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| 1 | Brain tumor-targeted drug delivery strategies显示文摘Despite the application of aggressive surgery,radiotherapy and chemotherapy in clinics,brain tumors are still a difficult health challenge due to their fast development and poor prognosis.Brain tumor-targeted drug delivery systems,which increase drug accumulation in the tumor region and reduce toxicity in normal brain and peripheral tissue,are a promising new approach to brain tumor treatments.Since brain tumors exhibit many distinctive characteristics relative to tumors growing in peripheral tissues,potential targets based on continuously changing vascular characteristics and the microenvironment can be utilized to facilitate effective brain tumor-targeted drug delivery.In this review,we briefly describe the physiological characteristics of brain tumors,including blood–brain/brain tumor barriers,the tumor microenvironment,and tumor stem cells.We also review targeted delivery strategies and introduce a systematic targeted drug delivery strategy to overcome the challenges. | Xiaoli Wei Xishan Chen Man Ying Weiyue Lu | 2014 | Acta Pharmaceutica Sinica B2014，4，3： | 14 |
| 2 | Improvement of the Surface Pressure Operator in GRAPES and Its Application in Precipitation Forecasting in South China显示文摘在这研究,我们调查了涉及在当前的全球、地区性的吸收和预言系统吸收表面压力的问题,葡萄。吸收表面压力的一个新计划被建议,包括一个新插值计划和使清醒的背景协变性。新计划考虑车站举起和模型地形学之间的差别,并且它特别处理在第一模型水平的下面在举起定位的车站。对比实验用原版和新吸收计划被进行。新插值计划和更新的背景协变性的影响被调查。我们的结果证明新插值计划利用了更多的观察并且改进了集体分析的质量。背景协变性用源于帕里什和 Derber 在 1992 建议的技术的统计被使清醒。当吸收表面压力时,实验证明更新的垂直协变性可以在空气的高水平在分析上有积极影响。如果在高水平的背景地的质量是差的,这影响可能是更重要的。一系列吸收实验被执行测试新计划的有效性。相应模拟实验作为起始的条件用两个计划的分析被进行。结果显示新计划导致在华南的海水平压力和降水的更好的预报,特别预报中等并且大雨。 | HUANG Yanyan XUE Jishan WAN Qilin CHEN Zitong DING Weiyu ZHANG Chengzhong | 2013 | Advances in Atmospheric Sciences2013，30，2： | 10 |
| 3 | Mutation profile and its correlation with clinicopathology in Chinese hepatocellular carcinoma patients显示文摘Background:Hepatocellular carcinoma(HCC)is one of the most common causes of cancer worldwide.Although many studies have focused on oncogene characteristics,the genomic landscape of Chinese HCC patients has not been fully clarified.Methods:A total of 165 HCC patients,including 146 males and 19 females,were enrolled.The median age was 55 years(range,27-78 years).Corresponding clinical and pathological information was collected for further analysis.A total of 168 tumor tissues from these patients were selected for next-generation sequencing(NGS)-based 450 panel gene sequencing.Genomic alterations including single nucleotide variations(SNV),short and long insertions and deletions(InDels),copy number variations,and gene rearrangements were analyzed.Tumor mutational burden(TMB)was measured by an algorithm developed in-house.The top quartile of HCC was classified as TMB high.Results:A total of 1,004 genomic alterations were detected from 258 genes in 168 HCC tissues.TMB values were identified in 160 HCC specimens,with a median TMB of 5.4 Muts/Mb(range,0-28.4 Muts/Mb)and a 75%TMB of 7.7 Muts/Mb.The most commonly mutated genes were TP53,TERT,CTNNB1,AXIN1,RB1,TSC2,CCND1,ARID1A,and FGF19.SNV was the most common mutation type and C:G>T:A and guanine transformation were the most common SNVs.Compared to wild-type patients,the proportion of Edmondson grade III-IV and microvascular invasion was significantly higher in TP53 mutated patients(P<0.05).The proportion of tumors invading the hepatic capsule was significantly higher in TERT mutated patients(P<0.05).The proportion of Edmondson grade I-II,alpha fetoprotein(AFP)<25μmg/L,and those without a history of hepatitis B was significantly higher in CTNNB1 mutated patients(P<0.05).CTNNB1 mutations were associated with TMB high in HCC patients(P<0.05).Based on correlation analysis,the mutation of TP53 was independently correlated with microvascular invasion(P=0.002,OR=3.096)and Edmondson grade III-IV(P=0.008,OR=2.613).The mutation of TERT was independently correlated with tumor invasion of the liver capsule(P=0.001,OR=3.030),and the mutation of CTNNB1 was independently correlated with AFP(<25μmg/L)(P=0.009,OR=3.414).Conclusions:The most frequently mutated genes of HCC patients in China were