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| 1 | Molecular evolution and functional divergence of HAK potassium transporter gene family in rice(Oryza sativa L.)显示文摘The high-affinity K+(HAK) transporter gene family is the largest family in plant that functions as potassium transporter and is impor-tant for various aspects of plant life.In the present study,we identified 27 members of this family in rice genome.The phylogenetic tree divided the land plant HAK transporter proteins into 6 distinct groups.Although the main characteristic of this family was established before the origin of seed plants,they also showed some differences between the members of non-seed and seed plants.The HAK genes in rice were found to have expanded in lineage-specific manner after the split of monocots and dicots,and both segmental duplication events and tandem duplication events contributed to the expansion of this family.Functional divergence analysis for this family provided statis-tical evidence for shifted evolutionary rate after gene duplication.Further analysis indicated that both point mutant with positive selection and gene conversion events contributed to the evolution of this family in rice. | Zefeng Yang Qingsong Gao Changsen Sun Wenjuan Li Shiliang Gu Chenwu Xu | 2009 | Journal of Genetics and Genomics2009，36，3： | 21 |
| 2 | PKM2 promotes reductive glutamine metabolism显示文摘Objective:Pyruvate kinases M(PKM),including the PKM1 and PKM2 isoforms,are critical factors in glucose metabolism.PKM2promotes aerobic glycolysis,a phenomenon known as'the Warburg effect'.The purpose of this study was to identify the roles of PKM2 in regulating cellular metabolism.Methods:The CRISPR/Cas9 system was used to generate the PKM-knockout cell model to evaluate the role of PKM in cellular metabolism.Lactate levels were measured by the Vitros LAC slide method on an autoanalyzer and glucose levels were measured by the autoanalyzer AU5800.The metabolism of ^(13)C_6-glucose or ^(13)C_5-glutamine was evaluated by liquid chromatography/mass spectrometry analyses.The effects of PKM on tumor growth were detected in vivo in a tumor-bearing mouse model.Results:We found that both PKM1 and PKM2 enabled aerobic glycolysis,but PKM2 converted glucose to lactate much more efficiently than PKM1.As a result,PKM2 reduced glucose levels reserved for intracellular utilization,particularly for the production of citrate,and thus increased theα-ketoglutarate/citrate ratio to promote the generation of glutamine-derived acetylcoenzyme A through the reductive pathway.Furthermore,reductive glutamine metabolism facilitated cell proliferation under hypoxia conditions,which supports in vivo tumor growth.In addition,PKM-deletion induced a reverse Warburg effect in tumorassociated stromal cells.Conclusions:PKM2 plays a critical role in promoting reductive glutamine metabolism and maintaining proton homeostasis.This study is helpful to increase the understanding of the physiological role of PKM2 in cancer cells. | Miao Liu Yuanyuan Wang Yuxia Ruan Changsen Bai Li Qiu Yanfen Cui Guoguang Ying Binghui Li | 2018 | Cancer Biology & Medicine2018，15，4： | 6 |
| 3 | The effect of environmental factors on spatial variability in land use change in the high-sediment region of China's Loess Plateau显示文摘In areas with topographic heterogeneity, land use change is spatially variable and influenced by climate, soil properties, and topography. To better understand this variability in the high-sediment region of the Loess Plateau in which soil loss is most severe and sediment diameter is larger than in other regions of the plateau, this study builds some indicators to identify the characteristics of land use change and then analyze the spatial variability as it is affected by climate, soil property, and topography. We build two indicators, a land use change intensity index and a vegetation change index, to characterize the intensity of land use change, and the degree of vegetation restoration, respectively. Based on a subsection mean method, the two indicators are then used to assess the spatial variability of land use change affected by climatic, edaphic, and topographic elements. The results indicate that: 1) Land use changed significantly in the period 1998–2010. The total area experiencing land use change was 42,302 km2, accounting for 22.57%of the study area. High-coverage grassland, other woodland, and forest increased significantly, while low-coverage grassland and farmland decreased in 2010 compared with 1998. 