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| 1 | A matched cohort study of laparoscopy-assisted and open total gastrectomy for advanced proximal gastric cancer without serosa invasion显示文摘 | Lin Jianxian Huang Changming Zheng Chaohui Li Ping Xie Jianwei Wang Jiabin Lu Jun | 2014 | Chinese Medical Journal2014，，3： | 11 |
| 2 | Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy显示文摘病理学的心脏的肥大是心失败的不可避免的 forerunner。不管心脏的肥大的病原学, cardiomyocyte mitochondrial 改变总是在这上下文被观察。mitochondrial 先锋蛋白质的进口调节在 pathophysiological 下面维持 mitochondrial 功能的外部膜(汤姆) 建筑群管理的 mitochondrial 的 translocases;然而,它在病理学的心脏的肥大的发展的角色仍然保持不清楚。这里,我们证明 Tom70 是在从人和试验性的动物的病理学的 hypertrophic 心的 downregulated。在 Tom70 表示的减小在 vivo 并且在 vitro 生产了不同病理学的 cardiomyocyte 肥大。指向 Tom70 的眼的 atrophy-1 的有缺点的 mitochondrial 进口触发了细胞内部的氧化应力,它导致了病理学的细胞的回答。重要地,如果有到多样的 pro-hypertrophic 的完整的抵抗的 cardiomyocytes 侮辱,增加了 Tom70 层次。一起,这些结果表明 Tom70 充当安排 hypertrophic 压力和 mitochondrial 回答决定病理学的心脏的肥大的一个分子的开关。 | Jun Li Man Qi Changming Li Dan Shi Dasheng Zhang Duanyang Xie Tianyou Yuan Jing Feng Yi Liu Dandan Liang Xinran Xu Jinjin Chen Liang Xu Hong Zhang Jiangchuan Ye Fei LV Jian Huang Luying Peng Yi-Han Chen | 2014 | Cell Research2014，24，8： | 9 |
| 3 | Prevalence, risk factors, and survival associated with pulmonary hypertension and heart failure among patients with underlying coronary artery disease: a national prospective, multicenter registry study in China显示文摘Background: Coronary artery disease (CAD) is the commonest cause of heart failure (HF), whereas pulmonary hypertension (PH) has not been established or reported in this patient population. Therefore, we assessed the prevalence, risk factors, and survival in CAD-associated HF (CAD-HF) complicated with PH.Methods: Symptomatic CAD-HF patients were continuously enrolled in this prospective, multicenter registry study. Echocardiography, coronary arteriography, left and right heart catheterization (RHC), and other baseline clinical data were recorded. Patients were followed up and their survival was recorded.Results: One hundred and eighty-two CAD-HF patients were enrolled, including 142 with HF with a preserved ejection fraction (heart failure with preserved ejection fraction [HFpEF];left ventricular ejection fraction [LVEF] ≥50%) and 40 with a reduced ejection fraction (heart failure with reduced ejection fraction [HFrEF];LVEF < 50%). PH was diagnosed with RHC in 77.5% of patients. Patients with PH showed worse hemodynamic parameters and higher mortality. HFrEF-PH patients had worse survival than HFpEF-PH patients. CAD-HF patients with an enlarged left ventricular end-diastolic diameter and reduced hemoglobin were at higher risk of PH. Nitrate treatment reduced the risk of PH. Elevated creatinine and mean pulmonary arterial pressure (mPAP), diastolic pressure gradient (DPG) ≥7 mmHg, and previous myocardial infarction (MI) entailed a higher risk of mortality in CAD-HF patients with PH.Conclusions: PH is common in CAD-HF and worsens the hemodynamics and survival in these patients. Left ventricle enlargement and anemia increase the risk of PH in CAD-HF. Patients may benefit from nitrate medications. Renal impairment, elevated mPAP, DPG ≥7 mmHg, and previous MI are strong predictors of mortality in CAD-HF-PH patients.Trial Registration: ClinicalTrials.gov, NCT02164526. | Li Huang Lingpin Pang Qing Gu Tao Yang Wen Li Ruilin Quan Weiqing Su Weifeng Wu Fangming Tang Xiulong Zhu Jieyan Shen Jingzhi Sun Guangliang Shan Changming Xiong Shian Huang Jianguo He | 2022 | Chinese Medical Journal2022，，15： | 4 |
| 4 | Cloning and expression of SgCYP450-4from Siraitia grosvenorii显示文摘CYP450 plays an essential role in the development and growth of the fruits of Siraitia grosvenorii. However, little is known about the SgCYP450-4 gene in S. grosvenorii. Here, based on transcriptome data, a full-length c DNA sequence of SgCYP450-4 was cloned by reverse transcriptasepolymerase chain reaction(RT-PCR) and rapid-amplification of c DNA ends(RACE) strategies. SgCYP450-4 is 1677 bp in length(Gen Bank accession No. AEM42985.1) and contains a complete open reading frame(ORF) of 1422 bp. The deduced protein was composed of 473 amino acids, the molecular weight is 54.01 kDa, the theoretical isoelectric point(PI) is 8.8, and the protein was predicted to possess cytochrome P450 domains. SgCYP450-4 gene was highly expressed in root, diploid fruit and fruit treated with hormone