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| 1 | Solid state fermentation of rapeseed cake with Aspergillus niger for degrading glucosinolates and upgrading nutritional value显示文摘Background:Rapeseed cake is a good source of protein for animal feed but its utilization is limited due to the presence of anti-nutritional substances,such as glucosinolates(GIs),phytic acid,tannins etc.In the present study,a solid state fermentation(SSF) using Aspergillus niger was carried out with the purpose of degrading glucosinolates and improving the nutritional quality of rapeseed cake(RSC).The effects of medium composition and incubation conditions on the GIs content in fermented rapeseed cake(FRSC) were investigated,and chemical composition and amino acid in vitro digestibility of RSC substrate fermented under optimal conditions were determined.Results:After 72 h of incubation at 34℃,a 76.89%decrease in GIs of RSC was obtained in solid medium containing 70%RSC,30%wheat bran at optimal moisture content 60%(w/w).Compared to unfermented RSC,trichloroacetic acid soluble protein(TCA-SP),crude protein and ether extract contents of the FRSC were increased(P< 0.05) 103.71,23.02 and 23.54%,respectively.As expected,the contents of NDF and phytic acid declined(P< 0.05) by 9.12 and 44.60%,respectively.Total amino acids(TAA) and essential amino acids(EAA) contents as well as AA in vitro digestibility of FRSC were improved significantly(P< 0.05).Moreover,the enzyme activity of endoglucanase,xylanase,acid protease and phytase were increased(P<0.05) during SSF.Conclusions:Our results indicate that the solid state fermentation offers an effective approach to improving the quality of proteins sources such as rapeseed cake. | Changyou Shi Jun He Jie Yu Bing Yu Zhiqing Huang Xiangbing Mao Ping Zheng Daiwen Chen | 2015 | Journal of Animal Science and Biotechnology2015，6，3： | 32 |
| 2 | Doxorubicin-conjugated pH-responsive gold nanorods for combined photothermal therapy and chemotherapy of cancer显示文摘Cancer chemotherapy can be hindered by drug resistance which leads to lower drug efficiency.Here,we have developed a drug delivery system that tethers doxorubicin to the surface of gold nanorods via a pHsensitive linkage(AuNRs@DOX),for a combined photothermal and chemical therapy for cancer.First,AuNRs@DOX is ingested by HepG2 liver cancer cells.After endocytosis,the acidic pH triggers the release of doxorubicin,which leads to chemotherapeutic effects.The gold nanorods are not only carriers of DOX,but also photothermal conversion agents.In the presence of an 808 nm near-infrared laser,AuNRs@DOX significantly enhance the cytotoxicity of doxorubicin via the photothermal effect,which induces elevated apoptosis of hepG2 cancer cells,leading to better therapeutic effects in vitro and in vivo. | Jin Chen Xiao Li Xinlian Zhao QianQian Wu Huihui Zhu Zhengwei Mao Changyou Gao | 2018 | Bioactive Materials2018，3，3： | 5 |
| 3 | A High-Performance Hierarchical Snapshot Scheme for Hybrid Storage Systems显示文摘With the increased snapshot operations(creation or deletion), the performance of storage system will degrade severely whether in Copy on write(COW)or Redirect on write(ROW). This paper presents a novel snapshot scheme which could use of storage resources effectively and keep the historical data accurately for SSDHDD-hybrid storage system. SSD(source volume) stores all the active data and executes read/write operations without responding to snapshot operations. In contrast,HDDs(snapshot volume) store the writing data sequentially in the form of logs and are responsible for backup and snapshot operations. In this way, the hybrid storage system can get the high throughput power via SSD even the snapshot functions are active and HDDs can keep pace with the high Input/Output operations per second(IOPS)capability of the SSD. Logs are combined and kept in a separate image volume by the controller. So, fine-grained Recovery point objective(RPO) and good Recovery time objective(RTO) can be achieved. Experiment results show that the prototype can achieve excellent I/O performance while snapshot operations are active and consume a few extra storage space. | YU Xiao TAN Yu'an ZHANG Changyou LIANG Chen Khaled AOURRA ZHENG Jun ZHANG Quanxin | 2018 | Chinese Journal of Electronics2018，27，1： | 5 |
