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| 1 | 北冰洋海冰/气候系统及其对全球气候的影响显示文摘结合前人对北冰洋海冰、气候系统的研究成果和 1 999年 8月在北冰洋对海冰的现场观测 ,本文综述了海冰分布、厚度的变化 ,海冰表面特征、积雪变化及北冰洋天气、气候特征和分区。讨论了北极海冰与南极海冰的差异。文章认为 ,北冰洋与周围地区气候变化趋势的不一致 ,主要是由于夏季在北冰洋海冰与开阔水域的相间分布、海冰漂移、融化吸热 ,均衡了周围大气、海洋温度的变化。 | 康建成 颜其德 孙波 温家洪 汪大立 孙俊英 孟广林 Kumiko Goto-Azuma | 1999 | 极地研究1999，11，4： | 22 |
| 2 | 北极楚科奇海海冰特征研究——以1999年夏季为例显示文摘对北冰洋楚科奇海海冰分布、厚度、气 /冰 /海界面温度场观测 ,钻取海冰冰芯 ,观测冰结构的变化 ,发现 3种海冰组合结构 :1)表面融化型 ;2 )表面和底部融化型 ;3)整体融化型 .海冰结构形成的热力学过程为 :在气 /冰界面上 ,海冰上表面吸收辐射能使冰体升温 ,出现表面融化 ;在冰 /海水界面上 ,海冰盘与开阔水域的相间分布、相对运动 ,将周围温度较高的水体输送到海冰的底部 ,加热、融化海冰底部 ;冰体升温 ,冰晶间盐水膜首先融化 ,分离冰晶 ,破坏海冰整体结构 .冰的相变吸热 ,使其温度维持在融点 。 | 康建成 孙波 孙俊英 孟广琳 GOTO-AZUMA Kumiko 张小伟 | 2002 | 冰川冻土2002，24，2： | 8 |
| 3 | Effect of periodontal treatment on adipokines in type 2 diabetes显示文摘The association between adipokines and inflammatory periodontal diseases has been studied over the last two decades. This review was intended to explore the observation that periodontal therapy may lead to an improvement of adipokines in diabetic patients. In summary, substantial evidence suggests that diabetes is associated with increased prevalence, extent and severity of periodontitis. Numerous mechanisms have been elucidated to explain the impact of diabetes on the periodontium. However, current knowledge concerning the role of major adipokines indicates only some of their associations with the pathogenesis of periodontitis in type 2 diabetes. Conversely, treatment of periodontal disease and reduction of oral inflammation may have positive effects on the diabetic condition, although evidence for this remains somewhat equivocal. | Hiroshi Ogawa Teerasak Damrongrungruang Sayaka Hori Kaname Nouno Kumiko Minagawa Misuzu Sato Hideo Miyazaki | 2014 | World Journal of Diabetes2014，5，6： | 8 |
| 4 | Argon plasma coagulation for superficial esophageal squamous-cell carcinoma in high-risk patients显示文摘AIM: To evaluate the usefulness and safety of argon plasma coagulation (APC) for superficial esophageal squamous-cell carcinoma (SESC) in high-risk patients. METHODS: We studied 17 patients (15 men and 2 women, 21 lesions) with SESC in whom endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), and open surgery were contraindicated from March 1999 through February 2009. None of the patients could tolerate prolonged EMR/ESD or open surgery because of severe concomitant disease (e.g., liver cirrhosis, cerebral infarction, or ischemic heart disease) or scar formation after EMR/ESD and chemoradiotherapy. After conventional endoscopy, an iodine stain was sprayed on the esophageal mucosa to determine the lesion margins. The lesion was then ablated by APC. We retrospectively studied the treatment time, number of APC sessions per site, complications, presence or absence of recurrence, and time to recurrence.RESULTS: The median duration of follow-up was 36 mo (range: 6-120 mo). All of the tumors were macroscopically classified as superficial and slightly depressed type (0-Ⅱc). The preoperative depth of invasion was clinical T1a (mucosal cancer) for 19 lesions and clinical T1b (submucosal cancer) for 2. The median treatment time was 15 min (range: 10-36 min). The median number of treatment sessions per site was 2 (range: 1-4). The median hospital stay was 14 d (range: 5-68 d). Among the 17 patients (21 lesions), 2 (9.5%) had recurrence and underwent additional APC with no subsequent evidence of recurrence. There were no treatment-related complications, such as bleeding or perforation. CONCLUSION: APC is considered to be safe and effective for the management of SESC that cannot be resected endoscopically because of underlying disease, as well as for the control of recurrence after EMR and local recurrence after chemoradiotherapy. | Kumiko Tahara Satoshi Tanabe Kenji Ishido Katsuhiko Higuchi Tohru Sasaki Chikatoshi Katada Mizutomo Azuma Kento Nakatani Akira Naruke Myungchul Kim Wasaburo Koizumi | 2012 | World Journal of Gastroenterology2012，18，38： | 4 |