TP53,TERT,and CTNNB1,which mainly lead to the occurrence and development of HCC by regulating the P53 pathway,Wnt pathway,and telomere repair pathway.There were more patients with microvascular invasion and Edmondson III-IV grade in TP53 mutated patients and more patients with hepatic capsule invasion in TERT mutated patients,while in CTNNB1 mutated patients,there were more patients with Edmondson I-II grade,AFP<25μmg/L,and a non-hepatitis B background.Also,the TMB values were significantly higher in CTNNB1 mutated patients than in wild type patients. | Shuo Wang Huasheng Shi Tao Liu Manjiang Li Sanshun Zhou Xuan Qiu Zusen Wang Weiyu Hu Weidong Guo Xiaoqian Chen Honglin Guo Xiaoliang Shi Junping Shi Yunjin Zang Jingyu Cao Liqun Wu | 2021 | Hepatobiliary Surgery and Nutrition2021，10，2： | 8 |
| 4 | Dynamics of ecosystem carbon stocks during vegetation restoration on the Loess Plateau of China显示文摘In the last few decades, the Loess Plateau had experienced an extensive vegetation restoration to reduce soil erosion and to improve the degraded ecosystems. However, the dynamics of ecosystem carbon stocks with vegetation restoration in this region are poorly understood. This study examined the changes of carbon stocks in mineral soil(0–100 cm), plant biomass and the ecosystem(plant and soil) following vegetation restoration with different models and ages. Our results indicated that cultivated land returned to native vegetation(natural restoration) or artificial forest increased ecosystem carbon sequestration. Tree plantation sequestered more carbon than natural vegetation succession over decades scale due to the rapid increase in biomass carbon pool. Restoration ages had different effects on the dynamics of biomass and soil carbon stocks. Biomass carbon stocks increased with vegetation restoration age, while the dynamics of soil carbon stocks were affected by sampling depth. Ecosystem carbon stocks consistently increased after tree plantation regardless of the soil depth; but an initial decrease and then increase trend was observed in natural restoration chronosequences with the soil sampling depth of 0–100 cm. Moreover, there was a time lag of about 15–30 years between biomass production and soil carbon sequestration in 0–100 cm, which indicated a long-term effect of vegetation restoration on deeper soil carbon sequestration. | WANG Kaibo DENG Lei REN Zongping SHI Weiyu CHEN Yiping SHANG-GUAN Zhouping | 2016 | Journal of Arid Land2016，8，2： | 7 |
| 5 | Homozygous loss-of-function mutations in FSIP2 cause male infertility with asthenoteratospermia显示文摘Male infertility, as a major issue of human reproduction health, prevents successful natural conception. Asthenoteratospermia mainly presents one or multiple anomalies in head, neck and tail of spermatozoa, and impairs sperm function and motility (Coutton et al., 2015). Recurrent abnormalities of the fibrous sheath lead to multiple morphological abnormaliries of the sperm flagella (MMAF), which is a quite frequent type of asthenoteratospermia in male infertility (Chemes et al., 1987;Ben Khelifa et al, 2014). | Wangjie Liu Huan Wu Li Wang Xiaoyu Yang Chunyu Liu Xiaojin He Weiyu Li Jiajia Wang Yujie Chen Hongyan Wang Yang Gao Shuyan Tang Shenmin Yang Li Jin Feng Zhang Yunxi Cao | 2019 | Journal of Genetics and Genomics2019，46，1： | 7 |
| 6 | Spatio-temporal analysis and simulation on shallow rainfall-induced landslides in China using landslide susceptibility dynamics and rainfall I-D thresholds显示文摘An empirical simulation method to simulate the possible position of shallow rainfall-induced landslides in China has been developed.This study shows that such a simulation may be operated in real-time to highlight those areas that are highly prone to rainfall-induced landslides on the basis of the landslide susceptibility index and the rainfall intensity-duration(I-D) thresholds.First,the study on landslide susceptibility in China is introduced.The entire territory has been classified into five categories,among which high-susceptibility regions(Zone 4-'High' and 5-'Very high') account for 4.15%of the total extension of China.Second,rainfall is considered as an external triggering factor that may induce landslide