| 4 | Data-driven Transient Stability Assessment Based on Kernel Regression and Distance Metric Learning显示文摘Transient stability assessment(TSA) is of great importance in power systems. For a given contingency, one of the most widely-used transient stability indices is the critical clearing time(CCT), which is a function of the pre-fault power flow.TSA can be regarded as the fitting of this function with the prefault power flow as the input and the CCT as the output. In this paper, a data-driven TSA model is proposed to estimate the CCT. The model is based on Mahalanobis-kernel regression,which employs the Mahalanobis distance in the kernel regression method to formulate a better regressor. A distance metric learning approach is developed to determine the problem-specific distance for TSA, which describes the dissimilarity between two power flow scenarios. The proposed model is more accurate compared to other data-driven methods, and its accuracy can be further improved by supplementing more training samples.Moreover, the model provides the probability density function of the CCT, and different estimations of CCT at different conservativeness levels. Test results verify the validity and the merits of the method. | Xianzhuang Liu Yong Min Lei Chen Xiaohua Zhang Changyou Feng | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，1： | 4 |
| 5 | SDICN: A Software Defined Deployable Framework of Information Centric Networking显示文摘the Information-Centric Networking(ICN) paradigm is proved to have the advantages of decreasing data delivery latency, enhancing user mobility, etc. However, current implementations of ICN require changing the infrastructure of Internet, which hinders its deployment and development. Meanwhile, Software Defined Networking(SDN) emerges as a viable solution to facilitate the deployment of new network paradigm without disrupting production traffic by decoupling the control plane from data forwarding plane. In this paper, the essential properties which reflect ICN working principles are summarized, and a framework called SDICN is designed in accordance to the SDN philosophy. The algorithmic frameworks of SDICN which can satisfy the essential properties are designed based on the programmability and virtualization functions of SDN. Based on Open Flow and data center technology, a prototype of SDICN is implemented. By comparing the performance with the CCNx, the SDICN is proved to be feasibility and availability. | WANG Xiulei CHEN Ming HU Chao WENG Xi XING Changyou | 2016 | China Communications2016，13，3： | 4 |
| 6 | A convergence analysis for a class of practical variance-reduction stochastic gradient MCMC显示文摘Stochastic gradient Markov chain Monte Carlo(SG-MCMC) has been developed as a flexible family of scalable Bayesian sampling algorithms. However, there has been little theoretical analysis of the impact of minibatch size to the algorithm's convergence rate. In this paper, we prove that at the beginning of an SG-MCMC algorithm, i.e., under limited computational budget/time, a larger minibatch size leads to a faster decrease of the mean squared error bound. The reason for this is due to the prominent noise in small minibatches when calculating stochastic gradients, motivating the necessity of variance reduction in SG-MCMC for practical use. By borrowing ideas from stochastic optimization, we propose a simple and practical variance-reduction technique for SG-MCMC, that is efficient in both computation and storage.More importantly, we develop the theory to prove that our algorithm induces a faster convergence rate than standard SG-MCMC. A number of large-scale experiments, ranging from Bayesian learning of logistic regression to deep neural networks, validate the theory and demonstrate the superiority of the proposed variance-reduction SG-MCMC framework. | Changyou CHEN Wenlin WANG Yizhe ZHANG Qinliang SU Lawrence CARIN | 2019 | Science China(Information Sciences)2019，62，1： | 3 |
