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| 1 | Airport gate assignment problem with deep reinforcement learning显示文摘With the rapid development of air transportation in recent years,airport operations have attracted a lot of attention.Among them,airport gate assignment problem(AGAP)has become a research hotspot.However,the real-time AGAP algorithm is still an open issue.In this study,a deep reinforcement learning based AGAP(DRL-AGAP)is proposed.The optimization object is to maximize the rate of flights assigned to fixed gates.The real-time AGAP is modeled as a Markov decision process(MDP).The state space,action space,value and rewards have been defined.The DRL-AGAP algorithm is evaluated via simulation and it is compared with the flight pre-assignment results of the optimization software Gurobiand Greedy.Simulation results show that the performance of the proposed DRL-AGAP algorithm is close to that of pre-assignment obtained by the Gurobi optimization solver.Meanwhile,the real-time assignment ability is ensured by the proposed DRL-AGAP algorithm due to the dynamic modeling and lower complexity. | 赵家明 Wu Wenjun Liu Zhiming Han Changhao Zhang Xuanyi Zhang Yanhua | 2020 | High Technology Letters2020，26，1： | 3 |
| 2 | An improved U-Net for cell confluence estimation显示文摘Cell confluence is an important metric to determine the growth and the best harvest time of adherent cells. At present, the evaluation of cell confluence mainly relies on experienced labor, and thus it is not conducive to the automated cell culture. In this paper, we proposed an improved U-Net algorithm(called DU-Net) for the segmentation of adherent cells. First, the general convolution was replaced by the dilated convolution to expand the receptive fields for feature extraction. Then, the convolutional layers were combined with the batch normalization layers to reduce the dependence of the network on initialization. As a result, the segmentation accuracy and F1-score of the proposed DU-Net for adherent cells with low confluence(<50%) reached 96.94% and 93.87%, respectively, and for those with high confluence(≥50%), they reached 98.63% and 98.98%, respectively. Further, the paired t-test results showed that the proposed DU-Net was statistically superior to the traditional U-Net algorithm. | BAI Hua LU Changhao MA Ming YAN Shulin ZHANG Jianzhong HAN Zhibo | 2022 | Optoelectronics Letters2022，18，6： | 2 |
| 3 | Photocrosslinking silver nanoparticles–aloe vera–silk fibroin composite hydrogel for treatment of full-thickness cutaneous wounds显示文摘Damage to the skin causes physiological and functional issues.The most effective treatment approach is the use of wound dressings.Silk fibroin(SF)is a promising candidate biomaterial for regulating wound healing;however,its antibacterial properties and biological activity must be further improved.In this study,a photocrosslinking hydrogel was developed to treat full-thickness cutaneous wounds.The composite hydrogel(Ag-AV-SF hydrogel)was prepared by introducing the silver nanoparticles(AgNPs)and aloe vera(AV)as the modifiers.In vitro study exhibited great antibacterial ability,biocompatibility and cell-proliferation and-migration-promoting capacities.It also showed the pH-response releasing properties which release more AgNPs in a simulated chronic infection environment.The healing effect evaluation in vivo showed the healing-promoting ability of the Ag-AV-SF hydrogel was stronger than the single-modifiers groups,and the healing rate of it reached 97.02%on Day 21,higher than the commercial wound dressing,silver sulfadiazine(SS)cream on sale.Additionally,the histological and protein expression results showed that the Ag-AV-SF hydrogel has a greater effect on the pro-healing regenerative phenotype with M2 macrophages at the early stage,reconstructing the blood vessels networks and inhibiting the formation of scars.In summary,the Ag-AV-SF hydrogel developed in this study had good physical properties,overwhelming antibacterial properties,satisfactory biocompatibility and significantly promoting effect on cell proliferation,migration and wound healing.Overall,our results suggest that the Ag-AV-SF hydrogel we developed has great potential for improving the wound healing in clinical treatment. | Yangkun Liu JinChuan Fan MingQi Lv Kepeng She Jiale Sun Qingqing Lu Changhao Han SongTao Ding Shuang Zhao GuiXue Wang YuChan Zhang GuangChao Zang | 2021 | Regenerative Biomaterials2021，8，6： | 2 |
