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| 1 | CT arterial portography and CT hepatic arteriography in detection of micro liver cancer显示文摘AIM To recognize the characteristic findings of micrQliver cancer (MLC) and to evaluate the effect of CT arterial portography (CTAP) and CT hepatic arteriography (CTHA) in diagnosis of MLC. METHODS Between April 1996 to December 1998, CTAP and CTHA were performed in 12patients with MLC, which were not detect ed byconventional CT examinations. After CTHA, 3 mL-- 5 mL mixture of lipiodol, doxorubic in andmitomycin C were injected into hepatic arterythrough the catheter, and then followed up by CTthree or four weeks later (Lipiodol CT LP-CT).RESULTS A total of 22 micro--tumors (0 .2 cm 0.6 cm in diameter ) were detected in 12patients, which manifested as small perfusiondefects in CTAP and small round enhancement inCTHA. The rate of detectability of CTAP andCTHA was 68.2% (15/ 22) and 77.3% (17/ 22)respectively, and the rate of the simultaneoususe of both procedures reached 86. 4% (19/ 22 ).All micro--tumors were demonstrated as punctatelipiodol deposit fool in LP--CT. After LP--CT, theelevated serum level of Q-fetoprotein (AFP)dropped to the normal level in all patients.CONCLUSION The CTAP and CTHA are the mostsensitive imaging methods for detecting microIiver cancer. Confirmed by the change of theelevated serum AFP level and lipiodol depositfool in LP-CT, small perfusion defects in CTAPand punctate enhancement in CTHA may suggestmicro--liver cancer. | Li L Wu PH Mo YX Lin HG Zheng L Li JQ Lu LX Ruan CM Chen L | 1999 | World Journal of Gastroenterology1999，5，3： | 16 |
| 2 | Identification of tumor associated single-chain Fv by panning and screening antibody phage library using tumor cells显示文摘AIM:To study the feasibility of panning and screeningphage-displaying recombinant single-chain variablefragment (ScFv) of anti-tumor monoclonal antibodiesfor fixed whole cells as the carriers of mAb-bindingantigens.ME,ODS: The recombinant phage displaying librariesfor anti-colorectal tumor mAb MC3Ab, MC5Ab andanti-gastric tumor mAb MGD1 was constructed.Panning and screening were carried outby means ofmodified fixation of colorectal and gastric tumor cellsexpressed the mAb-binding antigens. Concordance ofbinding specificity to tumor cells between phageclones and parent antibodies was analyzed. Thephage of positive clones was identified withcompetitive ELISA, and infected by E.coli HB2151 toexpress soluble ScFv.RESULTS:The ratio of positive clones to MC3-ScF-MC5-ScFv and MGD1-ScFv were 60 %, 24 % and 30 %. MC3-ScFv had Mr 32 000 confirmed by Western blot. Thespecificity to antigen had no difference between 4positive recombinant phage antibodies and MC3Ab.CONCLUSION:The modified process of fixing wholetumor cells is efficient, convenient and feasible to panand screen the phage-displaying ScFv of anti-tumormonoclonal antibodies. | Nie, YZ He, FT Li, ZK Wu, KC Cao, YX Chen, BJ Fan, DM | 2002 | World Journal of Gastroenterology2002，8，4： | 12 |
| 3 | Nuclear transcription factors and lipid homeostasis in liver显示文摘The liver plays a major role in the regulation ofglucose,lipid and energy metabolism.Increasedhepatic fat deposit is a very common feature in obese,insulin-resistant patients,in metabolic syndrome,alcoholic steatohepatitis(ASH)and nonalchoholic fattyliver disaseas(NAFLD).As a central organ for wholebody lipid metabolism,disruption of the normalmechanisms for synthesis,transport and removal/ | CHEN Ya-xi HUANG Ai-long RUAN Xiong-zhong Centre for Lipid Research,Key Laboratory of Molecular Biology on Infectious Diseases,Ministry of Education Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010,China(Chen YX,Huang AL and Ruan XZ) | 2007 | Chinese Medical Journal2007，，24： | 8 |