initiation.Real-time satellite-based TMPA3B42 products may provide real rainfall spatial and temporal patterns,which may be used to derive rainfall duration time and intensity.By using a historical record of 60 significant past landslides,the rainfall I-D equation has been calibrated.The rainfall duration time that may trigger a landslide has resulted between 3 hours and 45 hours.The combination of these two aspects can be exploited to simulate the spatiotemporal distribution of rainfall-induced landslide hazards when rainfall events exceed the rainfall I-D thresholds,where the susceptibility category is 'high' or 'very high'.This study shows a useful tool to be part of a systematic landslide simulation methodology,potentially providing useful information for a theoretical basis and practical guide for landslide prediction and mitigation throughout China. | LI WeiYue LIU Chun Marco SCAIONI SUN WeiWei CHEN Yu YAO DongJing CHEN Sheng HONG Yang ZHANG KaiHang CHENG GuoDong | 2017 | Science China Earth Sciences2017，60，4： | 5 |
| 7 | Vulnerability to drought-induced cavitation in shoots of two typical shrubs in the southern Mu Us Sandy Land, China显示文摘Salix psammophila and Caragana korshinskii are two typical shrubs in the southern Mu Us Sandy Land of China which are threatened by increasing water deficits related to climate change and large-scale human activities(e.g. coal mining and oil exploitation). In this study, we assessed their vulnerability to xylem embolism and the related anatomical traits in two-year-old regenerated shoots of these two shrubs to understand how they cope with drought environment. We also evaluated the in situ hydraulic safety margins to hydraulic failure from measurements of annual predawn and midday leaf water potentials. The results showed that S. psammophila stems had a higher water transport capacity than C. korshinskii stems. The stem xylem water potentials at 12%, 50% and 88% loss of conductivity were –1.11, –1.63 and –2.15 MPa in S. psammophila, respectively, and –1.37, –2.64 and –3.91 MPa in C. korshinskii, respectively. This suggested that C. korshinskii was more resistant to cavitation than S. psammophila. Compared with S. psammophila, C. korshinskii had shorter maximum vessel length, lower vessel density, smaller conductive area and higher wood density, which may contribute to its more resistant xylem. The in situ hydraulic safety margins indicated that even during the driest periods, both shrubs lived well above the most critical embolism thresholds, and the hydraulic safety margin was wider in C. korshinskii than in S. psammophila, suggesting that the regenerated shoots of both shrubs could function normally and C. korshinskii had greater hydraulic protection. These results provide the basis for an in-depth understanding of the survival, growth and functional behavior of these two shrubs under harsh and dry desert environments. | LI Yangyang CHEN Weiyue CHEN Jiacun SHI Hui | 2016 | Journal of Arid Land2016，8，1： | 5 |
| 8 | In vivo retention of poloxamer-based in situhydrogels for vaginal application in mouse and rat models显示文摘The purpose of this study is to evaluate the in vivo retention capabilities of poloxamer-based in situ hydrogels for vaginal application with nonoxinol-9 as the model drug. Two in situ hydrogel formulations, which contained 18% poloxamer 407 plus 1% poloxamer 188(GEL1, relative hydrophobic)or 6% poloxamer 188(GEL2, relative hydrophilic), were compared with respect to the rheological properties, in vitro hydrogel erosion and drug release. The vaginal retention capabilities of these hydrogel formulations were further determined in two small animal models, including drug quantitation of vaginal rinsing fluid in mice and isotope tracing with99 m Tc in rats. The two formulations exhibited similar phase transition temperatures ranging from 27 to 32 1C. Increasing the content of poloxamer 188 resulted in higher rheological moduli under body temperature, but slightly accelerated hydrogel erosion and drug release. When compared in vivo, GEL1 was eliminated significantly slower in rat vagina than GEL2,while the vaginal retention of these two hydrogel formulations behaved similarly in mice. In conclusion,increases in the hydrophilic content of formulations led to faster hydrogel erosion, drug release andintravaginal elimination. Rats appear to be a better animal model than mice to evaluate the in situ hydrogel for vaginal application. | Yu Liu Fujin Yang Linglin Feng Long Yang Lingyun Chen Gang Wei Weiyue Lu | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 5 |
