 | Electro-enhancement of division of plant protoplast-derived cells显示文摘 | Rech E L Ochatt S J Chand P K | 1987 | Protoplasma1987，141，23： | 1 |
| 19 | Design and synthesis of benzoic acid derivatives as influenza neuraminidase inhibitors using structure-baced drug design 显示文摘 | Chand P Babu Y S Bantia S | 1997 | J Med Chem1997，40，： | 1 |
| 20 | Influence of foaming agent on wear and mechanical properties of surface modified rice husk filled polyvinylchloride显示文摘 | CHAND N FAHIM M SHARMA P | 2012 | Wear2012，，： | 1 |
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