|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 急性ST段抬高型心肌梗死行急诊经皮冠状动脉介入治疗的二联和三联抗血小板治疗比较显示文摘在药物洗脱支架(DES)时代,对于急诊经皮冠状动脉介入治疗(PCI)的急性ST段抬高型心肌梗死(STEMI)患者,三联抗血小板治疗优于还是相同于二联抗血小板治疗?结论仍不明确。 | Chen KY Rha SW Li YJ 刘兵 | 2009 | 中国心血管杂志2009，14，5： | 23 |
| 2 | 半边旗提取物5F对非小细胞肺癌NCI-H460细胞生长的抑制作用显示文摘目的研究半边旗提取物5F对非小细胞肺癌NCI-H460细胞生长的抑制作用。方法MTT法检测5F对NCI-H460细胞的生长抑制作用;用PI-Hoechst荧光双染法和TUNEL法检测细胞凋亡;流式细胞仪检测5F对DNA含量的影响。结果5F抑制NCI-H460细胞的生长,其效果与5F的浓度和作用时间相关,24、48、72h的IC50分别为:21.40、4.52、1.02μg/ml;荧光双染色法显示经5F作用后细胞出现变形,染色质浓缩,产生凋亡小体;细胞被阻滞在G2/M期。结论5F在体外能有效地抑制NCI-H460细胞的生长,其作用可能是通过诱导其凋亡产生的。 | 刘义 吴科锋 李立 George G CHEN Michael KY HSIN Malcolm J UNDERWOOD 梁念慈 | 2009 | 肿瘤防治研究2009，36，1： | 9 |
| 3 | Copper transportion of WD protein in hepatocytes from Wilson disease patients in vitro显示文摘AIM: To study the effect of copper transporting P-type ATPase in copper metabolism of hepatocyte and pathogenesis of Wilson disease (WD).METHODS: WD copper transporting properties in some organelles of the cultured hepatocytes were studied from WD patients and normal controls. These cultured hepatocytes were incubated in the media of copper 15mg.L-1 only, copper 15 mg. L-1 with vincristine (agonist of P-type ArPase) 0.5mg. L-1, or copper 15 mg. L-1 withvanadate (antagonist of P-type ATPase) 18.39 mg. L-1separately. Microsome (endoplasmic reticulum and Golgi apparatus), lysosome, mitochondria, and cytosol were isolated by differential centrifugation. Copper contents in these organelles were measured with atomic absorption spectrophotometer, and the influence in copper transportion of these organelles by vanadate and vincristine were comparatively analyzed between WD patients and controls.WD copper transporting P-type ATPase was detected by SDS-PAGE in conjunction with Western blot in liver samples of WD patients and controls.RESULTS: The specific WD proteins (Mr155 000 lanes) were expressed in human hepatocytes, including the control and WD patients. After incubation with medium containing copper for 2 h or 24 h, the microsome copper concentration in WD patients was obviously lower than that of controls,and the addtion of vanadate or vincristine would change the copper transporting of microsomes obviously. When incubated with vincristine, levels of copper in microsome were significantly increased, while incubated with vanadate,the copper concentrations in microsome were obviously decreased. The results indicated that there were Wdproteins, the copper transportion P-type ATPase in the microsome of hepatocytes. WD patients possessed abnormal copper transporting function of WD protein in the microsome, and the agonist might correct the defect of copper transportion by promoting the activity of copper transportion P-type ATPase.CONCLUSION: Copper transportion P-type ATPase plays an important role in hepatocytic copper metabolism.Dysfunction of hepatocytic WD protein copper transportion might be one of the most important factors for WD. | Guo-Qing Hou~1 Xiu-Ling Liang~2 Rong Chen~2 Li-Wen Tang~3 Ying Wang~2 Ping-Yi Xu~2 Ying-Ru Zhang~2 Cui-Hua Ou~2 1 Department of Neurology.Guangzhou First Municipal People’s Hospital,Guangzhou Medical College,Guangzhou 510180,Guangdong Province.China2 Department of Neurology.First Affiliated Hospital.Sun Yat-Sen University of Medical Sciences.Guangzhou 510080.Guangdong Province.China3 Department of Pharmacology,University of Kentucky.Lexington,KY 40506.USA | 2001 | World Journal of Gastroenterology2001，7，6： | 4 |
| 4 | The association between frailty and vascular dementia显示文摘 | Daniel KY Chan Vivek Srinivasan Ciaran Upton Xueli Chen Roman Romero-Ortuno | 2015 | 中华老年医学杂志2015，34，12： | 4 |