| 4 | Expression of macrophage migration inhibitory factor in acute ischemic myocardial injury显示文摘 | Lai KW Chen YX | 2003 | J Histochem Cytochem2003，51，5： | 1 |
| 5 | Mesenchymal stem celltherapy for diabetes through paracrine mechanisms显示文摘 | Xu YX Chen L Wang R | 2008 | Med Hypotheses2008，71，3： | 1 |
| 6 | Proteome analysis of muhidrug resistance in vincristine-resistant human gastric cancer cell line SGC7901/VCR 显示文摘 | Yang YX Xiao ZQ Chen ZC | 2006 | Proteomics2006，6，6： | 1 |
| 7 | Proteome analysis of mul- tidrug resistance in vincristine- resistance human gastric cancer cell line SCK37901/VCR显示文摘 | Yang YX Xiao ZQ Chen ZC | 2006 | Proteomics2006，6，6： | 1 |
| 8 | SMAD signaling,a novel pathway of angiotensinⅡ-induce renal fibrosis显示文摘 | Huang XR Li JH Chen YX | 2001 | J Am Soc Nephrol2001，12，： | 1 |
| 9 | Effects of lard on the formation of volatiles from the Maillard reaction of cysteine with xylose显示文摘 | Xu YX Chen QC Lei SJ | 2011 | Society of Chemical Industry2011，91，12： | 1 |
| 10 | In vitro study of the relationship between the structure of ginsenoside and its antioxidative or prooxidative activity in free radical induced hemolysis of human erythrocytes显示文摘 | Luo XY Liu GZ Chen YP Wang ZC Sun YX | 2003 | J Agric Food Chem2003，51，： | 1 |
| 11 | Dexamethasone enhances cell resistance to chemotherapy through increasing adhesion to extracellular matrix in human ovarian cancer cells显示文摘 | Chen YX Wang Y Fu CC | 2009 | Endocr Relat Cancer2009，23，： | 1 |
| 12 | Differential Patterns of MicroRNA Expression in Neuroblastoma Are Correlated with Prognosis,Differentiation,and Apoptosis显示文摘 | Chen YX Raymond LS | 2007 | Cancer Res2007，67，3： | 1 |
| 13 | Effects of taurine on proliferation and apoptosis of hepatic stellate cells in vitro显示文摘 | Chen YX Zhang XR Xie WF Li S | 2004 | Hepatobiliary Pancreat Dis Int2004，3，1： | 1 |
| 14 | Identification of cancer stem cell-like side population cells in human nasopharyngeal carcinoma cell line 显示文摘 | Wang J Guo LP Chen LZ Zeng YX Lu SR | 2007 | Cancer Res2007，67，8： | 1 |
| 15 | Determining the role of external beam radiotherapy in unresectable intrahepatic ch- olangiocarcinoma: a retrospective analysis of 84 patients 显示文摘 | Chen YX Zeng ZC Tang ZY | 2010 | BMC Cancer2010，10，： | 1 |
| 16 | The prognostic and risk-stratified value of hearttype fatty acid-binding protein in septic patients in the emergency department显示文摘 | Chen YX Li CS | 2014 | J Crit Care2014，29，4： | 1 |
| 17 | Panorama phylogenetic diversity and distribution of type A influenza viruses based on their six internal gene sequences显示文摘 | Chen JM Sun YX | 2009 | Virology Journal2009，6，： | 1 |
| 18 | p38 mitogen-activated protein kinase inhibition attenuates bum-induced liver injury in rats 显示文摘 | Chen XL Xia ZF Yu YX | 2005 | Bums2005，31，： | 1 |
| 19 | Heat shock protein 27:clue to understanding estrogen-mediated atheroprotection显示文摘 | Rayner K Chen YX Siebert T | | 0，，： | 1 |
| 20 | Relativity of hippocampal-HPA- PTSD显示文摘 | Chen SY He W Shi YX | 2010 | Chin Foreign Med Treat2010，25，： | 1 |
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