| 4 | Dynamic oxidation mechanism of carbon fiber reinforced SiC matrix composite in high-enthalpy and high-speed plasmas显示文摘This work employed an inductively coupled plasma wind tunnel to study the dynamic oxidation mechanisms of carbon fiber reinforced SiC matrix composite(C_(f)/SiC)in high-enthalpy and high-speed plasmas.The results highlighted a transition of passive/active oxidations of SiC at 800–1600℃and 1–5 kPa.Specially,the active oxidation led to the corrosion of the SiC coating and interruption of the SiO_(2) growth.The transition borders of active/passive oxidations were thus defined with respect to oxidation temperature and partial pressure of atomic O in the high-enthalpy and high-speed plasmas.In the transition and passive domains,the SiC dissipation was negligible.By multiple dynamic oxidations of C_(f)/SiC in the domains,the SiO_(2) thickness was not monotonously increased due to the competing mechanisms of passive oxidation of SiC and dissipation of SiO_(2).In addition,the mechanical properties of the SiC coating/matrix and the C_(f)/SiC were maintained after long-term dynamic oxidations,which suggested an excellent thermal stability of C_(f)/SiC serving in thermal protection systems(TPSs)of reusable hypersonic vehicles. | Lingwei YANG Xueren XIAO Liping LIU Jie LUO Kai JIANG Xinxing HAN Changhao ZHAO Jun ZHANG Guolin WANG | 2022 | Journal of Advanced Ceramics2022，11，2： | 1 |
| 5 | Interoceptive regulation of skeletal tissue homeostasis and repair显示文摘Recent studies have determined that the nervous system can sense and respond to signals from skeletal tissue,a process known as skeletal interoception,which is crucial for maintaining bone homeostasis.The hypothalamus,located in the central nervous system(CNS),plays a key role in processing interoceptive signals and regulating bone homeostasis through the autonomic nervous system,neuropeptide release,and neuroendocrine mechanisms.These mechanisms control the differentiation of mesenchymal stem cells into osteoblasts(OBs),the activation of osteoclasts(OCs),and the functional activities of bone cells.Sensory nerves extensively innervate skeletal tissues,facilitating the transmission of interoceptive signals to the CNS.This review provides a comprehensive overview of current research on the generation and coordination of skeletal interoceptive signals by the CNS to maintain bone homeostasis and their potential role in pathological conditions.The findings expand our understanding of intersystem communication in bone biology and may have implications for developing novel therapeutic strategies for bone diseases. | Yao Xiao Changhao Han Yunhao Wang Xinshu Zhang Rong Bao Yuange Li Huajiang Chen Bo Hu Shen Liu | 2023 | Bone Research2023，11，3： | 1 |
| 6 | High-safety and high-voltage lithium metal batteries enabled by nonflammable diluted highly concentrated electrolyte显示文摘Lithium metal batteries(LMBs)show great promise for achieving energy densities over 400 Wh·kg^(-1).However,highly flammable organic electrolytes are a long-lasting problem that triggers safety hazards and hinders the commercial application of LMBs.Here,a nonflammable diluted highly concentrated electrolyte(DHCE)with ethoxy(pentafluoro)cyclotriphosphazene(PFPN)as a diluent is developed to simultaneously achieve high safety and cycling stability of high-voltage LMBs.The optimal DHCE not only ensures reversible Li deposition/dissolution behavior with a superior average Coulombic efficiency(CE)over 99.1%on lithium metal anode(LMA),but also suppresses side reactions and stress crack on the LiCoO_(2)(LCO)under high cut-off voltage.The newly developed DHCE exhibits high thermal stability,showing complete nonflammability and reduced heat generation between the electrolyte and delithiated LCO/cycled LMA.This work offers an opportunity for rational designing nonflammable electrolytes toward high-voltage and safe LMBs. | Han Zhang Ziqi Zeng Shuping Wang Yuanke Wu Changhao Li Mengchuang Liu Xinlan Wang Shijie Cheng Jia Xie | 2024 | Nano Research2024，17，4： | 0 |
| 7 | Numerical simulation of the dynamic effects of grounding icebergs on summer circulation in Prydz Bay,Antarctica显示文摘The Regional Ocean Modeling System(ROMS)is employed to create a three-dimensional numerical model of the summer circulation in the Prydz Bay region,Antarctica.Consistent with the currents measured using an underway acoustic Doppler current profiler during a Chinese cruise,the simulated current field illustrates the major features of the Prydz Bay circulation,including the Antarctic Slope Current(ASC)along the continental shelf break,the cyclonic Prydz Bay Gyre,and the Prydz Bay Eastern Coastal Current(PBECC).The effects of grounding icebergs D15 and B15 on the circulation in Prydz Bay are investigated via numerical simulations.The results indicate that these giant grounding icebergs substantially affect the flows into and within the bay,which may differ with the different grounding locations.As grounding iceberg D15 is located close to the southwestern part of the West Ice Shelf(WIS),it cuts off the coastal current along the outer edge of the WIS,and the ASC can only enter Prydz Bay from the west side of iceberg D15,whereupon it becomes a main source of the PBECC.Iceberg D15 also weakens the circulation in the bay in general.The relatively small iceberg B15 entered Prydz Bay from 2007 to 2009 and grounded on the southwestern section of the Four Ladies Bank.The numerical experiments indicate that iceberg B15 guides the ASC flowing into the bay around its west side and reduces the width of the inflow on the eastern side of the Prydz Bay Channel.The grounding of iceberg B15 has also led to adjustments of the circulation within the bay,among which the most significant is that the outflow along the western flank of Fram Bank has shifted to the west and become more intensive. | HAN Yuxin SHI Jiuxin HOU Saisai XIAO Changhao | 2022 | Advances in Polar Science2022，33，2： | 0 |
