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| 1 | Mesenchymal stem cells over-expressing hepatocyte growth factor improve small-for-size liver grafts regeneration显示文摘 | Yu, Y. Yao, A. H. Chen, N. Pu, L. Y. Fan, Y. Lv, L. Sun, B. C. Li, G. Q. Wang, X. H. | 2007 | 南京医科大学学报(自然科学版)2007，27，10： | 45 |
| 2 | Formation history and protolith characteristics of granulite facies metamorphic rock in Central Cathaysia deduced from U-Pb and Lu-Hf isotopic studies of single zircon grains显示文摘The petrochemical as well as zircon U-Pb and Lu-Hf isotopic studies of granulite facies metamorphic rock from the Taoxi Group in eastern Nanling Range, Central Cathaysia indicate that its protolith is the sedimentary rock with low maturation index. The clastic materials are mostly from middle Neoproterozoic (~736 Ma) granitoid rocks with minor Neoarchaean and Paleoproterozoic rocks. The timing of this Neoproterozoic magmatism is in agreement with the second period of magmatism widespread surrounding the Yangtze Block. Hf isotopic data indicate that the Neoproterozoic granitoids resulted from the recycled Paleoproterozoic mantle-derived crustal materials. The sedimentary rock was deposited in Late Neoproterozoic Era, and carried into low crust in Early Paleozoic. The partial melting of the meta-sedimentary rock took place at about 480 Ma and subsequently granulite facies metamorphism occurred at ca. 443 Ma. The zircons forming during this time interval (Early Paleozoic) show large Hf isotope variations, and their -Hf(t) values increase from -13.2 to +2.36 with decreasing age, suggesting the injection of mantle-derived materials during partial melting and metamorphism processes in the Early Paleozoic. Calculation results show that this metamorphic rock, if evolved to Mesozoic, has similar isotopic composition to the nearby Mesozoic high Si peraluminous granites, implying that this kind of granulite facies metamorphic rock is probably the source material of some Mesozoic peraluminous granitoids in eastern Nanling Range. | YU Jinhai ZHOU Xinmin Y. S. O'Reilly ZHAO Lei W. L. Griffin WANG Rucheng WANG Lijuan CHEN Xiaomin | 2005 | Chinese Science Bulletin2005，50，18： | 35 |
| 3 | Variability in rainfall threshold for debris flow after the Chi-Chi earthquake in central Taiwan,China显示文摘The purpose of this study is to analyze variability in rainfall threshold for debris flow(critical rainfall for debris flow triggering) after the ML 7.3 Chi-Chi earthquake in central Taiwan in 1999. Two study sites with different geological conditions were surveyed in the earthquake area. Streambed surveys were conducted to continuously monitor debris flows between 1999 and 2006. During the 7-year study period,every debris flow event was identified,and the streambed characterized. Results show that the rainfall threshold for debris flow was remarkably lower just after the Chi-Chi Earthquake,but gradually recovered. To date,this rainfall threshold is still lower than the original level prior to the earthquake. This variability in rainfall threshold is closely related to the amount of sediment material in the initiation area of debris flow,which increased rapidly due to landslides resulting from the earthquake. With the increase in sediment material,the rainfall threshold was lowered severely during the first year following the Chi-Chi earthquake. However,heavy rainfalls mobilized the sediment material,causing debris flows and transporting sediment downstream. With the decrease in sediment material,the rainfall threshold recovered gradually over time. Furthermore,debris flows occurred only in the subbasins that had sufficient sediment material to cause significant movement. Hence,these results confirm that the sediment material in the initiation area of debris flow is a crucial component of the rainfall threshold for debris flow. | C. L. SHIEH Y. S. CHEN Y. J. TSAI J. H. WU | 2009 | International Journal of Sediment Research2009，24，2： | 35 |