| 9 | Clinical efficacy of comprehensive therapy based on traditional Chinese medicine patterns on patients with pneumoconiosis: a pilot double-blind, randomized, and placebo-controlled study显示文摘Effective therapy options for pneumoconiosis are lacking.Traditional Chinese medicine(TCM)presents a favorable prospect in the treatment of pneumoconiosis.A pilot study on TCM syndrome differentiation can evaluate the clinical efficacy and safety of TCM and lay a foundation for further clinical research.A double-blind,randomized,and placebo-controlled trial was conducted for 24 weeks,in which 96 patients with pneumoconiosis were randomly divided into the control and treatment groups.Symptomatic treatment was conducted for the two groups.The treatment group was treated with TCM syndrome differentiation,and the control group was treated with placebo.The primary outcomes were the six-minute walking distance(6MWD)and the St.George Respiratory Questionnaire(SGRQ)score.The secondary outcomes were the modified British Medical Research Council Dyspnea Scale(mMRC),Chronic Obstructive Pulmonary Disease Assessment Test(CAT),Hospital Anxiety and Depression Scale(HADS),and pulmonary function.Only 83 patients from the 96 patients with pneumoconiosis finished the study.For the primary outcome,compared with the control groups,the treatment group showed a significantly increased 6MWD(407.90 m vs.499.51 m;95%confidence interval(CI)47.25 to 135.97;P<0.001)and improved SGRQ total score(44.48 vs.25.67;95%CI 27.87 to 9.74;P<0.001).The treatment group also significantly improved compared with the control group on mMRC score(1.4 vs.0.74;95%CI 1.08 to 0.23;P=0.003),CAT score(18.40 vs.14.65;95%CI 7.07 to 0.43;P=0.027),and the total symptom score(7.90 vs.5.14;95%CI 4.40 to 1.12;P<0.001).No serious adverse events occurred.This study showed that TCM syndrome differentiation and treatment had a favorable impact on the exercise endurance and quality of life of patients with pneumoconiosis. | Jiansheng Li Hulei Zhao Yang Xie Jieya Li Qingwei Li Xuexin Chen Weiyu Zhang | 2022 | Frontiers of Medicine2022，16，5： | 5 |
| 10 | Ambient Backscatter Communications over NOMA Downlink Channels显示文摘In this paper,we investigate the performance of commensal ambient backscatter communications(AmBC)that ride on a non-ortho go nal multiple access(NOMA)downlink transmission,in which a backscatter device(BD)splits part of its received signals from the base station(BS)for energy harvesting,and backscatters the remaining received signals to transmit information to a cellular user.Specifically,under the power consumption constraint at BD and the peak transmit power constraint at BS,we derive the optimal reflection coefficient at BD,the optimal total transmit power at BS,and the optimal power allocation at BS for each transmission block to maximize the ergodic capacity of the ambient backscatter transmission on the premise of preserving the outage performance of the NOMA downlink transmission.Furthermore,we consider a scenario where the BS is restricted by a maximum allowed average transmit power and the reflection coefficient at BD is fixed due to BD’s low-complexity nature.An algorithm is developed to determine the optimal total transmit power and power allocation at BS for this scenario.Also,a low-complexity algorithm is proposed for this scenario to reduce the computational complexity and the signaling overheads.Finally,the performance of the derived solutions are studied and compared via numerical simulations. | Weiyu Chen Haiyang Ding Shilian Wang Daniel Benevides daCosta Fengkui Gong Pedro Henrique Juliano Nardelli | 2020 | China Communications2020，17，6： | 4 |