2) Land use change occurred primarily west of the Yellow River, between 35 and 38 degrees north latitude. The four transformation types, including(a) low-coverage grassland to medium-coverage grassland,(b) medium-coverage grassland to high-coverage grassland,(c) farmland to other woodland, and(d) farmland to medium-coverage grassland, were the primary types of land use change, together constituting 60% of the area experiencing land use change. 3) The spatial variability of land use change was significantly affected by properties of dryness/wetness, soil conditions and slope gradient. In general, land use changed dramatically in semi-arid regions, remained relativelystable in arid regions, changed significantly in clay-rich soil, remained relatively stable in clay-poor soil, changed dramatically in steeper slopes, and remained relatively stable in tablelands and low-lying regions. The increase in vegetation coincided with increasing changes in land use for each physical element. These findings allow for an evaluation of the effect of the Grain to Green Program, and are applicable to the design of soil and water conservation projects on the Loess Plateau of China. | LUO Ya YANG Shengtian ZHAO Changsen LIU Xiaoyan LIU Changming WU Linna ZHAQ Haigen ZHANG Yichi | 2014 | Journal of Geographical Sciences2014，24，5： | 5 |
| 4 | Comprehensive analysis of changes to catchment slope properties in the high-sediment region of the Loess Plateau, 1978-2010显示文摘To control soil erosion and restore the degraded environment in the Loess Plateau, a large number of measures related to soil and water conservation have been employed that have profoundly affected catchment properties. This study constructed three indicators to characterize changes to the catchment slope, proposed both a method for a regression analysis of adjacent images and a sequence model, and applied multisource remotely sensed images and GIS spatial clustering analysis technologies to extract thematic information and comprehensively analyze the catchment change characteristics. The results indicate that the catchment slope properties changed significantly. At catchment scale, the average values of ARC, DVC and ART were 6.43%, 25.57% and 4.30%, respectively. There were six clustering types of catchment slope property changes. The maximum and minimum of the average similarities of the clustering types were 0.992 and 0.935. Each slope control measures had a distinct effect on catchment slope; the dominating factor of each clustering type was identified as: Type 1: D-VC, Type 2: D-VCLU, Type 3: D-LUVC, Type 4: D-TAVC, Type 5: D-TAC and Type 6: D-MFC. Type 5 and Type 1 covered the largest areas, respectively occupying 37.28% and 31.01%. Catchment slope property changes also had distinct types that depended on their geomorphological conditions. These findings provide a useful basis from which to further study catchment slope hydrological and soil erosion processes. | ZHOU Xu YANG Shengtian LIU Xiaoyan LIU Changming ZHAO Changsen ZHAO Haige ZHOU Qiuwen WANG Zhiwei | 2015 | Journal of Geographical Sciences2015，25，4： | 2 |
| 5 | Pozzolanic activity of burned coal gangue and its effects on structure of cement mortar显示文摘 | Zhang Changsen | 2006 | Journal of Wuhan University of Technology-Mater. Sci. Ed2006，，4： | 1 |