and pollination. At 10 days after treatment with pollination and hormones, the expression of SgCYP450-4had the highest level and then decreased over time, which was consistent with the development of fruits of S.Grosvenorii. Hormonal treatment could significantly induce the expression of SgCYP450-4. These results provide a reference for regulation of fruit development and the use of parthenocarpy to generate seedless fruit, and provide a scientific basis for the production of growth regulator application agents. | Dongping Tu Xiaojun Ma Huan Zhao Changming Mo Qi Tang Liuping Wang Jie Huang Limei Pan | 2016 | Acta Pharmaceutica Sinica B2016，6，6： | 3 |
| 5 | Grain Refiner for TiAl Intermetallic Compounds显示文摘The effect of BN addition on the grain size and rnechanical properties of Ti-34.1 wt-%Al alloy was investigated. It has been found that BN is an effective grain refiner for TiAl base alloys, The addition of a small arnount of BN to TiAl can change the coarse columnar grains of as-cast rnicrostructure into the fine equiaxed grains. It has been also determined that Ti-34.1 wt-%Al-1.0 wt-%BN alloy has better mechanical properties and | Yuehui HE Yexiang LIU Baiyun HUANG Xuanhui QU and Changming LEI (Powder Metallurgy Research Institute, Central South University of Technology, Changsha, 410083, China) | 1994 | Journal of Materials Science & Technology1994，10，3： | 2 |
| 6 | Textbook Outcome as a measure of surgical quality assessment and prognosis in gastric neuroendocrine carcinoma:A large multicenter sample analysis显示文摘Objective:Quality assurance is crucial for oncological surgical treatment assessment.For rare diseases,singlequality indicators are not enough.We aim to develop a comprehensive and reproducible measurement,called the'Textbook Outcome'(TO),to assess the quality of surgical treatment and prognosis of gastric neuroendocrine carcinoma(G-NEC)patients.Methods:Data from patients with primary diagnosed G-NEC included in 24 high-volume Chinese hospitals from October 2005 to September 2018 were analyzed.TO included receiving a curative resection,≥15 lymph nodes examined,no severe postoperative complications,hospital stay≤21 d,and no hospital readmission≤30 d after discharge.Hospital variation in TO was analyzed using a case mix-adjusted funnel plot.Prognostic factors of survival and risk factors for non-Textbook Outcome(non-TO)were analyzed using Cox and logistic models,respectively.Results:TO was achieved in 56.6%of 860 G-NEC patients.TO patients had better overall survival(OS),disease-free survival(DFS),and recurrence-free survival(RFS)than non-TO patients(P<0.05).Moreover,TO patients accounted for 60.3%of patients without recurrence.Multivariate Cox analysis revealed non-TO as an independent risk factor for OS,DFS,and RFS of G-NEC patients(P<0.05).Increasing TO rates were associated with improved OS for G-NEC patients,but not hospital volume.Multivariate logistic regression revealed that nonlower tumors,open surgery,and>200 mL blood loss were independent risk factors for non-TO patients(P<0.05).Conclusions:TO is strongly associated with multicenter surgical quality and prognosis for G-NEC patients.Factors predicting non-TO are identified,which may help guide strategies to optimize G-NEC outcomes. | Qiyue Chen Zhongliang Ning Zhiyu Liu Yanbing Zhou Qingliang He Yantao Tian Hankun Hao Wei Lin Lixin Jiang Gang Zhao Ping Li Chaohui Zheng Changming Huang on behalf of the Study Group for Gastric Neuroendocrine Tumors | 2021 | Chinese Journal of Cancer Research2021，33，4： | 2 |
| 7 | Construction and biological characterisation of recombinant porcine circovirus type 2 expressing the V5 epitope tag显示文摘 | Liping Huang Yuehua Lu Yanwu Wei Longjun Guo Hongli Wu Feiyan Zhang Yujie Fu Changming Liu | 2011 | Virus Research2011，，2： | 2 |
| 8 | Dual confinement of polysulfides in boron-doped porous carbon sphere/graphene hybrid for advanced Li-S batteries显示文摘由做硼的多孔的碳范围和 graphene (BPCS-G ) 组成的混合结构被设计了并且向解决 polysulfide 梭问题综合了,它是当前的 Li-S 电池的最关键的问题。显示出高表面区域的建议混合结构(870 m 2??????????????? ? €畧湡湩?? 挠瑹獯湩 ?????? ㄠ‰ ????????????? 吠 ?? €?‰ ??????? ‰ ?????????????????????????? ￡桴?? | Wei Ai Jiewei Li Zhuzhu Du Chenji Zou Hongfang Du Xin Xu Yu Chen Hongbo Zhang Jianfeng Zhao Changming Li Wei Huang Ting Yu | 2018 | Nano Research2018，11，9： | 2 |