| 7 | Biomedical polymers: synthesis, properties, and applications显示文摘Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation. | Wei-Hai Chen Qi-Wen Chen Qian Chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao Chengqiang Tang Jinqiang Wang Lei Wang Meng-Hua Xiong Lichen Yin Kuo Zhang Zhanzhan Zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He Jian Ji Xiqun Jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei Sun Hao Wang Jun Wang Haihua Xiao Fu-Jian Xu Zhiyuan Zhong Xian-Zheng Zhang Xuesi Chen | 2022 | Science China Chemistry2022，65，6： | 2 |
| 8 | Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients显示文摘 | Jing-Ping Zhang Jing Yan Jing Xu Xiong-Hao Pang Min-Shan Chen Li Li Changyou Wu Sheng-Ping Li Limin Zheng | 2009 | Journal of Hepatology2009，，5： | 2 |
| 9 | A Pragmatic Method to Determine Transient Stability Constrained with Interface Real Power Flow Limits via Power System Scenario Similarity显示文摘In practical power systems,operators generally keep interface flowing under the transient stability constrained with interface real power flow limits(TS-IRPFL)to guarantee transient stability of the system.Many methods of computing TS-IRPFL have been proposed.However,in practice,the method widely used to determine TS-IRPFL is based on selection and analysis of typical scenarios as well as scenario matching.First,typical scenarios are selected and analyzed to obtain accurate limits,then the scenario to be analyzed is matched with a certain typical scenario,whose limit is adopted as the forecast limit.In this paper,following the steps described above,a pragmatic method to determine TS-IRPFL is proposed.The proposed method utilizes data-driven tools to improve the steps of scenario selection and matching.First of all,we formulate a clear model of power system scenario similarity.Based on the similarity model,we develop a typical scenario selector by clustering and a scenario matcher by nearest neighbor algorithm.The proposed method is pragmatic because it does not change the existing procedure.Moreover,it is much more reasonable than the traditional method.Test results verify the validity of the method. | Xianzhuang Liu Yong Min Lei Chen Xiaohua Zhang Changyou Feng Wei Hu | 2020 | CSEE Journal of Power and Energy Systems2020，6，1： | 1 |
| 10 | Preparation and cellular uptake of PLGA particles loaded with lamivudine显示文摘Poly (D, L-lactide-co-glycolide )(PLGA ) nanoparticles 与 lamivudine 装载了并且与牛的浆液白朊(BSA ) 涂经由一个双乳剂方法被准备。象内部水的阶段,器官的阶段的集中和粒子尺寸和药陷阱效率上的 ultrasonication 时间的体积那样的实验参数的影响被调查,获得有 260 nm 的一条直径和 35% 的药陷阱效率的 PLGA 粒子。粒子被扫描电子显微镜学和发射度电子显微镜学观察,显示出核心壳结构。发现那 58 mg BSA 的 BCA 试金在 1 个 g LPB 粒子上 / 在是在场的。装载 lamivudine 在开始显示出一个爆炸版本并且处于生理的条件支撑了版本直到 24 h。低 pH 能从 PLGA 粒子加速 lamivudine 的版本,使 PLGA 粒子成为潜在的聪明的细胞内部的药搬运人。PLGA 粒子乐意地在一短时间以内被使内在化进人的肝房间并且不管装载 lamivudine 与孵化时间的延伸逐渐地增加了。粒子任何一个在 lysosomes 以内住了或转了到细胞质,但是不能进入房间原子核。房间生存能力显著地没不管 lamivudine 封装面对粒子被影响,建议这种粒子可以是细胞内部的反肝炎 B 药交货的一个好候选人。 | WANG Bing CHEN GuanQun MAO ZhengWei ZHANG YuYing YU DaHai GAO ChangYou | 2012 | Chinese Science Bulletin2012，57，31： | 1 |
| 11 | Analysis on Input Ripple Current Characteristics of Aviation StaticInverters显示文摘 | CHEN Zhong WANG Changyou CHEN Miao | 2012 | 中国电机工程学报2012，32，27： | 1 |
| 12 | IL-23 promotes CD4 + T cells to produce IL-17 in Vogt-Koyanagi-Harada disease显示文摘 | Wei Chi Peizeng Yang Bing Li Changyou Wu Haoli Jin Xuefei Zhu Lina Chen Hongyan Zhou Xiangkun Huang Aize Kijlstra | 2007 | The Journal of Allergy and Clinical Immunology2007，，5： | 1 |