| 5 | Enhanced plasma ghrelin levels in Helicobacter py/ori-colonized, interleukin-1-receptortype 1-homozygous knockout (IL-1R1-/-) mice显示文摘AIM: Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor, and it plays a role in stimulating the growth hormone secretion, food intake, body weight gain and gastric motility. Eradication of Helicobacterpylori (H pylori) was shown to be associated with increase of the body weight. On the other hand, H pylori infection evokes the release of gastric IL-lp. The present study was designed to investigate the involvement of the gastric IL-1 signal in the ghrelin dynamics in Hpylori-colonized mice. METHODS: Twelve-week-old female IL-1-receptor type 1-homozygous-knockout mice (IL-1R1-/-') and their wild-type littermates (WT) were orally inoculated with H pylori (Hp group), while other cohorts received oral inoculation of culture medium (Cont group). Thirteen weeks after the inoculation, the mice were examined. The plasma and stomach ghrelin levels and the gastric preproghrelin mRNA were measured. RESULTS: Although the WT mice with H pylori infection showed a significantly decreased body weight as compared with that of the animals without H pylori infection, H pylori infection did not influence the body weight of the IL-1R1-knockout (IL-1R1-/-) mice. In the H pylori-infected IL-1R1-/-mice, the total and active ghrelin levels in the plasma were significantly increased, and the gastric ghrelin level was decreased. No significant differences were noted in the gastric preproghrelin mRNA expression. CONCLUSION: Ghrelin secretion triggered by H pylori infection might be suppressed by IL-1β, the release of which is also induced by the infection, resulting in the body weight loss of mice with H pylori infection. | Yuka Abiko Hidekazu Suzuki Tatsuhiro Masaoka Sachiko Nomura Kumiko Kurabayashi Hiroshi Hosoda Kenji Kangawa Toshifumi Hibi | 2005 | World Journal of Gastroenterology2005，11，27： | 3 |
| 6 | A Study on Cyclone Aila Recovery in Koyra, Bangladesh:Evaluating the Inclusiveness of Recovery with Respect to Predisaster Vulnerability Reduction显示文摘The need to consider disaster risk reduction at the time of recovery is well-recognized. Viable disaster risk reduction measures should resolve the root causes of predisaster vulnerabilities. Accordingly, we investigated the recovery from the impact of Cyclone Aila in Koyra Upazila, Bangladesh, which was severely damaged by this2009 cyclone. Our research focused on understanding preAila vulnerabilities to cyclone impact and examined the degree of inclusion of vulnerability reduction measures within the recovery process. A composite methodology that included an institutional survey, key informant interviews,collection of the judgment of experts, focus group discussions, and a score-based quantification technique was adopted. Through a process of understanding pre-Aila vulnerabilities, recognition of the root causes of these inherent weaknesses, and identification of appropriate measures for pre-Aila vulnerability reduction, a set of 23 indicators were selected to represent the most desirable vulnerability reduction measures to implement duringrecovery. A score-based technique was applied to measure the degree of inclusion of vulnerability reduction within the recovery with respect to the indicators. The scoring result shows that the degree of inclusion of vulnerability reduction within the recovery was poor. The result specifies that among the 23 indicators of potential vulnerability reduction measures, 10 are completely missing and the rest are only partially included. The overall findings imply that the Koyra community continues to live with a vulnerability similar to that of the pre-Aila period. | Md.Shibly Sadik Hajime Nakagawa Rezaur Rahman Rajib Shaw Kenji Kawaike Kumiko Fujita | 2018 | International Journal of Disaster Risk Science2018，9，1： | 2 |
| 7 | Human pluripotent stem cells:Towards therapeutic development for the treatment of lifestyle diseases显示文摘There are two types of human pluripotent stem cells: Embryonic stem cells(ESCs) and induced pluripotent stem cells(iPSCs),both of which launched themselves on clinical trials after having taken measures to overcome problems: Blocking rejections by immunosuppressants regarding ESCs and minimizing the risk of tumorigenicity by depleting exogenous gene components regarding iP SCs.It is generally assumed that clinical applications of human pluripotent stem cells should be limited to those cases where there are no alternative measures for treatments because of the risk in transplanting those cells to living bodies.Regarding lifestyle diseases,we have already several therapeutic options,and thus,development of human pluripotent stem cell-based therapeutics tends to be avoided.Nevertheless,human pluripotent stem cells can contribute to the development of new therapeutics in this field.As we will show,there is a case where only a short-term presence of human pluripotent stem-derived cells can exert long-term