3篇
您的检索式：作者名="Changjun Tie"
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| 1 | Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics显示文摘The imbalance between oxidants and antioxidants in cancer cells would evoke oxidative stress-induced cell death,which has been demonstrated to be highly effective in treating malignant tumors.Sonodynamic therapy(SDT)adopts ultrasound(US)as the excitation source to induce the production of reactive oxygen species(ROS),which emerges as a noninvasive therapeutic strategy with deep tissue penetration depth and high clinical safety.Herein,we construct novel sonoactivated oxidative stress amplification nanoplatforms by coating MnO_(2) on Au nanoparticle-anchored black phosphorus nanosheets and decorating soybean phospholipid subsequently(Au/BP@MS).The Au/BP@MS exhibit increased ROS generation efficiency under US irradiation in tumor tissues due to Au/BP nanosensitizer-induced improvement of electron-hole separation as well as MnO_(2)-mediated O_(2) generation and GSH depletion,thus leading to notable inhibition effect on tumor growth.Moreover,tumor microenvironment-responsive biodegradability of Au/BP@MS endows them with enhanced magnetic resonance imaging guidance and clinical potential for cancer theranostics. | Ting Chen Weiwei Zeng Changjun Tie Mian Yu Huisong Hao Yang Deng Qianqian Li Hairong Zheng Meiying Wu Lin Mei | 2022 | Bioactive Materials2022，7，4： | 1 |
| 2 | A MODIFIED PRECONDITIONER FOR PARAMETERIZED INEXACT UZAWA METHOD FOR INDEFINITE SADDLE POINT PROBLEMS显示文摘 | Xinhui Shao Chen Li Tie Zhang Changjun Li | 2018 | Journal of Computational Mathematics2018，36，4： | 0 |
| 3 | Tumor Microenvironment-Specific Chemical Internalization for Enhanced Gene Therapy of Metastatic Breast Cancer显示文摘Benefiting from treating diseases at the genetic level,gene therapy has been considered a new revolution in the biomedical field.However,the extracellular and intracellular barriers during gene transport such as enzymatic degradation and endo-/lysosomal sequestration significantly compromise the therapeutic efficacy.Though photochemical internalization(PCI)has emerged as a promising approach for causing endo-/lysosomal leakage with translocation of the internalized molecules into the cytosol,its effect is still unsatisfactory due to the insufficient light penetration depth.Here,we develop tumor microenvironment-specific enhanced gene delivery by means of ROS generated from the in situ cascaded catalytic reactions in tumors involving GOx-mediated redox reaction and Mn2+-mediated Fenton-like reaction.The efficient enzymatic protection and successful endo-/lysosomal escape of cargo gene complexes have been demonstrated.Moreover,anti-Twist siRNA-loaded G@MMSNs-P exhibit tumor-specific biodegradation,excellent T1-weighted MR imaging,and significant inhibitory effects against breast cancer growth and pulmonary metastasis. | Yun Zhou Mian Yu Changjun Tie Yang Deng Junqing Wang Yunfei Yi Fan Zhang Chenyi Huang Hairong Zheng Lin Mei Meiying Wu | 2021 | Research2021，，1： | 0 |
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