| 5 | Characteristics associated with falls among the elderly within aged care wards in a tertiary hospital: a retrospective case-control study显示文摘背景下降是在住院病人背景的最经常报导的不利事件。我们在一所第三级的医院里照顾病房进行了在内的住院病人下降的回顾的盒子控制研究调查受不了下降和秋天相关的 characteristics.Methods 的老病人的联系特征连续回顾的代表性的设计跨越的 2006 年 7 月到 2008 年 12 月。耐心的组:所有年老的照顾住院病人的信息受不了 1 或更多的下降从事件信息管理系统(IIMS ) 被提取。关于特别承认的进一步的细节从病人的医药记录被获得,例如,病人包围下降的特征和情形。秋天随机没受不了的照顾病人选择了,在一样的经期从医院被解除的人,为控制组服务了。在有单个秋天和周期性的下降的病人之中的特征,以及 non-fallers 被比较。438 下降的结果评估了, 71.9% 发生在病人的房间里并且 18.9% 在病人的洗澡间 / 厕所。分别地,普通活动是移动 / 转移和拿的淋浴 / 厕所 70.3% , 12.1% 当发生掉落时;并且下降的时间在上午 9:00-11:00 期间有一座高山峰当掉落时,许多是无助的。为秋天的普通作出贡献因素是内在的因素。有周期性的下降的病人是更可能的有更低的微型心理的州的检查(MMSE ) 分数。逻辑回归分析比五个星期,痴呆和击是独立风险因素周期性的下降了的长显示出一些停留;并且在招待所 / 护士家 preadmission,有活动性的需要的帮助,认知缺陷,击,不能自制和关节炎 / 骨质疏松症的生活是为在一个年老的照顾病房的 fall.Conclusions 的独立风险因素,下降独立地与周期性的因素被联系。认知缺陷 / 痴呆是一个强壮的风险因素下降,并且导致秋天的主要原因是内在的因素。为有认知缺陷 / 痴呆和行为的混乱的病人,提供特殊、有效的干预具有为在医院背景在一个年老的照顾病房减少秋天的发生的首要的重要性。 | CHEN Xue-li LIU Yun-hu Daniel KY Chan SHEN Qing Huong Van Nguyen | 2010 | Chinese Medical Journal2010，，13： | 2 |
| 6 | Hypusine is required for a sequence-specific interaction of eukaryotic initiation factor 5A with postsystematic evolution of ligands by exponential enrichment RNA显示文摘 | Xu A Chen KY | 2001 | J Biol Chem2001，276，4： | 1 |
| 7 | Oral cancer plasma tumor marker identified with bead-based affinity-fractionated proteomic technology 显示文摘 | Cheng A J Chen LC Chien KY | 2005 | Clin Chem2005，51，： | 1 |
| 8 | Cholesterol-lowering nutraceuticals and functional foods 显示文摘 | Chen ZY Jiao R Ma KY | 2008 | J Agric Food Chem2008，56，： | 1 |
| 9 | Arthroscopic suture repair of peripheral tears of triangular fibrocartilage complex using a volar portal显示文摘 | Chen AC Hsu KY Chang CH | | 0，，11： | 1 |
| 10 | Identification of mRNA that binds to eukaryotic initiation factor 5A by affinity co-purification and differential display显示文摘 | Xu A Jao DL Chen KY | 2004 | Biochem J2004，384，3： | 1 |
| 11 | Oral cancer plasma tumor marker identified with bead-based affinity-fractionated proteomic technology显示文摘 | Cheng AJ Chen LC Chien KY | 2005 | Clin Chem2005，51，12： | 1 |
| 12 | Prognosis and treatment of squamous cell carcinoma from a mature cystic teratoma of the ovary显示文摘 | CHEN RJ CHEN KY CHANG TC | 2008 | J Formos Med Assoc2008，107，11： | 1 |
| 13 | The role of tyrosine kinase Etk/Bmx in EGF-induced apoptosis of MDA-MB-468 breast cancer cells 显示文摘 | Chen KY Huang LM Kung HJ | 2004 | Oncogene2004，23，10： | 1 |
| 14 | Fungal empyerna thoracis an emerging clinical entity显示文摘 | Kosc Chen KY Hsueh PR | 2000 | Chest2000，117，16： | 1 |
| 15 | A 10-year experience with bacteriology of acute thoracic empyema: emphasis on Klebsiella pneumoniae in patients with diabetes melli- tus 显示文摘 | Chen KY Hsueh PR Liaw YS | 2000 | Chest2000，117，6： | 1 |
| 16 | Pulmonary fungal infection:emphasis on microbiolgical spectra,patients outcome and prognostic factors显示文摘 | CHEN KY KO SC HSUCH PR | 2001 | Chest2001，120，1： | 1 |
| 17 | Gne-environment interaction between angiotensinogen and chronic exposure to occupational noise contribute to hypertension显示文摘 | Hwang BF Chang TY Chen KY | | 0，，： | 1 |
| 18 | Stable and high energy generation by a strain of Bacillus subtilis in a microbial fuel cell 显示文摘 | Nimje VR Chen CY Chert CC Jean JS Reddy AS Fan CW Pan KY Liu HT Chen JL | 2009 | JPower Sourc2009，190，2： | 1 |
| 19 | Epidermal growth factor-induced cyclooxygenase-2 enhances head and neck squamous cell carcinoma metastasis through fibronectin up-regulation 显示文摘 | Hsu JY Chang KY Chen SH | 2015 | Oncotarget2015，6，3： | 1 |
| 20 | Subtalar distractional realignment arthrodesis with wedge bone grafting and lateral decompression for caleaneal-malunion显示文摘 | Chen YJ Huang TJ Hsu KY | 1998 | J Trauma1998，45，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员