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| 1 | Clinical characteristics and outcome of hepatocellular carcinoma in alcohol related and cryptogenic cirrhosis: a prospective study显示文摘BACKGROUND: Non-alcoholic fatty liver disease(NAFLD) is becoming a leading cause of chronic liver disease. Hepatocellular carcinoma(HCC) is one of its complications. Although the pathophysiology is unclear, it is reasonable to expect that cryptogenic cirrhosis related HCC(cryptogenic HCC) behaves differently to other types of HCC. This study prospectively compared patients with cryptogenic HCC and those with HCC related to alcoholic cirrhosis. METHODS: A total of 150 consecutive patients with HCC(89 cryptogenic HCC and 61 alcohol related HCC) referred to our unit over a 23-month period were studied. Their demographic data, liver function, tumor characteristics and outcomes were compared.RESULTS: Alcohol related HCC was seen only in males. Compared with cryptogenic HCC, alcohol related HCC had significantly higher aspartate aminotransferase/alanine aminotransferase(AST/ALT) ratio(1.7 vs 1.4, P=0.002), model for endstage liver disease score(13 vs 11, P=0.018) and Child's score(7 vs 6, P=0.037). No significant difference was seen in platelet counts, serum sodium and AST to platelet ratio index. Single nodular tumors were more common in cryptogenic HCC,while diffuse type tumors and macroscopic vascular invasion were common in alcohol related HCC. In patients who could not be offered any treatment because of advanced tumors or poor liver function, alcohol related HCC had a significantly lower median survival(5.3 months) compared with cryptogenic HCC(9.3 months, P=0.034).CONCLUSIONS: Compared with cryptogenic HCC, alcohol related HCC had worse liver function and aggressive tumor morphology at presentation, and a higher proportion was untreatable. In patients who could not be treated, median survival was lower in patients with alcohol related HCC than in those with cryptogenic HCC. | Rohan C Siriwardana Maduni A Niriella Anuradha S Dassanayake Chandika Liyanage Bhagya Gunathilaka Subani Jayathunge Hithanadura J de Silva | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，4： | 5 |
| 2 | Rapid, whole blood diagnostic test for detecting anti-hantavirus antibody in rats显示文摘 | Takako Amada Kumiko Yoshimatsu Shumpei P. Yasuda Kenta Shimizu Takaaki Koma Nobuhito Hayashimoto Chandika D. Gamage Sanae Nishio Akira Takakura Jiro Arikawa | 2013 | Journal of Virological Methods2013，，： | 1 |
| 3 | Ultrasound Guided NeedleAspiration versus Surgical Drainage in the management of breast abscesses:a Ugandan experience显示文摘 | Alphonce B Chandika Anthony M Gakwaya Elsie Kiguli-Malwadde | | 0，，05： | 1 |
| 4 | Prevention of i- atrogenic bite duct injuries in difficult laparoscopic cholecystee- tomies: is the naso-biliary drain the answer?显示文摘 | Chandika AH Liyanage Y Sadakari HK | 2009 | J Hepato- biliary Pancreat Surg2009，16，： | 1 |
| 5 | Duodenum-preserving local excision of a gastrointestinal stromal tumor显示文摘BACKGROUND:Duodenal gastrointestinal stromal tumors (GISTs) are rare. Because of the complex anatomy of the duodenum, the methods of resection of these tumors are controversial and diverse. METHODS:We report a case of a duodenal GIST in the anterolateral wall of the second part of the duodenum, which was successfully managed by local excision. The surgery was facilitated by preoperative mapping with Indian ink and navigation by endoscopy to assess the adequacy of resection and to avoid injury to the ampulla. RESULT:Reconstruction was successful with a duodeno-jejunostomy and protected by a nasoduodenal drain. CONCLUSION:The patient had no postoperative complications and the tumor was confirmed to be a GIST of the duodenum successful with an adequate resection margin. | Chandika AH Liyanage Sanjaya Abeygunawardhana Sumudu Kumarage Kemal I Deen | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，2： | 1 |
| 6 | Surgical management and outcome in patients with radial nerve lesions显示文摘 | Kim DH Kam AC Chandika P | 2001 | J Neurosurg2001，95，： | 1 |
| 7 | Surgical management and outcome in patients with radial nerve lesions 显示文摘 | Kim DH Kam AC Chandika P | 2001 | J Neurosurg2001，95，： | 1 |
| 8 | Effects of simulated acid rain on germination, seedling growth and oxidative metabolism of recalcitrant-seeded Trichilia dregeana grown in its natural seed bank显示文摘 | Chandika Ramlall Boby Varghese Syd Ramdhani | 2015 | Physiologia Plantarum2015，153，1： | 1 |
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