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| 1 | Exploring an Integrative Therapy for Treating COVID-19:A Randomized Controlled Trial显示文摘Objectives:To develop a new Chinese medicine(CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome(ARDS)in COVID-19 patients.Methods:A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized,controlled two-arm trial.The two arms of the trial consist of a control therapy(alpha interferon inhalation,50(x g twice daily;and lopinavir/ritonavir,400 and 100 mg twice daily,respectively)and a testing therapy(control therapy plus Keguan-119.4 g twice daily)by random number table at 1:1 ratio with 24 cases each group.After 2-week treatment,adverse events,time to fever resolution,ARDS development,and lung injury on newly diagnosed COVID-19 patients were assessed.Results:An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events.Based on this result,the study was expanded to include a total of 48 participants(24 cases each arm).The results show that compared with the control arm,the testing arm exhibited a significant improvement in time to fever resolution(P=0.035),and a significant reduction in the development of ARDS(P=0.048).Conclusions:Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients.(Trial registration No.NCT 04251871 at www.clinicaltrials.gov). | WANG Jia-bo WANG Zhong-xia JING Jing ZHAO Peng DONG Jing-hui ZHOU Yong-feng YANG Guang NIU Ming ZHAO Xu JIANG Tian-jun Bl Jing-feng XU Zhe ZHANG Ping WU Dan BAI Zhao-fang GUO Yu-ming YU Si-miao SUN Yong-qiang ZHANG Zi-teng ZHAN Xiao-yan LI Peng-yan DING Jin-biao ZHAO Peng-fei SONG Xue-ai TANG Jian-yuan HE Dong-chu CHEN Zhu QIN En-qiang WANG Rui-lin XIAO Xiao-he | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 18 |
| 2 | Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis.显示文摘 | Zhang J Liu Q Chen Q Liu NQ Li FL Lu ZB Qin C Zhu H Huang YY He W Zhao BL | 2006 | 中国生物学文摘2006，20，9： | 17 |
| 3 | 脑卒中后认知运动干预对步态和平衡影响显示文摘当认知和运动任务同时完成时,会发生认知运动干预(CMI)。该技术已用于运动医学康复来增强疗效。本综述和荟萃分析研究了在脑卒中患者中,CMI用于改善步态和平衡的疗效。本文检索了多个数据库,筛选出了发表于1972年到2014年间的随机对照试验——包括成年脑卒中患者CMI治疗组和对照组。主要评价指标为步态和平衡评定,次要评价指标为日常生活能力以及功能独立性评定。 | Wang XQ Pi YL Chen BL 吴毅 | 2015 | 中国康复2015，30，5： | 13 |
| 4 | Jiaotai Pill (交泰丸) Alleviates Insomnia through Regulating Monoamine and Organic Cation Transporters in Rats显示文摘Objective To reveal the effect and mechanism of Jiaotai Pill(交泰丸,JTP)on insomniac rats.Methods The insomniac model was established by intraperitoneal injection of p-chlorophenylalanine(PCPA).In behavioral experiments,rats were divided into control,insomniac model,JTP[3.3 g/(kg•d)],and diazepam[4 mg/(kg•d)]groups.The treatment effect of JTP was evaluated by weight measurement(increasement of body weight),open field test(number of crossings)and forced swimming test(immobility time).A high performance liquid chromatography-electrochemical detection(HPLC-ECD)method was built to determine the concentration of monoamine transmitters in hypothalamus and peripheral organs from normal,model,JTP,citalopram[30 mg/(kg•d)],maprotiline[40 mg/(kg•d)]and bupropion[40 mg/(kg•d)]groups.Expressions of serotonin transporter(SERT),dopamine transporter(DAT),and norepinephrine transporter(NET)were analyzed by quantitative polymerase chain reaction(qPCR)and Western blot in normal,model and JTP groups.A high performance liquid chromatography-electrospray ionization mass spectrometry(HPLC-ESI-MS/MS)method was established to determine the pharmacokinetics,urine cumulative excretion of metformin in vivo,and tissue slice uptake in vitro,which were applied to assess the activity of organic cation transporters(OCTs)in hypothalamus and peripheral organs.Results Compared with the insomniac model group,the body weight and spontaneous locomotor were increased,and the immobility time was decreased after