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| 1 | Deep sedation during gastrointestinal endoscopy: Propofol-fentanyl and midazolam-fentanyl regimens显示文摘AIM: To compare deep sedation with propofol-fentanyl and midazolam-fentanyl regimens during upper gastrointestinal endoscopy. METHODS: After obtaining approval of the research ethics committee and informed consent, 200 patients were evaluated and referred for upper gastrointestinal endoscopy. Patients were randomized to receive propofol-fentanyl or midazolam-fentanyl (n = 100/group).We assessed the level of sedation using the observer's assessment of alertness/sedation (OAA/S) score and bispectral index (BIS). We evaluated patient and physician satisfaction, as well as the recovery time and complication rates. The statistical analysis was performed using SPSS statistical software and included the MannWhitney test, χ 2 test, measurement of analysis of variance, and the κ statistic. RESULTS: The times to induction of sedation, recovery, and discharge were shorter in the propofolfentanyl group than the midazolam-fentanyl group. According to the OAA/S score, deep sedation events occurred in 25% of the propofol-fentanyl group and 11% of the midazolam-fentanyl group (P = 0.014). Additionally, deep sedation events occurred in 19% of the propofol-fentanyl group and 7% of the midazolamfentanyl group according to the BIS scale (P = 0.039). There was good concordance between the OAA/S score and BIS for both groups (κ = 0.71 and κ = 0.63, respectively). Oxygen supplementation was required in 42% of the propofol-fentanyl group and 26% of the midazolam-fentanyl group (P = 0.025). The mean time to recovery was 28.82 and 44.13 min in the propofolfentanyl and midazolam-fentanyl groups, respectively (P < 0.001). There were no severe complications in either group. Although patients were equally satisfied with both drug combinations, physicians were more satisfied with the propofol-fentanyl combination. CONCLUSION: Deep sedation occurred with propofolfentanyl and midazolam-fentanyl, but was more frequent in the former. Recovery was faster in the propofol-fentanyl group. | Marcos Eduardo Lera dos Santos Fauze Maluf-Filho Dalton Marques Chaves Sergio Eiji Matuguma Edson Ide Gustavo de Oliveira Luz Thiago Ferreira de Souza Fernanda C Simoes Pessorrusso Eduardo Guimares Hourneaux de Moura Paulo Sakai | 2013 | World Journal of Gastroenterology2013，19，22： | 16 |
| 2 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 3 | Treatment of high-grade dysplasia and intramucosal carcinoma using radiofrequency ablation or endoscopic mucosal resection + radiofrequency ablation: Meta-analysis and systematic review显示文摘BACKGROUND The progression of Barrett's esophagus(BE) to early esophageal carcinoma occurs sequentially; the metaplastic epithelium develops from a low-grade dysplasia to a high-grade dysplasia(HGD), resulting in early esophageal carcinoma and,eventually, invasive carcinoma. Endoscopic approaches including resection and ablation can be used in the treatment of this condition.AIM To compare the effectiveness of radiofrequency ablation(RFA) vs endoscopic mucosal resection(EMR) + RFA in the endoscopic treatment of HGD and intramucosal carcinoma.METHODS In accordance with PRISMA guidelines, this systematic review included studies comparing the two endoscopic techniques(EMR + RFA and RFA alone) in the treatment of HGD and intramucosal carcinoma in patients with BE. Our analysis included studies involving adult patients of any age with BE with HGD or intramucosal carcinoma. The studies compared RFA and EMR + RFA methods were included regardless of randomization status.RESULTS The seven studies included in this review represent a total of 1950 patients, with742 in the EMR + RFA group and 1208 in the RFA alone group. The use of EMR +RFA was significantly more effective in the treatment of HGD [RD 0.35(0.15,0.56)] than was the use of RFA alone. The evaluated complications(stenosis,bleeding, and thoracic pain) were not significantly different between the two groups.CONCLUSION Endoscopic resection in combination with RFA is a safe and effective method in the treatment of HGD and intramucosal carcinoma, with higher rates of remission and no significant differences in complication rates when compared to the use of RFA alone. | Mileine Valente de Matos Alberto Machado da Ponte-Neto Diogo Turiani Hourneaux de Moura Ethan Dwane Maahs Dalton Marques Chaves Elisa Ryoka Baba Edson Ide Rubens Sallum Wanderley Marques Bernardo Eduardo Guimar?es Hourneaux de Moura | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，3： | 2 |