| 9 | Reappraise role of lymph node status in patterns of recurrence following curative resection of gastric adenocarcinoma显示文摘Objective: To examine the association between lymph node status and recurrence patterns in completely resected gastric adenocarcinoma.Methods: We retrospectively assessed 1,694 patients who underwent curative gastrectomy from January 2010 to August 2014. Patients stratified according to lymph node status and recurrence patterns among different subgroups were compared.Results: Of all, 517(30.5%) patients developed recurrent disease, and complete data of recurrence could be obtained in 493(95.4%) patients. For p^(N0) patients, the patterns of recurrence were different according to p T stage: locoregional recurrence was most common in patients with p T1-2 disease(57.1%), distant recurrence was most common in patients with p T3 disease(57.1%), and peritoneal recurrence was most common in patients with p T4 a disease(66.7%). For p^(N+) patients, distant metastasis was most common pattern irrespective of p T stage. The site-specific trend of recurrence showed that locoregional recurrence increased within 5 years in patients with p^(N0)-2 disease but plateaued 3 years after surgery in patients with p N3 disease. Time to recurrence was significantly longer for the p^(N0) patients compared with the p^(N+) patients(median: 25 vs. 16 months, P=0.001).Moreover, post-recurrence survival was significantly better for the p^(N0) patients than for the p^(N+) patients(median:12 vs. 6 months, P<0.001), especially in patients with non-peritoneal recurrence, late recurrence, single recurrence,and receipt of potential curative treatment.Conclusions: Among clinicopathologic factors, lymph node status is the most important factor associated with recurrence patterns after curative gastrectomy. Lymph node status may be used as an adjunct in clinical decisionmaking about postoperative therapeutic and follow-up strategies. | Yihui Tang Jianxian Lin Junpeng Lin Jiabin Wang Jun Lu Qiyue Chen Longlong Caolj Mi Lin Ruhong Tu Changming Huang Ping Li Chaohui Zheng Jianwei Xie | 2021 | Chinese Journal of Cancer Research2021，33，3： | 1 |
| 10 | Aluminum alloy pistons reinforced with SiC fabricated by centrifugal casting 显示文摘 | HUANG Xiaoyu LIU Changming L Xunjia | 2011 | Journal of Materials Processing Technology2011，211，9： | 1 |
| 11 | MICROSTRUCTURE AND MECHANICAL PROPERTIES OF TiAl+Nd ALLOYS显示文摘MICROSTRUCTUREANDMECHANICALPROPERTIESOFTiAl+NdALLOYS￥LeiChangming;HeYuehui;ChenShiqi;QuXuanhui;HuangBaiyun(Researchinstituteo... | Lei Changming He Yuehui Chen Shiqi Qu Xuanhui Huang Baiyun(Research institute of powder MetallurgyCentral South University of Technology, Changsha 410083) | 1996 | 中国有色金属学会会刊:英文版1996，6，3： | 1 |
| 12 | Intuitionistic fuzzy c-means clustering algorithm withneighborhood attraction in segmenting medical image显示文摘 | Huang Wenching Lin Pingkuo Wu Changming | 2014 | Soft Computing2014，22，5： | 1 |
| 13 | Enhanced Th1-biased immune efficacy of porcine circovirus type 2 Cap-protein-based subunit vaccine when coadministered with recombinant porcine IL-2 or GM-CSF in mice显示文摘 | Yiping Wang Yuehua Lu Dan Liu Yanwu Wei Longjun Guo Hongli Wu Liping Huang Jianbo Liu Changming Liu | 2015 | Applied Microbiology and Biotechnology2015，，3： | 1 |
| 14 | Effects of surfactants on extraction of phenanthrene in spiked sand显示文摘 | Huang C R Shu H Y | 2000 | Chemosphere2000，41，8： | 1 |
| 15 | Mapping fractional cropland covers in Brazil through integrating LSMA and SDI techniques applied to MODIS imagery显示文摘MODIS time-series imagery is promising for generating regional and global land cover products.For Brazil,however,accurate fractional cropland covers(FCC)information is difficult to obtain due to frequent cloud coverage and the mixing-pixel problem.To address these problems,this study developed an innovative approach to mapping the FCC of the Mato Grosso State,Brazil through integrating Linear Spectral Mixture Analysis(LSMA)and Seasonal Dynamic Index(SDI)models.With MOD13Q1 time-series EVI imagery,a SDI was developed to represent the phenology of croplands.Furthermore,fractional land covers(e.g.,vegetation,soil,and low albedo components)were derived with the LSMA algorithms.A stepwise regression model was established to estimate the FCC at the regional scale.Finally,ground truth cropland cover information was extracted from Landsat TM imagery using a hybrid method.Results indicated that the combination of multiple feature variables produced better results when compared with individual variables.Through cross-validation and comparative analysis,the coefficient of determination(R^(2))between the reference and estimated FCCs reached 0.84 with a Root Mean Square Error(RMSE)of 0.13.This indicates that the proposed method effectively improved the accuracy of fractional cropland mapping.When compared to the traditional per-pixel“hard”classification,the sub-pixel level maps illustrated detailed cropland spatial distribution patterns. | Changming Zhu Xin Zhang Qiaohua Huang | 2019 | International Journal of Agricultural and Biological Engineering2019，12，1： | 1 |