therapeutic effects even after they are rejected.In those cases,immunologically rejections of ESC-or allogenic iP SC-derived cells may produce beneficial outcomes by nullifying the risk of tumorigenesis without deterioration of therapeutic effects.Another utility of human pluripotent stem cells is the provision of an innovative tool for drug discovery that are otherwise unavailable.For example,clinical specimens of human classical brown adipocytes(BAs),which has been attracting a great deal of attention as a new target of drug discovery for the treatment of metabolic disorders,are unobtainable from living individuals due to scarcity,fragility and ethical problems.However,BA can easily be produced from human pluripotent stem cells.In this review,we will contemplate potential contribution of human pluripotent stem cells to therapeutic development for lifestyle diseases. | Miwako Nishio Masako Nakahara Akira Yuo Kumiko Saeki | 2016 | World Journal of Stem Cells2016，8，2： | 2 |
| 8 | Indirect inguinal hernia containing portosystemic shunt vessel: A case report显示文摘BACKGROUND Inguinal hernia repair is one of the most common general surgical operations worldwide.We present a case of indirect inguinal hernia containing an expanded portosystemic shunt vessel.CASE SUMMARY We report a 72-year-old man who had a 4 cm×4 cm swelling in the right inguinal region,which disappeared with light manual pressure.Abdominal-pelvic computed tomography(CT)revealed a right inguinal hernia containing an expanded portosystemic shunt vessel,which had been noted for 7 years due to liver cirrhosis.We performed Lichtenstein’s herniorrhaphy and identified the hernia sac as being indirect and the shunt vessel existing in the extraperitoneal cavity through the internal inguinal ring.Then,we found two short branches between the expanded shunt vessel and testicular vein in the middle part of the inguinal canal and cut these branches to allow the shunt vessel to return to the extraperitoneal cavity of the abdomen.The hernia sac was returned as well.We encountered no intraoperative complications.After discharge,groin seroma requiring puncture at the outpatient clinic was observed.CONCLUSION If an inguinal hernia patient has portal hypertension,ultrasound should be used to determine the contents of the hernia.When atypical vessels are visualized,they may be shunt vessels and additional CT is recommended to ensure the selection of an adequate approach for safe hernia repair. | Masahiro Yura Kikuo Yo Asuka Hara Keita Hayashi Yuki Tajima Yasushi Kaneko Hiroto Fujisaki AkiraHirata Kiminori Takano Kumiko Hongo Kimiyasu Yoneyama Motohito Nakagawa | 2021 | World Journal of Clinical Cases2021，9，2： | 2 |
| 9 | Association Between Serum Uric Acid and Development of Type 2 Diabetes显示文摘 | Kodama Satoru Saito Kazumi Yachi Yoko Asumi Mihoko Sugawara Ayumi Totsuka Kumiko Saito Aki Sone Hirohito | 2009 | Diabetes Care2009，，： | 2 |
| 10 | Simultaneous removal of dissolved organic matter and bromide from drinking water source by anion exchange resins for controlling disinfection by-products显示文摘Anion exchange resins(AERs) with different properties were evaluated for their ability to remove dissolved organic matter(DOM) and bromide, and to reduce disinfection by-product(DBP) formation potentials of water collected from a eutrophic surface water source in Japan. DOM and bromide were simultaneously removed by all selected AERs in batch adsorption experiments. A polyacrylic magnetic ion exchange resin(MIEX) showed faster dissolved organic carbon(DOC) removal than other AERs because it had the smallest resin bead size. Aromatic DOM fractions with molecular weight larger than 1600 Da and fluorescent organic fractions of fulvic acid- and humic acid-like compounds were efficiently removed by all AERs. Polystyrene AERs were more effective in bromide removal than polyacrylic AERs. This result implied that the properties of AERs, i.e. material and resin size, influenced not only DOM removal but also bromide removal efficiency. MIEX showed significant chlorinated DBP removal because it had the highest DOC removal within 30 min, whereas polystyrene AERs efficiently removed brominated DBPs, especially brominated trihalomethane species. The results suggested that, depending on source water DOM and bromide concentration,selecting a suitable AER is a key factor in effective control of chlorinated and brominated DBPs in drinking water. | Athit Phetrak Jenyuk Lohwacharin Hiroshi Sakai Michio Murakami Kumiko Oguma Satoshi Takizawa | 2014 | Journal of Environmental Sciences2014，26，6： | 2 |