| 6 | Data-driven Probabilistic Static Security Assessment for Power System Operation Using High-order Moments显示文摘In this letter,a new formulation of Lebesgue integration is used to evaluate the probabilistic static security of power system operation with uncertain renewable energy generation.The risk of power flow solutions violating any pre-defined operation security limits is obtained by integrating a semialgebraic set composed of polynomials.With the high-order moments of historical data of renewable energy generation,the integration is reformulated as a generalized moment problem which is then relaxed to a semi-definite program(SDP).Finally,the effectiveness of the proposed method is verified by numerical examples. | Guanzhong Wang Zhiyi Li Feng Zhang Ping Ju Hao Wu Changsen Feng | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，5： | 1 |
| 7 | Two-step catalytic hydrodeoxygenation of fast pyrolysis oil to hydrocarbon liquid fuels显示文摘 | Xu Xingmin Zhang Changsen Liu Yonggang Zhai Yunpu Zhang Ruiqin | 2013 | Chemosphere2013，93，： | 1 |
| 8 | Expression and purification of the first nucleotide-binding domain and linker region of human multidrug resistance gene product:comparison of fusions to glutathione S-transferase,thioredoxin and maltosebinding protein显示文摘 | Wang Changsen Castro A F Wilkes D M | 1999 | Biochemical Journal1999，338，1： | 1 |
| 9 | Mechani- cal performances and microstructures of cement containing copper tailings 显示文摘 | Changsen Zhang Tingting Zhou Qisheng Wu | 2014 | Asian Journal of Chemistry : An Inter- national Quarterly Research Journal of Chemistry2014，26，5： | 1 |
| 10 | Acoustic emission characterization of damage in hybrid fiber-reinforced polymer rods 显示文摘 | Yujin L Changsen S Farhad A | 2004 | J Compos Constr2004，8，1： | 1 |
| 11 | A soil erosion assessment of the upper Mekong River inYunnan Province, China 显示文摘 | Zhou Qiuwen Yang Shengtian Zhao Changsen | 2014 | Mountain Research andDevelopment2014，34，1： | 1 |
| 12 | Fe-MCM-41 from Coal-Series Kaolin as Catalysts for the Selective Catalytic Reduction of NO with Ammonia显示文摘 | Shuiping Li Qisheng Wu Guosen Lu Changsen Zhang Xueran Liu Chong Cui Zhiye Yan | 2013 | Journal of Materials Engineering and Performance2013，，12： | 1 |
| 13 | A monotone operator function via Furuta-type inequality with negative powers显示文摘 | Y Changsen Z Hongliang | 2003 | Math Inequal Appl2003，，2： | 1 |
| 14 | On a new geometric constant related to the von Neumann-Jordan constants显示文摘 | Changsen Y Fenghui W | 2006 | J Math Anal Appl2006，324，： | 1 |
| 15 | Theoretical and experimental investigations into crack detection with BOTDA distributed fiber pptic sensors 显示文摘 | Feng Xin Zhou Jing Sun Changsen | 2013 | Journal of Engineering Mechanics2013，139，12： | 1 |
| 16 | Bench- scale fluidized-bed fast pyrolysis of peanut shell for bio-oil production显示文摘 | Changsen Zhang Ruiqin Zhang Xipeng Li | 2011 | Environmental Progress & Sustainable Energy2011，30，1： | 1 |
| 17 | A characterizations of chaotic order显示文摘 | Yang Changsen Gao Fugen | 2006 | J Inequal Appl2006，11，： | 1 |
| 18 | On the strong extreme points of P0( ) 显示文摘 | Yang changsen | 2001 | Scientism Mathematical Japonica2001，54，2： | 1 |
| 19 | Effect of vibration extrusion on high-density polyethylene 显示文摘 | Gao Xueqin Zhang Jie Chen Changsen | 2007 | J Appl Polym Sci2007，106，： | 1 |
| 20 | Heteromerization of TRP channel subunits: extending functional diversity显示文摘Transient receptor potential(TRP)channels are widely found throughout the animal kingdom.By serving as cellular sensors for a wide spectrum of physical and chemical stimuli,they play crucial physiological roles ranging from sensory transduction to cell cycle modulation.TRP channels are tetrameric protein complexes.While most TRP subunits can form functional homomeric channels,heteromerization of TRP channel subunits of either the same subfamily or different subfamilies has been widely observed.Heteromeric TRP channels exhibit many novel properties compared to their homomeric counterparts,indicating that co-assembly of TRP channel subunits has an important contribution to the diversity of TRP channel functions. | Wei Cheng Changsen Sun Jie Zheng | 2010 | Protein & Cell2010，1，9： | 1 |
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