| 4 | What is going on in magnesium alloys?显示文摘China has been developed into one of the most active regions in terms of both fundamental and applied research on magnesium(Mg) and its alloys in the world from a solid base laid by its prominent metallurgist and materials scientists over the past decades. Nowadays, a large number of young-generation researchers have been inspired by their predecessors and become the key participants in the fields of Mg alloys, which consequently led to the establishment of China Youth Scholar Society for Magnesium Alloys Research in 2015. Since then, the first two China Youth Scholars Symposiums on Mg Alloys Research had been held at Harbin(2015) and Chongqing(2016) China, respectively. A number of crucial research interests related to fundamental and applied Mg research were discussed at the conferences and summarized in this short perspective, aiming to boost far-reaching initiatives for development of new Mg-based materials to satisfy the requirements for a broad range of industrial employments. Herein, four main aspects are included as follows: i) Plastic deformation mechanism and strengthening strategy, ii) Design and development of new Mg-based materials, iii) Key service properties, and iv) New processing technologies. | X.J. Wang D.K. Xu R.Z. Wu X.B. Chen Q.M. Peng L. Jin Y.C. Xin Z.Q. Zhang Y. Liu X.H. Chen G. Chen K.K. Deng H.Y. Wang | 2018 | Journal of Materials Science & Technology2018，34，2： | 35 |
| 5 | Identification of differentially expressed genes in omental adipose tissues of obese patients by suppression subtractive hybridization显示文摘 | Qiu, J. Ni, Y. H. Gong, H. X. Fei, L. Pan, X. Q. Guo, M. Chen, R. H. Guo, X. R. | 2007 | 南京医科大学学报(自然科学版)2007，27，4： | 34 |
| 6 | Intracellular tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus. Role of JAK/STAT signaling显示文摘 | Zeng, Y. Zhang, X. H. Huang, Z. Cheng, L. Yao, S. H. Qin, D. Chen, X. Y. Tang, Q. Lv, Z. G. Zhang, L. Lu, C. | 2007 | 南京医科大学学报(自然科学版)2007，27，5： | 31 |
| 7 | Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro显示文摘Gastrin and cyclooxygenase-2(COX-2) playimportant roles in the carcinogenesis and progression ofgastric cancer.However,it remains unknown whether the combination of cholecystokinin-2(CCK-2) receptor antagonist plus COX-2 inhibitor exerts synergistic anti-tumor effects on human gastric cancer.Here,we demonstrated that the combination of AG-041R(a CCK-2 receptor antagonist) plus NS-398(a selective COX-2 inhibitor) treatment had synergistic effects on proliferation inhibition,apoptosis induction,down-regulation of Bcl-2 and up-regulation of Bax expression in MKN-45 cells.These results indicate that simultaneous targeting of CCK-2 receptor and COX-2 may inhibit gastric cancer development more effectively than targeting either molecule alone.(C)2008 Elsevier Ireland Ltd.All rights reserved. | Sun, W. H. | 2008 | 南京医科大学学报(自然科学版)2008，28，9： | 30 |
| 8 | Common Genetic Variants in Pre-MicroRNAs Were Associated With Increased Risk of Breast Cancer in Chinese Women显示文摘 | Hu, Z. B. Liang, J. Wang, Z. W. Tian, T. Zhou, X. Y. Chen, J. P. Miao, R. F. Wang, Y. Wang, X. R. Shen, H. B. | 2009 | 南京医科大学学报(自然科学版)2009，29，4： | 29 |
| 9 | COMPUTERIZED SIMULATION AND EXPERIMENTAL RESEARCH ON SOFT-SWITCHING ARC WELDING INVERTER POWER SOURCE显示文摘Based on the existing component models in the Pspice software package, a combined model for Insulat- ed the Bipolar Transistor (IGBT) is established, in which a non - linear is introduced to represent the parasitic capacitance. Using this model, computerized simulation is conducted for the FB - ZVZCS - PWM soft - ewitching converter,the switching and energy-transferring characteristics of the components are analyzed.The simulation results are testified by experiments.It is proved that by abopting appropriate models,computerized simulation becomes an effective tool for investigation of arc welding inverter power source. | S. J. Chen S. Y. Yin L. Feng and L. Y. Li( 1) School of Materials Science and Engineering, Beijing Polytechnic University, Beijing 100022, China 2)National Key Laboratory of Advanced Welding Production Technology, HIT, Harbin 150001, China) | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，1： | 24 |