| 11 | Overexpression of a 60-kDa heat shock protein enhances cytoprotective function of small intestinal epithelial cells显示文摘 | Makiko Takada Michiro Otaka Taiji Takahashi Yuko Izumi Kumiko Tamaki Tomoyoshi Shibuya Naoto Sakamoto Taro Osada Sou Yamamoto Ryuichi Ishida Masaru Odashima Hideaki Itoh Sumio Watanabe | 2010 | Life Sciences2010，，13： | 2 |
| 12 | Development of a serotyping enzyme-linked immunosorbent assay system based on recombinant truncated hantavirus nucleocapsid proteins for New World hantavirus infection显示文摘 | Takaaki Koma Kumiko Yoshimatsu Midori Taruishi Daisuke Miyashita Rika Endo Kenta Shimizu Shumpei P. Yasuda Takako Amada Takahiro Seto Ryo Murata Haruka Yoshida Hiroaki Kariwa Ikuo Takashima Jiro Arikawa | 2012 | Journal of Virological Methods2012，，1： | 2 |
| 13 | Change in location of cytokine-induccd neutrophil chemoattractants (CINCs) in pulmonary silicosis 显示文摘 | Junko H Kumiko A Hiroaki M | 2003 | Experimental and Molecular Pathology2003，75，1： | 1 |
| 14 | Genetic Diversity of Hantaviruses Isolated in China and Characterization of Novel Hantaviruses Isolated from Niviventer confucianus and Rattus rattus显示文摘 | Hua Wang Kumiko Yoshimatsu Hideki Ebihara | 2000 | Virology2000，278，： | 1 |
| 15 | Radiation dose reduction in hepatic multidetector computed tomography with a novel adaptive noise reduction filter显示文摘 | Yoshinori Funama Kazuo Awai Osamu Miyazaki Taiga Goto Yoshiharu Nakayama Masamitchi Shimamura Kumiko Hiraishi Shinichi Hori Yasuyuki Yamashita | 2008 | Radiation Medicine2008，，3： | 1 |
| 16 | Different expressions of BDNF, NT3, and NT4 in muscle and nerve after various types of peripheral nerve injuries 显示文摘 | Takao O Michio S Kumiko O | 2005 | Journal of the Peripheral Nervous System2005，10，： | 1 |
| 17 | Renin-angiotensin systemmodulates oxidative stress-lnduced en-dothelial cell apoptosis in rats显示文摘 | Masahiro A Kumiko N Hang X | 2005 | Hypertension2005，45，： | 1 |
| 18 | Antioxidant activity of Magnolol, honokiol, and related phenolic compounds显示文摘 | Masahiro Ogata Midori Hoshi Kumiko Shimotohno Shiro Urano Toyoshige Endo | 1997 | Journal of the American Oil Chemists’ Society1997，，5： | 1 |
| 19 | Quantitative analysis of brain perfusion SPECT in Alzheimer's disease using a fully automated regional cerebral blood flow quantification software,3DSRT显示文摘 | Seiju Kobayashi Masaru Tateno Kumiko Utsumi | | 0，，01： | 1 |
| 20 | LC-MS/MS method for the quantitation of serum tocilizumab in rheumatoid arthritis patients using rapid tryptic digestion without IgG purification显示文摘The quantitation of serum tocilizumab using liquid chromatography tandem-mass spectrometry(LC-MS/MS)method has not been widely applied in clinical settings because of its time-consuming and costly sample pretreatments.The present study aimed to develop a validated LC-MS/MS method for detecting serum tocilizumab by utilizing immobilized trypsin without an immunoglobulin G purification step and evaluate its applicability in the treatment of rheumatoid arthritis(RA)patients administered intravenously or subcutaneously with tocilizumab.The tocilizumab-derived signature peptide was deciphered using a nano-LC system coupled to a hybrid quadrupole-orbitrap mass spectrometer.The serum tocilizumab was rapidly digested by immobilized trypsin for 30 min.The chromatographic peak of the signature peptide and that of the internal standard were separated from the serum digests for a total run time of 15 min.The calibration curve of serum tocilizumab concentration was linear with a range of 2-200 μg/mL.The intra-and inter-day accuracy and relative standard deviation(RSD)were 90.7%-109.4%and<10%,respectively.The serum tocilizumab concentrations in the RA patients receiving intravenous and subcutaneous injections were 5.8-28.9 and 2.4-63.5 μg/mL,respectively.The serum tocilizumab concentrations using the current method positively correlated with those using the enzyme-linked immunosorbent assay,although a systematic error was observed between these methods.In conclusion,a validated LC-MS/MS method with minimal sample pretreatments for monitoring serum tocilizumab concentrations in RA patients was developed. | Takashi Mochizuki Kaito Shibata Takafumi Naito Kumiko Shimoyama Noriyoshi Ogawa Masato Maekawa Junichi Kawakami | 2022 | Journal of Pharmaceutical Analysis2022，12，6： | 1 |
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