| 11 | Downregulation of KCTD12 contributes to melanoma stemness by modulating CD271显示文摘Objective: Cancer metastasis remains the primary cause of cancer-related death worldwide.In a previous study, we found that levels of BTB/POZ domain-containing protein KCTD12 are lower in metastatic melanoma cells than in parental melanoma cells.The purpose of this study was to identify the roles of KCTD12 in cancer metastasis.Methods: The Cancer Genome Atlas(TCGA) datasets were used to evaluate the relationship between KCTD12 and skin cutaneous melanoma(SKCM) prognosis.The effects of endogenous KCTD12 on biological behaviors were examined using the MTT assay.The impacts of KCTD12 on melanoma stemness were explored using spheroid formation assay.KCTD12 knockout A375 cells were generated to confirm the inhibitory effect of KCTD12 on CD271, and a mouse metastatic model was used to determine the impact of KCTD12 on melanoma metastasis in vivo.Results: KCTD12 levels were lower in lung metastatic cells than in paired parental melanoma cells, and low KCTD12 expression indicated a poor prognosis in SKCM.Cancer metastasis-related capacities were higher in lung metastatic cells than in parental melanoma cells.Moreover, KCTD12 knockdown enhanced tumor growth and metastasis both in vitro and in vivo.Mechanistically, the interaction between KCTD12 and CD271 might be responsible for the stemness transformation after KCTD12 knockdown.Conclusions: This study identifies for the first time the role of the interaction between KCTD12 and CD271 in inducing melanoma cell stemness transformation.Moreover, KCTD12 repression enhances melanoma cell growth, adhesion, migration and invasion. | Weiyu Shen Yumei Li Bifei Li Liping Zheng Xiaodong Xie Jingqing Le Yusheng Lu Tao Li Fan Chen Lee Jia | 2019 | Cancer Biology & Medicine2019，16，3： | 4 |
| 12 | Treatment of spinal tuberculosis with ultrashort-course chemotherapy in conjunction with partial excision of pathologic vertebrae显示文摘 | Zili Wang Zhaohui Ge Weidong Jin Yongdong Qiao Huiqiang Ding Haoning Zhao Zhikai Lin Jun Chen Weiyu Yang | 2007 | The Spine Journal2007，，6： | 3 |
| 13 | Comparative study on the deviation characteristics of post-earthquake intensity evaluation based on two intensity attenuation relationship models显示文摘We collect the isoseismal data of 488 earthquakes in western China and 182 earthquakes in eastern China after 1900.The least square method is used to establish two models of the seismic intensity attenuation relationship partitions in China,based on the major and minor axis ellipse models,and the area and the major axis radius,respectively.The two models are applied to the calculation of the intensity circle of the earthquake events with a magnitude M_(S)≥5.0 from 2008 to 2019,and the actual intensity is compared with the model intensity value as an indicator to verify the consistency between the actual intensity and the value from the empirical statistical model.Three real earthquake results are selected to calculate the major and minor axis and area of the ellipse using the two intensity attenuation relationship models.After comparison,we summarize the deviation characteristics of the intensity value,and put forward corresponding improvement suggestions. | Jing Ren Zhiqiang Li Shuaitang Huang Zhuantiao Tan Yahui Chen Qi Yao Weiyu Ma | 2021 | Earthquake Research Advances2021，1，2： | 2 |
| 14 | Developmental toxicity of TCBPA on the nervous and cardiovascular systems of zebrafish (Danio rerio): A combination of transcriptomic and metabolomics显示文摘Tetrachlorobisphenol A(TCBPA),a widely used halogenated flame retardant,is frequently detected in environmental compartments and human samples.However,unknown developmental toxicity and mechanisms limit the entire understanding of its effects.In this study,zebrafish(Danio rerio)embryos were exposed to various concentrations of TCBPA while a combination of transcriptomics,behavioral and biochemical analyzes as well as metabolomics were applied to decipher its toxic effects and the potential mechanisms.We found that TCBPA could interfere with nervous and cardiovascular development through focal adhesion and extracellular matrix-receptor(ECM-receptor)interaction pathways through transcriptomic analysis.Behavioral and biochemical analysis results indicated abnormal swimming behavior of zebrafish larvae.Morphological observations revealed that TCBPA could cause the loss of head blood vessels.Metabolomic analysis showed that arginine-related metabolic pathways were one of the main pathways leading to TCBPA developmental toxicity.Our study demonstrated that by using omics,TCBPA was shown to have neurological and cardiovascular developmental toxicity and the underlying mechanisms were uncovered and major pathways identified. | Wentao Liu Yifan Pan Lu Yang Yun Xie Xuanyue Chen Jing Chang Weiyu Hao Lifei Zhu Bin Wan | 2023 | Journal of Environmental Sciences2023，，5： | 2 |