| 13 | The moisture distribution of high moisture content rough rice during harvesting storage and drying显示文摘 | Li Changyou Liu Jiangtao Chen Lina | 2003 | Drying Technology2003，21，6： | 1 |
| 14 | Self-Organizing Mechanism for Cloud Services and Performance Analysis显示文摘To improve the performance and robustness in service discovery, a self-organizing mechanism for service alliances of Service Providers (SPs) is proposed in this paper. According to the similarity of service content, an SP publishes its services in a partition of SPs to construct connections between highly similar SPs. These SPs constitute a self-organized distributed environment. A self-organizing protocol is designed to ensure the correctness of the construction of the alliances. The protocol consists of four stages - initiating stage, developing stage, developed stage and degradation stage. The experimental results demonstrate that this protocol ensures the self-property. The visualization of alliance developing stages illustrates that sub-alliances are sp lit in balance and self-connected. Compared with the Random Walker algorithm, the time cost and the number of forwarded messages in alliance-based mechanism is lower in service discovery. On three typical topologies (Grid, Random-Graph, Power-Law), the success rate of service discovery is much higher, which shows that self-organized alliances are helpful to enhance the discovery performance. | Zhang Changyou Shao Lixiang Li Wenqing Li Hangtong Chen Sicong | 2012 | China Communications2012，9，6： | 1 |
| 15 | Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients显示文摘 | Jing-Ping Zhang Jing Yan Jing Xu Xiong-Hao Pang Min-Shan Chen Li Li Changyou Wu Sheng-Ping Li Limin Zheng | 2009 | Journal of Hepatology2009，，5： | 1 |
| 16 | The moisture distribution of high moisture content rough rice during harvesting, storage, and drying显示文摘 | Li Changyou Liu Jiangtao Chen Lina | 2003 | Drying Technology2003，21，6： | 1 |
| 17 | In?vitro and in?vivo biological performance of collagen-chitosan/silicone membrane bilayer dermal equivalent显示文摘 | Lie Ma Yanchao Shi Yixin Chen Haiguang Zhao Changyou Gao Chunmao Han | 2007 | Journal of Materials Science: Materials in Medicine2007，，11： | 1 |
| 18 | Energy-Aware GPU Programming at Source-Code Levels显示文摘To enhance the energy efficiency and performance of algorithms with Graphics Processing Unit (GPU) accelerators in source-code development, we consider the power efficiency based on data transfer bandwidth and power consumption in key situations. First, a set of primitives is abstracted from program statements. Then, data transfer bandwidth and power consumption in different granularity sizes are considered and mapped into proper primitives. With these mappings, a programmer can intuitively determine the power efficiency and performance in different running states of a thread. Finally, this intuition enables the programmer to tune the algorithm in order to achieve the best energy efficiency and performance. Using these power-aware principles, two Fast Fourier Transform (FFT) methods are compared. The mapping between power consumption and primitives is helpful for algorithm tuning in source-code levels. | Changyou Zhang Kun Huang Xiang Cui Yifeng Chen | 2012 | Tsinghua Science and Technology2012，17，3： | 1 |
| 19 | Preface显示文摘Biomaterials have attracted massive attention for healthcare and biomedical applications such as diagnosis,prevention,therapy and tissue regeneration.In particular,the polymeric biomaterials have become one of the most attractive and influential research topics.They have various applications for biosensor,imaging,targeting,drug delivery, | GAO ChangYou CHEN GuoPing | 2014 | Science China Chemistry2014，57，4： | 1 |
| 20 | Distance approximat- ing dimension reduction of riemannian manifolds显示文摘 | Fleischer R Chen Changyou Zhang Junping | 2009 | IEEE Trans on Systems Man and Cybernetics Part B: Cybernetics2009，40，1： | 1 |
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