| 4 | Effectiveness of implant surface decontamination using a highpressure sodium bicarbonate protocol:an in vitro study显示文摘 | Nemer Vieira LF Lopes de Chaves e Mello Dias EC Cardoso ES | 2012 | Implant Dent2012，21，5： | 1 |
| 5 | Endoscopic Detection of Early Esophageal Squamous Cell Carcinoma in Patients with Achalasia: Narrow-Band Imaging versus Lugol’s Staining显示文摘 | Edson Ide Fred Olavo Arag?o Andrade Carneiro Mariana Souza Varella Fraz?o Dalton Marques Chaves Rubens Ant?nio Aissar Sallum Eduardo Guimar?es Hourneaux de Moura Paulo Sakai Ivan Cecconello Fauze Maluf-Filho Everson L. A. Artifon | 2013 | Journal of Oncology2013，，： | 1 |
| 6 | Simultaneous determination of Ca, P, Mg, K and Na in biodiesel by axial view inductively coupled plasma optical emission spectrometry with internal standardization after multivariate optimization显示文摘 | Dos Santos EJ Herrmann AB Chaves ES | 2007 | Journal of Analytical Atomic Spectrometry2007，22，10： | 1 |
| 7 | Persistent bacterial colonization of Porphyromonas gingivalis 显示文摘 | Chaves ES Jeffcoat MK Ryerson CC | 2000 | J Clin Periodontal2000，27，： | 1 |
| 8 | Effects of a bisphosphonate on experimental periodontitis in monkeys 显示文摘 | Brunsvold MA Chaves ES Kornman KS | 1992 | J Periodontol1992，63，10： | 1 |
| 9 | Effects of a bisphosphonate on experimental periodontitis in monkeys显示文摘 | Brunsvold MA Chaves ES Kornman KS | 1992 | J Periodontol1992，63，10： | 1 |
| 10 | Genetic diversity, antimicrobial resistance and toxigentic profiles of Bacillus cereus isotlated from food in Brazil over three decades显示文摘 | Chaves JQ Pires ES Vivoni AM | 2011 | Int J Food microbiol2011，147，1： | 1 |
| 11 | MyD88 or TRAM knockdown regulates interleukin(IL)-6,IL-8,and CXCL12 mRNA expression in human gingival and periodontal ligament fibroblasts显示文摘 | Morandini AC Chaves Souza PP Ramos-Junior ES | 2013 | J Periodontol2013，84，9： | 1 |
| 12 | Effects of a bisphosphonate on experimental periodontitis in monkeys 显示文摘 | Brunsvold AM Chaves ES Wornman KS | 1992 | J Perionont1992，63，： | 1 |
| 13 | Short chain fatty acids are effective in short-term treatment of chronic radiation proctitis显示文摘 | Anabela Pinto M.D. Paulo Fidalgo M.D. Marília Cravo M.D. Ph.D. Jaime Mid?es M.D. Paula Chaves M.D. Joaninha Rosa M.D. Maria dos Anjos Birto M.D. Carlos Nobre Leit?o M.D. Ph.D | 1999 | Diseases of the Colon & Rectum1999，，6： | 1 |
| 14 | Genetic diversity, antimicrobial resistance and toxigenic profiles of Bacillus cereus isolated from food in Brazil over three deeades显示文摘 | Chaves JQ Pires ES Vivoni AM | 2011 | Int J Food Mierobiol2011，147，1： | 1 |
| 15 | Relationship of ' bleeding on probing' and 'gingival index bleeding ' as clini- cal parameters of gingival inflammation 显示文摘 | Chaves ES Wood RC Jones AA | 1993 | J Clin Periodon- tol1993，20，： | 1 |
| 16 | Hyperbaric oxygen therapy protects the liver from apoptosis caused by ischemia reperfusion injury in rats显示文摘 | Chaves JC Fagundes DJ Sim(o)es Mde J | 2009 | Microsurgery2009，29，7： | 1 |
| 17 | Interacting molecular loops in the mammalian circadian clock显示文摘 | Shearman LP Sriram S Weaver DR Maywood ES Chaves I Zheng BH Kume K Lee CC van der Horst GTJ Hastings MH Reppert SM | | 0，，5468： | 1 |
| 18 | Toll-like receptor 2 knockdown modulates interleukin(IL)-6 and IL-8 but not stromal derived factor-1(SDF-1/CXCL12)in human periodontal ligament and gingival fibroblasts显示文摘 | Morandini AC Chaves Souza PP Ramos-Junior ES | 2013 | J Periodontol2013，84，4： | 1 |
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