| 15 | Research progress of rare earth separation methods and technologies显示文摘Strategical elements,such as rare earth elements,play a crucial role in the industry,especially in producing high-tech materials.Major global industries have developed a strong dependence on rare earth materials.Every year,there are innovations in industries such as modern technology,green energy,or communications technology,which need more strategic metals to improve investment profitability.This article reviews advances in rare earth separation methods and techniques to guide and recommend the best extractants,depending on leaching conditions and the final target product.Each method for separating and extracting agents is individually revised in terms of the mechanism and interaction of providing rare earth elements.This paper also evaluates past and current trends of these methods and technical extractants and identifies their strengths and weaknesses. | Mory Traore Aijun Gong Yiwen Wang Lina Qiu Yuzhen Bai Weiyu Zhao Yang Liu Yi Chen Ying Liu Huilin Wu Shuli Li Yueyi You | 2023 | Journal of Rare Earths2023，41，2： | 2 |
| 16 | Study on the Protection of Settlements and Tangible Cultural Heritage along the Fukouxing from the Perspective of Cultural Route显示文摘The eight Taihang Xing routes are natural passages among Taihang Mountains.As one of the passage,Fukouxing is an important channel for communication between Changzhi City,Shanxi Province and Handan City,Hebei Province,which deeply influences the development of the history of the two places.As a typical linear cultural heritage,Fukouxing has the basic elements of cultural route,and there are rich tangible cultural heritage along the passage.From the perspective of cultural route,the study identifies and investigates the heritage resources of settlements and tangible heritage along the Fukouxing route,and then puts forward effective heritage protection strategies in accordance with the heritage characteristics of Fukouxing,based on the analysis of heritage value. | WANG Xiaodong CHEN Weiyu YANG Mengjie | 2021 | Journal of Landscape Research2021，13，6： | 2 |
| 17 | Efficient and adaptive web replication using content clustering 显示文摘 | Chen Yan Qiu Lili Chen Weiyu | 2003 | IEEE Journal on Selected Areas in Communications2003，21，6： | 1 |
| 18 | Managerial Ownership and Firm Valuation:Evidence from Japanese Firms显示文摘 | Carl R Chen Weiyu Guo Vivek Mande | 2003 | Pacific-Basin Finance Journal2003，11，3： | 1 |
| 19 | The Estimation and Control of the Electroslag Remelting Melt Rate by Mechanism-Based Modeling显示文摘 | Wanzhou Li Weiyu Wang Yuechen Hu Yixing Chen | 2012 | Metallurgical and Materials Transactions B2012，，2： | 1 |
| 20 | Lagrangian duality and saddle points for sparse linear programming显示文摘The sparse linear programming(SLP) is a linear programming problem equipped with a sparsity constraint, which is nonconvex, discontinuous and generally NP-hard due to the combinatorial property involved.In this paper, by rewriting the sparsity constraint into a disjunctive form, we present an explicit formula of the Lagrangian dual problem for the SLP, in terms of an unconstrained piecewise-linear convex programming problem which admits a strong duality under bi-dual sparsity consistency. Furthermore, we show a saddle point theorem based on the strong duality and analyze two classes of stationary points for the saddle point problem. At last,we extend these results to SLP with the lower bound zero replaced by a certain negative constant. | Chen Zhao Ziyan Luo Weiyue Li Houduo Qi Naihua Xiu | 2019 | Science China Mathematics2019，62，10： | 1 |
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