| 8 | Proton radiation effects on high-speed silicon Mach-Zehnder modulators for space application显示文摘In this paper,performance degradation effects on high-speed silicon Mach-Zehnder modulators under proton radiation were investigated for future space environment applications.The test devices were exposed to 3-MeV protons of three fluence levels(5×10,2×10,and 5×10ions/cm~2),which is comparable to the radiation amount for operating in a harsh space environment after several decades.The performance of the silicon modulator after radiation was characterized in terms of modulation efficiency and eye diagram.The results illustrate that the modulation efficiency is significantly reduced after proton radiation and shows an obvious decrease with increasing radiation fluence.The extinction ratios of the on-off keying(OOK)eye diagram are obviously dropped with increasing radiation fluence and correspond well to modulation efficiency degradation.Furthermore,three representative states for data transmission are demonstrated under three fluences,from still working to the critical state and eventually complete fail.Displacement damage and ionization damage are the two major mechanisms during proton radiation,which lead to the bulk defects and accumulating defect charges and cause performance degradation of silicon Mach-Zehnder modulators. | Changhao HAN Zhaoyi HU Yuansheng TAO Engang FU Yandong HE Fenghe YANG Jun QIN Xingjun WANG | 2022 | Science China(Information Sciences)2022，65，12： | 0 |
| 9 | Association of branched-chain amino acid intake trajectory in adulthood with the risk of type 2 diabetes and its related risk factors显示文摘To the Editor:Type 2 diabetes(T2D)showed increasing prevalence worldwide and put a huge burden on healthcare systems.[1]Branched-chain amino acids(BCAAs,including Leucine,Isoleucine,and Valine),a prominent group of essential amino acids,are important nutrition signals that have important effects on protein synthesis,glucose homeostasis,and nutrient-sensitive signaling pathways.Plasma BCAA can predict the development of T2D,whereas the studies of dietary BCAA on T2D risk showed conflicting results.[2]Most of the researches about dietary BCAAs used a single or limited number of measurements,ignoring the dynamic changes of dietary BCAA levels throughout life and their relevance to the development of diabetes.A life-course approach using multiple dietary BCAA measurements over time may shed new light on dietary BCAA trajectories and their relation to T2D risk.Therefore,in the current study,we first use latent class mixed model(LCMM)to characterize BCAA intake trajectories over 18 years in longitudinal data from China and investigate the association of BCAA intake trajectories with the risk of T2D and its biomarkers after adjusting for potential confounding factors. | Weiqi Wang Tianshu Han Wanying Hou Xiyun Ren Wei Duan Zhipeng Liu Changhao Sun | 2022 | Chinese Medical Journal2022，，1： | 0 |
| 10 | A comprehensive review on polyurethane modified asphalt: Mechanism, characterization and prospect显示文摘Polyurethane(PU),with excellent physical and chemical properties and high designability,is one of the ideal materials for asphalt modification in the future.In this paper,based on the limitations of traditional asphalt modifiers,the preparation process,relative advantages and development prospects of PU as asphalt modifiers are described.Subsequently,the spatial structure,physical and chemical properties of PU synthetic raw materials were combined with the modification properties of PU to analyze the effect and influence of PU on asphalt modification.Specifically,polyurethane modified asphalt(PUMA)is divided into thermoplastic polyurethane modified asphalt(TP-PUMA)and thermosetting polyurethane modified asphalt(TS-PUMA).The gain effect of TPPUMA in high-temperature performance,low-temperature performance,aging resistance,fatigue resistance,weathering performance and bonding performance is obvious.In addition,it has good storage stability.With excellent road performance,TS-PUMA makes up for the shortcomings of epoxy asphalt in terms of lowtemperature performance and compatibility.Finally,due to the development trend of functional diversification of modified asphalt,the research basis and status of several new modified asphalts based on PU properties are described.Because the systematic study of PUMA is insufficient,this paper proposes corresponding research.To provide guidance and ideas for the research of PU modified asphalt. | Peiliang Cong Changhao Liu Zhiyu Han Yuanfeng Zhao | 2023 | Journal of Road Engineering2023，3，4： | 0 |
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