| 10 | Shifts of the Kuroshio axis over the last 20 000 years显示文摘Core 255 from the southern Okinawa Trough was selected to monitor the shift of the Kuroshio axis over the last 20 000 years. During the last glacial maximum the Kuroshio axis had ever shifted outside the Okinawa Trough. It entered the Okinawa Trough again at about 6 500 a BP, leading to abrupt increase of sedimentation rate, distinctly coarser sediment and remarkably increased abundance of foraminiferal indicators of the Kuroshio in the core. But, during about 4 000-3 000 a BP the abundance of the Kuroshio indicator Pulleniatina obliquiloculata sharply decreased again, indicating that the Kuroshio axis had ever shifted easterly for a short period or the Kuroshio was weakened and that moment. | Jian Zhimin Y. Saito Wang Pinxian Li Baohua Chen Ronghua | 1998 | Chinese Science Bulletin1998，43，12： | 20 |
| 11 | Functional Variant in microRNA-196a2 Contributes to the Susceptibility of Congenital Heart Disease in a Chinese Population显示文摘 | XU , J. Hu, Z.B. Xu, Z.F. Gu, H.Y Yi, L. Cao, H. L. Chen, J. P. Tian, T. Liang, J. Lin, Y. Qiu, W. S. Ma, H.X. Shen, H. B Chen, Y. J. | 2009 | 南京医科大学学报(自然科学版)2009，29，11： | 20 |
| 12 | EFFECT OF CHEMICAL COMPOSITION ON RETAINED AUSTENITE IN TRIP STEEL显示文摘The systematic chemical compositions including common C, Si, Mn, Al, and micro- alloying elements of Ti and Nb were designed for high volume fraction of retained austenite as much as possible. The thermo-cycle experiments were conducted by using Gleeble 2000 thermo-dynamic test machine for finding the appropriate composition. The experimental results showed that chemical composition had a significant effect on retained austenite, and the appropriate compositions were determined for commercial production of TRIP steels. | Y. Chen and X. ChenWuhan University of Science and Technology, Wuhan 430081, ChinaQ.F. Wang, G.L. Yuan and. C. Y. LiTechnical Center of Wuhan Iron and Steel Co., Wuhan 430080, ChinaX. Y. Li and Y.X. WangCentral Iron and Steel Research Institute, Beijing 1 | 2002 | Acta Metallurgica Sinica(English Letters)2002，15，4： | 19 |
| 13 | GIS-based risk analysis of debris flow:an application in Sichuan,southwest China显示文摘Debris flow is a serious geologic hazard in China.It is estimated that nationally debris flows cause up to 2 billion RMB(250 million US$) in damages and 300-600 deaths and injuries annually.To mitigate debris flow hazards,it is necessary to map,model,and identify zones of debris flow hazards and vulnerability as to inform the local people about the potential risk with a geographic information system.This research presents a regional scale case study modeling debris flow risk(hazard and vulnerability) in Sichuan Province,Southwestern China.In this area,3,290 debris flows have been identified and the spatial-temporal distribution and activity characteristics of them have been documented.Based on the available meteorological data,a Digital Elevation Model with the rate of 1:250,000 and a regional geological map,the 24-hr rainfall threshold(y) for debris flow occurrence is closely related(significant at 99% confidence level) to the index(x) defined using a geology factor(rock hardness:a) and a topographical factor(channel gradient:d) where y = 21 + 10200 / x,in which x = 2.7 × ea + 1000 × d.The discipline is constructive in developing the rainfall threshold for debris flow activity in remote mountainous areas that lack data.For a given watershed,a four-level debris flow hazard map is developed by comparing the rainfall threshold to the design rainfall intensities with 50-,20-,and 5-year average recurrence intervals,respectively.The degree of debris flow vulnerability is determined by the watershed socio-economic conditions.A four-class debris flow risk map,at the final phase of the research,is generated by combining debris flow hazards and vulnerability.With the debris flow risk assessment,the Sichuan Province is classified into the slight,moderate,severe and very severe regions,which accounts for 36%,19%,20% and 25% of total area respectively. | B. F. DI N. S. CHEN P. CUI Z. L. LI Y. P. HE Y. C. GAO | 2008 | International Journal of Sediment Research2008，23，2： | 19 |