| 16 | Ultrathin covalent organic framework nanosheet-based photoregulated metal-free oxidase-like nanozyme显示文摘The exploration of low-cost and metal-free nanozymes with oxidase-mimicking activity is highly desired due to their attractive properties and potential applications.However,it is still challenging and remains unexploited to fully realize oxidase-like nanozyme in the emerging covalent organic frameworks(COFs)due to their polymeric nature and weak photoelectric activity.We herein report the first example of the preparation and oxidase-mimicking activity of novel ultrathin two-dimensional(2D)COF(termed as TTPA-COF)nanosheets.The ultrathin TTPA-COF nanosheets with hexagonal layered structure are constructed from two flexible photoactive(diarylamino)benzene-based linkers,and exhibit remarkable catalytic activity toward the oxidation of 3,3',5,5'-tetramethylbenzidine(TMB)in the presence of O_(2) due to their large specific surface areas and abundant active sites.Moreover,it is worth noting that the nanozyme activity could be regulated by external light irradiation.Based on the oxidasemimicking activity of TTPA-COF nanosheets,a green colorimetric sensor is proposed for the sensitive and selective determination of glutathione(GSH)in a wide linear range of 0.5–40μM with a detection limit of 0.5μM.This work reported here would open new avenues for the exploration of low-cost and high-efficiency nanozymes,as well as extend the application of 2D COF nanosheets in the fields of catalysis and sensing. | Yongwu Peng Minchu Huang Liangjun Chen Chengtao Gong Nanjun Li Ying Huang Changming Cheng | 2022 | Nano Research2022，15，10： | 1 |
| 17 | Identification of a New Antigen Epitope in the Nuclear Localization Signal Region of Porcine Circovirus Type 2 Capsid Protein显示文摘 | Guo Longjun Lu Yuehua Huang Liping Wei Yanwu Liu Changming | 2011 | EN2011，，3： | 1 |
| 18 | Performance Analysis of Relay Based NOMA Cooperative Transmission under Cognitive Radio Network显示文摘This paper proposes a hybrid spectrum accessing mechanism by using NOMA-based cooperative transmission and beam-forming technology.In this mechanism,the secondary user employs spectrum-sensing technology to detect the existence of the primary user.If the primary user does not exist,the secondary source user directly transmits data to the destination user.If the primary user exists,the secondary source user finds the optimal relay according to certain selection principle before transmitting data to the destination user through the chosen relay node.For the signal receiving stage,the secondary user takes use of beam-forming technology to receive the signal from both the secondary source and the secondary relay node.Meanwhile the interference from the primary user is cancelled out in the stage.Furthermore,the outage probability for secondary user in the proposed mechanism is theoretically derived.Finally,the simulation results show that compared with the traditional mechanism,the proposed system model can not only guarantee the continuity of secondary transmission,but also significantly reduce the outage probability of secondary transmission. | Yinghua Zhang Jian Liu Yunfeng Peng Yanfang Dong Guozhong Sun Hao Huang Changming Zhao | 2020 | Computers, Materials & Continua2020，，4： | 1 |
| 19 | Im- proved volatile fatty acid production during waste activated sludge anaerobic fermentation by different bio-surfactants显示文摘 | HUANG Xiangfeng SHEN Changming LIU Jia | 2015 | Chemical Engineering Journal2015，264，： | 1 |
| 20 | Face feature extraction approach based on LDA & Gabor wave- let invariant moment 显示文摘 | Huang Rongbing Su Changming Lang Fangnian | 2010 | Journal of Computational Infor- mation Systems2010，6，4： | 1 |
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