treatment with JTP(P<0.01).Both serotonin and dopamine contents in hypothalamus and peripheral organs were increased(P<0.01).The norepinephrine content was increased in peripheral organs and decreased in hypothalamus(P<0.05 or P<0.01).At the same time,SERT,DAT,OCT1,OCT2,and OCT3 were down-regulated in hypothalamus and peripheral organs(P<0.05).NET was down-regulated in peripheral organs and up-regulated in hypothalamus(P<0.05 or P<0.01).Moreover,the activity of OCTs in hypothalamus and peripheral organs was inhibited(P<0.05).Conclusion JTP alleviates insomnia through regulation of monoaminergic system and OCTs in hypothalamus and peripheral organs. | LI Zhi-hui MA Peng-kai HUANG Yun-fang ZHANG Zhe ZHENG Wei CHEN Jian-hua GUO Chang-e CHEN Ning Bl Xin-ning ZHANG Yu-jie | 2021 | Chinese Journal of Integrative Medicine2021，27，3： | 3 |
| 5 | IL-1 receptor-associated kinase and low molecular weight GTPase RhoA signal molecules are required for bacterial lipopolysaccharide-induced cytokine gene transcription显示文摘 | Chen LY Zuraw BL Liu FT | 2002 | J Immunol2002，169，7： | 1 |
| 6 | Quantitative analysis of the effect of the mutation frequency on the affinity maturation of single chain Fv antibodles显示文摘 | Daugherty PS Chen G Iverson BL | 2000 | Proc Natl Acad Sci U S A2000，97，5： | 1 |
| 7 | Internet use,abuse,and dependence among students at a southeastern regional university显示文摘 | Fortson BL Scotti JR Chen YC | | 0，，02： | 1 |
| 8 | The electrophysiological effects of alcoholized rhubarb solution in feline heart in vivo显示文摘 | Jin BL Xie LH Chen DC | 1993 | Methods Find Exp Clin Pharmacol1993，15，1： | 1 |
| 9 | RhoA regulates dendrite branching in hippocampal neurons by decreasing cypin protein levels显示文摘 | Chen H Firestein BL | 2007 | J Neurosci2007，27，31： | 1 |
| 10 | Preparation andcharacteriza- tion of nanocrystal grain TiO2 porous microsphere显示文摘 | Zhang BL Chen BS Shi KY etc | 2003 | Applied Ca- talysisB : Enviromental2003，40，： | 1 |
| 11 | Mechanistic investigations of horseradish peroxidase-catalyzed degradation of single-walled carbon nanotubes显示文摘 | Allen BL Kotchey GP Chen YN | | 0，，： | 1 |
| 12 | Salicylate-induced peripheral auditory changes and tonotopic reorganization of au- ditory eortex显示文摘 | Stolzberg D Chen GD Allman BL | 2011 | Neuroseience2011，180，： | 1 |
| 13 | ent-Kaurene Diterpenoids from Isodon rubescens显示文摘 | Li BL Chen SN Shi ZX | 2000 | Phytochemistry2000，，： | 1 |
| 14 | Inhibition of multi-drug resistance of ovarian carcinoma by small interfering RNA targeting to MRP2 gene 显示文摘 | Ma JJ Chen BL Xin XY | 2009 | Arch Gynecol Obstet2009，279，2： | 1 |
| 15 | Systematic back muscle exercise after percutaneous vertebroplasty for spinal osteoporotic compression fracture patients:a randomized controlled trial显示文摘 | Chen BL Zhong Y Huang YL | | 0，，06： | 1 |
| 16 | Defective functions of circulating CD4+CD25+ and CD4+CD25-T cells in patients with chronic ordinary urticaria显示文摘 | Chen WC Chiang BL Liu HE | | 0，，02： | 1 |
| 17 | Fenofibrate decreases asymmetric dlmethylarginine level in cultured endothelial cells by inhibiting NF-kappaB activity 显示文摘 | Yang TL Chen MF Luo BL | 2005 | Naunyn Schmiedeberg''s Arch Pharmacol2005，371，5： | 1 |
| 18 | Contrasting post-traumatic serial changes for D-Di mer and PAl-1 in critically injured patients显示文摘 | Chen JP Rowe D W Enderson BL | 1999 | Thromb Res1999，94，： | 1 |
| 19 | A syndrome of altered cardiovascular,craniofacial,neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2显示文摘 | Loeys BL Chen J Neptune ER | 2005 | Nat Genet2005，37，： | 1 |
| 20 | Adjacent segment degener- ation after single-segment PLIF: the risk factor for degeneration and its impact on clinical outcomes 显示文摘 | Chen BL Wei FX Ueyama K | 2011 | Eur Spine J2011，20，11： | 1 |
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