| 14 | 冷水机利用变流量冷冻水的若干设计问题显示文摘目前变水量冷冻水系统的设计一般都采用一、二次双环路方式。但这种双环路配置方式会产生:使用两个水泵增加设备投资;冷冻水送水及回水的混合影响冷水机在部分负荷时的效率;实际的高负荷空调需求条件与最大设计工况条件不吻合时不能充分利用冷水机的全负荷容量等不良后果。设计单环路空调冷冻水系统可以避免上述问题。讨论了单环路变流量系统的长处以及可能产生的问题,并提供在整个运行范围内,能够实现安全、稳定和可靠的冷水机控制策略。 | Original by Thomas B. Hartman Translation by Liu Xuemin Reviewed by Steve Y. Chen | 1997 | 暖通空调1997，27，3： | 18 |
| 15 | Effective gene targeting in rabbits using RNA-guided Cas9 nucleases显示文摘 | Dongshan Yang Jie Xu Tianqing Zhu Jianglin Fan Liangxue Lai Jifeng Zhang Y. Eugene Chen | 2014 | Journal of Molecular Cell Biology2014，8，1： | 18 |
| 16 | Interactions of IL-12A and IL-12B Polymorphisms on the Risk of Cervical Cancer in Chinese Women显示文摘 | Chen, X. J. Han, S. P. Wang, S. N. Zhou, X. Y. Zhang, M. F. Dong, J. Shi, X. Y. Qian, N. F. Wang, X. R. Wei, Q. Y. Shen, H. B. Hu, Z.B. | 2009 | 南京医科大学学报(自然科学版)2009，29，3： | 16 |
| 17 | Dual Phosphorylation of Suppressor of Fused (Sufu) by PKA and GSK3 beta Regulates Its Stability and Localization in the Primary Cilium显示文摘 | Chen, Yon Yue, Shen Xie, Lu Pu, Xiao-hong Jin, Tion Cheng, Steven Y. | 2011 | 南京医科大学学报(自然科学版)2011，31，6： | 15 |
| 18 | ACE2/Ang-(1-7) signaling and vascular remodeling显示文摘The renin-angiotensin system(RAS)regulates vascular tone and plays a critical role in vascular remodeling,which is the result of a complex interplay of alterations in vascular tone and structure.Inhibition of the RAS has led to important pharmacological tools to prevent and treat vascular diseases such as hypertension,diabetic vasculopathy and atherosclerosis.Angiotensin converting enzyme 2(ACE2)was recently identified as a multifunctional monocarboxypeptidase responsible for the conversion of angiotensin(Ang)II to Ang-(1-7).The ACE2/Ang-(1-7)signaling has been shown to prevent cellular proliferation,pathological hypertrophy,oxidative stress and vascular fibrosis.Thus,the ACE2/Ang-(1-7)signaling is deemed to be beneficial to the cardiovascular system as a negative regulator of the RAS.The addition of the ACE2/Ang-(1-7)signaling to the complexities of the RAS may lead to the development of novel therapeutics for the treatment of hypertension and other vascular diseases.The present review considers recent findings regarding the ACE2/Ang-(1-7)signaling and focuses on its regulatory roles in processes related to proliferation,inflammation,vascular fibrosis and remodeling,providing proof of principle for the potential use of ACE2 as a novel therapy for vascular disorders related to vascular remodeling. | ZHANG ZhenZhou CHEN LaiJiang ZHONG JiuChang GAO PingJin OUDIT Gavin Y. | 2014 | Science China(Life Sciences)2014，57，8： | 14 |
| 19 | Pregnancy outcomes and risk factors for low birth weight and preterm delivery among HIV-infected pregnant women in Guangxi, China显示文摘在中国的背景六省在 2009 和五个省在这个国家说明了所有报导 HIV/AIDS 案例的 70-80 说明了属于的 HIV cases.Because Guangxi 的 78 所有报导 mother-to-child 传播( MTCT )两个组,加节目的 Mother-to-Child 传播( PMTCT )的预防在那里被建立理解更好低的出生重量( LBW )和 preterm 交货( PD )出生结果和他们的联系风险因素 better.Methods 怀孕结果被检验在之中95 CI 1.11-25.55 ) 并且 CD4 房间计数 100-199 cells/l (AOR 3.40;95 Cl 1.03-11.25,与 CD4 房间计数 350 cells/l 相比) , gestational 年龄 37 星期(AOR 4.38;95 CI 1.29-14.82,与 37 个星期相比) ,母亲的重量 45 kg (AOR 5.64;95 Cl 1.09-29.07 ) 并且母亲的重量 45-54 kg (AOR 3.55;95 Cl 1.31-9.60,与 55 kg 相比) 在注册,和 HIV RNA 100 在注册的 000 copies/ml (AOR 4.22;95 Cl 1.24-14.32 ) 并且 20 000-99 999 (AOR 2.77;95 CI 1.01-7.77,与 20 000 copies/ml 相比) 与 LBW.For PD 的更高的风险被联系,仅仅母亲的注射药使用作为 HIV 传播的线路(AOR 5.30; 95 CI 1.33-21.14 ,与通过性传播感染 HIV 的那些相比)显著地与 PD.Conclusions 更低的 CD4 房间计数的更高的风险被联系,在注册的更高的 HIV RNA 病毒的负担与 LBW.Optimal 胎儿的照顾被联系包括更早胎儿的屏蔽和 HIV 诊断,对更早的 PMTCT 预防或 HIV treatent 批评阻止 HIV 的传播到婴儿并且也阻止 LBW 怀孕结果。 | Yu Lan Li Wen-ying Chen, Ray Y. Tang Zhi-rong Pang Jun Gui Xiu-zhi Meng Xiu-ning Zhang Fu-jie | 2012 | Chinese Medical Journal2012，，3： | 10 |
| 20 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
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